Clinical trials: Knee Osteoarthritis
Osteoarthritis
Patient Controlled Epidural Analgesia Versus Local Infiltration Analgesia Following Knee Arthroplasty
The purpose of this study was to determine if the method of peri-operative analgesia used following total Knee Replacement surgery affected the progress towards rehabilitation goals and to determine whether the analgesia had any…
- Trial name
- NCT02478372
- Testing
- Patient Controlled Epidural (PCEA), Local Infiltration Analgesia (LIA)
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Golden Jubilee National Hospital
Osteoarthritis, Knee
Intra-articular Injections of Platelet-rich Plasma, Hyaluronic Acid, or Corticosteroids for Knee Osteoarthritis
To assess if there are any differences among platelet-rich plasma, hyaluronic acid, and corticosteroid knee intra-articular injection regarding function and pain.
- Trial name
- NCT04980105
- Testing
- Platelet-rich plasma, Hyaluronic acid, Methylprednisolone acetate injectable suspension (DEPO-MEDROL®)
- Where
- Iraq
- Volunteers
- 150 people
- Sponsor
- University of Wasit
Knee Osteoarthritis
Bespoke vs Standard Instrumentation in TKR
Total knee replacements are operations that are offered to patients who have severe arthritis pain that is affecting daily activities that is no longer controlled with painkillers.
- Trial name
- SPHERE (NCT05579951)
- Testing
- Patient specific instrumentation, Conventional
- Where
- United Kingdom
- Volunteers
- 172 people
- Sponsor
- Manchester University NHS Foundation Trust
Osteoarthritis, Knee
Randomised Controlled Trial PFC Versus CKS Total Knee Prostheses
The purpose of this study is to compare the functional outcome of two different total knee prostheses in a prospective randomised study.
- Trial name
- NCT00228137
- Where
- Netherlands
- Volunteers
- 90 people
- Sponsor
- Radboud University Medical Center
Osteoarthritis
Collaborative Model of Care Between Orthopaedics and Allied Healthcare Professionals Trial (CONnACT)
Osteoarthritis knee is the leading cause of chronic disability among older adults. Our current model of care is doctor-centric and inefficient leading to suboptimal use of allied health intervention for effective lifestyle and…
- Trial name
- NCT03809975
- Testing
- Multidisciplinary Community Program, Current model of care
- Where
- 2 sites in Singapore
- Volunteers
- 114 people
- Sponsor
- Tan Tock Seng Hospital
Knee Osteoarthritis
Comparison of Hyaluronic Acid and Platelet-rich Plasma Injections
This study aims to compare the effects of hyaluronic acid injection and platelet rich plasma injection in terms of pain, physical function and femoral cartilage thickness in short term treatment in patients with knee…
- Trial name
- NCT03761472
- Testing
- Hyaluronic acid injection, Platelet-rich plasma injection
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bezmialem Vakif University
the Treatment of Knee Osteoarthritis
Intra-articular Administration of Med Device Made of Biological Vegetal Matrix for the Treatment of Knee Osteoarthritis
A pre-market randomized, parallel group, single-blind, clinical study with a Medical Device, made of vegetal material, to evaluate the efficacy and safety of one knee injection of the investigational device versus active…
- Trial name
- NCT05925595
- Testing
- Medical Device Iniettabile Ginocchio
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Bios-Therapy, Physiological Systems for Health S.p.A
Knee Osteoarthritis
Combination of PRP and XLHA Prepared With RegenMatrix Medical Device To Treat Moderate to Severe Knee Osteoarthritis
In this clinical trial the investigator assess the safety and efficacy of a single injection of a combination of cross-linked hyaluronic acid (HA) with autologous platelet-rich plasma (PRP) obtained with the RegenMatrix medical…
- Trial name
- NCT05727371
- Testing
- Regen Matrix-PRP-XLHA, Hylan G-F 20
- Where
- 13 sites in France
- Volunteers
- 280 people
- Sponsor
- RegenLab France SAS
Knee Osteoarthritis
Outcome of TKA Using Customized Cutting Block Compared With Conventional Intramedullary Cutting Guide
Customized cutting block and conventional cutting guide are both effective in improving accuracy and function of OA knee patients.
- Trial name
- NCT02128464
- Testing
- Patient specific cutting guides, Standard knee cutting guides
- Where
- Thailand
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Osteoarthritis of the Knee
Prospective Randomized Trial of Navigated and Conventional TKA
Evaluation of the component position and kinematics after navigated and conventional Total Knee Arthroplasty.
- Trial name
- NCT01022099
- Testing
- Implantation of a Total Knee Arthroplasty
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Technische Universität Dresden
Osteoarthritis, Knee
Efficacy and Safety of Celecoxib Versus Ibuprofen in the Treatment of Osteoarthritis of the Knee (United States)
To compare the efficacy and safety of celecoxib versus ibuprofen in subjects with osteoarthritis (OA) of the knee.
- Trial name
- NCT00620867
- Testing
- Ibuprofen, celecoxib
- Where
- 33 sites in United States
- Volunteers
- 393 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Osteoarthritis, Knee
Safety & Efficacy FloGraft (Micronized Human Amnion Chorion Membrane)® in Adults With Pain Due to OA of the Knee
Safety \& Efficacy of FloGraft (Micronized Human Amnion Chorion Membrane)® in Adults With Pain Due to Osteoarthritis of the Knee.
- Trial name
- OA (NCT03441607)
- Testing
- mHACMb
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Applied Biologics, LLC
Hip and Knee Joint Osteoarthritis, Hip and Knee Joint Arthroplasty
Effectiveness of Exercise Programs Following Total Hip and Knee Joint Arthroplasty
The purpose of the study was to evaluate the effectiveness of balance exercises added to typical joint range of motion and muscle strengthening exercises on balance in patients following total hip or knee joint arthroplasty
- Trial name
- NCT01555307
- Testing
- Typical range of motion and muscle strengthening exercises, and balance exercises, Typical group
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoarthritis, Knee
A Long-Term Safety and Efficacy Study of Lorecivivint in Subjects With Osteoarthritis of the Knee
Study OA-07 was a randomized, double-blind, placebo-controlled, Phase 3, multicenter, 2-year clinical trial that enrolled subjects from the recently completed Study OA-11 (NCT03928184).
- Trial name
- NCT04520607
- Testing
- Lorecivivint
- Where
- 42 sites in United States
- Volunteers
- 276 people
- Sponsor
- Biosplice Therapeutics, Inc.
Osteoarthritis, Knee
Weight Loss and Physical Activity in Overweight/Obese Individuals With Knee Osteoarthritis
This is a substudy to a randomised trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864).
- Trial name
- NCT02910544
- Testing
- Intensive dietary intervention
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Parker Research Institute
Obesity, Osteo Arthritis Knee
Group Education & Lifestyle Modification's Impact on Weight Loss & Quality Life of Patients with OA
Patients referred to Calgary's Alberta Hip \& Knee Clinic, while awaiting consultation with an orthopedic surgeon for hip or knee osteoarthritis, will be offered the opportunity to participate in a dietary counseling program with…
- Conditions
- Obesity, Osteo Arthritis Knee, Osteoarthritis, Hip
- Trial name
- NCT04439019
- Testing
- Lifestyle and dietary modification program
- Where
- Canada
- Sponsor
- Alberta Hip and Knee Clinic
Knee Osteoarthritis
Health Aid for Knee Osteoarthritis
Knee osteoarthritis is a common condition that can cause pain, stiffness, and difficulty with daily activities. Many patients interpret these symptoms as signs of ongoing joint damage, which can influence their expectations and…
- Trial name
- KOA-HAID (NCT07669532)
- Testing
- Health Aid, Decision Aid
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- David Ring
Osteoarthritis, Knee
CONNACT OA Knee Cohort
CONNACT OA knee cohort is a prospective longitudinal cohort study where we aim to collect sociodemographic, psychosocial, clinical, health utilization and cost data in order to better understand the Asian OA knee cohort and…
- Trial name
- CONNACT (NCT04942236)
- Where
- 3 sites in Singapore
- Volunteers
- 500 people
- Sponsor
- Tan Tock Seng Hospital
Knee, Osteoarthritis
Amniotic Suspension Allograft Injection for Knee Osteoarthritis
There have been few clinical trials on ASA for the treatment of knee osteoarthritis, and there is currently no literature reporting the optimal treatment dosage.
- Trial name
- ASAIKO (NCT06704893)
- Testing
- ASA injection 40 mg group, ASA injection 20 mg group, HA injection group
- Where
- 2 sites in Taiwan
- Volunteers
- 160 people
- Sponsor
- Chang Gung Memorial Hospital
Osteoarthritis, Pain
Study of Efficacy, Safety of Fulranumab Monotherapy for OA of Hip or Knee, PAI3003
The purpose of this study is to demonstrate the efficacy, safety, and tolerability of fulranumab as Monotherapy compared with placebo in participants with signs and symptoms of osteoarthritis of the hip or knee that are not…
- Trial name
- NCT02289716
- Testing
- Fulranumab 1 mg, Fulranumab 3 mg
- Where
- 28 sites in United States, Belgium and 6 more
- Volunteers
- 41 people
- Sponsor
- Janssen Research & Development, LLC
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