Clinical trials: Knee Osteoarthrosis
Knee Osteoarthritis
Intra-Articular Injection in Moderate Knee Osteoarthritis
AqueousJoint is a new intra-articular (IA) injectable joint lubricant for patients suffering from knee Osteoarthritis developed by Liposphere LTD.
- Trial name
- NCT05412836
- Testing
- AqueousJoint
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Lipo-Sphere
Osteoarthritis (Knee)
Total Knee Arthroplasty Utilizing Adductor Canal Block: Effect on Quadriceps Sparing
The purpose of this study is to investigate whether there is quantitative motor-sparing of the quadriceps muscles following adductor canal nerve block versus femoral nerve block.
- Trial name
- NCT02081911
- Testing
- High Volume Adductor Canal Block, Low Volume Adductor Canal Block, Femoral Nerve Block
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Hospital for Special Surgery, New York
Knee Osteoarthritis
Comparison of the Effects of Static and PNF Hamstring Stretching Exercises in Patients With Knee Osteoarthritis
The aim of this study is to determine and compare the effects of static and PNF hamstring stretching exercises on joint pain, hamstring flexibility and functional status in patients with knee osteoarthritis.
- Trial name
- NCT04645238
- Testing
- Static Stretching, PNF Stretching
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Dokuz Eylul University
Total Knee Arthroplasty, Knee Replacement
Investigating Patient Satisfaction With Smart Knee Implants
The main goal of this study is to see if there is a connection between the social and economic resources available in a patient's neighborhood (measured by the Area Deprivation Index, ADI) and their recovery after knee…
- Conditions
- Total Knee Arthroplasty, Knee Replacement, Knee Replacement Arthroplasty, Knee Osteoarthritis
- Trial name
- NCT06968143
- Testing
- Smart Knee Implant
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Osteoarthritis, Knee
STepped Exercise Program for Knee OsteoArthritis
Knee osteoarthritis (OA) is one of the most common chronic conditions and a leading cause of disability among Veterans. Although exercise is known to improve pain, physical abilities, and other outcomes for patients who have knee…
- Trial name
- STEP-KOA (NCT02653768)
- Testing
- Stepped Exercise Program, Arthritis Education
- Where
- United States
- Volunteers
- 345 people
- Sponsor
- VA Office of Research and Development
Knee Disease, Knee Deformity
Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery
The ultrasound-guided selective blockade of the saphenous nerve in the adductor canal provides effective analgesia and reduces postoperative pain in patients undergoing arthroscopic medial meniscectomy.
- Conditions
- Knee Disease, Knee Deformity, Knee Pain Chronic, Knee Arthropathy
- Trial name
- NCT06084403
- Testing
- 20 ml volume adductor canal block, 30 ml volume adductor canal block, 40 ml volume adductor canal block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bursa City Hospital
Knee Osteoarthritis
Evaluating the Efficacy of Lateral Heel Wedges of Osteoarthritis of the Knee
This study is looking at the efficacy of a sloped insole in patients with knee osteoarthritis. Regularly wearing a sloped insole over the course of one year will result in a wider joint space by x-ray in 60% of the subjects, a…
- Trial name
- NCT02254473
- Testing
- Wedge Insert, Flat Insert
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Anterior Cruciate Ligament Injuries, Knee Osteoarthritis
Optimizing Movement After Anterior Cruciate Ligament Injury
Fifty percent of teenagers and young adults who suffer an anterior cruciate ligament (ACL) injury develop knee osteoarthritis (OA) within 15 years.
- Trial name
- NCT05363683
- Testing
- Squat Biofeedback, Standard Care
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Nebraska
Knee Osteoarthritis
Effects of Platelet-Rich Plasma and Ozone Therapy in Knee Osteoarthritis
Knee osteoarthritis can frequently occur with advancing age. In cases of pain that persists despite hot/cold applications, drug therapy and exercise, intra-articular injections are considered.
- Trial name
- NCT06631456
- Testing
- PRP injection, Ozone therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Knee Osteoarthritis
Effectiveness of Oral Hyaluronic Acid in Knee Osteoarthritis
This study was a randomized, double-blind, placebo-controlled study evaluating the efficacy of an oral liquid HA supplement (A+HA) in symptoms relief and improvement of quality of life in knee osteoarthritis patients with mild…
- Trial name
- NCT04352322
- Testing
- A+HA(tm)
- Where
- Taiwan
- Volunteers
- 47 people
- Sponsor
- China Medical University Hospital
Osteoarthritis, Osteoarthritis of the Hip or Knee
Conversations in Health Literacy Using AI Technology for Osteoarthritis Patients
The goal of this clinical trial is to assess the use of a generative artificial intelligence large language model chatbot in improving decision making factors in patients with hip and knee osteoarthritis.
- Trial name
- CHAT-OA (NCT06778486)
- Testing
- Artificial Intelligence Chatbot
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Davis
Knee Osteoarthritis, Edema
Control of Edema in the Knee in Patients With Knee Osteoarthritis
The aim of this study was to compare the effectiveness of exercise and classical massage in the control of knee edema in patients with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, Edema, Edema Leg
- Trial name
- NCT06010394
- Testing
- conventional physiotherapy, exercises for the knee area, payment oriented massage
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Uskudar University
Knee Osteoarthritis
The Effect of "Laying on of Hands" in Older Women With Knee Osteoarthritis
Osteoarthritis (OA) is the most common form of chronic degenerative joint disease, as well as the main cause of pain and disability in older persons worldwide.
- Trial name
- NCT02917356
- Testing
- Spiritual laying on of hands (SP), Non-spiritual Laying on of Hands, Control group
- Where
- Brazil
- Volunteers
- 105 people
- Sponsor
- Federal University of Juiz de Fora
Knee Arthritis Osteoarthritis, Chronic Knee Pain
The Predictive Value of Ultrasonographic Quadriceps Muscle Parameters for Genicular Nerve Block Outcomes in Knee Osteoarthritis
The goal of this observational study is to learn whether thigh muscle structure can help predict pain relief after a genicular nerve block in people with knee osteoarthritis.
- Trial name
- NCT07781059
- Testing
- genicular nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Marmara University
Osteoarthritis, Knee
Residual Pain After Successful Implant of Metaphyseal Sleeves in Total Knee Arthroplasty
: Total knee revision arthroplasty is increasing in daily practice and will become more relevant in the years to come. Bone loss is a significant challenge in total knee arthroplasty (TKA) especially in revision procedures.
- Trial name
- NCT04995679
- Testing
- Implant of metaphyseal sleeves in Total knee arthroplasty
- Where
- Italy
- Volunteers
- 85 people
- Sponsor
- University of Milan
Osteoarthritis, Knee, Knee Osteoarthritis
AP-003-C Study to Confirm the Efficacy of Ampion™ in Adults With Pain Due to Severe Osteoarthritis of the Knee
This is a phase 3 randomized study to confirm the efficacy of an intra-articular injection of Ampion™ in adults with pain due to severe osteoarthritis of the knee.
- Conditions
- Osteoarthritis, Knee, Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic
- Trial name
- NCT03182686
- Testing
- 4 mL injection of Ampion
- Where
- 13 sites in United States
- Volunteers
- 168 people
- Sponsor
- Ampio Pharmaceuticals. Inc.
Exercise
Effectiveness of Mulligan Mobilization Technique and Core Stabilization Exercise With Knee Osteoarthritis
Osteoarthritis (OA) is a chronic disease process characterized by degeneration and inflammation in the joint cartilage and subchondral bone, synovial fluid and joint capsule.
- Trial name
- NCT04540341
- Testing
- Mulligan mobilization, Core stabilization, Conventional therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Pamukkale University
Knee Osteoarthritis, Total Knee Replacement
The Effect of Laser Acupuncture Intervention to the Prognosis After TKR Surgery
This study protocol is mainly focus on the patients, who suffer pain, swelling, or range of motion limitation after total knee replacement (TKR) surgery procedure,would be relieved by use non-invasive laser acupuncture to stimuli…
- Trial name
- NCT05263856
- Testing
- laser acupuncture
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- China Medical University Hospital
Knee Osteoarthritis, Knee Arthroplasty
Evaluation of Fixation Achievable in Revision Total Knee Arthroplasty Implementing Latest-Generation Implant Technology
This is a prospective randomized control trial that aims to investigate fixation of implants after revision total knee replacement.
- Trial name
- NCT03276351
- Testing
- Long-Stemmed with Hybrid Fixation, Short-Stemmed with Augmented Fixation
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoarthritis
Single-use Efficiency Instruments With Patient Specific Technique (MyKnee®) Versus Traditional Metal Instruments With Conventional Surgical Technique
To compare economic factors and the rate of adverse events between two types of instrumentation used for total knee replacement: Single-use Efficiency Instruments with Patient Specific Technique (MyKnee®) Traditional Metal…
- Trial name
- NCT03148379
- Testing
- Customized patient instruments, Traditional Metal Instruments
- Where
- 5 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medacta USA
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