Clinical trials: Knee Osteoarthritis
Osteoarthritis, Knee, Chronic Pain
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
The main purpose of this study is to test the safety and efficacy of study drug for the treatment of knee pain due to osteoarthritis (OA).
- Trial name
- OA07 (NCT07641517)
- Testing
- LY4065967
- Where
- 36 sites in United States, Puerto Rico
- Volunteers
- 150 people
- Sponsor
- Eli Lilly and Company
Osteoarthritis
Knee Injection RCT
Hypothesis: Ketorolac injection is a cost-effective adjunct in the nonoperative treatment of knee osteoarthritis (OA) compared to steroids and viscosupplementation.
- Trial name
- NCT03694821
- Testing
- Ketorolac Tromethamine Injection, Methylprednisolone Acetate Injection, Hylan G-F 20
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- UConn Health
Osteoarthritis, Knee, Healthy Subjects
Predictors for Analgesic Effect to Standardized Exercise Therapy for Osteoarthritic Pain
Pain sensitization has been associated with pain severity in people with knee osteoarthritis (KOA) and a neuropathic pain component has been identified in up to 30% of KOA patients.
- Trial name
- NCT03718663
- Testing
- Physiotherapy-guided Evidence-based Exercise Therapy, Part 2: Military training
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Kristian Kjær Petersen
Knee Osteoarthritis
Phase 2B Micronized DHACM vs. Saline in the Treatment of Knee Osteoarthritis
The purpose of this study is to determine the safety and efficacy of the 40 mg and 100 mg doses of allogeneic micronized dehydrated human amnion/chorion membrane (micronized DHACM) injectable compared to 0.9% sodium chloride…
- Trial name
- NCT05796765
- Testing
- Micronized DHACM 40 mg, Micronized DHACM 100 mg, Saline
- Where
- 14 sites in United States
- Volunteers
- 43 people
- Sponsor
- MiMedx Group, Inc.
Obesity, Overweight
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo.
- Conditions
- Obesity, Overweight, Osteoarthritis, Knee
- Trial name
- AMAZE 6 (NCT07509307)
- Testing
- NNC0487-0111
- Where
- 81 sites in United States, Australia and 9 more
- Volunteers
- 400 people
- Sponsor
- Novo Nordisk A/S
Osteoarthritis
Perioperative Pain Control With Celecoxib (Celebrex) in Total Knee Arthroplasty
We propose that administration perioperative celecoxib is effective to control postoperative VAS pain scores, improve rehabilitation results, and decrease narcotics usage in total knee replacement patients.
- Trial name
- NCT00598234
- Testing
- Celecoxib (Celebrex)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Knee Osteoarthritis
Effects of KT and Rigid Taping in Knee OA.
The purpose of the study is to compare the effects of kinesio taping and rigid taping in Knee Osteoarthritis to alleviate symptoms like pain, reduce range of motion and functional limitations.
- Trial name
- NCT05946434
- Testing
- Kinesio Tape Group, Rigid Tape Group
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Osteoarthritis Knee
Efficacy and Safety Study of Individualized and Standardized Acupuncture Treatment for Knee Osteoarthritis
The purpose of this study is to verify the efficacy and safety of acupuncture treatments (Individualized, Standardized acupuncture) for patients with knee osteoarthritis (OA).
- Trial name
- NCT01569230
- Testing
- Standardized Acupuncture, Individualized Acupuncture, Waiting
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Eun Jung Kim
Knee Osteoarthritis, Hip Osteoarthritis
Daycase Hip and Knee Arthroplasty in Møre and Romsdal Trial
The DART Study is a prospective, multicentre observational cohort study evaluating day-case pathways for patients undergoing primary total hip arthroplasty, total knee arthroplasty, or unicompartmental knee arthroplasty at three…
- Conditions
- Knee Osteoarthritis, Hip Osteoarthritis, Osteonecrosis, Osteoarthritis
- Trial name
- DART (NCT07834034)
- Testing
- Total Hip Arthroplasty, Total Knee Arthroplasty, Unicondylar knee artrhoplasty
- Where
- 3 sites in Norway
- Volunteers
- 300 people
- Sponsor
- Helse Møre og Romsdal HF
Osteoarthritis (OA) of the Knee
The Effects of Knee Brace and Muscle Training on Osteoarthritis Patients
A new non-weight-bearing knee brace has been developed to correct abnormal alignment and reduce joint pressure, showing promising results in alleviating knee osteoarthritis symptoms compared to traditional braces.
- Trial name
- NCT07246109
- Testing
- knee brace
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- China Medical University Hospital
Osteoarthritis, Knee, Osteoarthritis, Hip
A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip
The primary objective of the study is to evaluate the efficacy of fasinumab compared with placebo, when administered for up to 16 weeks in patients with pain due to osteoarthritis (OA) of the knee or hip.
- Trial name
- FACT OA1 (NCT03161093)
- Testing
- Fasinumab, Naproxen
- Where
- 139 sites in United States, Denmark and 10 more
- Volunteers
- 3,307 people
- Sponsor
- Regeneron Pharmaceuticals
Osteoarthritis
Efficacy and Safety of Lumiracoxib in Patients With Primary Knee Osteoarthritis(OA)
This 39-week, open label study is designed to assess long-term efficacy, safety and tolerability of lumiracoxib 100mg od in patients with osteoarthritis (OA) of the knee who participated in the 13-week core CCOX189A2360 study.
- Trial name
- NCT00475800
- Testing
- Lumiracoxib
- Where
- 6 sites in United States, Canada
- Volunteers
- 833 people
- Sponsor
- Novartis
Osteo Arthritis Knee, Chronic Pain
Addition of Transcranial Direct Current Stimulation and Transcutaneous Electrical Nerve Stimulation to an Education and Exercise Program in Subjects With Chronic Pain Due to Knee Osteoarthritis
Knee osteoarthritis has a very high prevalence in the population over 50 years of age. Patients with osteoarthritis often suffer from chronic pain that becomes disabling, affecting both quality of life and mental and physical…
- Trial name
- NCT05138471
- Testing
- transcranial direct current stimulation (tDCS), TENS, Exercise and General Education
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- Universidad de Murcia
Knee Osteoarthritis
Sanomechanics® Rehabilitative Technology
Rehabilitative Sanomechanics Method (RSM) of exercise designed to restore normal subperiosteal transmission of in-joint pressures and normalizing contact pressures on cartilages, will reduce pain in the affected joints and…
- Trial name
- NCT05512507
- Testing
- Physical Therapy Program
- Volunteers
- 15 people
- Sponsor
- PolyOrth International
Osteo Arthritis Knee
Comprehensive Knee Osteoarthritis Index (CKOAI): Scale Development, Validation and Reliability Testing
Background: Symptoms, balance, mobility, activities of daily life (ADL) and quality of life (QoL) are to be considered in rehabilitation of the individuals with knee osteoarthritis (IKOA).
- Trial name
- CKOAI (NCT03498833)
- Testing
- Test-retest reliability testing
- Where
- India
- Volunteers
- 52 people
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Osteoarthritis, Knee, Anterior Cruciate Ligament Injuries
Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury
The goal of this randomized clinical trial is to evaluate the effects of vibration on factors related to the risks of post-traumatic knee osteoarthritis and secondary anterior cruciate ligament (ACL) injury in individuals who…
- Conditions
- Osteoarthritis, Knee, Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Quadriceps Muscle Atrophy
- Trial name
- NCT04875052
- Testing
- Experimental: Whole Body Vibration, Experimental: Local Muscle Vibration, Standard ACL Rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoarthritis, Knee, Obesity
Effects of Diet Control and Resistance Exercise Training on Obesity Adults With Knee Osteoarthritis
The purpose of this study was to investigate the effects of obesity on knee degenerative arthritis on body composition after dietary control and elastic resistance exercise; and whether persistent exercise habits and dietary…
- Conditions
- Osteoarthritis, Knee, Obesity, Diet, Healthy, Training Group, Sensitivity
- Trial name
- NCT03973463
- Testing
- Elastic knee joint movement
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital
Osteoarthritis, Knee
Pre-operative Intravenous Steroid in Total Knee Replacement for Pain Relief and Recovery
Osteoarthritis of the knee is a common and important condition in our society. Despite various anesthetic methods and pain medications, pain after operation still remains as a challenge.
- Trial name
- NCT03082092
- Testing
- Methylprednisolone Sodium Succinate
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Queen Elizabeth Hospital, Hong Kong
Knee Arthritis Osteoarthritis
Different Hold Durations in Isometric Exercises
this stuy tries to evaulate the best contraction (hold time) during isometric effort that can provide the best therapeutic effects on muscular performance in patients with knee osteoarthritis
- Trial name
- NCT07198204
- Testing
- isometric exercises, therapeutic ultrasound, Transcutanous electrical nerve stimulation
- Where
- Egypt
- Volunteers
- 127 people
- Sponsor
- University of Hail
Osteoarthritis, Knee
Strawberries and Knee Osteoarthritis (OA)
The proposed study aims to examine the hypothesis that strawberry supplementation will lower serum biomarkers of inflammation and improve knee function in patients with symptomatic osteoarthritis (OA).
- Trial name
- NCT02518347
- Testing
- FDS-Strawberry
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oklahoma State University
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