Clinical trials: Knee Osteoarthritis
Osteoarthritis of the Knee
Serum and Synovium Protease Inhibitor Levels in Primary and Secondary Osteoarthritic Joints
Osteoarthritis (OA) is the irreversible degeneration of articular cartilage and underlying bone. It poses a major healthcare problem as it is the leading cause of joint disease and disability in the United States.
- Trial name
- NCT01613833
- Testing
- Blood Draw, Joint Aspirate Harvest
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Scuderi, Gaetano J., M.D.
Arthritis, Degenerative
3VM for Treatment of Chronic Osteoarthritis Knee Pain
A double-blind, placebo-controlled, randomized dose ranging study for the use of 3VM1001 Cream, 2g three times daily, 3g three times daily, or 3g four times daily for treatment of chronic pain associated with osteoarthritis of…
- Trial name
- NCT03142178
- Testing
- Experimental: 3VM1001 active 2g Cream 3 times daily, Experimental: 3VM1001 active 3g Cream 3 times daily, Experimental: 3VM1001 active 3g Cream 4 times daily
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- CDA Research Group, Inc.
Knee Osteoarthritis
Deep Versus Superficial Heating in Patients With Knee Osteoarthritis
Heat therapy is frequently prescribed to patients with symptomatic knee osteoarthritis (OA). Deep hyperthermia via localized microwave diathermy is effective in several musculoskeletal painful conditions.
- Trial name
- NCT01343147
- Testing
- Microwave diathermy, Superficial hyperthermia
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Catholic University of the Sacred Heart
Osteoarthritis of the Knee
Total Knee Arthroplasty Functional Outcomes Study Research Design
The purpose of this study is to obtain patient oriented and clinically oriented physical function outcomes both pre-operatively and post-operatively in patients receiving a total knee arthroplasty.
- Trial name
- NCT02228538
- Testing
- Total knee arthroplasty patients
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Restor3D
Osteoarthritis, Knee
Blood Levels of Local Anaesthetic in Knee Arthroplasty Using a Continuous Infusion Device
The primary goal is to evaluate ropivacaine blood concentrations during and after local anaesthetic (ropivacaine) infiltration - the Caledonian technique - for total knee replacement surgery.
- Trial name
- BLOCKS-II (NCT01935648)
- Testing
- Ropivacaine
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Golden Jubilee National Hospital
Osteoarthritis
A Study to Examine the Efficacy of the Arthritis Self Management Program
This study will examine the efficacy of the Arthritis Self Managemnet Program (ASMP)and determine changes in health resource utilization after completeing the ASMP program.
- Trial name
- NCT00297726
- Testing
- Self-Management Program
- Volunteers
- 64 people
- Sponsor
- Alberta Bone and Joint Health Institute
Orthopedic Disorder
r-ESWT in Moderate Knee Osteoarthritis
This study aims to compare the efficacy of r-ESWT treatment with sham-ESWT on pain, walking speed, physical function, and isokinetic muscle strength in knee osteoarthritis.
- Trial name
- NCT04243135
- Testing
- ESWT
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Mustafa Kemal University
Knee Osteoarthritis
Comparative Usability Evaluation of Sustained Acoustic Medicine (SAM) Devices and Topical Gel for OA Knee Pain
The purpose of this study is to evaluate the usability of the ultrasound devices and common pain relief gel. The ability of the three treatment approaches to reduce pain, stiffness, and functionality as measured by NRS scale and…
- Trial name
- NCT05050448
- Testing
- Sustained Acoustic Device with 2.5% Diclofenac Patch, 1% Diclofenac Topical Gel
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ZetrOZ, Inc.
Joint Disease
Post Market Follow-Up Study of the EVOLUTION® Total Knee Arthroplasty System With Cruciate Sacrificing Inserts
MPO is conducting this PMCF study to evaluate the safety and efficacy of its EVOLUTION® Total Knee Arthroplasty (TKA) components marketed in the EU.
- Trial name
- AMETHYST (NCT02351414)
- Testing
- Total Knee Arthroplasty (EVOLUTION®)
- Where
- 5 sites in United States, Belgium and 3 more
- Volunteers
- 150 people
- Sponsor
- MicroPort Orthopedics Inc.
Meniscus Injury, Osteoarthritis, Knee
The Effect of Commercially Available Footwear Interventions in Meniscectomy Patients
Injuries to the meniscus are common in sport. A meniscectomy is often performed to manage symptoms associated with the meniscal injury. Following a meniscectomy individuals are highly likely to develop knee osteoarthritis (OA).
- Conditions
- Meniscus Injury, Osteoarthritis, Knee, Footwear
- Trial name
- MENI-FOOT (NCT03379415)
- Testing
- Footwear, Gait analysis
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Salford
Knee Osteoarthritis
Safety of Single Doses of SAR113945 and Efficacy and Safety of a New Formulation Given Into the Knee in Osteoarthritis Patients / Part II
Study objectives: Part 1 TDU11685 To assess in patients with knee Osteoarthritis (OA), the safety, tolerability and pharmacokinetics (PK) of single intra-articular doses of SAR113945.
- Trial name
- NCT01598415
- Testing
- SAR113945
- Where
- 2 sites in Germany
- Volunteers
- 130 people
- Sponsor
- Sanofi
Osteoarthritis
Sigma CR150 Versus Sigma CR Knee RCT
This study will compare two very similar designs of knee replacement device. One device (Sigma CR150) is a slightly modified version of the original (Sigma CR) and has been modified to enhance/accommodate higher flexion.
- Trial name
- NCT01418378
- Testing
- Sigma CR150, Sigma CR
- Where
- 4 sites in India, Singapore and 1 more
- Volunteers
- 191 people
- Sponsor
- DePuy International
Knee Osteoarthritis
Development and Improvement of an Acceptance and Commitment-based Treatment for the Prevention of Chronic Pain After Total Knee Arthroplasty
Reducing the incidence of chronic post-surgical pain after Total Knee Arthroplasty (TKA) is paramount. NOPAIN, a technology-enhanced Acceptance and Commitment-based treatment, will be developed, tested and improved for this…
- Trial name
- NOPAIN (NCT05769998)
- Testing
- Acceptance and Commitment-based treatment, Treatment as usual
- Where
- Italy
- Volunteers
- 210 people
- Sponsor
- Istituto Auxologico Italiano
Acupuncture Therapy
Using Omics Technology to Explore the Mechanism of Acupuncture Treatment of Different Acupoints of Knee Osteoarthritis
In recent years, commonly used Omics techniques, including genomics, proteomics, metabolomics, have been applied in the studies on the mechanism of acupuncture effect.
- Trial name
- NCT04733352
- Testing
- acupuncture
- Where
- 2 sites in Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Osteoarthritis of the Knee
Evaluation of Amniotic Fluid Product in Knee Osteoarthritis
A study evaluating Amniotic Fluid compared to a Saline Placebo Injection in the treatment of subjects with osteoarthritic (OA) knee pain
- Trial name
- NCT02768155
- Testing
- Amniotic Fluid 4.0ml dose, Amniotic Fluid 2.0ml dose
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- MiMedx Group, Inc.
Osteoarthritis of the Knee, Total Knee Replacement
Prophecy Guide Outcomes in Total Knee Replacement Surgery
This project aims to assess two different techniques used to position the knee replacement implant during surgery. The patients will be randomised to receive either the following: 1.
- Trial name
- NCT01163708
- Testing
- Prophecy Technique, Navigation System
- Where
- 2 sites in Australia
- Volunteers
- 188 people
- Sponsor
- Global Orthopaedic Technology
Osteoarthritis, Knee
PFC Sigma Fixed and Mobile Knee Study
The primary objective of this investigation is to evaluate the performance (in terms of post-operative active range of motion at one year) of the P.F.C. Sigma and P.F.C.
- Trial name
- NCT00208325
- Testing
- P.F.C Sigma Fixed Bearing total knee system, P.F.C Sigma RP Mobile Bearing knee system
- Where
- 4 sites in United Kingdom
- Volunteers
- 754 people
- Sponsor
- DePuy International
Osteoarthritis
Identification of Biochemical and Biomechanical Markers for Cartilage Degeneration in the Knee Joint (IBBM-CKJ)
The association between varus malalignment and dynamic knee loading / adduction moment and progression of knee joint cartilage degeneration in the lateral compartment is unclear and has not been studied in detail before.
- Trial name
- IBBM-CKJ (NCT02555514)
- Volunteers
- 100 people
- Sponsor
- Dr. Jan Siewe
Osteoarthritis, Knee
Efficacy and Safety of Intraarticular Sodium Hyaluronate Single Injection in Patients With Osteoarthritis of the Knee
A Phase III, prospective, multicentre, non-controlled, with consecutive participant enrollment in order to evaluate the efficacy, safety and duration of the effects of the viscosupplementation with a preparation of sodium…
- Trial name
- NCT03852914
- Testing
- Sodium hyaluronate 2%
- Where
- 10 sites in Spain
- Volunteers
- 93 people
- Sponsor
- Tedec-Meiji Farma, S.A.
Osteoarthritis (OA) of the Knee
Novel Extended-Release Bupivacaine Polymer for Sustained Pain Relief Following Total Knee Arthroplasty
Participants are being invited to take part in a research study about pain control after total knee replacement surgery (also called total knee arthroplasty or TKA).
- Trial name
- NCT07775248
- Testing
- Periarticular Injection, Adductor Canal Block, Bupivacaine-Meloxicam
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Henry Ford Health System
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