Clinical trials: Knee Osteoarthritis
Osteoarthritis
A Comparison of the Design of Tibia Stems in Cemented Total Knee Arthroplasty - Wedge Stem Versus I-beam Stem.
The purpose of this study is to compare the early migration and periprosthetic bone changes of two cemented total knee arthroplasties with different tibial stem design.
- Trial name
- NCT00175136
- Testing
- Maxim TKA
- Where
- Denmark
- Volunteers
- 54 people
- Sponsor
- University of Aarhus
Osteoarthritis, Knee
Postoperative Pain Control Results Using Periarticular Versus Intra-capsular Injection of Bupivacaine Liposome Injectable Suspension in Total Knee Arthroplasty
The purpose of this study is to determine quantitative and qualitative differences in post-operative pain relief for patients undergoing primary total knee arthroplasty (TKA) who receive administration of a newly approved, long…
- Trial name
- NCT02166632
- Testing
- Intracapsular Injection, Periarticular Injection
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Broward Health
Diabetes Mellitus, Steroid Diabetes
Effect of Corticosteroid Injections on Blood Glucose
The purpose of this study is to measure the effect of various corticosteroids administered to the shoulder, knee and hip joints in diabetic patients on resultant blood glucose readings.
- Conditions
- Diabetes Mellitus, Steroid Diabetes, Shoulder Osteoarthritis, Knee Osteoarthritis
- Trial name
- CSI (NCT05048264)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Osteoarthritis, Knee
Treatment and Duration Effect of Pentosan Polysulfate Sodium (PPS) in Participants With Knee Osteoarthritis Pain
The purpose of this study is to measure the duration of treatment effect with subcutaneous injections of pentosan polysulfate sodium (PPS) compared with placebo in adult participants with knee osteoarthritis (OA) pain.
- Trial name
- NCT04814719
- Testing
- Pentosan Polysulphate Sodium
- Where
- 2 sites in United States, Australia
- Volunteers
- 133 people
- Sponsor
- Paradigm Biopharmaceuticals Ltd.
Osteoarthritis of the Knee, Traumatic Arthritis of the Knee
Long-Term Multicenter Evaluation of the E1® Tibial Bearing
This study has been designed to document the long-term outcome of the E1® Tibial Bearings used with the Vanguard® Knee System in 500 patients receiving total knee arthroplasty.
- Trial name
- NCT01374230
- Testing
- Total knee arthroplasty
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Knee Osteoarthritis
Digital Motivation to Decrease Inactive Behaviour in Patients With Knee Osteoarthritis
Physical inactivity is a major risk behaviour with a potential for causing premature death, particularly among people with mobility limitations, such as knee osteoarthritis.
- Trial name
- NCT03339011
- Testing
- Motivational SMS text message
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- Marius Henriksen
Knee Osteoarthritis
Efficacy of Different Doses of Pregabalin as a Multimodal Analgesic Agent in Postoperative Pain Control After Total Knee Arthroplasty
The purpose of this study is to compare the efficacy of 75 mg of Pregabalin and 150 mg of Pregabalin in postoperative pain control after TKA.
- Trial name
- NCT05447364
- Testing
- Pregabalin 75mg, Pregabalin 150mg
- Where
- Thailand
- Volunteers
- 82 people
- Sponsor
- Thammasat University
Knee Osteoarthristis
Efficacy of Intra-articular Injection of Human Amniotic Suspension Allograft and Platelet-rich Plasma in the Treatment of Knee Osteoarthritis.
A double-blind, randomized controlled trial designed to evaluate the symptomatic modulating efficacy of amniotic suspension allograft (ASA) in comparison to platelet-rich plasma (PRP), hyaluronic acid (HA) and normal saline (NS)…
- Trial name
- NCT04698265
- Testing
- Human amniotic suspension allograft (ASA)
- Volunteers
- 150 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Osteoarthritis of Knee Joint
Allogeneic Mesenchymal Stem Cells for Osteoarthritis
This study is designed to know the safety and efficacy of 2 different doses of mesenchymal stem cells in patients suffering from osteoarthritis of knee joint.
- Trial name
- NCT01448434
- Testing
- Ex- vivo cultured adult allogeneic MSCs, Plasmalyte-A
- Where
- 4 sites in Malaysia
- Volunteers
- 72 people
- Sponsor
- Stempeutics Research Pvt Ltd
Osteoarthritis, Knee
A Study to Investigate the Safety and Effectiveness of Different Doses of Sprifermin in Participants With Osteoarthritis of the Knee
This was a multicenter, randomized, double-blind, placebo-controlled, parallel-group Phase 2 trial of Sprifermin administered intra-articularly in participants with primary osteoarthritis of the knee and Kellgren-Lawrence Grade 2…
- Trial name
- FORWARD (NCT01919164)
- Testing
- Sprifermin
- Where
- 13 sites in United States, Argentina and 6 more
- Volunteers
- 549 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Osteoarthritis
Medico-economic Interest of the Patient Matched Cutting Blocks (Ancillary) MyKnee ® LBS During the Poses of Complete Prosthesis of Knee GMK ®. Multicentric, Prospective, Controlled, Opened, Randomised Study About a Medical Device. (My Knee)
Over 70.000 total knee arthroplasty (TKA) are performed in France every year, with a 10% yearly increase since the early 1990s. The clinical experience shows a strong rate of success on pain relief and on function.
- Trial name
- MY Knee (NCT01818401)
- Testing
- the prosthesis GMK ® without the ancillary MyKnee ® LBS, Matched patient cutting blocks MyKnee ® LBS
- Where
- France
- Volunteers
- 95 people
- Sponsor
- Nantes University Hospital
Knee Osteoarthritis
Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis
Introduction: Osteoarthritis of the knee is a very common disease. However there are few treatment options for these patients. Botulinum toxin type A is an option for chronic pain.
- Trial name
- NCT02829281
- Testing
- Botulinum Toxin Type A, Triamcinolone hexacetonide, Saline
- Where
- Brazil
- Volunteers
- 105 people
- Sponsor
- Federal University of São Paulo
Unilateral Knee Osteoarthritis
Durolane Compared to Saline in Patients With Unilateral Knee Osteoarthritis
This was a study that compared Durolane injections to saline injections in the treatment of unilateral osteoarthritis of the knee.
- Trial name
- NCT01806207
- Testing
- Durolane injection, Saline injection
- Where
- United Kingdom
- Volunteers
- 218 people
- Sponsor
- Galderma R&D
ERAS, Knee Osteoarthritis
Enhanced Recovery After Surgery Protocols in Total Knee Arthroplasty Via Midvastus Approach
The study aimed to investigate the impact of enhanced recovery after surgery (ERAS) protocols on the clinical effect of total knee arthroplasty (TKA) via the midvastus approach
- Trial name
- NCT04873544
- Testing
- ERAS protocols for TKA
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Osteoarthritis
Rosehip Powder for Knee Osteoarthritis
The aim of this study is to compare three combinations of preparations in a comparative trial program on rosehip powder for knee OA.
- Trial name
- NCT01430481
- Testing
- Rosehip powder
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Frederiksberg University Hospital
Osteo Arthritis Knee, Central Sensitisation
Central Sensitization in Knee Osteoarthritis
The stimuli that activate nociceptors cause the dorsal horn of the spinal cord neurons to be sensitive to low-intensive afferent stimuli by decreasing the excitation threshold in patients with osteoarthritis.
- Trial name
- NCT04308967
- Testing
- balance exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Cukurova University
Arthroplasty, Bone Morphing
Is It Possible to Obtain Reliable MPTA and LDFA Values Using Imageless Navigation in Total Knee Arthroplasty? Comparison Between Preoperative CT Scan Measurements and Intraoperative Bone Morphing Before and After Articular Cartilage Removal
Title: Evaluation of Image-less Navigation Accuracy in Total Knee Arthroplasty (CARNAVAL) Summary: The purpose of this study is to evaluate the accuracy of an imageless navigation system in measuring key anatomical angles (MPTA…
- Conditions
- Arthroplasty, Bone Morphing, Knee Osteoarthritis
- Trial name
- CAR-NAV-AL (NCT07574775)
- Testing
- Non-image-based Computer-Assisted Navigation with Bone Morphing
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Osteoarthritis in the Knee
Effects of Therapeutic Touch on Osteoarthritis of the Knee
This study is to evaluate the efficacy of the Kreiger/Kunz method of Therapeutic Touch on function, pain perception and quality of life in persons with Osteoarthritis in the knee.
- Trial name
- NCT00759512
- Testing
- Therapeutic Touch
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Toledo Health Science Campus
Degenerative Osteoarthritis
Continuous Distal Adductor Canal Block With Periarticular Local Anesthetic Infiltration Versus Continuous Distal Adductor Canal Block Alone for Analgesia After Total Knee Arthroplasty
Continuous administration of local anesthetics to the distal adductor canal could spread into the popliteal fossa and contribute to analgesic effects on posterior knee pain.
- Trial name
- NCT05427019
- Testing
- Distal adductor canal block, Distal adductor canal block and Periarticular block
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Yonsei University
Osteoarthritis, OA
Autologous Alpha-2 Macroglobulin Rich Plasma, Safety and Efficacy in Symptomatic Moderate Knee Osteoarthritis
The purpose of this study is to determine the effectiveness and safety of autologous alpha-2 macroglobulin rich plasma (A2MRP) injections in the treatment of knee osteoarthritis (OA).
- Conditions
- Osteoarthritis, OA, Knee Osteoarthritis
- Trial name
- A2MRP (NCT06329492)
- Testing
- Autologous Alpha-2 Macroglobulin Rich Plasma (A2MRP)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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