Clinical trials: Knee Extension
Osteo Arthritis Knee
Utilization of a Knee Brace With Extension Swing
The purpose of this research is to help determine if use of the Guardian brace during prehab and post-op rehab after TKA can help improve functional outcomes and reduce the incidence of post-operative flexion contractures which…
- Trial name
- NCT05179044
- Testing
- Guardian Sport Rehabilitator knee brace
- Where
- United States
- Sponsor
- NYU Langone Health
Hamstring Shortness, Patellofemoral Pain Syndrome
Effect of Specific Versus General Hamstring Stretch on Clinical Outcomes in Patellofemoral Pain Syndrome (PFPS)
This randomized, Single-blind, parallel-group trial will compare the effects of three hamstring stretching interventions-general hamstring Muscle Energy Technique (MET), medial hamstring MET, and lateral hamstring MET-each…
- Conditions
- Hamstring Shortness, Patellofemoral Pain Syndrome, Hamstring Flexibility, Patellofemoral Pain (PFPS)
- Trial name
- PFPS (NCT07013617)
- Testing
- Transcutaneous Electrical Nerve Stimulation Device, Strength exercises for lower limb, Hamstring Stretch Muscle Energy Technique(MET) (General )
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Constrained Insert in Knee Arthroplasty
Primary Constrained Condylar Knee Arthroplasty Without Stem Extensions: Prevalence and Risk Factors
While performing a primary TKA in consecutive patients, a constrained insert may be necessary when adequate stability and soft tissue balance are not obtained.
- Trial name
- NCT03202225
- Testing
- constrained polyethylene
- Where
- Thailand
- Volunteers
- 246 people
- Sponsor
- Navamindradhiraj University
Periarticular Block, Osteoarthritis (OA)
Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA
Prospective Cohort of patients who are scheduled for a Robot Assisted Total Knee Arthroplasty (RATKA). A prospective survey of patient reported outcome measures (Numeric Rating Scale) will be obtained postoperatively of 72 hours…
- Conditions
- Periarticular Block, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee, Pain After Surgery
- Trial name
- NCT07430085
- Testing
- bupivacaine-meloxicam (extended release), Bupivacaine, Ketorolac
- Volunteers
- 150 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Healthy
Comparison of Muscle Energy Technique and Eccentric Training on Hamstring Flexibility in Healthy Young Adults
Flexibility is the ability of a muscle to lengthen and allow one joint (or more than one joint in series) to move through a full range of motion (ROM).Adequate flexibility is important to maintain balance, agility and…
- Trial name
- NCT05315063
- Testing
- Eccentric Training, Muscle Energy Technique (PIR)
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Osteoarthritis, Chronic Pain
A Study of Embeda (Kadian NT, ALO-01) in Subjects With Pain Due to Osteoarthritis of the Hip or Knee
The purpose of this study is to evaluate the efficacy of Kadian NT (ALO-01) compared with placebo for treating moderate to severe chronic pain over a 12 week period.
- Trial name
- NCT00420992
- Testing
- ALO-01 (Morphine Sulfate Plus Naltrexone Hydrochloride Extended Release)
- Where
- 81 sites in United States
- Volunteers
- 547 people
- Sponsor
- Pfizer
Osteoarthritis, Knee
Treatment of Knee Osteoarthritis With PAAG-OA
This is a multi-center, randomized, double-blind clinical investigation to compare the effectiveness of intra-articular polyacrylamide hydrogel (PAAG-OA) and a hyaluronic acid, Synvisc-One to induce symptomatic benefit in…
- Trial name
- ROSA (NCT04045431)
- Testing
- PAAG-OA, Synvisc-One
- Where
- 3 sites in Denmark
- Volunteers
- 238 people
- Sponsor
- Contura
Osteoarthritis
Delivra Joint Health Cream In The Treatment Of Pain Caused By Osteoarthritis Of The Knee
The current clinical trial is designed to test the analgesic and anti-inflammatory efficacy of a topical cream compared to a placebo cream. The study population will be those with mild to moderate osteoarthritis of the knee.
- Trial name
- NCT02193711
- Testing
- Topical Arthritis Cream
- Where
- 2 sites in Canada
- Volunteers
- 160 people
- Sponsor
- Delivra, Inc.
Electromyographic Response to Blood Flow Restriction Exercise in Healthy Adults
Electromyographic Response to Blood Flow Restriction Exercise in Healthy Adults
This pilot randomized contralateral within-participant study evaluated the immediate neuromuscular response to low-load knee extension exercise performed with and without blood flow restriction in healthy young adults.
- Trial name
- NCT07654608
- Testing
- Bilateral low-load knee extension exercise protocol, Pneumatic blood flow restriction cuff
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universidad de Extremadura
Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee
Extended Post-operative Oral TXA in Primary THA
The goal of this clinical trial is to learn if extended post-operative oral tranexamic acid (TXA) - a medication that reduces bleeding by slowing the breakdown of blood clots - can improve functional recovery following surgery in…
- Trial name
- NCT07685743
- Testing
- Extended oral tranexamic acid regimen
- Volunteers
- 170 people
- Sponsor
- Oregon Health and Science University
Osteoarthritis, Knee
A Study to Evaluate Safety and Tolerability of MIV-711 in Osteoarthritis Patients
This is a multicentre, open-label, one-arm Phase II extension study to evaluate the safety and tolerability of MIV-711 in patients with knee joint osteoarthritis (OA).
- Trial name
- NCT03037489
- Testing
- MIV-711
- Where
- 4 sites in Bulgaria, Georgia and 2 more
- Volunteers
- 50 people
- Sponsor
- Medivir
Osteochondral Defect
Follow-Up Study Evaluating the Long Term Outcome of ChondroMimetic in the Treatment of Osteochondral Defects in the Knee
To investigate the long-term efficacy and safety of the medical device, ChondroMimetic, in subjects who were treated in the interventional study 0MCM0107 for osteochondral defects of the knee.
- Trial name
- NCT03385642
- Testing
- ChondroMimetic
- Where
- Hungary
- Volunteers
- 15 people
- Sponsor
- Collagen Solutions
Osteoarthritis, Knee
Experimental Study of Strength Training to Activate the Quadriceps Muscle After Total Knee Arthroplasty
Background: Progressive strength training is a training modality used in rehabilitation after total knee arthroplasty (TKA). Strength deficits up to 80% in the quadriceps muscle is shown to be present in the operated leg after…
- Trial name
- NCT01713140
- Testing
- 1 strength training set performed until contraction failure
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Chronic Ankle Instability, CAI
Assessment of Torso Musculature and Hamstring Flexibility in Patients With Chronic Ankle Instability
The purpose of this study is to assess torso musculature in terms of static and dynamic core muscle endurance tests and hamstring flexibility in non-athletic patients with unilateral chronic ankle instability.
- Trial name
- NCT06925191
- Testing
- Group A (Experimental): 29 affected ankles of both genders diagnosed with Chronic ankle instability (CAI) who met the inclusion criteria. Group B (Control): 29 matched non-affected with CAI
- Where
- Egypt
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Cairo University
Total Knee Arthroplasty
Joint Movement to Increase Range of Motion in Knee Joint After Primary Total Knee Arthroplasty
The goal of this clinical trail is to investigate if specific active exercises, with a certain daily frequency improves the range of motion (ROM) in the knee joint after primary- or revision total knee arthroplasty (TKA) The main…
- Trial name
- ROM (NCT06188091)
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 83 people
- Sponsor
- Nordsjaellands Hospital
Primary Knee Replacement Surgery
Does Supplementing of Quadriceps Strength With Exoskeleton After Total Knee Arthroplasty in High Risk Population Reduce Transfer to Extended Care Facility (ECF)
This study involves an exoskeleton which is believed to increase quadriceps muscle strength in the rehabilitation phase after TKA and reduce the discharge the such patients in Extended care facility (ECF) .
- Trial name
- NCT03762603
- Testing
- Robotic exoskeleton device
- Where
- United States
- Sponsor
- Stanford University
Venous Thromboembolism
Extended Venous Thromboembolism Prophylaxis Comparing Rivaroxaban to Aspirin Following Total Hip and Knee Arthroplasty
In this study the investigators want to look at whether using aspirin instead of rivaroxaban (after initial treatment with rivaroxaban) works as well at preventing blood clots while also reducing risk of bleeding and is more cost…
- Trial name
- EPCAT II (NCT01720108)
- Testing
- rivaroxaban and ASA
- Where
- Canada
- Volunteers
- 3,426 people
- Sponsor
- David Anderson
Thromboembolism, Arthroplasty Replacement, Knee
Safety Study of Stopping Thromboprophylaxis Based on Ultrasound Results After Total Knee Replacement
The purpose of this study is to determine whether stopping Low Molecular Weight Heparin (LMWH) thromboprophylaxis is safe after total knee joint replacement.
- Trial name
- NCT00362492
- Testing
- Bilateral ultrasound examination 7+/- 2 after surgery
- Where
- 17 sites in France
- Volunteers
- 850 people
- Sponsor
- University Hospital, Caen
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction
The goal of this clinical trial is to learn whether taking oral tranexamic acid (TXA) for one week after anterior cruciate ligament (ACL) reconstruction improves recovery in adolescents and young adults aged 14 to 25 years.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Pain, Postoperative
- Trial name
- NCT07880743
- Testing
- Tranexamic Acid
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Dave Bernholt
Total Knee Arthroplasty
Measuring Every Day (MED) Study
Achieving adequate range of motion post Total Knee Arthroplasty(TKA) is an important goal for return to optimum function. Traditionally, adequate range of motion has been achieved by a combination of in-home and outpatient…
- Trial name
- MED (NCT03010605)
- Testing
- Measuring Every Day Device, Physical Therapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- The Christ Hospital