Clinical trials: Knee Osteoarthrosis
Knee Osteoarthritis
Efficacy and Safety of Hymovis ONE® (32mg/4ml) Intrarticular Injection in Active Patients With Knee Overuse Syndrome
The aim of this study is to evaluate the efficacy and safety of Hymovis® ONE (32 mg/4 ml) single intra-articular injection, in the management of pain caused by knee osteochondral lesions.
- Trial name
- NCT04661111
- Testing
- Hymovis® ONE (32 mg/4 ml)
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Osteoarthritis (OA) of the Knee
INJECTABLE COLD ENERGY THERAPY FOR THE MANAGEMENT OF CHRONIC PAIN ASSOCIATED WITH OSTEOARTHRITIS OF THE KNEE
The goal of this clinical trial is to evaluate the effectiveness of Neural Ice for pain management associated with knee osteoarthritis in adults aged 22-80 years.
- Trial name
- ICE (NCT06700109)
- Testing
- Neural Ice, Triamcinolone acetate
- Where
- 15 sites in United States
- Volunteers
- 263 people
- Sponsor
- Brixton Biosciences, Inc.
Osteoarthritis Knee
Efficacy and Safety Study of Individualized and Standardized Acupuncture Treatment for Knee Osteoarthritis
The purpose of this study is to verify the efficacy and safety of acupuncture treatments (Individualized, Standardized acupuncture) for patients with knee osteoarthritis (OA).
- Trial name
- NCT01569230
- Testing
- Standardized Acupuncture, Individualized Acupuncture, Waiting
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Eun Jung Kim
Knee Osteoarthritis
Digital Motivation to Decrease Inactive Behaviour in Patients With Knee Osteoarthritis
Physical inactivity is a major risk behaviour with a potential for causing premature death, particularly among people with mobility limitations, such as knee osteoarthritis.
- Trial name
- NCT03339011
- Testing
- Motivational SMS text message
- Where
- Denmark
- Volunteers
- 38 people
- Sponsor
- Marius Henriksen
Osteoarthritis, Knee, Diabete Type 2
Increased Blood Glucose Levels After Steroid Injection
a sample of 600 patients diagnosed as Knee osteoarthritis injected with 40 mg triamcinolone, recorded their morning fasting blood glucose levels for 7 days before injection used as the baseline blood glucose level, which was…
- Trial name
- NCT06228911
- Testing
- steroid (triamcinolone)
- Where
- Syria
- Volunteers
- 600 people
- Sponsor
- Syrian Private University
Knee Osteoarthritis
Effects of KT and Rigid Taping in Knee OA.
The purpose of the study is to compare the effects of kinesio taping and rigid taping in Knee Osteoarthritis to alleviate symptoms like pain, reduce range of motion and functional limitations.
- Trial name
- NCT05946434
- Testing
- Kinesio Tape Group, Rigid Tape Group
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Osteoarthritis, Hip Osteoarthritis
Wharton's Jelly-derived Mesenchymal Stem Cells in Osteoarthritis
This phase I/II study will enroll 100 subjects with mild to moderate osteoarthritis of the hip/knee/ glenohumeral joint will be enrolled according to strict inclusion and exclusion criteria.
- Conditions
- Osteoarthritis, Hip Osteoarthritis, Knee Osteoarthritis, Glenohumeral Osteoarthritis
- Trial name
- NCT03866330
- Testing
- Intraarticular injection of WJMSC
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Osteoarthritis, Knee
Osteoarthritis Running & Cartilage Assessment
Knee osteoarthritis (OA) is a debilitating disease affecting millions of Canadians. Exercise is a core treatment for knee OA, and is advocated by all clinical guidelines.
- Trial name
- ORCA (NCT04325334)
- Testing
- Running volume increase
- Where
- Canada
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Osteoarthritis, Knee
EVALUATION OF THE CAPACITY OF A BIOMARKER BASED ON THE RAMAN ANALYSIS OF SYNOVIAL FLUID
Osteoarthritis (OA) is the most common joint disease in the world and induces major physical, psychological, societal and economic burdens. The management of osteoarthritis is complex.
- Trial name
- VISCODIAG (NCT04931121)
- Testing
- Viscosupplements
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Osteotomy, Malalignment, Bone
Comparison Between TOMOFIX and BodyCAD Fine Osteotomy
This is a single centre, randomised, patient blinded pilot study that will assign 40 participants with medial knee osteoarthritis undergoing medial opening wedge high tibial osteotomy (MOWHTO) to either current standard of care…
- Conditions
- Osteotomy, Malalignment, Bone, Osteoarthritis, Knee
- Trial name
- NCT06250530
- Testing
- High tibial osteotomy using TOMOFIX, High tibial osteotomy using BodyCAD
- Volunteers
- 40 people
- Sponsor
- Western University, Canada
Degenerative Joint Disease of Knee, Osteoarthritis
A Randomized Controlled Trial for Partial Knee Arthroplasty
This is a prospective, multi-center, two-arm, randomized, controlled post-market study to evaluate and compare the clinical accuracy of component placement in robotic-assisted UKA and that of traditional methods.
- Conditions
- Degenerative Joint Disease of Knee, Osteoarthritis, Traumatic Arthritis, Varus Deformity
- Trial name
- NCT05037734
- Testing
- Persona Partial Knee System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Diabetes Mellitus, Type 2, Hyperglycemia Due to Type 2 Diabetes Mellitus
Pre-emptive Insulin to Prevent High Glucose After a Knee Steroid Injection in Adults With Type 2 Diabetes
Steroid injections used to treat painful joints can temporarily increase glucose levels in people with type 2 diabetes. This study will test whether a short course of pre-emptive neutral protamine Hagedorn, NPH, insulin can…
- Conditions
- Diabetes Mellitus, Type 2, Hyperglycemia Due to Type 2 Diabetes Mellitus, Osteoarthritis, Knee
- Trial name
- PREVENT-SIH (NCT07757464)
- Testing
- Insulin Isophane Human, NPH, Pre-emptive Algorithm, Triamcinolone Acetonide Knee Injection
- Where
- Pakistan
- Volunteers
- 125 people
- Sponsor
- Shifa International Hospital
Knee Osteoarthritis
Telehealth Exercise and Mindfulness for Pain in Osteoarthritis - Stage 1B
The goal of this randomized controlled trial (RCT) is to test the feasibility of an 10-week telehealth mindful exercise intervention compared to a telehealth exercise only intervention for people with knee osteoarthritis (OA).
- Trial name
- TEMPO-1B (NCT06684587)
- Testing
- Exercise Program, Mindful Exercise
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Boston University Charles River Campus
Revision Total Knee Arthroplasty, Osteoarthritis, Knee
Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty
Many patients who receive knee replacement surgery must return for a revision (or repeat) surgery due to ongoing pain, stiffness, infection, or implant loosening.
- Trial name
- GUMBO (NCT06951477)
- Testing
- Revision Total Knee Arthroplasty
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoarthritis, Knee
Estimate Serum Oxytocin PD Range in the Periphery
The main purpose of this study is to define the maximum effect oxytocin (naturally occurring hormone that is made in the brain) has on pain from a 5 minute heat probe applied to the skin and to get an estimate for the…
- Trial name
- NCT04431193
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Osteoarthritis, Chronic Pain
Preoperative Catastrophizing Predicts Pain Outcome After Shoulder, Knee and Hip Arthroplasty
Psychologic status is associated with poor outcome after joint arthroplasty and perhaps chronic pain. To enhance the therapeutic effect of a psychologic intervention, the specific disorders or pain-related beliefs that…
- Conditions
- Osteoarthritis, Chronic Pain, Catastrophization
- Trial name
- NCT02361359
- Testing
- Psychological questionnaires
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Hospital Ambroise Paré Paris
Knee Osteoarthritis
Dose-Response Effect of Intra-Articular Ozone in Knee Osteoarthritis
The goal of this clinical trial is to evaluate the clinical efficacy of different doses of intra-articular ozone injections combined with exercise in patients aged 40-75 diagnosed with Grade 2-3 knee osteoarthritis.
- Trial name
- NCT07678996
- Testing
- ozone injection, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kayseri City Hospital
Osteoarthritis, Knee
A Study of Oxytocin PK After IV Administration in Healthy Subjects and Advanced Knee Arthritis Subjects
The main purpose of this study is to sample the blood and calculate the pharmacokinetics (PK) of oxytocin. This is an unblinded, sequential study of subjects, all of whom will receive an intravenous (IV) infusion of oxytocin…
- Trial name
- NCT04429880
- Testing
- Oxytocin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Knee Osteoarthritis
Effects of a Yoga Program on the Functionality of Individuals
There is a notable and emerging use of structured exercise programs incorporating Yoga for chronic musculoskeletal pain. However, regarding knee osteoarthritis (KOA), the effectiveness of Yoga remains uncertain to justify its…
- Trial name
- NCT07006883
- Testing
- Therapeutic exercise, Yoga therapeutic exercise
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- University of Nove de Julho
Knee Osteoarthritis
Liposomal Bupivacaine vs Adductor Canal Block in Total Knee Arthroplasty
This study is being done to evaluate the outcomes of patients undergoing total knee replacement with two different methods of local pain control:shots of liposomal bupivacaine, a long acting anesthetic, directly into the knee…
- Trial name
- NCT02863120
- Testing
- liposomal bupivacaine, bupivacaine HCl, Ropivacaine
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Texas Orthopaedics, Sports and Rehabilitation Associates
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