Clinical trials: Knee Osteoarthritis
Knee Osteoarthritis
Minimally Invasive Surgical Approaches In Total Knee Arthroplasty
The hypothesis of the proposed study is that performing total knee arthroplasty through a mini subvastus approach results in statistically significant differences in one or more of the above functional outcome measures, when…
- Trial name
- NCT01461356
- Testing
- Minimally invasive total knee replacement, Standard approach total knee replacement
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis
Stimulate Brain and Reduce Knee Pain Due to Degeneration
Osteoarthritis (OA) knee is chronic, slowly progressive, degenerative disease of joint which affects articular cartilage and accompanied by pain, swelling and loss of function .
- Trial name
- NCT04320875
- Testing
- Transcranial direct current stimulation, Conventional Physiotherapy
- Volunteers
- 80 people
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
First-in-human Single Ascending Dose Study of LNA043 in Patients Scheduled for Total Knee Replacement
This study is designed to evaluate the safety and tolerability of ascending single doses of LNA043 given intra-articularly into the human knee joint prior to its removal at total knee replacement surgery.
- Trial name
- NCT02491281
- Testing
- LNA043
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Knee Osteoarthritis, Chronic Knee Pain
Selective Nerve Ablation for Chronic Knee Pain: A Retrospective Study
SAVE-KNEE is a single-center retrospective observational cohort study evaluating outcomes of ultrasound-guided cryoneurolysis, radiofrequency ablation and chemical neurolysis for chronic knee pain in routine clinical care.
- Trial name
- SAVE-KNEE (NCT07835672)
- Testing
- Ultrasound-Guided Cryoneurolysis, Ultrasound-Guided Radiofrequency Ablation, Ultrasound-Guided Chemical Neurolysis
- Where
- Poland
- Volunteers
- 746 people
- Sponsor
- Michał Bartoszewicz
Pain
Long-term Safety of PF-00345439 (Oxycodone)
Long-Term Safety Of PF-00345439 (Oxycodone) In Patients With Moderate To Severe Chronic Low Back Pain Or Osteoarthritis
- Trial name
- NCT01559701
- Testing
- PF-00345439
- Volunteers
- 823 people
- Sponsor
- Pain Therapeutics
Osteoarthritis
Effectiveness Of Single Doses Of Ibuprofen In Patients With Osteoarthritis Of The Knee
To demonstrate that new drugs work, many complex multidose studies are often required. The intent of this study is to use Ibuprofen as an example of a marketed pain relief drug to validate a simpler single dose model for future…
- Trial name
- NCT00372801
- Testing
- Ibuprofen
- Where
- Australia
- Volunteers
- 36 people
- Sponsor
- GlaxoSmithKline
Knee Osteoarthritis (Kellgren-Lawrence Grade 1-3)
Targeted Rehabilitation Versus Standard Care in Managing Medial Knee Pain and Varus Malalignment: A Randomized Control Trial
Medial knee pain with varus alignment is common in active adults and is associated with increased medial joint loading, cartilage loss, and progression of knee osteoarthritis.
- Trial name
- NCT07410429
- Testing
- Conventional Knee Physical Therapy Program, Targeted Alignment-Focused Exercise Program for Varus Knee
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Patient Reported Outcome, Knee Osteoarthritis
Substitution of the PCL in TKA With UC or PS Design
RCT comparing UC and PS TKA
- Conditions
- Patient Reported Outcome, Knee Osteoarthritis, Knee Arthroplasty
- Trial name
- NCT04679857
- Testing
- TKA
- Where
- Germany
- Volunteers
- 127 people
- Sponsor
- Technische Universität Dresden
Osteoarthritis
The Role of Intra-Operative Intracapsular Blocks in Post-Operative Pain Management Following Total Knee Arthroplasty
The purpose of this study is to use a new combination of anesthesia techniques in an attempt to minimize early pain after surgery and improve the patient's ability to participate more fully with physical therapy.
- Trial name
- NCT00620828
- Testing
- Ropivicaine 0.5%
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Duke University
Osteoarthritis, Knee
The Effects of End-of-range Grade A+ Mobilization Following Acute Primary TKA
The purpose of the study is to find the best way to mobilize a knee after total knee arthroplasty (TKA). In particular, the aim of this study will be to investigate the advantages of adding a gentle knee mobilization to the…
- Trial name
- NCT02105857
- Testing
- grade A+ knee mobilization
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- University of Lausanne Hospitals
Osteoarthritis
Application of Radiostereometric Analysis (RSA) to Triathlon Knee Components Inserted Using the OtisMed Custom-fit Total Knee Replacement System
The OtisMed Custom-fit system for total knee replacements replaces conventional surgical techniques for templating and intra-operative instrumentation with a preoperative virtual surgery process that utilizes 3D models of the…
- Trial name
- NCT01262430
- Testing
- OtisMed, Computer Assisted Surgery (CAS)
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- Dalhousie University
Osteoarthritis of the Knee
Study to Characterize the Local Duration of Exposure From FX006 in Patients With Osteoarthritis of the Knee
The purpose of this study was to characterize the local duration of exposure of TCA for 2 doses of FX006 relative to 40 mg of TCA IR in patients with OA of the knee.
- Trial name
- NCT02003365
- Testing
- FX006 10 mg, FX006 40 mg, TCA IR 40 mg
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Osteoarthritis (OA)
A Placebo-Controlled Study of Collagen Hydrolysate in Subjects With Knee Osteoarthritis (OA)
This study is designed to evaluate, by MRI, knee cartilage and structure in all subjects. Half the subjects in this study will take collagen hydrolysate each day for 48 weeks and the other half of the subjects will take a placebo…
- Trial name
- NMR (NCT00536302)
- Testing
- Collagen Hydrolysate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- GELITA
Osteoathritis
Medial-Wedge Insole is Highly Effective in the Treatment of Valgus Knee Osteoarthritis
To assess the efficacy of medial-wedge insole in valgus knee osteoarthritis (OA). We hypothesized that medial-wedged insoles are biomechanically effective and should reduce lateral compartment loading in persons with valgus knee…
- Trial name
- NCT00467337
- Testing
- Medial-Wedge Insole intervention
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Varus Deformity, Valgus Deformity
Prospective Multi-Center Study on Vanguard With E1 Bearing
Evaluate Clinical Performance of Vanguard Knee with E1 Bearing in Korean Patient Population
- Conditions
- Varus Deformity, Valgus Deformity, Posttraumatic Deformity, Osteoarthritis, Knee
- Trial name
- VGRDE1 (NCT02088372)
- Testing
- Vanguard with E1 PS Bearing
- Where
- 4 sites in South Korea
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Efficacy of AI-Driven and Traditional Physical Therapy Programs in Patients With Knee Osteoarthritis
This study aims to compare the effectiveness of an artificial intelligence (AI)-guided physical therapy program with a traditional physical therapy program in patients with knee osteoarthritis.
- Trial name
- NCT07774195
- Testing
- AI-Guided Physical Therapy Program, Traditional Physical Therapy Program, Lifestyle Modification and Joint Protection Education
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Osteoarthritis, Knee
Clinical Outcomes of MP Persona vs. Persona Knee-PS
Knee osteoarthritis (OA) is a highly prevalent condition that results in substantial pain and loss of function. The end stage treatment for knee OA is total knee arthroplasty (TKA), a common and safe procedure typically performed…
- Trial name
- MP-Persona (NCT03681977)
- Testing
- Zimmer MP Persona, Zimmer Persona Knee-PS
- Where
- 3 sites in Canada
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Lady Davis Institute
Osteoarthritis, Knee
Trial Comparing Three Single Dose Injections for Knee Osteoarthritis
This study is a 3-arm, double-blind, randomized trial comparing the clinical outcomes of Zilretta, Synvisc One, and Monovisc for knee OA.
- Trial name
- NCT05492851
- Testing
- Zilretta, Synvisc-One 48 MG in 6 ML Prefilled Syringe, Monovisc 88 MG Per 4 ML Prefilled Syringe
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Ohio State University
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Low Back Pain, Knee Osteoarthritis
Central Sensitization in Patients Seeking Outpatient Physical Therapy Services
This is an observational study to examine presence of CS in patients with knee osteoarthritis (OA), chronic LBP (CLBP), and chronic neck pain (CNP) seeking outpatient physical therapy (PT) services.
- Conditions
- Low Back Pain, Knee Osteoarthritis, Neck Pain
- Trial name
- NCT05467592
- Testing
- Standard Physical Therapy care
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Kansas Medical Center
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