Clinical trials: Knee Extension
Osteoarthritis
A Study of Pain Relief in Osteoarthritis
The purpose of this study is to compare the safety and pain-relieving ability of Vicodin CR to placebo in subjects with osteoarthritis (OA) of the hip or knee.
- Trial name
- NCT00298974
- Testing
- hydrocodone / acetaminophen extended release
- Where
- 83 sites in United States
- Volunteers
- 873 people
- Sponsor
- Abbott
Osteoarthritis; Knee
IDEA-033 Three Months Dose Finding in OA Followed by IDEA-033 Three Months Extension in OA
The study objective is the eluciation of the dose-response function in efficacy (and possibly safety) in order to determine an optimal dose with respect to efficacy and safety.
- Trial name
- NCT00316784
- Testing
- IDEA-033 (and rescue medication)
- Volunteers
- 704 people
- Sponsor
- IDEA AG
Osteoarthritis
Extension Study Of Tanezumab In Osteoarthritis
Safety extension study of Phase 3 Osteoarthritis trials with Tanezumab
- Trial name
- NCT00809783
- Testing
- tanezumab
- Where
- 226 sites in United States
- Volunteers
- 2,147 people
- Sponsor
- Pfizer
Osteoarthitis, Chronic Pain
Efficacy and Safety of Tapentadol Extended Release Tablets in the Treatment of Moderate to Severe Pain in Subjects With Knee Osteoarthritis
The purpose of this study was to examine a low and high dose of tapentadol extended release tablet taken orally twice a day to reduce pain in subjects suffering from chronic moderate to severe pain due to osteoarthritis of the…
- Conditions
- Osteoarthitis, Chronic Pain, Knee Pain
- Trial name
- NCT00745069
- Testing
- tapentadol HCl
- Volunteers
- 670 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Arthritis Knee
Quantitative Assessment of Walking (Squawk) With the Canary canturioTM te (CTE) Tibial Extension
The objective of this prospective study is to demonstrate accuracy of a limp detection model using a healthcare provider assessment as the non-reference standard.
- Trial name
- NCT05693818
- Testing
- Clinical Limping Evalution
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Canary Medical
Osteoarthritis of the Knee
An Extension Study of Duloxetine in Osteoarthritis and Knee Pain (Extension of F1J-JE-HMGX, NCT02248480)
The purpose of this study is to assess the safety and efficacy of duloxetine in participants with osteoarthritis and knee pain. The study will last for 1 year.
- Trial name
- NCT02335346
- Testing
- Duloxetine
- Where
- Japan
- Volunteers
- 93 people
- Sponsor
- Eli Lilly and Company
Pain, Postoperative
A Phase I Dose-escalation Study of a Single Administration of Extended-Release Injectable Suspension (ND-340)
This study focused on ND-340 extended release injection suspension for patients undergoing total knee arthroplasty with a one-time nerve blockade to assess drug side effects, pharmacokinetics and the effect of pain relief after…
- Trial name
- NCT04515953
- Testing
- ND-340, IV-PCA
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Nang Kuang Pharmaceutical Co., Ltd.
Osteoarthritis
Intra-articular Polyacrylamide Hydrogel in Gonarthrosis
The OLE was aimed to assess long-term safety and efficacy of one and two courses of IA HBISA in patients with knee osteoarthritis.
- Trial name
- NCT06429319
- Testing
- Hydrous biopolymer with silver ions "Argiform" (HBISA) endoprosthesis of synovial fluid NOLTREX™
- Where
- 4 sites in Russia
- Volunteers
- 65 people
- Sponsor
- Research Centre BIOFORM
Osteoarthritis
Analgesic Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Knee
To study the efficacy and safety of naproxcinod vs. placebo and naproxen in the treatment of signs and symptoms of Osteoarthritis.
- Trial name
- NCT00542555
- Testing
- Naproxcinod 375 mg, Naproxen, Naproxcinod 750 mg
- Volunteers
- 918 people
- Sponsor
- NicOx
Osteoarthritis Knee
Gel-One Treatment in Knee Osteoarthritis
The purpose of this study is to determine whether Gel-One demonstrates a superior effectiveness in osteoarthritis (OA) knee pain compared with phosphate buffered saline (PBS) injections.
- Trial name
- NCT01934218
- Testing
- Gel-One, PBS
- Where
- 41 sites in United States
- Volunteers
- 814 people
- Sponsor
- Seikagaku Corporation
Knee Osteoarthritis
CRx-102 Osteoarthritis Multicenter Evaluation Trial
CRx-102 is a synergistic combination drug candidate containing the cardiovascular drug dipyridamole and a very low dose of the glucocorticoid prednisolone.
- Trial name
- COMET-1 (NCT00521989)
- Testing
- CRx-102 (2.7/90), Prednisolone, CRx-102 (2.7/180)
- Where
- 58 sites in United States, Canada
- Volunteers
- 279 people
- Sponsor
- Zalicus
Osteoarthritis, Knee
A Study of the Efficacy and Safety of EUFLEXXA™ for Treatment of Painful Osteoarthritis of the Knee
This multicenter, randomized, double-blind study will be performed in approximately 600 subjects with chronic idiopathic osteoarthritis (OA) of the knee. An open-label safety extension will follow.
- Trial name
- NCT00379236
- Testing
- EUFLEXXA™
- Where
- United States
- Volunteers
- 588 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Tibial Fractures
Efficacy Study of Surgical Technique in Intramedullary Tibia Nailing, Using Trigen META Tibia Nails
Multicentre Prospective Randomized Clinical Trial, to evaluate patients after surgery for extra-articular tibial fractures treated with Smith\& Nephew's Trigen META intramedullary nailing system; comparing two surgical…
- Trial name
- TrigenMETA (NCT01358292)
- Testing
- Semi-extended Surgical Technique, Standard Surgical Technique
- Where
- 5 sites in Germany, Spain and 1 more
- Volunteers
- 95 people
- Sponsor
- Smith & Nephew Orthopaedics AG
Articular Cartilage Disorder of Knee, Articular Cartilage; Degeneration
Efficacy and Safety Study of Intra-Articular Injections of Autologous Peripheral Blood Stem Cells Following Subchondral Drilling Surgery for the Treatment of Articular Cartilage Injury in the Knee
This is a 24-month, multicenter, randomized, open-label, standard treatment-controlled, parallel-group, Phase 2 study for adults with large or complicated knee articular cartilage lesions and are candidates for knee joint…
- Trial name
- NCT03101163
- Testing
- Autologous peripheral blood stem cells and hyaluronic acid, Hyaluronic acid
- Where
- 2 sites in United States, Malaysia
- Volunteers
- 120 people
- Sponsor
- KLSMC Stem Cells, Inc.
Osteoarthritis, Chronic Pain
A Study of Embeda (Kadian NT, ALO-01) in Subjects With Pain Due to Osteoarthritis of the Hip or Knee
The purpose of this study is to evaluate the efficacy of Kadian NT (ALO-01) compared with placebo for treating moderate to severe chronic pain over a 12 week period.
- Trial name
- NCT00420992
- Testing
- ALO-01 (Morphine Sulfate Plus Naltrexone Hydrochloride Extended Release)
- Where
- 81 sites in United States
- Volunteers
- 547 people
- Sponsor
- Pfizer
Osteoarthritis, Knee
Treatment of Knee Osteoarthritis With PAAG-OA
This is a multi-center, randomized, double-blind clinical investigation to compare the effectiveness of intra-articular polyacrylamide hydrogel (PAAG-OA) and a hyaluronic acid, Synvisc-One to induce symptomatic benefit in…
- Trial name
- ROSA (NCT04045431)
- Testing
- PAAG-OA, Synvisc-One
- Where
- 3 sites in Denmark
- Volunteers
- 238 people
- Sponsor
- Contura
Osteoarthritis
Delivra Joint Health Cream In The Treatment Of Pain Caused By Osteoarthritis Of The Knee
The current clinical trial is designed to test the analgesic and anti-inflammatory efficacy of a topical cream compared to a placebo cream. The study population will be those with mild to moderate osteoarthritis of the knee.
- Trial name
- NCT02193711
- Testing
- Topical Arthritis Cream
- Where
- 2 sites in Canada
- Volunteers
- 160 people
- Sponsor
- Delivra, Inc.
Osteoarthritis, Knee
A Study to Evaluate Safety and Tolerability of MIV-711 in Osteoarthritis Patients
This is a multicentre, open-label, one-arm Phase II extension study to evaluate the safety and tolerability of MIV-711 in patients with knee joint osteoarthritis (OA).
- Trial name
- NCT03037489
- Testing
- MIV-711
- Where
- 4 sites in Bulgaria, Georgia and 2 more
- Volunteers
- 50 people
- Sponsor
- Medivir
Osteochondral Defect
Follow-Up Study Evaluating the Long Term Outcome of ChondroMimetic in the Treatment of Osteochondral Defects in the Knee
To investigate the long-term efficacy and safety of the medical device, ChondroMimetic, in subjects who were treated in the interventional study 0MCM0107 for osteochondral defects of the knee.
- Trial name
- NCT03385642
- Testing
- ChondroMimetic
- Where
- Hungary
- Volunteers
- 15 people
- Sponsor
- Collagen Solutions
Knee Osteoarthritis
Follow-up Study for Participants of Jointstem Phase 3 Clinical Trial
The purpose of this follow-up study is to investigate the efficacy and safety of autologous Adipose Tissue derived Mesenchymal stem cells (JOINTSTEM®) in patient with severe Knee Osteoarthritis.
- Trial name
- NCT04427930
- Testing
- JOINTSTEM
- Where
- 4 sites in South Korea
- Volunteers
- 129 people
- Sponsor
- R-Bio