Clinical trials: Knee Osteoarthritis
Gonarthrosis, Diabetes
The Role of SCUBE-1 in Ischemia-reperfusion Injury
One consequence of tissue damage caused by tourniquet is ischemia-reperfusion injury. Short-term ischemia leads to vasodilatation and reactive hyperemia resulting in post-ischemic reperfusion microcirculation failure and tissue…
- Trial name
- NCT03389607
- Testing
- spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Osteoarthritis
Efficacy and Safety of Diclofenac Sodium Gel in Knee Osteoarthritis
This study will test the efficacy and safety of topical diclofenac sodium gel in the treatment of knee osteoarthritis.
- Trial name
- NCT00171626
- Testing
- Diclofenac Topical Sodium Gel 1%
- Where
- United States
- Volunteers
- 480 people
- Sponsor
- Novartis
Osteoarthritis
Efficacy and Safety of ATB-346 Versus Placebo in Osteoarthritis Patients
The primary objective of this study is to evaluate the efficacy of a 14-day dosing regimen of ATB-346 at doses of 150 mg, 200 mg and 250 mg compared to placebo in reducing osteoarthritis knee pain as measured by changes in the…
- Trial name
- NCT03978208
- Testing
- ATB-346 low dose, ATB-346 mid-dose, ATB-346 standard dose
- Where
- 35 sites in Canada
- Volunteers
- 381 people
- Sponsor
- Antibe Therapeutics Inc.
Osteoarthritis, Osteoarthritis, Hip
Incorporating Wearable Technology for Enhanced Rehabilitation Monitoring After Hip and Knee Replacement
This study focuses on the impact of osteoarthritis (OA), a leading cause of disability among older adults, with the hip and knee joints being particularly affected.
- Trial name
- MOVEUP-WT (NCT06157190)
- Testing
- Unsupervised monitoring
- Where
- Belgium
- Volunteers
- 1,144 people
- Sponsor
- PXL University College
Knee Osteoarthritis, Quality of Life
Psychometric Properties of the Short Form 12-item (SF-12) Health Questionnaire in Individuals With Knee Osteoarthritis
Knee Osteoarthritis (OA) is one of the most common joint diseases with chronic low-severity inflammation. 80% of individuals with knee OA have limited movements; It was found that 25% of them could not do their daily work.
- Trial name
- SF-12 (NCT06004024)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Meltem Meran Çağlar
Osteoarthritis, Knee
Experimental Study of Strength Training to Activate the Quadriceps Muscle After Total Knee Arthroplasty
Background: Progressive strength training is a training modality used in rehabilitation after total knee arthroplasty (TKA). Strength deficits up to 80% in the quadriceps muscle is shown to be present in the operated leg after…
- Trial name
- NCT01713140
- Testing
- 1 strength training set performed until contraction failure
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Osteo Arthritis Knee, Degenerative Joint Disease of Knee
Intra-articular Transplantation of Autologous Adipose Derived Stromal Vascular Faction (SVF) for Treatment of Osteoarthritis of the Knee
Researchers are trying to determine the safety and feasibility of autologous, adipose derived stromal vascular fraction injections in the treatment of knee osteoarthritis
- Trial name
- NCT03940950
- Testing
- Autologous Adipose-Derived SVF (Stromal Vascular Fraction)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis
The Effect of Osteopathic Manual Therapy on Vascular Supply
The purpose of this study is to determine if the use of osteopathic manual therapy can influence the vascular supply to the knee, knee range of motion, balance and knee pain, in a group of subjects with knee osteoarthritis.
- Trial name
- NCT01020591
- Testing
- Osteopathic evaluation, Osteopathic evaluation with treatment
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Nova Scotia Health Authority
Osteoarthritis, Knee, Depressive Symptoms
Study on Brain Structure and Function of Pain-related Emotion Disorder
By the method of multi-mode Magnetic Resonance Imaging, 5 patients with knee osteoarthritis are selected in this trial to observe the possible differences in the brain structure and function from the 5 healthy volunteers.
- Conditions
- Osteoarthritis, Knee, Depressive Symptoms, Anxiety State
- Trial name
- NCT03912610
- Testing
- Functional magnetic resonance examination
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Zhoujie
Localized Primary Osteoarthritis of Hip, Localized Primary Osteoarthritis of Knee
Phase III Study of CG100649 in Osteoarthritis Patients
6-week Efficacy Study The objective of this study is to prove the safety and non-inferiority of analgesic efficacy of CG100649 2 mg vs. celecoxib 200 mg, and analgesic superiority of CG100649 2 mg vs.
- Trial name
- NCT01765296
- Testing
- CG100649, Celecoxib
- Where
- 14 sites in South Korea
- Volunteers
- 362 people
- Sponsor
- CrystalGenomics, Inc.
Osteoarthritis
Intra-articular Polyacrylamide Hydrogel in Knee Osteoarthritis
The aim of this double-blinded controlled study is to assess clinical efficacy and safety of intra-articular HBISA Endoprosthesis of Synovial Fluid (polyacrylamide hydrogel) in comparison with placebo (0.9% sodium chloride…
- Trial name
- NCT03897686
- Testing
- hydrous biopolymer with silver ions "Argiform", saline solution
- Where
- 4 sites in Russia
- Volunteers
- 144 people
- Sponsor
- Research Centre BIOFORM
Osteoarthritis, Knee
Synovitis in Patients With Osteoarthritis
To study synovial membrane (SM) inflammation in suprapatellar fossa in advanced knee osteoarthritis (OA), and to correlate the pathological features with clinical findings.
- Trial name
- NCT05617573
- Testing
- Total knee arthroplasty due to advanced osteoarthritis.
- Where
- China
- Volunteers
- 272 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Knee Osteoarthritis
Neurofeedback for Pain Sensitization in Knee Osteoarthritis
The goal of this clinical trial is to learn whether a training method called neurofeedback is safe and practical to use in people with knee osteoarthritis (knee OA).
- Trial name
- NCT07832682
- Testing
- FWR Down-Conditioning Neurofeedback
- Volunteers
- 50 people
- Sponsor
- Northeastern University
Osteoarthritis, Knee
The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics
The purpose of this study is to determine the impact of a regular course of treatment with Hyaluronic acid (HA) injections on gait in knee osteoarthritis (OA) patients.
- Trial name
- NCT00778076
- Testing
- Hyaluronic acid
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Western Ontario, Canada
Osteo Arthritis Knee
Effects of Retro-walking in Patients With Knee OA
Osteoarthritis is degenerative joint disease that cause deterioration of the articular cartilage and neighboring tissue and lead to osteophyte formation, weakening of surrounding muscles, ligamentous laxity and inflammation of…
- Trial name
- NCT06130774
- Testing
- Retro walking and conventional, conventional therapy
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Osteoarthritis, Knee
Calypso Knee System Clinical Study
A clinical study to evaluate the safety and effectiveness of the Calypso Knee System when used in subjects with symptomatic osteoarthritis of the medial compartment of the knee.
- Trial name
- NCT03671213
- Testing
- Calypso Knee System (Implantable Shock Absorber)
- Where
- 5 sites in United States
- Volunteers
- 81 people
- Sponsor
- Moximed
Gonarthrosis, Neuropathic Pain, Nociceptive Pain
Functional Brain MRI to Understand Pain Phenotypes in Knee Osteoarthritis
Some people with knee osteoarthritis (gonarthrosis) experience pain differently. In some, the pain is described as "nociceptive" (directly related to the joint), while in others it has "neuropathic" characteristics (related to…
- Trial name
- INDIGO (NCT07668674)
- Testing
- blood sampling, Resting-state functional MRI
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Knee Osteoarthristis
Precision Rehabilitation: Mechanisms and Efficacy of Vibration in Exercise Training for Degenerative Knee Osteoarthritis
Knee osteoarthritis (OA) is a common degenerative disease in older populations. Chronic pain, quadriceps weakness, limited daily activities, lack of mobility, and balance and walking dysfunction are the most common symptoms.
- Trial name
- NCT06616896
- Testing
- vibration
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Knee Osteoarthritis
Knee Pain Ejiao Paste for Knee Osteoarthritis
To explore the analgesic efficacy of Knee Pain Ejiao Paste in the treatment of knee osteoarthritis (Qi and Blood Deficiency Pattern) after 12 weeks, using an Ejiao-free clear paste as a parallel control and incorporating a…
- Trial name
- NCT07504562
- Testing
- Knee Pain Ejiao Paste, Knee Pain Ejiao-free Clear Paste
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- ShuGuang Hospital
Knee Osteoarthritis
Comparison of Custom and Standard Total Knee Replacements
Total knee arthroplasty (TKA) is the most common surgery in North America and the second most common in Europe. One of the most critical issues for stability and durability of the interventional is the prosthesis-bone geometric…
- Trial name
- NCT06122727
- Testing
- total knee arthroplasty
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Ortopedico Rizzoli
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