Clinical trials: Knee Joint
Knee Osteoarthritis
A Safety and Efficacy Study of Anti-inflammatory (Canakinumab) and Cartilage Stimulating (LNA043) Drugs Injected Into the Knee Joint of Participants With Knee Osteoarthritis (OA)
The study was established to show safety and efficacy of canakinumab and LNA043 in patients with knee osteoarthritis (OA).
- Trial name
- NCT04814368
- Testing
- canakinumab, LNA043
- Where
- 11 sites in United States, Czechia and 4 more
- Volunteers
- 23 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis, Rheumatoid Arthritis
Comparison of Rotating vs. Fixed Platform of the COLUMBUS Knee Prosthesis
A population of 100 patients randomised to rotating and fixed PE inlays in the Columbus knee prosthesis received a navigated TKR.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic; Arthrosis
- Trial name
- NCT00822640
- Testing
- Total Knee Arthroplasty
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Aesculap AG
Knee Osteoarthritis
A Study Evaluating the Safety and Efficacy of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis
This phase 2 study is a placebo-controlled, double-blind, parallel group study of four concentrations of SM04690 (0.03, 0.07, 0.15, and 0.23 mg per 2 mL injection) injected intraarticularly (IA) into the target knee joint of…
- Trial name
- NCT03122860
- Testing
- SM04690
- Where
- 74 sites in United States
- Volunteers
- 700 people
- Sponsor
- Biosplice Therapeutics, Inc.
Osteoarthritis Knee Pain
A Study in the Treatment of Osteoarthritis Knee Pain
To gather data on whether a new drug for osteoarthritis knee pain will be safe and have an effect on pain levels.
- Trial name
- NCT00790790
- Testing
- LY545694 49 mg, LY545694 105 mg
- Where
- 10 sites in United States, Puerto Rico and 1 more
- Volunteers
- 147 people
- Sponsor
- Eli Lilly and Company
Proprioceptive Disorders
Evaluation of Proprioceptive Abilities While Wearing an Elastic Orthosis in Patients With Proprioceptive Knee Deficits
The objective of the study is to compare, with or without wearing an elastic proprioceptive knee brace, the functional proprioceptive capacity of the knee in patients suffering from proprioceptive deficit.
- Trial name
- CAPROG (NCT05435040)
- Testing
- proprioceptive knee brace, No knee brace
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Thuasne
Osteoarthritis
Safety of Diclofenac Sodium Gel in Knee Osteoarthritis
This study will test the efficacy and safety of topical Voltaren in the treatment of knee osteoarthritis.
- Trial name
- NCT00171691
- Testing
- Diclofenac Topical Sodium Gel 1%
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Novartis
Articular Cartilage
Study of the Treatment of Articular Repair (STAR)
This study is a prospective, longitudinal, multi-center, within patient evaluation of patients with articular cartilage defects of the knee who have had an inadequate response to a prior non-Carticel surgical treatment.
- Trial name
- NCT00158613
- Testing
- Carticel (autologous cultured chondrocyte) implantation
- Where
- 28 sites in United States, Canada
- Volunteers
- 126 people
- Sponsor
- Vericel Corporation
Analgesia
Safety of F14 Following Total Knee Replacement
Open-label single-arm study in which all subjects receive F14 as part of a scheduled TKR and multimodal analgesia
- Trial name
- NCT04860635
- Testing
- F14 (sustained release celecoxib)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Arthritis Innovation Corporation
Osteoarthritis, Varus Malalignment
Ellipse Intramedullary High Tibial Osteotomy Nail Study
The purpose of this study is to collect outcomes data in patients implanted with the Ellipse IM HTO Nail System.
- Trial name
- NCT02519218
- Testing
- Ellipse Technologies Intramedullary High Tibial Osteotomy Nail System
- Volunteers
- 6 people
- Sponsor
- Ellipse Technologies, Inc.
Total Knee Arthroplasty, Revision Total Knee Arthroplasty
Multigen Plus CCK and AMF TT Cones Follow Up Study
This study is aimed to provide a clinical and radiographic evaluation of 68 condylar-constrained Total Knee Arthroplasty (TKA) using a single type of prosthesis (Multigen Plus CCK configuration), alone or involving the AMF TT…
- Trial name
- NCT05314491
- Testing
- Multigen Plus CCK, AMF TT cones
- Where
- 3 sites in Portugal, Slovakia and 1 more
- Volunteers
- 68 people
- Sponsor
- Limacorporate S.p.a
Osteoarthritis, Rheumatoid Arthritis
PS150 Total Knee Arthroplasty Outcomes Registry
This registry is intended to evaluate the clinical outcomes of the DePuy P.F.C. Sigma PS150 RP Total Knee System. 200 participants will be enrolled prospectively or retrospectively and the follow up period will be 5 years.
- Trial name
- NCT02319291
- Testing
- P.F.C. Sigma PS150 RP Total Knee System
- Where
- 4 sites in Australia, South Korea
- Volunteers
- 175 people
- Sponsor
- DePuy Orthopaedics
Knee Osteoarthritis
Assessment of Protective Effect of JOINS on Cartilage in Knee Osteoarthritis
A Pilot study Randomized and Double-blinded Placebo controlled In 2 parallel group (JOINS 200mg:Placebo = 1:1) Overall 24 months treatment (JOINS:Placebo comparison up to 12 months, Additional follow-up assessment up to 24…
- Trial name
- Joins_Carp_Ⅳ (NCT01293955)
- Testing
- JOINS 200mg
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- SK Chemicals Co., Ltd.
Knee Arthropathy
Post-market Clinical Follow-up on the balanSys UNI Knee Prosthesis Implanted With a Spacer Block Surgical Technique
The purpose of the study is the evaluation of the clinical and radiological long-term performance of the balanSys UNI fix in a multicenter routine clinical setting.
- Trial name
- NCT04598568
- Testing
- balanSys UNI
- Volunteers
- 116 people
- Sponsor
- Mathys Ltd Bettlach
Osteoarthritis, Knee
Protocol for the Clinical Evaluation of Lyophilized Amniotic Fluid in the Treatment of Knee Osteoarthritis
To evaluate the efficacy of Lyophilized amniotic fluid as compared to the Saline Injection, placebo control in the treatment of moderate osteoarthritis of the knee.
- Trial name
- NCT03074526
- Testing
- Amniotic Fluid
- Where
- 4 sites in United States
- Volunteers
- 156 people
- Sponsor
- MiMedx Group, Inc.
Pain, Postoperative
Safety and Efficacy Study of KAI-1678 to Treat Subjects With Postoperative Pain
The purpose of this study is to determine whether KAI-1678 is effective in the treatment of postoperative pain following total hip or total knee replacement.
- Trial name
- NCT01015235
- Testing
- KAI-1678, Ketorolac Tromethamine
- Where
- New Zealand
- Volunteers
- 90 people
- Sponsor
- KAI Pharmaceuticals
Defect of Articular Cartilage
HyaloFAST Trial for Repair of Articular Cartilage in the Knee
The purpose of this study is to evaluate the safety and efficacy of Hyalofast® scaffold with bone marrow aspirate concentrate (BMAC) compared to microfracture in the treatment of symptomatic cartilage defects of the knee.
- Trial name
- FastTRACK (NCT02659215)
- Testing
- Hyalofast, Microfracture
- Where
- 48 sites in United States, Austria and 7 more
- Volunteers
- 200 people
- Sponsor
- Anika Therapeutics, Inc.
Venous Thromboembolism
Evaluation of AVE5026 as Compared to Enoxaparin for the Prevention of Thromboembolism in Patients Undergoing Elective Knee Replacement Surgery
The primary objective was to compare the efficacy of Semuloparin sodium (AVE5026) with Enoxaparin for the prevention of Venous Thromboembolic Events [VTE] in patients undergoing elective knee replacement surgery.
- Trial name
- SAVE-KNEE (NCT00718224)
- Testing
- Semuloparin sodium, Enoxaparin
- Where
- 17 sites in United States, Argentina and 15 more
- Volunteers
- 1,150 people
- Sponsor
- Sanofi
Gonarthrosis, Knee Osteoarthritis
Evaluation of Intra-articular Injection of Autologous Protein Solution ("APS(TM)") for the Treatment of Osteoarthritis (OA)
This prospective single-center study will evaluate the safety and tolerability of a single dose of "APS(TM)" treated patients with OA of the knee who have failed conservative OA therapy.
- Conditions
- Gonarthrosis, Knee Osteoarthritis, Osteoarthritis
- Trial name
- NCT01773226
- Testing
- Autologous Protein Solution "APS(TM)"
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- Zimmer Biomet
Arthroplasty
Arthroplasty Cements Outcomes - A Post-market Follow-up
A Post-Market Clinical Follow-Up (PMCF) Study to collect clinical data on safety and performance of all Teknimed Arthroplasty range of products: CEMFIX® and GENTAFIX® bone cements families and CEMSTOP® cement restrictor, and all…
- Trial name
- NCT06354543
- Testing
- Cemented joint arthroplasty
- Where
- 10 sites in France, Italy
- Volunteers
- 1,050 people
- Sponsor
- Teknimed
Osteoarthritis
A Study of the Efficacy and Safety of Synvisc® in Chinese Subjects With Symptomatic Osteoarthritis of the Knee(s)
Primary Objective: To evaluate the change of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) A1 subscore (walking pain) at 26 weeks compared to the Baseline score To evaluate the safety using the incidence…
- Trial name
- NCT01586338
- Testing
- Hylan G-F 20
- Where
- China
- Volunteers
- 237 people
- Sponsor
- Sanofi
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