Clinical trials: Knee Disease
Knee Osteoarthritis
Glucosamine Unum In Die [Once A Day] Efficacy (GUIDE) Trial: Glucosamine Sulfate in Patients With Knee Osteoarthritis
The primary objective of this study is to evaluate the efficacy and safety of glucosamine sulfate versus placebo on the symptoms of knee osteoarthritis after 6 months of treatment, using acetaminophen as a reference symptomatic…
- Trial name
- NCT00110474
- Testing
- Glucosamine sulfate, Acetaminophen
- Where
- 13 sites in Portugal, Spain
- Volunteers
- 300 people
- Sponsor
- Rottapharm
Knee Osteoarthritis, Cartilage Degeneration
Effectiveness of Autologous Adipose-derived Stem Cells in the Treatment of Knee Cartilage Injury
This study was aimed to evaluate the efficacy and safety of Autologous Adipose-derived Mesenchymal Stem Cell Gel combine with High tibial osteotomy therapy in the treatment of cartilage damage in the knee.
- Trial name
- NCT03955497
- Testing
- Autologous Adipose-derived Mesenchymal Stem Cell Gel, Sodium Hyaluronate, Extraction of abdominal fat
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Qilu Hospital of Shandong University
Depression, Anxiety, Pain
Rational-emotional Behavioral Therapy (REBT) in Patients With Osteoarthritis and Concomitant Diseases Before Arthroplasty
The objective of this study was evaluation of the effectiveness of REBT on the emotional state of orthopedic patients with comorbidities before and after arthroplasty.
- Trial name
- REBT (NCT05971797)
- Testing
- REBT
- Where
- Russia
- Volunteers
- 95 people
- Sponsor
- Federal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty
Knee Osteoarthritis, Hip Osteoarthritis
A Disease-based Treatment Study for Diagnosed Osteoarthritis Utilizing Adipose-derived Regenerative Cells
This is a prospective, multi-location safety and effectiveness study, and data registry of autologous adult ADRCs generated by the Transpose® RT System in subjects with OA in the shoulder, wrist, knee, hip, or ankle.
- Conditions
- Knee Osteoarthritis, Hip Osteoarthritis, Ankle Osteoarthritis, Shoulder Osteoarthritis
- Trial name
- NCT04405297
- Testing
- Adipose-derived regenerative cells
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Sanford Health
Patellofemoral Pain Syndrome, Exertional Lower Leg Pain
Prevention of Injuries by an Exercise Program - a RCT
Overuse injuries are a major concern for physical active individuals. Study hypothesis is that an exercise programme based on known intrinsic risk factors can prevent overuse injuries in soldiers undergoing basic military…
- Trial name
- NCT00348647
- Testing
- physical training program to prevent injuries
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Amager Hospital
Osteoarthritis, Knee
The Effect of Medical Exercise Therapy on Pain, Function and Physical Activity in Patients With Knee Osteoarthritis
The aim of the project is to investigate effects of medical exercise therapy (MET) on patients with knee osteoarthritis. MET is a common physical therapy intervention, and the project aim to strengthen the evidence of this…
- Trial name
- NCT02905747
- Testing
- Medical Exercise Therapy
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- Norwegian University of Science and Technology
Knee Injuries and Disorders, Hip Injuries
Randomized, Controlled Trial Comparing the Effectiveness of Sedation-Epidural Anesthesia to Spinal Anesthesia in Outpatient Hip or Knee Arthroplasty.
To our knowledge, no study has compared the difference between these two NA techniques. Early postoperative adverse events like uncontrolled pain, orthostatic hypotension, urinary retention, and prolonged motor block are linked…
- Conditions
- Knee Injuries and Disorders, Hip Injuries, Anesthesia
- Trial name
- RCT SEA vs SA (NCT06332443)
- Testing
- Spinal anesthesia, Sedation epidural anesthesia
- Where
- Canada
- Volunteers
- 132 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Knee Osteoarthritis
Follow-up Study for Participants Jointstem Clinical Trial
This study is a long term follow-up study to investigate the safety of autologous transplantation of Adipose Tissue derived Mesenchymal stem cells (MSCs) in patient with Knee Osteoarthritis.
- Trial name
- NCT03509025
- Testing
- Jointstem
- Where
- 2 sites in South Korea
- Volunteers
- 11 people
- Sponsor
- R-Bio
Osteoarthritis, Rheumatoid Arthritis
Total Knee Replacement Using Simplex® or Cobalt™ Bone Cement
The purpose of this study is to collect radiographic and clinical outcomes of total knee replacement using Simplex® or Cobalt™ Bone Cement.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Knee Arthritis
- Trial name
- NCT00589485
- Testing
- Simplex® Bone Cement, Cobalt™ Bone Cement
- Where
- United States
- Sponsor
- Zimmer Biomet
Osteoarthritis of the Knee
A Study of the Efficacy and Safety of CF101 to Patients With Osteoarthritis of the Knee
This study will test the effectiveness of CF101 in treating the symptoms of osteoarthritis (OA) of the knee. Eligible patients will be given either CF101 or matching placebo tablets and their symptoms will be evaluated over the…
- Trial name
- NCT00837291
- Testing
- CF101
- Where
- Israel
- Sponsor
- Can-Fite BioPharma
Knee Osteoarthritis, Hip Osteoarthritis
Quality of Care for Knee and Hip Osteoarthritis in Elderly Patients
Introduction: Hip and knee osteoarthritis (OA) was ranked in 2010 as the eleventh highest contributor to global disability. In France in 2014, non-spinal OA was the leading self-reported cause of morbidity among adults over…
- Conditions
- Knee Osteoarthritis, Hip Osteoarthritis, Quality of Healthcare, Elderly
- Trial name
- QSAMISA (NCT04170218)
- Where
- France
- Volunteers
- 405 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy Volunteer, Rheumatoid Arthritis
Phenomics in Autoimmune and Inflammatory Diseases
The family of inflammatory/autoimmune systemic diseases (IAD) form a continuum from pure inflammatory diseases to pure autoimmune diseases, encompassing a large panel of inflammatory diseases with some autoimmune components, and…
- Conditions
- Healthy Volunteer, Rheumatoid Arthritis, Ankylosing Spondylitis, Systemic Lupus Erythematosus/Antiphospholipid Syndrome
- Trial name
- TRANSIMMUNOM (NCT02466217)
- Testing
- 1: AID groups, 2: Control groups
- Where
- 2 sites in France
- Volunteers
- 537 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Knee Osteoarthritis (Knee OA)
Immediate Effect of Mobilization with Movement on Squat Self-reported Functional Ability, Pain Intensity, and Pain-free Range of Motion in People with Knee Osteoarthritis
Mobilization with movement (MWM) appears to reduce pain, improve knee range of motion, and enhance physical functioning in individuals with knee osteoarthritis (KOA).
- Trial name
- NCT06887868
- Testing
- Mobilization with movement
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Escola Superior de Tecnologia da Saúde do Porto
Osteoarthritis, Knee
Nutramax Joint Health Formulation Biochemical Response Study
The Nutramax test article is a nutritional supplement that contains several ingredients shown to potentially provide benefit to patients suffering from a painful and sometimes debilitating condition of the knee called…
- Trial name
- NCT02614274
- Testing
- Nutraceutical joint health formulation
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Osteoarthritis
ActaVisc and ActaVisc Mx Intra-articular Injection for Pain Associated With Osteoarthritis in the Knee
To evaluate the safety and performance of ActaVisc™ intra-articular injection (ActaVisc) and ActaVisc Mx, for management of pain associated with osteoarthritis in the knee in patients who have failed to respond adequately to…
- Trial name
- NCT00665574
- Testing
- ActaVisc and ActaVisc Mx Intra-articular Injection
- Where
- 2 sites in Latvia
- Volunteers
- 23 people
- Sponsor
- Carbylan Therapeutics, Inc.
Pain and Anterior Cruciate Ligament Reconstruction
Effectiveness of Dry Needling and STM on Pain Management for Anterior Cruciate Ligament Reconstruction (ACLR)
The purpose of this study is to determine if dry needling (DN) and soft tissue mobilization (STM) is superior to standard treatment protocol for affecting pain, pain medication usage and measurements of range of motion (ROM)…
- Trial name
- NCT03506685
- Testing
- Dry needling and STM
- Where
- United States
- Sponsor
- Keller Army Community Hospital
Deformity
External Fixator Assisted Genu Varum Correction
Assessment of accuracy of correction of genu varum more than 20 degrees using external fixator assisted plating. Intraoperatively, the operative time needed for completion of accurate correction, torniquet use, blood loss will be…
- Trial name
- NCT03443648
- Testing
- External fixator assisted plaing
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Assiut University
Osteoarthritis, Knee
Orthosensor vs Conventional Total Knee Arthroplasty
In a randomized-controlled fashion, this investigation will evaluate the use of the Verasense technology to achieve optimal TKA balance.
- Trial name
- NCT03628378
- Testing
- Verasense
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- Columbia University
Knee Arthroplasty, Total, Robotic-assisted
RObotic-assisted Versus Conventional Knee Endoprosthetic Techniques
Rationale for conducting the study: The ROCKET study evaluates the clinical and economic outcomes of robot-assisted total knee arthroplasty (RTKR) compared with conventional total knee arthroplasty (TKR).
- Conditions
- Knee Arthroplasty, Total, Robotic-assisted, Osteoarthritis of the Knee
- Trial name
- ROCKETS (NCT06389435)
- Testing
- Robot-assisted total knee arthroplasty, Conventional total knee arthroplasty
- Where
- 2 sites in Sweden
- Volunteers
- 1,600 people
- Sponsor
- Danderyd Hospital
Knee Osteoarthritis
Investigating the Impact of Ex Vivo Ozone Injection on Synovial Fluids in Patients Diagnosed With Knee Osteoarthritis
The objective of this study is to examine the effect of varying ozone doses on the levels of pro-inflammatory cytokines in synovial fluid collected from individuals with knee osteoarthritis.
- Trial name
- NCT05824052
- Testing
- Ozone injection
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Uskudar State Hospital