Clinical trials: Knee Joint
Knee Joint Pain
Effect of Topical PlexoZome® Levagen® Spray on Relief of Post Exercise Knee Joint Pain
This is a randomised, double-blind, placebo controlled, 2 arm parallel clinical trial to evaluate the effect of topical PlexoZome® Levagen® spray on relief of post exercise knee joint pain in healthy adults compared to placebo…
- Trial name
- NCT06351917
- Testing
- PlexoZome® Levagen® topical spray solution
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- RDC Clinical Pty Ltd
Subchondral Cyst
Knee Related Subchondral Bone Lesions Treated With IOBP
The study will be a prospective, multicenter clinical study evaluating clinical and patient reported outcome measures of subjects receiving IOBP® surgical technique using Angel cPRP and BMA processing system to treat subchondral…
- Trial name
- IOBP (NCT05314608)
- Testing
- IntraOsseous BioPlasty® (IOBP®) Surgical Technique into the knee
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Arthrex, Inc.
Mild Knee Osteoarthritis (WOMAC 20-32, VAS 2-4)
Efficacy of INTOFINE-JOINT SUPPORT DIETARY SUPPLEMENT on Bone and Joint Health
The goal of this clinical trial is to evaluate whether INTOFINE-JOINT SUPPORT DIETARY SUPPLEMENT improves joint health in adults aged 40-60 years with mild symptomatic knee osteoarthritis (defined by WOMAC total score 20-32 and…
- Trial name
- NCT07658950
- Testing
- INTOFINE-JOINT SUPPORT DIETARY SUPPLEMENT
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Hong Kong Junhuo Biotechnology Co., Limited
Osteoarthritis
A Study to Assess Efficacy and Safety of GLPG1972/S201086 in Participants With Knee Osteoarthritis
This study is a phase 2, 52-week international, multi-regional, multi-center, randomized, double-blind, placebo-controlled dose-ranging study for the treatment of osteoarthritis.
- Trial name
- Roccella (NCT03595618)
- Testing
- GLPG1972
- Where
- 44 sites in United States
- Volunteers
- 932 people
- Sponsor
- Lakefront Biotherapeutics NV
Osteoarthritis
Analgesic Efficacy And Safety of Tanezumab Added On To Diclofenac SR In Patients With Osteoarthritis Of The Knee Or Hip
The purpose of this study is to investigate the analgesic efficacy and safety of tanezumab added on to diclofenac SR in patients with osteoarthritis of the knee or hip currently experiencing partial benefit from, and are…
- Trial name
- NCT00864097
- Testing
- tanezumab, diclofenac
- Where
- 77 sites in Austria, France and 8 more
- Volunteers
- 607 people
- Sponsor
- Pfizer
Articular Cartilage Defect
Superiority of MACI® Versus Microfracture Treatment in Patients With Symptomatic Articular Cartilage Defects in the Knee
The objective of this trial is to demonstrate superior efficacy and safety of MACI compared with arthroscopic microfracture in the treatment of patients (aged 18 to 55 years) with symptomatic articular cartilage defects of the…
- Trial name
- SUMMIT (NCT00719576)
- Testing
- autologous cultured chondrocytes on porcine collagen membrane, Microfracture
- Where
- 20 sites in Czechia, France and 5 more
- Volunteers
- 144 people
- Sponsor
- Vericel Corporation
Osteoarthritis, Knee
A Study of LY2951742 in Participants With Mild to Moderate Osteoarthritis Knee Pain
The main purpose of this study is to test if LY2951742 relieves mild to moderate knee pain. The study drugs will be given as an injection under the skin and as an oral capsule.
- Trial name
- NCT02192190
- Testing
- LY2951742, Celecoxib
- Where
- 38 sites in United States
- Volunteers
- 268 people
- Sponsor
- Eli Lilly and Company
Osteoarthritis of Knee
Study to Assess the Effect of E-OA-07 on Acute Pain Response in Subjects Suffering From Knee OA
The repetitive motions associated with active life and many sports can increase the wear and tear to the joints that leads to decrease in flexibility and joint pain finally heading its way to osteoarthritis.
- Trial name
- Osteolanc (NCT02417506)
- Testing
- E-OA-07 (Lanconone), Ibuprofen
- Where
- India
- Volunteers
- 72 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Peripheral Arterial Disease Below the Knee, Peripheral Arterial Disease, Rutherford 4 and 5 with Possibility to Improve Vascularization
Below-the-Knee Interventions for Limb Salvage: Use of Multifunctional Angioplasty Balloon Catheters
Below-the-Knee Interventions for Limb Salvage: Use of Multifunctional Angioplasty Balloon Catheters ("BTK Multicath Registry") A non-randomized clinical registry This study is designed to obtain preliminary data on clinically…
- Trial name
- NCT06906055
- Testing
- Multicath, Standard of Care (SOC)
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Summa Therapeutics, LLC
Osteoarthritis of the Knee
Efficacy and Safety Study of PG201 Tablet in Patients With Osteoarthritis
The objective of this study was to explore the efficacy, dose-response and safety of PG201 tablet in Korean patients with osteoarthritis.
- Trial name
- NCT01122485
- Testing
- PG201
- Sponsor
- Helixmith Co., Ltd.
Osteoarthritis of the Knee
Polycan in Combination With Glucosamine for Treatment of Knee Osteoarthritis
The objectives of this study is to examine the Safety and Efficacy of black yeast beta-glucan produced from Aureobusidium pulluluns SM-2001 (Polycan), in combination with glucosamine in reducing knee osteoarthritis (OA) associated…
- Trial name
- NCT03717714
- Testing
- Glucosamine 1500 mg, Polycan 50mg + Glucosamine 750 mg, Polycan 50mg + Glucosamine 1500 mg
- Where
- Vietnam
- Volunteers
- 90 people
- Sponsor
- Vietstar Biomedical Research
Pain
A Real-World Evidence Study to Evaluate the Effects of Voltaren Use on Mobility and Quality of Life in Participants With Knee Osteoarthritis Pain
The purpose of this study is to investigate how topical diclofenac use can improve functional mobility and physical activity primarily, as well as other quality-of-life (QoL) parameters such as sleep, mood, and engagement in…
- Trial name
- NCT06379893
- Testing
- Voltaren Gel
- Where
- 8 sites in United States, Poland
- Volunteers
- 196 people
- Sponsor
- HALEON
Osteoarthritis of the Knee
Study of FX006 vs Normal Saline in Patients With Osteoarthritis of the Knee
The purpose of this study was to assess the magnitude and duration of pain relief of a single IA injection of 2 doses (16 and 32 mg) of FX006, an extended-release formulation of TCA, relative to normal saline (placebo control).
- Trial name
- NCT02116972
- Testing
- FX006 32 mg, FX006 16 mg
- Where
- 44 sites in United States, Canada
- Volunteers
- 310 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteoarthritis, Knee
Clinical Trial of YYD302 for Treatment of Osteoarthritis of the Knee
This is a multicenter, randomized, double-blinded, parallel, placebo-controlled, phase I/IIa clinical trial of YYD302 for treatment of osteoarthritis of the knee.
- Trial name
- NCT02965495
- Testing
- YYD302 2ml, YYD302 3ml
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Osteoarthritis, Knee and Hip
Change in Patient Reported Outcomes and Wish for Joint Surgery
Aim To investigate associations between within-person change in patient reported outcomes (PROMs) and wish for joint surgery during up to 12-month participation in a digital first-line intervention for knee and hip osteoarthritis…
- Trial name
- NCT05455177
- Testing
- Digital first-line intervention for osteoarthritis including exercise and education
- Where
- Sweden
- Volunteers
- 14,018 people
- Sponsor
- Joint Academy
Thrombosis, Venous
A Study to Evaluate the Efficacy and Safety of Fondaparinux for the Prevention of Venous Blood Clots in Patients With a Plaster Cast or Other Type of Immobilization for a Below-knee Injury Not Needing Surgery
The purpose of this study is to evaluate the efficacy and safety of fondaparinux in comparison with a heparin (nadroparin) in preventing deep vein thrombosis (blood clots in the leg veins), whether symptomatic or detected by…
- Trial name
- FONDACAST (NCT00843492)
- Testing
- Fondaparinux sodium, Nadroparin
- Where
- 122 sites in France, Germany and 4 more
- Volunteers
- 1,351 people
- Sponsor
- GlaxoSmithKline
Knee Osteoarthritis
Study of the Effect of Chondroitin Sulfate on Structural Changes in Knee Osteoarthritis Patients Assessed by MRI
The main purpose of this study is to compare the cartilage volume loss at the Baseline visit and after 24 months of treatment in patients treated with CHONDROITIN SULPHATE (CONDROSAN) 1200 mg daily vs.
- Trial name
- MOSAIC (NCT01354145)
- Testing
- Chondroitin sulfate, Celecoxib
- Where
- 5 sites in Canada
- Volunteers
- 194 people
- Sponsor
- Bioiberica
Osteo Arthritis Knee
MISHA Post-Market Clinical Study
Prospective evaluation of the safety and effectiveness of the MISHA Knee System. The study will collect data on the procedural and long-term adverse events, WOMAC pain and function scores, KSS satisfaction, subsequent surgical…
- Trial name
- NCT06118892
- Testing
- MISHA Knee System
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- Moximed
Peripheral Artery Disease, Critical Limb Ischemia
Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the Knee
A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the effect of Temsirolimus Perivascular Injection 0.1 mg/mL on the incidence of ischemia-driven major amputation, clinically driven target lesion…
- Trial name
- TANGO-3 (NCT04433572)
- Testing
- Temsirolimus
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Mercator MedSystems, Inc.
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Neocartilage Implant to Treat Cartilage Lesions of the Knee
ISTO Technologies, Inc. is proposing a clinical study with 225 subjects, to establish the safety and efficacy of the Neocartilage Implant for the treatment of ICRS Grade 3 and 4 articular cartilage lesions of the knee compared to…
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01400607
- Testing
- Neocartilage Implant/DeNovo® ET (Engineered Tissue Graft), Microfracture
- Where
- 9 sites in United States
- Volunteers
- 14 people
- Sponsor
- ISTO Technologies, Inc.
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