Clinical trials: Knee Osteoarthritis
Knee Osteoarthritis
Motor Imagery and Action Observation in Patients With Knee Osteoarthritis
The main objective of this study is to evaluate the effects of an exercise programme combined with motor imagery and action observation, both in the short and long term.
- Trial name
- NCT06398184
- Testing
- Exercise + motor imagery and action observation, Exercise
- Volunteers
- 40 people
- Sponsor
- Cardenal Herrera University
Knee Osteoarthritis, Knee Replacement
Physical Therapy Components for Maximum TKR Outcome
The overall goal of this study is to identify what Physical Therapy care components are associated with the best patient-reported functional outcome after Total Knee Replacement (TKR) surgery.
- Trial name
- NCT03120052
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- University of Massachusetts, Worcester
Avascular Necrosis of the Femoral Head, Coronary Artery Disease (CAD)
Desflurane Potentially Induces Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Perioperative Procedures by Modulating Cdc42 and Clock Proteins
This clinical trial investigates whether desflurane induces postoperative cognitive dysfunction (POCD) in elderly patients undergoing perioperative procedures by modulating Cdc42 and Clock proteins.
- Conditions
- Avascular Necrosis of the Femoral Head, Coronary Artery Disease (CAD), Benign Prostatic Hyperplasia (BPH), Cholecystitis
- Trial name
- NCT06772558
- Testing
- Desflurane Inhalation, mechanical ventilation (MV)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiaguang Duan
Osteoarthritis, Knee, Osteoarthritis, Hip
An Effectiveness, Safety and Quality of Life Measures With Hydromorphone HCL, Dilaudid CR (Controlled Release)
The purpose of this study was to characterize the effectiveness and safety of OROS hydromorphone HCL and OxyContin in patients with chronic osteoarthritis (OA) of the knee or hip who are receiving chronic nonsteroidal…
- Trial name
- NCT00399048
- Testing
- OROS hydromorphone HCL ; OxyContin
- Volunteers
- 140 people
- Sponsor
- Alza Corporation, DE, USA
Osteoarthritis
Quantitative Ultrasonography (US) Evaluation on Femoral Condyle Cartilage
The purpose of this study is to investigate the feasibility of using quantitative ultrasonography (US) evaluation to determine the severity of osteoarthritic femoral condyle cartilage erosion.
- Trial name
- US (NCT00630604)
- Sponsor
- Kaohsiung Medical University
Knee Osteoarthrosis, Total Knee Arthroplasty
Patients' Experiences of Information After Total Knee Arthroplasty - A Qualitative Interview Study
The aim of this qualitative interview study is to gain new and in-depth knowledge about patients' experiences of information following total knee arthroplasty. Participants will be interviewed in the recovery phase after surgery.
- Trial name
- NCT06994884
- Where
- 2 sites in Sweden
- Volunteers
- 16 people
- Sponsor
- Vastra Gotaland Region
Osteoarthritis, Chronic Pain
Imaging Pain Relief in Osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease and is the most common form of arthritis. Pain reduction and functional recovery are the key elements of the clinical management of OA.
- Trial name
- IPRO (NCT02208778)
- Testing
- Duloxetine, Remifentanil
- Where
- United Kingdom
- Volunteers
- 77 people
- Sponsor
- University of Nottingham
Knee Osteoarthritis
Treatment of Knee Osteoarthritis: Neuromuscular Electrical Stimulation and Low-level Laser.
The purpose of this study is to determine the effects of low-level laser therapy in combination with neuromuscular electrical stimulation on neuromuscular (muscular strength and morphology) and functional parameters (pain and…
- Trial name
- NCT02067871
- Testing
- Laser Therapy, Electrical Stimulation
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Marco Aurélio Vaz, PhD
Knee Osteoarthritis
Comparison of the in Vivo Stability of 2 Cementless TKA Designs
The goal of this randomized controlled trial is to analyze the stability of a cementless Total Knee Arthroplasty (TKA) over time and compare it to a well-documented implant in patients with knee osteoarthritis.
- Trial name
- ClessTKA (NCT05651009)
- Testing
- TKA
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Helse Møre og Romsdal HF
Osteoarthritis, Knee
Clinical Trial of YYC301 for Treatment of Osteoarthritis of the Knee
A Multi-center, Double-blinded, Randomized, Active-controlled, Parallel Design, phaseII Study to Investigate the Efficacy and Safety of YYC301 in Subject With Knee Osteoarthritis
- Trial name
- NCT03850587
- Testing
- Celecoxib 200mg, Tramadol 37.5Mg+ Celecoxib 200mg, Tramadol 75mg+ Celecoxib 200mg
- Where
- 10 sites in South Korea
- Volunteers
- 261 people
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Osteoarthritis, Knee
Effect of Topical and Intravenous Tranexamic Acid (TXA) on Thrombogenic Markers in Patients Undergoing Knee Replacement
Tranexamic acid (TXA) is a drug that is being used more frequently at the Hospital for Special Surgery to lessen the amount of blood loss after total knee replacement (TKR).
- Trial name
- TXA Knee (NCT02540226)
- Testing
- Intravenous tranexamic acid, Topical tranexamic acid, Intravenous saline
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthrosis
Nuclear Magnetic Resonance Therapy in Knee Osteoarthrosis
Nuclear Magnetic Resonance Therapy (NMRT) is gaining as a novel mode of therapy in osteoarthrosis. A prospective double blind randomised study of 100 patients was conducted to investigate efficacy of NMRT in the treatment of mild…
- Trial name
- NCT01603017
- Testing
- MRI therapy, MRI therapy (off)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- NHS Grampian
Teach-Back Communication, Arthritis
Analyzing Challenging Clinical Discussions in Orthopaedics
The goal of this study is to analyze patient:provider communication surrounding the discussion of difficult clinical conversations such as knee replacement options.
- Conditions
- Teach-Back Communication, Arthritis, Knee Osteoarthritis, Knee Arthropathy
- Trial name
- NCT03058393
- Testing
- Teach-Back Lesson
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Duke University
Knee Osteoarthritis
Investigating the Impact of Ex Vivo Ozone Injection on Synovial Fluids in Patients Diagnosed With Knee Osteoarthritis
The objective of this study is to examine the effect of varying ozone doses on the levels of pro-inflammatory cytokines in synovial fluid collected from individuals with knee osteoarthritis.
- Trial name
- NCT05824052
- Testing
- Ozone injection
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Uskudar State Hospital
Sleep, Pain
Acupuncture for Pain and Sleep Disturbance in Knee Osteoarthritis
The hypotheses of this study are: In the older population with knee OA, When acupoints are chosen for both sleep and pain, there are additive effects on sleep improvement and pain relief (i.e. no interaction).
- Trial name
- NCT00694447
- Testing
- Acupuncture
- Where
- United States
- Sponsor
- Emory University
Osteoarthritis
Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections for Knee Osteoarthritis
Corticosteroid injections are commonly used for the symptomatic treatment of knee osteoarthritis. Common practice is to inject the joint with a combination of corticosteroid and local anesthetic, with the rationale of providing…
- Trial name
- NCT02576249
- Testing
- Ropivacaine, Normal saline, Methylprednisolone
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Mayo Clinic
Osteoarthritis, Knee
Mesenchymal Stem Cell Therapy for Knee Osteoarthritis
The study is a multicentered, randomized, double-blinded, placebo-controlled study conducted on the unilateral knee of 120 patients.
- Trial name
- NCT05288725
- Testing
- Bone Marrow Derived MSCs, Corticosteroid, Bone Marrow Aspirate
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Next Generation Regenerative Medicine LLC
Osteoarthritis
A Study to Evaluate the DePuy Minimally Invasive Unicompartmental Knee
The primary purpose of this investigation is to evaluate the surgical performance of the DePuy Minimally Invasive (Preservation) Unicompartmental Knee and Instrumentation in a Multi-centre setting.
- Trial name
- NCT00734084
- Testing
- Preservation Unicompartmental Knee
- Where
- Australia
- Volunteers
- 247 people
- Sponsor
- DePuy International
Knee Osteoarthritis
Comparison of Short-term Effects of Extracorporeal Shock Wave Therapy, Low-level Laser Therapy and Pulsed Electromagnetic Field Therapy in Knee Osteoarthritis
120 patients with Kellgren-Lawrence grade 2-3 knee osteoarthritis will be randomized into four groups: Control group, Extracorporeal shock wave therapy (ESWT) (once a week for 3 sessions), Low-level laser therapy (LLLT) (twice a…
- Trial name
- NCT06717633
- Testing
- extracorporeal shock wave therapy, low-level laser therapy, pulsed electromagnetic field therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul Medeniyet University
Osteoarthritis of Knee, Osteoarthritis, Knee
A Study to Evaluate Efficacy and Safety of AMZ001 for the Treatment of Knee Osteoarthritis Symptoms
This is a multicenter, randomized, double-blind, placebo-controlled, parallel group, 6-week trial of a formulation of AMZ001 once daily versus placebo once daily.
- Trial name
- AMZ001 (NCT06693648)
- Testing
- AMZ001 Diclofenac gel
- Where
- 11 sites in United States, China and 3 more
- Volunteers
- 549 people
- Sponsor
- Amzell
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