Clinical trials: Knee Osteoarthrosis
Analgesia
Radiofrequency in Knee Osteoarthritis
Knee osteoarthritis is one of the most common causes of chronic pain and disability worldwide, particularly in middle-aged and elderly populations.
- Trial name
- NCT07700784
- Testing
- Laser genicular nerve ablation, Conventional radiofrequency genicular nerve ablation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Knee Osteoarthritis
Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis
This is a clinical trial of people who have pain due to knee osteoarthritis at Northwestern University Feinberg School of Medicine. The study will last for about 20 weeks.
- Trial name
- PREDICT (NCT06245109)
- Testing
- Duloxetine, Celecoxib
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Northwestern University
Osteoarthritis, Knee
Efficacy and Safety of Intraarticular Sodium Hyaluronate Single Injection in Patients With Osteoarthritis of the Knee
A Phase III, prospective, multicentre, non-controlled, with consecutive participant enrollment in order to evaluate the efficacy, safety and duration of the effects of the viscosupplementation with a preparation of sodium…
- Trial name
- NCT03852914
- Testing
- Sodium hyaluronate 2%
- Where
- 10 sites in Spain
- Volunteers
- 93 people
- Sponsor
- Tedec-Meiji Farma, S.A.
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Home-Based Strategies for Knee Osteoarthritis
Knee osteoarthritis (KOA) is a common chronic joint condition leading to pain, functional limitations, and reduced quality of life.
- Trial name
- NCT07212647
- Testing
- Home Exercise Group, Topical Therapy Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 83 people
- Sponsor
- Istanbul University - Cerrahpasa
Knee Osteoarthritis, Obesity
Development of a Mind Body Program for Obese Knee Osteoarthritis Patients With Comorbid Depression
Knee osteoarthritis (OA) is the most common joint disorder in the U.S. and a leading cause of disability. Depression and obesity are highly comorbid among knee osteoarthritis patients, and the combination of obesity and…
- Conditions
- Knee Osteoarthritis, Obesity, Depression
- Trial name
- GetHealthy-OA (NCT04334278)
- Testing
- GetHealthy-OA, Health Enhancement Program
- Where
- 2 sites in United States
- Volunteers
- 66 people
- Sponsor
- University of Kentucky
Osteoarthritis
Allograft Transplantation in the Treatment of Osteoarthritis of the Metatarsophalangeal (MTP) Joint of the Great Toe
Using the concept of an implant acting as a spacer and stabilizer, the proposed study will evaluate the use of allograft knee meniscus in the treatment of MTP joint osteoarthritis of the great toe.
- Trial name
- MTP (NCT01673347)
- Testing
- Meniscal Allograft
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Paul Fortin, MD
Hip Osteoarthritis
Study of the Clinical and Radiographic Results of a Fixed Polyethylene Posteriorly Stabilized Cemented Total Knee Prosthesis With a Minimum Follow-up of 1 Year.
The knee replacement market is experiencing constant growth. Alongside this growth, there is also an increasing interest in customizing implantation based on specific phenotypes to restore the morphology of the native knee.
- Trial name
- PTG-Anatomic (NCT07313449)
- Where
- France
- Volunteers
- 960 people
- Sponsor
- University Hospital, Strasbourg, France
Osteoarthritis (OA) of the Medial Knee Compartment
European Post-Market Study for Medial Knee Osteoarthritis Treated With the Atlas Knee System for Load Reduction
The objective of this study is to collect post market data on safety and performance of the Atlas Knee System in patients with osteoarthritis (OA) of the medial knee compartment through a 24 months post-operative follow-up period.
- Trial name
- Atlas-PMCF (NCT02663414)
- Testing
- Atlas Knee System
- Sponsor
- Moximed
Knee Osteoarthritis
Prospective Multi-centre Outcomes Study of Persona Knee System in Total Knee Arthroplasty
This is a prospective, multi-centre, non comparative, post market clinical follow-up study involving orthopaedic surgeons skilled in TKA and experienced implanting the devices included in this study.
- Trial name
- NCT04461626
- Testing
- Persona fixed bearing knee system (All patients will receive Persona fixed bearing knee system)
- Where
- 18 sites in Australia, India and 4 more
- Volunteers
- 1,017 people
- Sponsor
- Zimmer Biomet
Osteoarthritis (Knee), Robotic Assisted Arthroplasty
Patient Satisfaction After Robotic-Assisted Versus Conventional Total Knee Arthroplasty
Total knee arthroplasty (TKA) remains the definitive treatment for advanced knee osteoarthritis and continues to be performed with increasing frequency worldwide.
- Trial name
- RoboTKA (NCT07914036)
- Testing
- Mako4 Robotic Arm Assisted Total Knee Arthroplasty, conventional total knee arthroplasty using Triathlon Total Knee System
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Osteoarthritis, Knee
Autologous Stem Cells in Osteoarthritis
Patients with osteoarthritis, a degenerative joint disease, that meet inclusion criteria will be allocated into two groups: The control group will receive Acetaminophen 750mg orally every 8 hours The experimental group will…
- Trial name
- NCT01485198
- Testing
- Bone Marrow Autologous Stem Cells Infusion, Acetaminophen
- Where
- 2 sites in Mexico
- Volunteers
- 61 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Hip and Knee Osteoarthritis
Screening for Hip and Knee Osteoarthritis in the General Population: Predictive Value of a Questionnaire and Prevalence Estimates
Objective: To study the feasibility and validity of a two-step telephone screening procedure for symptomatic knee and hip osteoarthritis (OA) in the general population.
- Trial name
- NCT00522080
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Arthroplasty, Replacement
Study to Evaluate the Safety and Effectiveness of the REAL INTELLIGENCE™ CORI™ in Total Knee Arthroplasty (TKA) Procedure
Background: REAL INTELLIGENCE™ CORI™ (CORI Robotics) is a computer-assisted orthopaedic surgical navigation and burring system. CORI Robotics is designed to help surgeons in planning and executing certain types of knee surgery…
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- CORI RCT TKA (NCT04848896)
- Testing
- CORI Robotics, Conventional Procedure
- Where
- 4 sites in Australia, China and 2 more
- Volunteers
- 140 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Knee
Brain Stimulation and Meditation for Pain After Total Knee Arthroplasty
Feasibility, acceptability, and preliminary efficacy of combined transcranial direct current stimulation and mindfulness for pain after total knee arthroplasty
- Trial name
- NCT05673720
- Testing
- active tDCS paired with active MBM
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Florida State University
Osteo Arthritis Knee
Measurement of Osteoarthritic Patient Pain Through Electrodermal Activity Signals
This pilot study aims to investigate the viability of using a smartwatch-based electrodermal activity (EDA) sensor to capture enough EDA signal to quantitatively assess pain in osteoarthritis subjects and test the feasibility of…
- Trial name
- NCT06701461
- Testing
- Electrodermal Activity signal
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Knee Osteoarthritis, Arthroplasty Complications
Joint Awareness After Total Knee Replacement
Total knee replacement (TKR) is accepted as treatment of choice for end stage gonarthrosis. It is performed cemented or cementless and although cemented implants were shown to decrease bone density more than cementless fixations…
- Trial name
- NCT06033625
- Testing
- CEMENTLESS TOTAL KNEE REPLACEMENT
- Volunteers
- 150 people
- Sponsor
- Saglik Bilimleri Universitesi
Osteo Arthritis Knee, Degenerative Joint Disease of Knee
Intra-articular Transplantation of Autologous Adipose Derived Stromal Vascular Faction (SVF) for Treatment of Osteoarthritis of the Knee
Researchers are trying to determine the safety and feasibility of autologous, adipose derived stromal vascular fraction injections in the treatment of knee osteoarthritis
- Trial name
- NCT03940950
- Testing
- Autologous Adipose-Derived SVF (Stromal Vascular Fraction)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Mayo Clinic
Osteoarthritis, Knee
Efficacy and Safety of an Active Pulsed Electromagnetic Field for the Treatment of Osteoarthritis of the Knee
The hypothesis of this study is that exposure to PEMF alters the cytokine environment of OA joints associated with a reduction of inflammation and improved homeostasis of the extracellular matrix (ECM), both potentially effecting…
- Trial name
- NCT02436590
- Testing
- Orthofix Physio-Stim Model 3315OA
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Orthofix Inc.
Osteoarthritis, Knee
An Intervention Study Evaluating the Effects of a Raspberry Leaf Extract in an Osteoarthritic Population.
A double-blind, randomized, placebo-controlled clinical study to evaluate the efficacy of raspberry extract to alleviate symptoms of osteoarthritis in the knee.
- Trial name
- NCT03703024
- Testing
- Raspberry Leaf Extract
- Where
- Ireland
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Atlantia Food Clinical Trials
Osteoarthritis, Knee
Adductor Canal Block Combined With Local Infiltration Analgesia vs Local Infiltration Analgesia Alone for Postoperative Pain in Total Knee Arthroplasty
Total knee arthroplasty (TKA) is commonly associated with significant postoperative pain, which may impair early mobilization and functional recovery.
- Trial name
- ADB_01 (NCT07517159)
- Testing
- Adductor Canal block, Local Infiltration Analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Ankara University
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