Clinical trials: Knee OA
Osteoarthritis, Knee
Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain
The purpose of this study is to measure the change in pain and function with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with subcutaneous injections of placebo in participants with knee osteoarthritis…
- Trial name
- NCT04809376
- Testing
- Pentosan Polysulfate Sodium twice weekly, Pentosan Polysulfate Sodium Fixed Dose, Pentosan Polysulfate Sodium once weekly
- Where
- 33 sites in United States, Australia
- Volunteers
- 602 people
- Sponsor
- Paradigm Biopharmaceuticals USA (INC)
Musculoskeletal Disorders, Knee Osteoarthritis (OA)
Effectiveness of a Mobile Telerehabilitation Tool Versus Conventional Treatment in Total Knee Arthroplasty
Knee arthroplasty is one of the most common surgical procedures, and early rehabilitation is essential for patient recovery, pain modulation and a faster reintegration into daily life activities.
- Trial name
- NCT06735547
- Testing
- Telerehabilitation, Conventional therapy group
- Where
- Colombia
- Volunteers
- 216 people
- Sponsor
- Sanitas University
Knee Osteoarthritis
Heart Rate Variability Guided Physical Activity and Exercise Prescription in Individuals With Knee Osteoarthritis
The aim of this trial is to conduct a 12-week randomised controlled trial comparing an HRV-guided home exercise program with traditional home exercise program for individuals with knee osteoarthritis (KOA), followed by 24-week…
- Trial name
- HOPE-OA (NCT07391449)
- Testing
- HRV-guided home exercise prescription, Traditional Home Exercise
- Where
- Hong Kong
- Volunteers
- 240 people
- Sponsor
- The Hong Kong Polytechnic University
Osteoarthritis of the Knee
Study to Characterize the PK and Local Extent and Duration of Exposure From FX006 in Patients With OA of the Knee
The objectives of this study were to characterize the local extent and duration of exposure of TA from FX006 and TCA IR, characterize the systemic PK of FX006 and TCA IR, and assess the safety and general tolerability of a single…
- Trial name
- NCT02637323
- Testing
- FX006 32 mg, TCA IR 40
- Where
- 4 sites in United States
- Volunteers
- 81 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Osteoarthritis
To Look at the Characteristics of Synovial Fluid and Cartilage Matrix in Osteoarthritic Knee After Hyaluronic Acid Injection
The purpose of this study is to identify novel imaging markers for characterizing the biochemical profiles in synovial fluid and cartilage matrix in OA knee joints after intra-articular HA (Euflexxa) injection using high field…
- Trial name
- NCT01895959
- Testing
- Euflexxa, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Osteoarthritic Knee Pain, Osteo Arthritis of the Knee
Effects of High-Intensity Laser Therapy Combined With Exercise in Patients With Knee Osteoarthritis
The goal of this clinical trial was to determine whether high-intensity laser therapy (HILT) combined with exercise improves pain, physical function, and muscle strength in people with knee osteoarthritis.
- Conditions
- Osteoarthritic Knee Pain, Osteo Arthritis of the Knee, Osteoarthitis, Osteoarthritis (OA) of the Knee
- Trial name
- HILT-KOA (NCT07630259)
- Testing
- High Intensity Laser Therapy, Exercise
- Where
- Chile
- Volunteers
- 31 people
- Sponsor
- Universidad Metropolitana de Ciencias de la Educacion
Osteoarthritis, Knee
A Controlled Study of an Herbal Topical Patch in Treating Osteoarthritis (OA) of the Knee
An evaluation of the safety and efficacy of an herbal patch in treating osteoarthritis pain of the right or left knee.
- Trial name
- NCT01183624
- Testing
- Herbal Patch
- Where
- 12 sites in China
- Volunteers
- 626 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Osteoarthritis, Pain
Study of Efficacy, Safety of Fulranumab Monotherapy for OA of Hip or Knee, PAI3002
The purpose of this study is to demonstrate the efficacy, safety, and tolerability of fulranumab as Monotherapy compared with placebo in participants with signs and symptoms of osteoarthritis of the hip or knee that are not…
- Trial name
- NCT02336698
- Testing
- Fulranumab 1 mg, Fulranumab 3 mg
- Where
- 32 sites in United States, Poland and 2 more
- Volunteers
- 18 people
- Sponsor
- Janssen Research & Development, LLC
Osteoarthritis, Knee Osteoarthritis
The Impact of a Seated Compact Elliptical Trainer on Individuals With Knee OA
Exercise is considered the most effective, non-drug treatment for reducing pain and improving movement in patients with osteoarthritis.
- Conditions
- Osteoarthritis, Knee Osteoarthritis, Arthritis, Joint Diseases
- Trial name
- NCT05857605
- Testing
- Exercise for Knee Osteoarthritis, Compact seated elliptical exercise machine- Cubii JR-1
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Shirley Ryan AbilityLab
Osteo Arthritis Knee
Effects of Compression Mobilization in OA Patients
The study Design was randomized control trial in which data was collected From Riphah Rehabilitation And Research Center and Pakistan Railway Hospital-IIMCT. Convenient sampling technique was used for data collection.
- Trial name
- NCT04944056
- Testing
- conventional physiotherapy, compression mobilization
- Where
- Pakistan
- Volunteers
- 39 people
- Sponsor
- Mir Arif Hussain
Osteoarthritis, Knee
Hip Joint Mobilizations and Strength Training in Patients With Knee OA Osteoarthritis
Knee osteoarthritis has been ranked 11th highest contributor to non-fatal burdens in the world. Many research studies have discussed the relationship of hip muscle with knee joint stating that impaired hip strength can be a…
- Trial name
- NCT04769531
- Testing
- Hip Joint Mobilizations, Hip joint Muscle strength training, knee strengthening and flexibility exercises
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Dow University of Health Sciences
Osteoarthritis (OA) of the Knee
Long-Term Effects of Mobithron Advance on Knee Osteoarthritis Aims to Investigate the Effects of Mobithron Advance on OA Progression
The goal of this clinical trial is to learn if the Mobithron Advance drug works to treat and slow the progression of osteoarthritis (OA) in patients. It will also learn about the safety and long-term effects of this drug.
- Trial name
- mobithron adv (NCT07323745)
- Testing
- Type 2 collagen
- Where
- Malaysia
- Volunteers
- 84 people
- Sponsor
- Universiti Sains Malaysia
Osteoarthritis of Knee
Study to Assess the Effect of E-OA-07 on Acute Pain Response in Subjects Suffering From Knee OA
The repetitive motions associated with active life and many sports can increase the wear and tear to the joints that leads to decrease in flexibility and joint pain finally heading its way to osteoarthritis.
- Trial name
- Osteolanc (NCT02417506)
- Testing
- E-OA-07 (Lanconone), Ibuprofen
- Where
- India
- Volunteers
- 72 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Osteoarthritis, Knee
Effects of Strength Training on Knee Osteoarthritis
To understand the effects of leg strengthening exercise, we will study the effects of strength training of the legs in four groups of people: (1) osteoarthritis (OA) with knee pain; (2) OA without knee pain; (3) no OA but elderly…
- Trial name
- NCT00000406
- Testing
- Progressive resistance exercise
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Indiana University
Osteoarthritis (OA) of the Knee
Native Alignment in the Setting of an Arthritic Knee in Total Knee Arthroplasty
The goal of this clinical trial is to learn if preparing the target alignment of the operative side in total knee arthroplasty (TKA) based on the non-arthritic side will give the patient better overall alignment, function, and…
- Trial name
- NCT06617338
- Testing
- CT scan unilateral knee, CT scan bilateral knee
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Louisville
Knee Osteoarthritis, Sarcopenia
The Effects of Pulsed Electromagnetic Field Therapy on Patients With End-stage of Knee Osteoarthritis
A double-blinded, randomizepd controlled trial to investigate the treatment effects of pulsed electromagnetic field (PEMF) on end stage of knee osteoarthritis patients with sarcopenia will be carried out.
- Trial name
- NCT05550428
- Testing
- home-based-exercise, active pulsed electromagnetic field（PEMF）therapy
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Osteoarthritis, Knee
Safety & Efficacy FloGraft (Micronized Human Amnion Chorion Membrane)® in Adults With Pain Due to OA of the Knee
Safety \& Efficacy of FloGraft (Micronized Human Amnion Chorion Membrane)® in Adults With Pain Due to Osteoarthritis of the Knee.
- Trial name
- OA (NCT03441607)
- Testing
- mHACMb
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Applied Biologics, LLC
Knee Osteoarthritis
A Safety and Efficacy Study of Anti-inflammatory (Canakinumab) and Cartilage Stimulating (LNA043) Drugs Injected Into the Knee Joint of Participants With Knee Osteoarthritis (OA)
The study was established to show safety and efficacy of canakinumab and LNA043 in patients with knee osteoarthritis (OA).
- Trial name
- NCT04814368
- Testing
- canakinumab, LNA043
- Where
- 11 sites in United States, Czechia and 4 more
- Volunteers
- 23 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis, Knee, Osteoarthritis, Hip
Surgical Joint Registry MBJRF
The purpose of this study is to follow the patient's short term and long term clinical outcome after undergoing joint replacement surgery.
- Trial name
- MBJRFREG (NCT03484325)
- Where
- United States
- Volunteers
- 990 people, healthy volunteers welcome
- Sponsor
- Memorial Bone and Joint Research Foundation
Osteoarthritis, Knee
The Safety/Efficacy of hUC Mesenchymal Stem Cells（19#iSCLife®-OA） Therapy for Patients With Osteoarthritis
The purpose of this study is verify the efficacy and safety of Human Umbilical Cord Mesenchymal Stem Cells (UC-MSC) therapy for patients with Osteoarthritis, and in addition, provide basis for exploring the treatment regimen of…
- Trial name
- NCT03383081
- Testing
- Low dose mesenchymal stem cells, High dose mesenchymal stem cells, Intraarticular injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sclnow Biotechnology Co., Ltd.