Clinical trials: Knee Osteoarthritis
Osteoarthritis, Knee
Effects of Blood-flow Restricted Exercise Compared to Standard Rehabilitation in Patients With Knee Osteoarthritis
The purpose of this study is to investigate the effect of low-intensity BFR exercise on joint pain, muscle mass, and mechanical muscle function compared to standard rehabilitering in adults with knee-OA.
- Trial name
- NCT05437770
- Testing
- BFR (Blood-Flow Restricted exercise), Standard rehabilitation
- Where
- Denmark
- Volunteers
- 96 people
- Sponsor
- Bispebjerg Hospital
Osteoarthritis of the Knee Joint
Correlation Between Alignment of Lower Limb and Clinical Outcome After Total Knee Prosthesis.
Evaluation of the clinical results after total knee prosthesis, and correlation with the alignment of the lower limb. Radiological measurements by means of 3D technology will be performed.
- Trial name
- NCT01666873
- Testing
- patients that undergo a total knee prosthesis
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Ghent
Osteo Arthritis Knee
Effectiveness of Pain Science Education in People With Symptomatic Knee Osteoarthritis
The aim of this study is to determine the effectiveness of the program integrated with pain science education for people with painful knee osteoarthritis (OA).
- Trial name
- NCT05649995
- Testing
- Pain science education driven physiotherapy program, Biomedical education driven physiotherapy program
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Marmara University
Osteoarthritis, Knee, Rheumatoid Arthritis
Early Biomarkers for ARthritic PAIN to Guide Improved Treatments for Arthritis
Osteoarthritis (OA) is a condition affecting the whole joint and is a major cause of pain and disability worldwide. Although OA is very common, the initial steps which lead to the development of pain and tissue damage are not…
- Conditions
- Osteoarthritis, Knee, Rheumatoid Arthritis, Spondyloarthritis, Psoriatic Arthritis
- Trial name
- ARPAIN (NCT03533569)
- Testing
- Intra-articular corticosteroid injection
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Osteoarthritis, Knee
Effect of Patellar Denervation on Post-operative Knee Pain and Knee Function in Total Knee Arthroplasty
This study is a double-blind randomized controlled trial aiming to investigate the effects of patellar denervation using electrocautery on postoperative knee pain and knee function in patients undergoing primary total knee…
- Trial name
- PD (NCT07342166)
- Testing
- Patellar Denervation
- Where
- Thailand
- Volunteers
- 64 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Knee Osteoarthritis
Effects of Platelet-Rich Plasma and Ozone Therapy in Knee Osteoarthritis
Knee osteoarthritis can frequently occur with advancing age. In cases of pain that persists despite hot/cold applications, drug therapy and exercise, intra-articular injections are considered.
- Trial name
- NCT06631456
- Testing
- PRP injection, Ozone therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Osteoarthritis, Knee
CBD for Knee Osteoarthritis
Osteoarthritis is a disease that affects millions of Americans and is the leading cause of persistent pain and physical disability in the older adult population.
- Trial name
- SLACK-OA (NCT06414473)
- Testing
- Cannabidiol (CBD) Extract
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Knee Osteoarthritis
Stability of Contemporary Knee Arthroplasty
Total joint replacement is an efficacious treatment for osteoarthritis of hips and knees. Both total knee replacement (TKR) and total hip replacements (THR) have excellent implant survivorship.
- Trial name
- NCT02861794
- Testing
- Medacta International, GMK Sphere medially stabilized knee
- Where
- Norway
- Volunteers
- 44 people
- Sponsor
- Oslo University Hospital
Knee Osteoarthritis, Edema
Control of Edema in the Knee in Patients With Knee Osteoarthritis
The aim of this study was to compare the effectiveness of exercise and classical massage in the control of knee edema in patients with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, Edema, Edema Leg
- Trial name
- NCT06010394
- Testing
- conventional physiotherapy, exercises for the knee area, payment oriented massage
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Uskudar University
Knee Osteoarthritis, Total Knee Arthroplasty
Analysis of Competitive Posterior Cruciate Retaining (PCR) and Posterior Stabilized (PS) Total Knee Arthroplasty (TKA)
The purpose of the study is to acquire kinematic in vivo fluoroscopy data from subjects who were implanted with Stryker Posterior Cruciate Retaining (PCR) , Stryker Posterior Stabilized (PS), Zimmer PCR, and Zimmer PS Total Knee…
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Knee
- Trial name
- NCT04321356
- Testing
- Triathlon PCR TKA, Triathlon PS TKA, Persona PCR TKA
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- The University of Tennessee, Knoxville
Osteoarthritis of the Knee
A Phase 2 Study To Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee Pain
NKTR-181 is being developed as an analgesic compound for the treatment of moderate to severe chronic pain - active as a mu agonist, but with inherent molecular properties designed to provide a unique clinical profile, including…
- Trial name
- NCT01619839
- Testing
- NKTR-181
- Where
- 34 sites in United States
- Volunteers
- 296 people
- Sponsor
- Nektar Therapeutics
Knee Arthritis Osteoarthritis
Comparing Pain Science Education to Biomedical Education for People With Knee Osteoarthritis: A Randomized Controlled Trial
Knee osteoarthritis (OA) is a common cause of pain and disability in older adults. Many people with knee OA believe that pain is primarily caused by joint damage or "wear and tear." These beliefs may contribute to fear of…
- Trial name
- NCT07823673
- Testing
- Pain Science Education, Biomedical Education
- Volunteers
- 82 people
- Sponsor
- McMaster University
Osteo Arthritis Knee
Incorporating Patient-Reported Outcomes Into Shared Decision Making With Patients With Osteoarthritis of the Hip or Knee
Osteoarthritis (OA) of the knee constitutes a major public health problem. Treatment options for knee OA range from lifestyle changes to pharmacological management to total knee replacement surgery.
- Trial name
- NCT04805554
- Testing
- Joint Insights decision aid
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Osteoarthritis, Post-traumatic Arthritis
Foundation Knee Study - Retrospective
The purpose of this study is to evaluate the use and efficacy of the Encore Foundation Knee System in a group of 200 patients for whom data has already been collected.
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Inflammatory Tissue Disorders, Arthritis Secondary to Other Diseases
- Trial name
- NCT00764894
- Testing
- Foundation Knee
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Encore Medical, L.P.
Knee Osteoarthritis
Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis
This study aims to investigate the effectiveness and safety of human umbilical cord mesenchymal stem cell injection in the articular cavity to treat moderate to severe knee osteoarthritis (OA), and whether it can achieve…
- Trial name
- NCT05160831
- Testing
- Human umbilical cord mesenchymal stem cells
- Volunteers
- 50 people
- Sponsor
- Southwest Hospital, China
Knee Osteoarthritis
Effect of a Patient Education in Pain Coping for Patients Scheduled for Total Knee Arthroplasty
The aim of this study is to investigate, whether a patient education with focus on pain coping is able to improve physical function and experienced pain level in patients with high levels of pain catastrophizing before Total Knee…
- Trial name
- NCT02587429
- Testing
- Patient education
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Regional Hospital West Jutland
Osteoarthritis, Knee
RCT Mesenchymal Stem Cells Versus Hyaluronic Acid in OA Knee):
The purpose of this study is to evaluate the therapeutic effect of adult autologous mesenchymal stem cells (abbreviated as MSCs) in patients with osteoarthritic knee and compare to intra articular injection of Synvisc-One.
- Trial name
- MSC (NCT04326985)
- Testing
- Autologous Mesenchymal Stem Cells Treatment (MSCs), Hyaluronic acid (HA)
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Osteoarthritis, Knee
A Controlled Study of an Herbal Topical Patch in Treating Osteoarthritis (OA) of the Knee
An evaluation of the safety and efficacy of an herbal patch in treating osteoarthritis pain of the right or left knee.
- Trial name
- NCT01183624
- Testing
- Herbal Patch
- Where
- 12 sites in China
- Volunteers
- 626 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Knee Osteoarthritis, Meniscus Tear
Effects of Kinesiotaping and Physiotherapy in Grade 2 Osteoarthritis Following Degenerative Meniscal Tears
Degenerative meniscal tears are a common cause of osteoarthritis commonly diagnosed in football players and are considered a major risk factor for the development of knee osteoarthritis.
- Trial name
- NCT06227078
- Testing
- Kinesiotaping
- Where
- Saudi Arabia
- Volunteers
- 56 people
- Sponsor
- Gopal Nambi
Osteoarthritis, Knee
Efficacy and Safety of a Intra-articular Injection, ENKO1, in Patients With Symptomatic Knee Osteoarthritis.
Clinical trial with medical device, multicenter, single-blind (blind third party evaluation), randomized, comparative and in two paralell groups, to demonstrate the treatment according to usual clinical practice, of the…
- Trial name
- ENKORE (NCT03762408)
- Testing
- ENKO 1, Durolane
- Where
- 18 sites in Spain
- Volunteers
- 175 people
- Sponsor
- OPKO Health, Inc.
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