Clinical trials: Knee Osteoarthritis
Physical Activity, Functional Disturbance
Effects of Dextrose on Knee Osteoarthritis
Using double blind, randomized controlled design to study the immediate, short-term and intermediate-term therapeutic effects of ultrasound guided hyaluronic acid injection and hyaluronic acid combined dextrose injection to…
- Trial name
- NCT03238183
- Testing
- dextrose, hyaluronic acid
- Where
- Taiwan
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Osteoarthritis
Study of OLP-1002 Injections for Reducing Moderate to Severe Pain Due to Osteoarthritis in Hip and/or Knee Joint
The study is designed to evaluate the efficacy, safety and tolerability of OLP-1002 Subcutaneous (SC) injections for reducing moderate to severe pain due to osteoarthritis in a hip and/or knee joint.
- Trial name
- NCT05216341
- Testing
- OLP-1002
- Where
- 7 sites in Australia
- Volunteers
- 134 people
- Sponsor
- OliPass Corporation
Knee Osteoarthritis
Safety Study of PTP-001 for Treating Knee Osteoarthritis
Evaluation of safety, tolerability, and efficacy of a single intra-articular (IA) injection of PTP-001, an allogeneic placental tissue particulate, in individuals with knee osteoarthritis (OA).
- Trial name
- NCT04632966
- Testing
- Biological: PTP-001
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Bioventus LLC
Osteoarthritis
Evaluation of DVD and Internet Decision Aids for Hip and Knee Osteoarthritis: Focus on Health Literacy
The purpose of this study is to advance the evidence base regarding methods for facilitating informed decisions among patients with knee and hip osteoarthritis by comparing DVD and online formats of decision aids for these…
- Trial name
- NCT01618097
- Testing
- DVD Decision Aid, Internet Based Decision Aid
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Duke University
Anterior Cruciate Ligament Injuries, Post-Traumatic Osteoarthritis of Knee
Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction
The goal of this pilot randomized clinical trial is to look into the efficacy of concentrated bone marrow aspirate (cBMA) in improving post traumatic osteoarthritis (PTOA) symptoms in patients undergoing revision anterior…
- Conditions
- Anterior Cruciate Ligament Injuries, Post-Traumatic Osteoarthritis of Knee, Bone Marrow Aspirate Concentrate, ACL Injury
- Trial name
- NCT06311513
- Testing
- Concentrated Bone Marrow Aspirate Injection, Revision Anterior Cruciate Ligament Reconstruction
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis
A Study of the Efficacy and Safety of VX-150 in Subjects With Osteoarthritis of the Knee
The Primary objective of this study is to evaluate the efficacy of VX-150 in the treatment of osteoarthritis pain
- Trial name
- NCT02660424
- Testing
- VX-150
- Where
- 12 sites in United States
- Volunteers
- 124 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Knee Injuries, Anterior Cruciate Ligament Rupture
Stopping OsteoARthritis After an ACL Tear
By 2040, 25% of Canadians will have osteoarthritis, a disabling joint condition. Most people think osteoarthritis only affects older adults, but 50% of the 700,000 Canadian youth who hurt their knee playing sports annually will…
- Conditions
- Knee Injuries, Anterior Cruciate Ligament Rupture, Osteoarthritis, Knee
- Trial name
- SOAR (NCT06195423)
- Testing
- Stop OsteoARthritis (SOAR) program, Living Well after ACLR program
- Where
- 2 sites in Canada
- Volunteers
- 210 people
- Sponsor
- University of British Columbia
Osteoarthritis, Rheumatoid Arthritis
A Prospective, Clinical Investigation of the Vanguard 360 Revision Knee
The purpose of this study is to evaluate performance of the Vanguard 360 revision knee system utilizing offset on either the tibial component, femoral component, or both in terms of the restoration of mechanical alignment…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Post Traumatic Deformity
- Trial name
- NCT01542580
- Testing
- Vanguard SSK 360 with PS Bearing, Vanguard SSK 360 with PSC bearing, Vanguard DA 360
- Where
- 12 sites in United States, Belgium and 6 more
- Volunteers
- 255 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Reinforcement of Placebo Response in Knee Osteoarthritis: A Randomised Trial
Saline intra-articular injections used as placebo treatments have been shown to provide pain relief in knee osteoarthritis (OA) It has further been shown that beneficial effects can be induced merely by having a conversation with…
- Trial name
- NCT05225480
- Testing
- Illness perception conversation, research motivation conversation
- Where
- Denmark
- Volunteers
- 103 people
- Sponsor
- Frederiksberg University Hospital
Osteoarthritis of Knees
The Effectiveness of Arthroscopic Cartilage Regeneration Facilitating Procedure for Patients With Knee Osteoarthritis
The aim of this study is to discuss the effect of gait pattern in patients receiving arthroscopic cartilage regeneration facilitating procedure (ACRFP) for treatment of osteoarthritis of knees.
- Trial name
- NCT03452423
- Testing
- ACRFP
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Knee Osteoarthritis
Knee Osteoarthritis and Thermal Spa Treatment
The goal of this interventional study is to evaluate the effectiveness at 6 months of the Enghien-les-Bains thermal spa treatment on functional disability and pain, assessed by the Minimal Clinically Important Improvement (MCII)…
- Trial name
- ENERGIE (NCT07370480)
- Testing
- Thermal spa sessions, Thermal water, Standard of Care for Knee Osteoarthritis
- Where
- 2 sites in France
- Volunteers
- 76 people
- Sponsor
- CEN Biotech
Knee Osteoarthritis
Inflammatory Targeted Laser Treatment of Knee Osteoarthritis
This study is conducted to evaluate the effectiveness of low-level laser therapy (LLLT) as an adjunct to exercise therapy in knee osteoarthritis (KOA).
- Trial name
- NCT03750279
- Testing
- Exercise therapy, LLLT
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University of Bergen
Osteoarthritis, Knee
Radiofrequency Ablation on Pain Relief of Knee Osteoarthritis
Introduction Osteoarthritis (OA) is a chronic, progressive disease with high disability and teratogenicity in the joints. Deterioration of the articular cartilage is the main problem associated with osteoarthritis, which…
- Trial name
- NCT05050396
- Testing
- Cooled versus thermocoagulant Radiofrequency Ablation in pain relief of knee osteoarthritis
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Assiut University
Knee Osteoarthritis
Hydrolyzed Collagen Formulation vs Placebo in Knee Osteoarthritis
The aim of the study is to compare the 6 months clinical outcome of the treatment with a single intra-articular collagen injection versus a single placebo (saline solution) infiltration in the infiltrative treatment of knee…
- Trial name
- NCT04998188
- Testing
- Collagen
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Osteoarthritis, Chronic Knee Pain
Genicular Nerve Radiofrequency Ablation Versus Hyaluronic Acid Injection for Knee Osteoarthritis Pain
The goal of this clinical trial is to learn if thermal radiofrequency ablation of the genicular nerves (the nerves that carry pain signals from the knee) works better than a single injection of hyaluronic acid into the knee to…
- Trial name
- RF-PROSPECTIU (NCT07901374)
- Testing
- Thermal Radiofrequency Ablation of the Genicular Nerves, Intra-articular Hyaluronic Acid
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Universitari Joan XXIII de Tarragona.
Analgesia
Intra-Articular Morphine Versus Bupivacaine on Knee Motion in Patients With Osteoarthritis
CONTEXT AND OBJECTIVE: Osteoarthritis causes pain and disability in a high percentage of elderly people. The aim of the present study was to compare the analgesic effect of intra-articular bupivacaine and morphine in patients…
- Trial name
- NCT00636415
- Testing
- morphine
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Unilateral Primary Osteoarthritis of Knee, Osteoarthritis Knee
Microdrilling Surgery for Full Thickness Chondral Lesions of the Knee Augmented With Concentrated Bone Marrow Aspirate, Platelet Rich Plasma and Hyaluronic Acid
This study seeks to evaluate a treatment for multiple full thickness chondral lesions in the knee. Eligible subjects will undergo a microdrilling surgery and up to 12 post operative intra-articular injections of bone marrow…
- Conditions
- Unilateral Primary Osteoarthritis of Knee, Osteoarthritis Knee, Degeneration; Articular Cartilage, Knee, Degenerative Lesion of Articular Cartilage of Knee
- Trial name
- NCT02285725
- Testing
- Microdrilling Surgery, Injections of BMAC + PRP + HA
- Volunteers
- 21 people
- Sponsor
- Joseph E. Broyles
Osteoarthritis, Knee
Fenugreek Wraps in Osteoarthritis of the Knee
This randomised controlled trial aims to investigate the efficacy of fenugreek wraps in the treatment of primary symptomatic osteoarthritis of the knee.
- Trial name
- BoGon (NCT03528824)
- Testing
- Fenugreek wrap, Diclofenac Gel
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Universität Duisburg-Essen
Knee Osteoarthritis
Bracing to Treat Knee Osteoarthritis in Elderly
Background: Osteoarthritis (OA) is highly prevalent in the elderly, with the knee being the most commonly affected joint in this population. Knee braces are often used to prevent common problems in knees during daily activities.
- Trial name
- NCT02443974
- Testing
- Brace (Fisiotensor®), Sleeve (Fisiotensor®)
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Federal University of São Paulo
Osteoarthritis, Knee, Orthopedic Disorder
Gait, Pain and Physical Activity After HTO
This study aims to investigate the relationship between pain, gait and activity intensity in HTO patients that are healed and have had their fixation plate removed.
- Trial name
- NCT04619550
- Testing
- High tibial osteotomy
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Winchester
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