Clinical trials: Knee Osteoarthritis
Knee Osteoarthritis
Effect of Combined Quadriceps and Calf Strengthening Program on Gait in Knee Osteoarthritis Patients
The aim of this study is to determine the effects of a combined quadriceps and calf strengthening program on gait, strength, pain, disability, functional mobility, and sleep quality in patients with knee osteoarthritis.
- Trial name
- NCT07402447
- Testing
- Group A (Combined Quadriceps and Calf Strengthening), Group B( Conventional)
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Riphah International University
Osteoarthritis
Allograft Transplantation in the Treatment of Osteoarthritis of the Metatarsophalangeal (MTP) Joint of the Great Toe
Using the concept of an implant acting as a spacer and stabilizer, the proposed study will evaluate the use of allograft knee meniscus in the treatment of MTP joint osteoarthritis of the great toe.
- Trial name
- MTP (NCT01673347)
- Testing
- Meniscal Allograft
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Paul Fortin, MD
Knee Osteoarthritis
Effects of Genicular Nerve Block in Knee Osteoarthritis
Genicular nerve block is a safe and effective therapeutic procedure for intractable pain associated with chronic knee osteoarthritis (OA). There is increasing support for the neuropathic component to the knee OA pain.
- Trial name
- NCT03781843
- Testing
- Genicular nerve block with lidocaine, Genicular nerve block with saline, Genicular nerve block with dextrose
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Osteoarthritis, Knee
Standard Versus Novel RFA for Chronic Knee Pain in Osteoarthritis
Brief Summary The goal of this pilot study is to evaluate the feasibility and safety of conducting a randomized comparison of two standard-of-care knee radiofrequency ablation (RFA) techniques in adults with chronic knee pain…
- Trial name
- NCT07674082
- Testing
- Radiofrequency ablation - 3-target technique, Radiofrequency ablation - 6-target technique
- Volunteers
- 24 people
- Sponsor
- Lawson Research Institute of St. Joseph's
Osteoarthritis of the Knee
Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection
Prospective single-masked (study participant will be masked), randomized controlled trial to examine the influence of BMAC on patient-reported outcomes (PROs) in patients with primary knee osteoarthritis.
- Trial name
- BMAC (NCT05985785)
- Testing
- Autologous bone marrow aspirate concentrate (BMAC), Corticosteroid injections, Crossover Autologous bone marrow aspirate concentrate (BMAC)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rush University Medical Center
Knee Osteoarthritis
Mulligan Rotational Movement Versus Medial Gapping Technique in Patients With Knee Osteoarthritis
Knee osteoarthritis is a progressive degenerative and non-inflammatory joint disorder. Due to the extensive use and stress placed on knee joint, it is a common site for painful disorders such as knee osteoarthritis.
- Trial name
- NCT05338840
- Testing
- MULLIGAN ROTATIONAL MOVEMENT, Medial gapping technique
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Prehabilitation, Knee Osteoarthritis
Effectiveness of a Prehabilitation Program for Hip or Knee Arthroplasty Surgery.
We live in an increasingly aging society in which the incidence of osteoarticular diseases increases, among which osteoarthritis (OA) stands out.
- Conditions
- Prehabilitation, Knee Osteoarthritis, Hip Osteoarthritis, Physical Therapy Modalities
- Trial name
- Preoperative (NCT06721897)
- Testing
- Prehabilitation Program, Non prehabilitation Program
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Jaén
Osteoarthritis
A Study for Moderate Osteoarthritis of the Knee
This is a study to determine whether Flexsure is Safe, Tolerable and Effective in relieving symptoms of Moderate Osteoarthritis of the Knee.
- Trial name
- Flexsure (NCT01478997)
- Testing
- Flexsure Capsules
- Where
- 2 sites in India
- Volunteers
- 76 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Arthroplasty, Replacement, Knee, Osteoarthritis, Knee
Knee Kinematics for Subjects With Zimmer-Biomet Posterior Cruciate Retaining or Posterior Stabilizing Total Knee Arthroplasty
25 subjects implanted with a Zimmer-Biomet Posterior Cruciate Retaining (PCR) total knee arthroplasty (TKA) and 25 subjects implanted with a Zimmer-Biomet Posterior Stabilizing (PS) TKA will be asked to perform stepping up and…
- Trial name
- PCR PS TKA (NCT04103515)
- Testing
- Zimmer-Biomet Posterior Cruciate Retaining total knee arthroplasty, Zimmer-Biomet Posterior Stabilizing total knee arthroplasty
- Where
- 3 sites in United States, France
- Volunteers
- 50 people
- Sponsor
- The University of Tennessee, Knoxville
Knee Osteoarthritis
Evaluation of the Effect of Pro Resolve® Sports on Treatment of Patients With Symptomatic Knee Osteoarthritis
The GAUDI study was a randomized, multicentre, double-blind, placebo-controlled, parallel-group pilot study conducted in 5 Spanish sites.
- Trial name
- GAUDÍ (NCT05633849)
- Testing
- SMP group
- Where
- 5 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Solutex GC S.L.
Anterior Knee Pain Syndrome
Does Arthroscopic Patellar Denervation With High Tibial Osteotomy Improve Anterior Knee Pain
Arthroscopy will be done in all cases before osteotomy to assess lat. Comp and grade of patellofemoral O.A Arthroscopic patellar denervation with vaper or diathermy will be done plus open wedge high tibial osteotomy in one group…
- Trial name
- NCT03615976
- Testing
- high tibial osteotomy with or without arthroscopic circumpatellar denervation with or without arthroscopic circumpatellar denervation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Knee Osteoarthritis, Knee Pain
The Effect of AposTherapy on Knee Pain
AposTherapy is a home based exercise program utilizing footwear that causes exercise with normal activity that may significantly improve function in patients with knee osteoarthritis since patients with knee osteoarthritis have…
- Trial name
- AposKnee (NCT03171168)
- Testing
- AposTherapy, Traditional Physical Therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Montefiore Medical Center
Knee Osteoarthritis, Pain, Postoperative
Influence of Patient Sex on Pain Control and Multimodal Analgesia in Total Knee Arthroplasty
The purpose of this study is to examine the influence of sex on postoperative pain, following total knee arthroplasty (TKA). Patients will first be stratified by sex and then be randomized into one of two multimodal analgesic…
- Trial name
- NCT04471233
- Testing
- Multimodal analgesia including pregabalin, Multimodal analgesia not including pregabalin
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Northwell Health
Chronic Pain, Osteoarthritis
Effects of tDCS and tUS on Pain Perception in OA of the Knee
The purpose of this study is to investigate the effects of transcranial direct current stimulation (tDCS) in conjunction with transcranial ultrasound (TUS) on pain perception and functional limitations in people with…
- Trial name
- NCT02330315
- Testing
- transcranial direct current stimulation (tDCS), transcranial ultrasound (TUS)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Spaulding Rehabilitation Hospital
Osteoarthritis, Knee
Intraosseous With Intra-articular Injection of Platelet Rich Plasma in Treatment of Knee Osteoarthritis
The aim of this study was to compare the efficacy of treatment in three groups of patients with knee osteoarthritis (OA) given a combination of intraosseous with intra-articular injection of platelet rich plasma (PRP)…
- Trial name
- NCT03329235
- Testing
- PRP, HA
- Volunteers
- 86 people
- Sponsor
- Cangzhou Central Hospital
Knee Osteoarthritis
Assessment of Safety and Efficacy of ARTHRUM 2.5% for Treatment of Painful Osteoarthritis of the Knee
ARTHRUM 2.5% MONO-INJECTION as symptomatic treatment by joint injection extends the conservative therapeutic arsenal in Knee osteoarthritis.
- Trial name
- ART-ONE75 (NCT06228274)
- Testing
- ARTHRUM 2.5%
- Volunteers
- 218 people
- Sponsor
- LCA Pharmaceutical
Osteoarthritis, Knee
Comparison Between Robotic-arm Assisted Total Knee Replacement and Traditional Total Knee Replacement
This is a multicenter, prospective, and case-control study. Five joint centers and 100 participants will be included. The study group used robotic-assisted modified kinematic alignment total knee replacement, and the control…
- Trial name
- NCT05391152
- Testing
- robotic assisted total knee replacement, traditional total knee replacement
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Knee Osteoarthritis, Arthroplasty Complications
Joint Awareness After Total Knee Replacement
Total knee replacement (TKR) is accepted as treatment of choice for end stage gonarthrosis. It is performed cemented or cementless and although cemented implants were shown to decrease bone density more than cementless fixations…
- Trial name
- NCT06033625
- Testing
- CEMENTLESS TOTAL KNEE REPLACEMENT
- Volunteers
- 150 people
- Sponsor
- Saglik Bilimleri Universitesi
Osteoarthritis, Knee
Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN
A previous multicenter trial led by Bioiberica S.A. has confirmed the efficacy and safety of DROGLICAN for the treatment of osteoarthritis (OA) in patients with severe pain.
- Trial name
- DRIP (NCT02821468)
- Testing
- Droglican, Paracetamol or oral NSAIDs excluding COX2 inhibitors
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Bioiberica
Chronic Musculoskeletal Pain
Network Modeling in Knee Osteoarthritis
This project seeks to understand inter-individual differences in chronic musculoskeletal pain (cMSKP). Our long-term objective is to develop clinically-feasible decision tools that enable whole-person assessment and management of…
- Trial name
- NCT07746284
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- George Mason University
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