Clinical trials: Knee Osteoarthrosis
Knee Osteoarthritis, Knee Arthroplasty
Quadriceps Sparing Versus Standard Total Knee Arthroplasty
This study is a randomized clinical trial comparing standard medial para-patellar total knee arthroplasty with a quadriceps sparing mid-vastus approach.
- Trial name
- NCT03081663
- Testing
- Quads-Sparing Approach, Medial Para-Patellar Approach
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoarthritis
Complex Āyurvedic Treatment in Osteoarthritis of the Knee Compared to Standard Care.
The aim of this study is to evaluate the effectiveness of a complex āyurvedic diagnosis and treatment compared to conventional standard care in patients with OA of the knee.
- Trial name
- CARAKA (NCT01225133)
- Testing
- Complex Ayurvedic Treatment, Conventional Care
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- Charite University, Berlin, Germany
Knee Arthroplasty, Total, Robotic-assisted
RObotic-assisted Versus Conventional Knee Endoprosthetic Techniques
Rationale for conducting the study: The ROCKET study evaluates the clinical and economic outcomes of robot-assisted total knee arthroplasty (RTKR) compared with conventional total knee arthroplasty (TKR).
- Conditions
- Knee Arthroplasty, Total, Robotic-assisted, Osteoarthritis of the Knee
- Trial name
- ROCKETS (NCT06389435)
- Testing
- Robot-assisted total knee arthroplasty, Conventional total knee arthroplasty
- Where
- 2 sites in Sweden
- Volunteers
- 1,600 people
- Sponsor
- Danderyd Hospital
Knee Osteoarthritis
Wedged Insoles for Management of Knee Osteoarthritis
Knee osteoarthritis (OA) is commonly treated using laterally wedged insoles. Although these insoles typically reduce knee abduction moments (KAM) - a variable associated with knee osteoarthritis - and thus are believed to be…
- Trial name
- NCT02067208
- Testing
- wedged insole
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University of Calgary
Knee Osteoarthritis
Effects Of Native Collagen Type 2 Treatment
The aim of this study was to evaluate symptomatic efficacy of native collagen type 2 on joint pain and function and its effects on urinary biological markers related to cartilage degeneration in patients with knee osteoarthritis.
- Trial name
- NCT02237989
- Testing
- paracetamol, paracetamol+native collagen type 2
- Volunteers
- 39 people
- Sponsor
- Eskisehir Osmangazi University
Osteoarthitis
CBD Knee Osteoarthritis Study
Osteoarthritis of the knee is a common cause of pain in the US. The currently available medicines for knee osteoarthritis sometimes are not effective at relieving the pain or have unacceptable side effects.
- Trial name
- NCT07638189
- Testing
- Cannabidiol (CBD)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Tennessee
Knee Osteoarthritis
End-range Mobilization on Pressure Pain Threshold
Pain in knee osteoarthritis (OA) represents increased pain intensity due to peripheral and central sensitivity. Pressure pain threshold (PPT) is a widely applied (used) method for measuring the magnitude of peripheral and central…
- Trial name
- NCT04273906
- Testing
- End-range mobilization
- Where
- Hungary
- Volunteers
- 40 people
- Sponsor
- University of Pecs
Osteoarthritis
Flavocoxid, A Plant-Derived Therapy, for the Treatment of Knee Osteoarthritis
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed to treat arthritis. The purpose of this study is to test the effectiveness of flavocoxid, a plant-derived compound, for the treatment of knee osteoarthritis…
- Trial name
- NCT00294125
- Testing
- Flavocoxid
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of Alabama at Birmingham
Osteoarthrosis, Knee
Total Knee Replacement With the Attune vs. the Press Fit Condylar (PFC) Sigma.
100 knees with primary osteoarthritis and scheduled for a total knee replacement (TKR) will be recruited from our waiting list. The patients will be randomized to become operated with the Attune or PFC total knee arthroplasty.
- Trial name
- Att16SM (NCT03077958)
- Testing
- Total Knee Replacement (2 different design)
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Osteoarthritis Knees Both, Pain, Chronic
Investigation of the Effectiveness of a Structured Squat-based Program in Knee Osteoarthritis Rehabilitation
The main purpose of the study is to examine the effect of squat-based exercise approach in individuals with knee osteoarthritis.
- Conditions
- Osteoarthritis Knees Both, Pain, Chronic, Walking, Difficulty
- Trial name
- NCT04588558
- Testing
- Flywheel exercise, Home exercise, Electrotherapy group
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Istanbul Medipol University Hospital
Total Knee Arthroplasty, Osteoarthritis
Kinematic Analysis: Posterior Stabilized, Fixed Bearing Total Knee Arthroplasty With Attune Knee System - Phase 2
A better understanding of knee joint kinematics is important to explain the premature polyethylene wear failures within total knee arthroplasties (TKAs) and to help design a prosthesis that most closely approximates the normal…
- Trial name
- NCT02613338
- Testing
- DePuy Attune posterior stabilizing fixed bearing knee system
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- The University of Tennessee, Knoxville
Osteoarthritis
A Long-Term, Placebo-Controlled X-Ray Study Investigating the Safety and Efficacy of SD-6010 in Subjects With Osteoarthritis of the Knee
The objective of this 2-year study is to evaluate the safety, tolerability and disease modifying efficacy of SD 6010, an inhibitor of inducible nitric oxide synthase (iNOS), in overweight and obese subjects with knee…
- Trial name
- ITIC (NCT00565812)
- Testing
- SD-6010
- Where
- 183 sites in United States, Argentina and 12 more
- Volunteers
- 1,457 people
- Sponsor
- Pfizer
Arthritis, Degenerative
Use of Autologous Adipose-Derived Stromal Vascular Fraction to Treat Osteoarthritis of the Knee
Autologous adipose-derived stromal vascular fraction (SVF) was used to treat 10 osteoarthritic knees of grade II or III (K-L scale) under IRB-approved protocol in a feasibility and safety study.
- Trial name
- NCT02276833
- Testing
- intra-articular space injection of SVF
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Renew Center, San Antonio, Texas
Hip Osteoarthritis, Knee Osteoarthritis
Prevalence,Natural History,Prognosis Factor,QualityofLife,Health Care Consumption and Social Consequences of Symptomatic Knee and Hip Osteoarthritis in France
The aim of the project is to assemble and to follow on a 10-year period a nationwide representative sample of lower limb OA patients.
- Trial name
- KHOALA (NCT00481338)
- Testing
- X-rays, biological samples, medical information about osteoarthritis
- Where
- 6 sites in France
- Volunteers
- 878 people
- Sponsor
- Central Hospital, Nancy, France
Knee Osteoarthritis
Effects of Sahrmann's Approach Versus Conventional Treatment Oin Patients With Knee Osteoarthritis
Osteoarthritis (OA) of the knee, also referred to as degenerative joint disease, is normally due to wear and tear and progressive cartilage loss in the articular cartilage.
- Trial name
- NCT07642258
- Testing
- Sahrmann's exercises, standard physical therapy treatment
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Partial Knee Replacement
Cemented vs. Cementless Unicompartmental Knee Arthroplasty
The primary study objective is to evaluate a cementless partial knee system that has a modular 3-D printed porous metal tibial component and a cemented partial knee system.
- Trial name
- NCT05616884
- Testing
- Cementless fixation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Anderson Orthopaedic Research Institute
Osteoarthritis Pain
Evaluate the Efficacy and Safety of ACP-044 in Subjects With Pain Associated With Osteoarthritis of the Knee
To evaluate the efficacy of ACP-044 compared with placebo in the treatment of pain associated with osteoarthritis of the knee
- Trial name
- NCT05008835
- Testing
- ACP-044 Dose A, ACP-044 Dose B
- Where
- 34 sites in United States
- Volunteers
- 61 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Investigate the Change in the Weight-bearing-line (WBL) Ratio of the Ankle Joint and Ankle Joint Line Orientation After HTO
Ankle Pain and Orientation After High Tibial Osteotomy as a Treatment of Medial Compartment Knee Osteoarthritis
Changes in demographics and physical activities of the young population have increased the number of patients with medial unicompartmental knee osteoarthritis (OA) requiring surgical intervention.
- Trial name
- NCT05183750
- Testing
- High tibial osteotomy
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Knee Osteoarthritis
tDCS for Pain Modulation in Knee Osteoarthritis
Knee osteoarthritis (KOA) is a common condition that causes long-lasting knee pain and difficulty with daily activities. Many patients have pain that is stronger than expected from joint changes because the nervous system becomes…
- Trial name
- KOA-tDCS (NCT07291791)
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Suez Canal University
Laparascopic Sleeve Gastrectomy, Obesity & Overweight
Impact Of Laparoscopic Sleeve Gastrectomy On Obesity-Related Comorbidities In Patients Over 65 Years
This study compares laparoscopic sleeve gastrectomy (a type of weight-loss surgery) with non-surgical care in adults aged 65 or older who have severe obesity and related health problems like type 2 diabetes, high blood pressure…
- Conditions
- Laparascopic Sleeve Gastrectomy, Obesity & Overweight, Obesity Type 2 Diabetes Mellitus, Obstructive Sleep Apnea (OSA)
- Trial name
- NCT07437716
- Testing
- Laparoscopic Sleeve Gastrectomy (LSG), Structured Dietary Counseling
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
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