Clinical trials: Knee Osteoarthritis
Meniscus Injury, Knee Osteoarthritis
Knee Arthroscopy Cohort Southern Denmark (KACS)
PURPOSE: To investigate the natural time course of patient-reported outcomes after meniscus surgery and identify factors associated with good and bad outcome after surgery.
- Trial name
- KACS (NCT01871272)
- Testing
- Arthroscopic Meniscus Surgery
- Where
- 4 sites in Denmark
- Volunteers
- 491 people
- Sponsor
- University of Southern Denmark
Knee OA, Osteoarthritis
Comparing Exercise Programs for Managing Knee Osteoarthritis
The goal of this clinical trial is to assess and compare the effectiveness of three different exercise modalities-whole-body vibration exercise, progressive resistance exercise, and home-based exercise -in improving quadriceps…
- Conditions
- Knee OA, Osteoarthritis, Osteoarthritis (OA) of the Knee
- Trial name
- NCT06711341
- Testing
- Whole-body Vibration (WBV) Training, Progressive Resistance Exercise (PRE), Home-Based Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Uludag University
Osteoarthritis, Knee
An Exploratory Clinical Study to Investigate the Effect of autoSTEM-OA and alloSTEM-OA in Participants With Knee Osteoarthritis
A phase 1 exploratory clinical study to investigate safety, tolerance and efficacy of a single intra-articular injection of autoSTEM-OA or alloSTEM-OA in participants with mild to moderate knee osteoarthritis
- Trial name
- NCT05789719
- Testing
- STEM-OA
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- StemMedical A/S
Osteoarthritis, Knee
Study To Assess The Efficacy And Safety Of The Medical Device Iracross Versus Iraline Administered Intra-Articular To Patients With Knee Osteoarthritis
Comparison with a non-inferiority design at 12 and 24 weeks on a larger scale is real to objectively evaluate the composite measurement of ROM, pain and basic activities like walking or performing daily activities (QoL) in a…
- Trial name
- NCT04574453
- Testing
- Iracross, Iraline
- Where
- Romania
- Volunteers
- 103 people
- Sponsor
- I.R.A. Istituto Ricerche Applicate S.p.A.
Osteoarthritis
Evaluation of the Latella™ Knee Implant System for Medial Osteoarthritis Pain Reduction
The objective of the Latella-US study is to demonstrate the safety and efficacy of the Latella Knee Implant System for the reduction of medial osteoarthritis pain.
- Trial name
- Latella-US (NCT02608957)
- Testing
- Latella Knee Implant System
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Cotera, Inc.
Knee Arthritis, Osteoarthritis
A Single-Center Phase 1 Study of ceAF for Knee Osteoarthritis (KOA)
Approximately 25 participants aged 18-70 years, with knee pain rated 4-7 on a 10-point visual analogue scale (VAS) and a disease duration of 6 months to 10 years, will be enrolled. The study has two parts.
- Trial name
- KOA (NCT07902128)
- Testing
- Animal early embryo extract
- Where
- China
- Volunteers
- 26 people
- Sponsor
- Anhui HygeianCells BioMedical Co., Ltd.
Osteoarthritis, Pain, Postoperative
Liposomal Bupivacaine Versus Standard Bupivacaine Plus Dexamethasone in Quadriceps Sparing Femoral Nerve Block and Wound Infiltration for Total Knee Arthroplasty
The purpose of this study is to compare the efficacy and duration of pain relief after total knee arthroplasty provided by a single injection of liposomal bupivacaine (EXPAREL®) versus standard bupivacaine with an adjuvant…
- Trial name
- NCT02624856
- Testing
- Liposomal bupivacaine, Bupivacaine plus dexamethasone
- Where
- United States
- Sponsor
- Albany Medical College
Osteoarthritis of the Knee
A Study to Evaluate Safety of Three Intra-articular Injections of Ampion in the Knee of Adults With Osteoarthritis Pain
Phase 1 will evaluate the safety of 3 intra-articular injections of Ampion™ administered 2 weeks apart to adults with osteoarthritis of the knee.
- Trial name
- NCT02184156
- Testing
- 4 mL injection of Ampion
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Knee Osteoarthritis
Periosteal Electrical Dry Needling in Knee Osteoarthritis
To determine the effect of periosteal electrical dry needling as an adjuvant to MWM in knee osteoarthritis for pain management, for improvement in functional activities and for ROM (Range Of Motion)
- Trial name
- NCT05398601
- Testing
- MOBILIZATION with MOVEMENT, Periosteal electrical dry needling
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Pain
Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of AZD1386 in Patients With Osteoarthritis (OA) of the Knee
The primary aim of this study is to investigate if AZD1386 is efficacious as an analgesic in patients with osteoarthritis of the knee and at what dose.
- Trial name
- OA19 (NCT00878501)
- Testing
- AZD1386
- Where
- 41 sites in Bulgaria, Canada and 5 more
- Volunteers
- 241 people
- Sponsor
- AstraZeneca
Total Knee Replacement
Innovative Gait Training for People With Knee Osteoarthritis Using Dual Belt Treadmill
Knee osteoarthritis (OA) is the most common form of arthritis and is the leading cause of chronic musculoskeletal pain and functional disability. Gait assessment is essential for the rehabilitation of people with knee OA.
- Trial name
- NCT05958212
- Testing
- Gait training program, Conventional training only
- Where
- Hong Kong
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Knee Osteoarthritis, Total Knee Arthroplasty
Open and Closed Platform Robotic-assisted Versus Conventional Total Knee Arthroplasty
REAL INTELLIGENCE™ CORI™ (CORI Surgical System) is a computer-assisted orthopedic surgical system. CORI Surgical System is designed to aid surgeons in planning and executing a procedure involving bone preparation for total knee…
- Trial name
- NCT06305065
- Testing
- KUNWU Navigation TKA procedure, CORI Surgical System TKA procedure, Conventional TKA procedure
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- Chinese University of Hong Kong
Knee Osteoarthritis
Effectiveness of Ultrasound Guided Adductor Canal Block on Chronic Pain in Knee Osteoarthritis
Adductor canal block has become popular as effective mean for pain relief following knee surgery.This block has not been checked in chronic pain patients.The purpose of this study is to assess the efficacy and safety of adductor…
- Trial name
- NCT02695654
- Testing
- Levobupivacaine, Clonidine
- Where
- Slovenia
- Volunteers
- 77 people
- Sponsor
- Mensur Salihovic
Knee Osteoarthritis, Arthropathy of Knee
A Prospective Clinical Trial Comparing Serum Mast Cell Tryptase (SMCT) Levels to Arthrofibrosis Rates Among Primary Total Knee Arthroplasty (TKA) Patients
This research is being done to see if the amount of an enzyme in blood (called serum mast cell tryptase) changes before and after surgery.
- Conditions
- Knee Osteoarthritis, Arthropathy of Knee, Arthrofibrosis
- Trial name
- NCT03598829
- Testing
- Tryptase, Serum test
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- Mayo Clinic
Osteoarthritis, Pain Syndrome
Intra-Articular, Single-shot Injection of Hyaluronic Acid and Corticosteroids in Knee Osteoarthritis
The aim of present study is to to investigate whether the combined injection of HA and CS was superior than HA alone in the treatment of knee OA.
- Conditions
- Osteoarthritis, Pain Syndrome, Intra-articular Injection
- Trial name
- NCT03047096
- Testing
- hyaluronic acid, hyaluronic acid and corticosteroids
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhongda Hospital
Knee Osteoarthritis
Prescribed Knee Brace Treatments for Osteoarthritis of the Knee (Knee OA)
The study is a non-controlled retro- and prospective multi center patient registry study. Subjects will be given a study ID number assigned at first brace fitting after consenting to partake.
- Trial name
- NCT04651673
- Testing
- This is a non interventional registry
- Where
- Sweden
- Volunteers
- 1,500 people
- Sponsor
- Össur Iceland ehf
Gonarthrosis
Therapeutic Effects of Kinesiotape in the Management of Gonarthrosis
This randomized controlled trial evaluated the effectiveness of kinesiotaping in addition to exercise for patients with knee osteoarthritis (gonarthrosis).
- Trial name
- NCT07124169
- Testing
- Kinesiotape + home exercise, Home exercise
- Volunteers
- 38 people
- Sponsor
- Fenerbahce University
Anterior Cruciate Ligament Rupture, Osteoarthritis, Knee
A Cohort Study of Non-surgical Treatment and Exercise Rehabilitation in Patients With Anterior Cruciate Ligament Rupture
This clinical trial compared the prognosis of surgical and non-surgical treatment in patients with complete anterior cruciate ligament rupture
- Trial name
- NCT05403905
- Testing
- non surgical treatment, surgical treatment
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University Third Hospital
Meniscus Lesion
Sterile Allogeneic Spongioflex® Allograft as Partial Meniscal Replacement After Incomplete Meniscal Loss
The goal of this clinical trial is to learn if partial meniscal replacement can prevent or postpone total meniscal replacement, in adult patients (female/male) with partial meniscal loss.
- Trial name
- NCT06376422
- Testing
- Spongioflex®, non-operated
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Sven Behrendt
Knee Osteoarthritis
Regenerative Medicine of Articular Cartilage: Characterization and Comparison of Chondrogenic Potential and Immunomodulatory Adult Mesenchymal Stem Cells
Articular cartilage can be the seat of many diseases including osteoarthritis and traumatic defaults. The cartilage has no intrinsic ability to repair resulting at long term in function loss in the joints.
- Trial name
- ARTHROSTEM (NCT01879046)
- Testing
- arthroplasty
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Nantes University Hospital
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