Clinical trials: Knee Joint Loading
Rehabilitation, ACL Reconstruction
Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes
The overall goal of this project is to reduce risk of second anterior cruciate ligament (ACL) injury in vulnerable populations (active athletes between 14 = 24 years old) through the identification of relative injury risk groups…
- Trial name
- NCT03190889
- Testing
- HOME, TNMT
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- Mayo Clinic
Osteoarthritis, Knee
Dual-task Gait Performance in People With Knee Osteoarthritis Before and After Knee Replacement Surgery
Knee Osteoarthritis (OA) is one of the most common conditions causing disability and limitation in the elderly population, with 13% of women and 10% of men over the age of 60 suffering from symptomatic knee osteoarthritis.
- Trial name
- NCT04877873
- Testing
- Gait analysis pre- and post- surgery
- Where
- Israel
- Volunteers
- 38 people
- Sponsor
- University of Haifa
Total Knee Arthoplasty
Antibiotic Loaded Cement After TKA
This study will provide us with clear information about the postoperative concentration of antibiotic reached in synovial fluid, thereby helping surgeons to determine if concentration could potentially prevent the growth and…
- Trial name
- NCT05429671
- Testing
- total knee arthroplasty, Tobramycin, Gentamicin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Knee Osteoarthritis
Effects of Two Bar Knee Off-Load Brace With Non Weight Bearing Strength Training Among Knee Osteoarthritis Patients
The current study is a single-blind, parallel-group randomized controlled trial involving 18 participants with knee osteoarthritis.
- Trial name
- NCT07562646
- Testing
- Two-Bar Knee Off-Load Brace with Non-Weight Bearing Strength Training Intervention, Standard Knee Off-Loader Brace with Non-Weight Bearing Strength Training Intervention
- Volunteers
- 18 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Knee Osteoarthritis
Cartilage Biomarker Response to Acute Mechanical Loading in Women With Knee Osteoarthritis: Comparison by Antiresorptive Treatment Status
This study evaluates how acute mechanical loading affects cartilage degradation biomarkers in postmenopausal women with mild-to-moderate knee osteoarthritis.
- Trial name
- NCT07881861
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Knee Injuries
Effect of Loading of Midazolam or Dexmedetomidine on Hemodynamics
Loading dose of dexmedetomidine is related hemodynamic instability such as bradycardia and hypertension.
- Trial name
- NCT02634021
- Testing
- dexmedetomidine group, midazolam group
- Where
- South Korea
- Sponsor
- Konkuk University Medical Center
Lower Limb Amputation Below Knee (Injury)
Restoration of Normative Postural Control
The objective of this proposal is to investigate the effects of training to use direct electromyographic (dEMG) control of a powered prosthetic ankle on transtibial amputees'. The aimed questions to answer: 1.
- Trial name
- NCT06452186
- Testing
- direct EMG controlled prosthetic ankle, PT guided prosthetic training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- North Carolina State University
ACL Injury
Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes
Females who participate in cutting and landing sports suffer anterior cruciate ligament (ACL) injuries at a 2 to 10-fold greater rate than males participating in the same high-risk sports.
- Trial name
- NCT01034527
- Testing
- Neuromuscular Training
- Where
- United States
- Volunteers
- 593 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Knee Osteoarthritis, Osteearthritis
Effect of 0° and 50° N-K Table Load Angles on Quadriceps Activation in Knee Osteoarthritis
Knee osteoarthritis (OA) is a common degenerative joint disease that leads to pain, reduced mobility, and functional limitation. Quadriceps femoris weakness plays a significant role in disease progression and disability.
- Trial name
- NCT07456254
- Testing
- Isotonic Quadriceps Exercise Using NK Table
- Where
- Indonesia
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Quadriceps Muscle
Macroscopic and Molecular Changes in Knee Muscular-tendon Unit in Response to Acute Resistant Load
The aim of this study is to determine the influence of acute resistance exercises on anatomical and biological changes in the quadriceps muscle and tendons of the knee
- Trial name
- NCT03950596
- Testing
- Acute resistant load exercises, Background Questionnaire, Pain Questionnaire
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Osteoarthritis, Knee
Reducing Knee Compression When Sleeping in Those With Knee OA
To determine whether a change in sleeping position so as to prevent the knee being 'pushed' into full extension when lying supine provides pain relief and/or symptom improvement in individuals with knee osteoarthritis (OA).
- Trial name
- NCT04188054
- Testing
- Change in sleeping position, No change in sleeping position
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Bradford
Transtibial Amputee, Loading
The Effect of Different Measurement-manufacturing Techniques on Load Distribution in Amputees
Alignment of the prosthesis with the stump is performed through the socket. Good socket stump fit provides near-normal posture and weight-transfer pattern. It also ensures that the walk is painless and low-energy.
- Conditions
- Transtibial Amputee, Loading, Conventional, 3D
- Trial name
- NCT04326712
- Testing
- conventional manufactured socket, 3D manufactured socket
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Marmara University
Patellar Tendinopathy, Jumper's Knee
Blood Flow Restriction Training for Treatment of Chronic Patellar Tendinopathy
The purpose of this study is to investigate the clinical and functional outcome of a 12-week rehabilitation regime consisting of Low-Load Blood Flow Restriction compared to Heavy-Slow Resistance training in male patients with…
- Trial name
- NCT04550013
- Testing
- Heavy-Slow Resistance training, Low-Load Blood Flow Restriction training
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- Bispebjerg Hospital
Pulmonary Embolism, Atrial Fibrillation
Study to Find Out the Appropriate Initial Dose of the Anticoagulant Drug Phenprocoumon
Oral anticoagulation is often initiated in hospitalized patients. Although the therapeutic range of phenprocoumon is narrow, the individual drug demands unfortunately vary greatly between persons.
- Conditions
- Pulmonary Embolism, Atrial Fibrillation, Hip Replacement Postoperative, Knee Replacement Postoperative
- Trial name
- NCT00586287
- Testing
- Algorithm for phenprocoumon, Phenprocoumon
- Where
- Switzerland
- Volunteers
- 302 people
- Sponsor
- Cantonal Hospital of St. Gallen
Patellar Tendinopathy, Jumper's Knee
Patellar Tendinopathy - The Effect of Load Magnitude in Exercise-based Treatment
The purpose of this project is to investigate if the magnitude of a loading based 12 weeks rehabilitation regime for patellar tendinopathy influence the clinical outcome, tendon structure and function.
- Trial name
- NCT03096067
- Testing
- Heavy slow resistance training, Moderate slow resistance training
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- Bispebjerg Hospital
Knee Osteoarthritis
Wedged Insoles for Management of Knee Osteoarthritis
Knee osteoarthritis (OA) is commonly treated using laterally wedged insoles. Although these insoles typically reduce knee abduction moments (KAM) - a variable associated with knee osteoarthritis - and thus are believed to be…
- Trial name
- NCT02067208
- Testing
- wedged insole
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University of Calgary
ACL Reconstruction, ACL Repair
Isokinetic Exercise Combined With Blood Flow Restriction: High-Load Vs Low-Load Training
The goal of this clinical trial is to see which type of strengthening exercise with a tight band (blood flow restriction) helps people recover better after ACL reconstruction.
- Trial name
- NCT07384780
- Testing
- High Load Isokinetic Training with Blood Flow Restriction, Low Load Isokinetic Training with Blood Flow Restriction
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Hypertrophy, Muscle Strength
Effect of Low-load Resistance Training vs. High-intensity Interval Training on Local Muscle Endurance
Local muscle endurance (LME) is the ability of a muscle(s) to resist fatigue and is needed for daily activities of life such as climbing stairs, lifting/moving objects, and in sport contexts like rock climbing, mixed martial…
- Conditions
- Hypertrophy, Muscle Strength, High-Intensity Interval Training, Resistance Training
- Trial name
- LLSIT (NCT05945641)
- Testing
- Low Load Resistance training, Sprint/High Intensity Interval Training
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Osteoarthritis, Knee, Osteoarthritis, Hip
Phase II Study of CG100649 for Primary Osteoarthritis in Male Subjects
The primary objective of this study is to evaluate the safety and efficacy of 3 loading and maintenance dose levels of CG100649 administered for 21 days in the treatment of osteoarthritis pain.
- Trial name
- NCT00530452
- Testing
- CG100649, Silicified microcrystalline cellulose + talc
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- CrystalGenomics, Inc.
Total Knee Replacement
The Efficacy of Low-load Blood Flow Restricted Resistance Before TKR
The primary aim of this study is to investigate the efficacy of 8 weeks of Low-load blood flow restricted exercise (BFRE) compared to receiving standard care only (no preoperative training) before total knee replacement (TKR) on…
- Trial name
- NCT04081493
- Testing
- Low-load blood flow restricted exercise
- Where
- 3 sites in Denmark
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Aarhus