Clinical trials: Knee Joint
Drug-Drug Interaction
Drug-Drug Interaction Study of Lorecivivint and Triamcinolone Acetonide in Healthy Volunteers
This study will be an open-label, parallel-arm study to determine if a prior intra-articular (IA) injection of lorecivivint (LOR) affects the safety, tolerability, and/or pharmacokinetics (PK) of a subsequent IA injection of the…
- Trial name
- NCT04598542
- Testing
- Lorecivivint (LOR), Triamcinolone acetonide (TA)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Biosplice Therapeutics, Inc.
Surgical Site Infection, Zonulin
Zonulin Biomarker for Diagnosis of Hip and Knee Infections
Prior studies investigating the etiopathogenesis of surgical site infection (SSI) traditionally suggested three main ways for the infection to occur: local contamination occurring during the surgery, hematogenous translocation of…
- Trial name
- NCT04666519
- Testing
- Zonulin Biomarker
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Osteo Arthritis Knee, Pain, Chronic
Study of the Effects of Photobiomodulation in Patients With Osteoarthritis
PhotoBioModulation (PBM) is a mature science with therapeutic efficacy in humans and animals, and with excellent results in different medical specialties without side effects.
- Conditions
- Osteo Arthritis Knee, Pain, Chronic, Inflammation
- Trial name
- NCT03924128
- Testing
- Photobiomodulation
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy
Is Standard 3-degree of External Rotation for Posterior Femoral Cut Relevant for Turkish Population
The aim of this study is to evaluate the posterior condylar angle of the distal femur in Turkish population and its concordance with the current standard prosthesis designs used in total knee arthroplasty and to evaluate…
- Trial name
- NCT04355182
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Gonarthrosis, Serum Albumin Low
PROGNOSTIC ROLE OF SERUM ALBUMIN LEVEL IN RADIOLOGICAL PROGRESSION OF GONARTHROSIS: IS IT A BIOMARKER IN ITSELF? A BIOMARKER ASSOCIATED WITH SYSTEMIC INFLAMMATION?
The aim of our study is to evaluate the prognostic roles of serum albumin level and systemic inflammation-related indices, including and not including serum albumin level, in the radiological progression of gonarthrosis.
- Trial name
- NCT06159751
- Testing
- serum albumin level
- Where
- Turkey (Türkiye)
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Ufuk University
Physical Therapy
Traditional PT v Internet Based PT After Total Knee Arthroscopy
Knee arthroscopy results in significant improvements in functional outcomes, pain relief and quality of life for patients suffering from mechanical symptoms associated with meniscal tears.
- Trial name
- NCT04843280
- Testing
- FORCE therapeutics (physical therapy), Traditional Outpatient Physical Therapy
- Where
- United States
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Acute Pain, Arthropathy of Knee
NSS-2-BRIDGE Study for Total Knee and Hip Arthroplasties, Bariatric, and Kidney Transplant Surgeries
The current opioid epidemic has led to a renewed interest in exploring non-pharmacological techniques to treat post-operative pain.
- Conditions
- Acute Pain, Arthropathy of Knee, Arthropathy of Hip, Pain, Postoperative
- Trial name
- NCT03834142
- Testing
- NSS-2 Bridge
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jacques E. Chelly
Osteoarthritis of the Knee
Genicular Radiofrequency Ablation for Unilateral Knee Arthroplasty Pain Management
Three primary reasons prolong hospital stays following unilateral knee arthroplasty. Pain is the primary reason followed by opioid drowsiness and nausea/vomiting side effects.
- Trial name
- RFA (NCT02925442)
- Testing
- t-RFA, C-RFA, Control
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Lyman Medical Research Foundation, Inc.
Total Knee Replacement
Knee4Life Project: Empowering Knee Recovery After Total Knee Replacement Through Digital Health
The research project will investigate the extent to which a smartphone camera sensor tool can help predict and measure knee stiffness and pain after Total Knee Replacement Surgery (TKR) and how a tool such as this could be…
- Trial name
- K4L (NCT06429462)
- Testing
- smartphone camera sensor tool
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Knee, Arthroscopy
Analgesic Control Following Knee Arthroscopy
This study aims to investigate the analgesic effects offered by bupivacaine and Durolane (a hyaluronic acid supplement) administered immediately following the completion of knee arthroscopy.
- Conditions
- Knee, Arthroscopy, Analgesia
- Trial name
- NCT01169389
- Testing
- Intraarticular injection, Intra-articular injection of 0.5% Bupivacaine
- Where
- Ireland
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Research and Innovation Foundation, Ireland
Knee Arthropathy
Motivational Feedback Following Total or Unicompartmental Knee Arthroplasty
The goal of this randomized controlled trial (RCT) nested in a prospective cohort study is to investigate whether physical activity (PA) following total knee arthroplasty (TKA) or unicompartmental knee arthroplasty (UKA) can be…
- Trial name
- KneeActivity (NCT06005623)
- Testing
- SENS Motion + Motivational Feedback
- Where
- 4 sites in Denmark
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Knee Osteoarthritis, Knee Pain Chronic
The Effect of PEMF for Patients With Knee OA
Health care costs are increasing alarmingly, which will impose an overwhelming economic burden to an aging society like that of Hong Kong.
- Trial name
- NCT05548712
- Testing
- Pulse Electromagnetic Field
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Osteoarthritis
An Investigation of ReNu™ Knee Injection in Patients With Osteoarthritis
This is a Prospective, Randomized study evaluating the efficacy of ReNu for the treatment of Kellgren-Lawrence grade 2 or 3 osteoarthritis.
- Trial name
- NCT02318511
- Testing
- Knee injection, ReNu amniotic allograft, Hyaluronic Acid
- Where
- 12 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NuTech Medical, Inc
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Lower Limb Amputation Above Knee (Injury)
The CYBERnetic Lower Limb Cocognitive Ortho-prosthesis Plus Plus, 1st Clinical Study (CLs++)
The aim of the study is to assess the efficacy and the usability of the cyberlegs ++ ortho prosthesis to improve the mobility and the quality of life in transfemoral amputees .
- Trial name
- NCT03376919
- Testing
- CLs++ gait training
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Knee Injuries and Disorders
Different Arm Positions During Single Leg Squat
The aim of this study is to compare the effects of different arm positions on muscle activity during single leg squat.
- Trial name
- NCT05420675
- Testing
- Single Leg Squat
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Osteoarthritis, Knee, Arthroplasty
Comparison of Three Knee Replacements
The present randomized controlled trial is designed to compare one novel total knee replacement (TKR) design and two conventional TKR designs in terms of functional outcome.
- Conditions
- Osteoarthritis, Knee, Arthroplasty, Total Knee Replacement
- Trial name
- NCT03339557
- Testing
- NexGen, Persona, PFC
- Where
- Finland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Coxa, Hospital for Joint Replacement
Osteoarthritis, Knee
Human Growth Hormone Injections in the Knee Joint to Treat Osteoarthritis
The goal of this clinical trial is to learn if growth hormone injections can be used to treat osteoarthritis (OA) in the knee. Human studies have shown that repeated injections of human growth hormone leads to the production of…
- Trial name
- NCT06354023
- Testing
- Recombinant human growth hormone
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- John Sledge
Knee Osteoarthritis
Evaluation of Femoral Cartilage Thickness After Treadmill and Tartan Track Walking
The aim of this study is to measure and compare the femoral cartilage deformation after walking on the treadmill and tartan floor in patients with knee osteoarthritis (OA) and healthy volunteers.
- Trial name
- NCT05316792
- Testing
- walking
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Osteoarthritis
Pain Expectations in Subjects With Osteoarthritis
The purpose of this research study is to test whether or not researchers can alter or change expectations on pain. The researchers will test whether there is an effect on the size of the pupil and responses to thermal heat…
- Trial name
- NCT02155257
- Testing
- Modafinil, Gabapentin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
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