Clinical trials: Knee Pain Chronic
Chronic Pain, Osteoarthritis
Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking WHO Step III Analgesics But Showing a Lack of Tolerability.
The main objective of the study is to evaluate the effectiveness, tolerability, and safety of tapentadol hydrochloride prolonged release (PR) in participants suffering from severe chronic pain due to osteoarthritis of the knee…
- Trial name
- NCT00982280
- Testing
- Tapentadol PR
- Where
- 24 sites in Australia, Denmark and 4 more
- Volunteers
- 82 people
- Sponsor
- Grünenthal GmbH
Knee Osteoarthritis, Knee Pain Chronic
Erector Spinae Plane Block Vs. IPACK Block with Adductor Canal Block for Total Knee Arthroplasty
Effect of Erector Spinae Plane Block and iPACK block with Adductor Canal Block on pain management, and NLR and PLR following knee arthroplasty
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NCT06233630
- Testing
- Control Test - spinal anesthesia, Ropivacaine 0.2% Injectable Solution ESPB, Ropivacaine 0.2% Injectable Solution iPACK+ACB
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Poznan University of Medical Sciences
Anterior Cruciate Ligament Rupture
Central Sensitization Symptoms and Psychosocial Factors in Athletes After ACL Reconstruction
The main research objective of this study is whether athletes who have sustained an anterior cruciate ligament injury, experience chronic nociplastic pain and psychosocial factors, including kinesiophobia and pain…
- Trial name
- NCT04393129
- Where
- Greece
- Volunteers
- 39 people
- Sponsor
- University of Thessaly
Chronic Pain, Osteo Arthritis Knee
Persistent Pain in Pharmacologically or Surgical Treated Osteoarthritis: Role of Mu-Limpho Marker
The goal of this prospective observational study is to analyze the percentage of expression of B and NK cells expressing Mu opioid receptor on their surface, named Mu-Lympho-Marker (MLM), to measure pain progression in…
- Trial name
- MLM (NCT06637709)
- Where
- Italy
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Patellofemoral Pain Syndrome, Knee Pain Chronic
Effects of Virtual Reality Rehabilitation and Muscle Energy Technique in Patients With Patellofemoral Pain Syndrome.
The aim of this randomized controlled trial is to determine the effects of Virtual reality rehabilitation and muscle energy techniques in patients with patellofemoral pain syndrome for reducing pain, enhancing knee range of…
- Trial name
- NCT05971966
- Testing
- Virtual Reality technique, Muscle energy technique
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Postoperative Pain, Cerebral Palsy
Popliteal Block for Postoperative Pain in Knee-ankle Soft Tissue Surgery in Cerebral Palsy
Popliteal block is a technique for providing postoperative pain management in children. In this randomized double-blinded study, the investigators evaluated the effects of preoperative popliteal nerve block on postoperative pain…
- Trial name
- NCT02507700
- Testing
- Popliteal block, Sevoflurane, Ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Diskapi Teaching and Research Hospital
Osteoarthritis, Pain Intensity Assessment
A Study to Evaluate 90-Day Safety of Tapentadol(CG5503) Immediate Release (IR) or Oxycodone Immediate Release in Patients With Chronic Pain
The purpose of this study is to evaluate the safety of CG5503 base Immediate Release(IR) 50 mg or 100 mg taken every 4 to 6 hours as needed over the long-term exposure of 90 days in patients who have chronic pain.
- Conditions
- Osteoarthritis, Pain Intensity Assessment, Arthralgia, Sciatica
- Trial name
- NCT00364546
- Testing
- CG 5503;tapentadol
- Volunteers
- 877 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Low Back Pain, Knee Arthritis Osteoarthritis
How Patient Education Helps Patients With Chronic Musculoskeletal Disorders Stick to Home Exercise for Pain Relief.
The study aims to evaluate the effectiveness of a structured patient education program in enhancing adherence to prescribed home exercise regimens in individuals with chronic low back pain, knee osteoarthritis, and shoulder pain.
- Conditions
- Low Back Pain, Knee Arthritis Osteoarthritis, Shoulder Disease, Shoulder and Upper Arm Injury
- Trial name
- NCT07764354
- Testing
- Educational with musculoskeletal condition, Standard physical therapy program
- Where
- Saudi Arabia
- Volunteers
- 120 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Osteoarthritis, Knee
Efficacy of Cooled and Monopolar Radiofrequency Ablation of the Geniculate Nerves for the Treatment of Chronic Osteoarthritic Knee Pain
This is a single center randomized controlled trial. Approximately 102 patients will be randomized to one of two treatment groups: cooled radiofrequency or conventional monopolar radiofrequency ablation.
- Trial name
- NCT02260869
- Testing
- Genicular nerve radiofrequency ablation, Pain Management Radiofrequency Kit
- Where
- 3 sites in United States
- Volunteers
- 79 people
- Sponsor
- Millennium Pain Center
Chronic Pain, Osteoarthritis
Effects of tDCS and tUS on Pain Perception in OA of the Knee
The purpose of this study is to investigate the effects of transcranial direct current stimulation (tDCS) in conjunction with transcranial ultrasound (TUS) on pain perception and functional limitations in people with…
- Trial name
- NCT02330315
- Testing
- transcranial direct current stimulation (tDCS), transcranial ultrasound (TUS)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Spaulding Rehabilitation Hospital
Osteoarthritis, Knee, Osteoarthritis, Hip
An Effectiveness, Safety and Quality of Life Measures With Hydromorphone HCL, Dilaudid CR (Controlled Release)
The purpose of this study was to characterize the effectiveness and safety of OROS hydromorphone HCL and OxyContin in patients with chronic osteoarthritis (OA) of the knee or hip who are receiving chronic nonsteroidal…
- Trial name
- NCT00399048
- Testing
- OROS hydromorphone HCL ; OxyContin
- Volunteers
- 140 people
- Sponsor
- Alza Corporation, DE, USA
Chronic Knee Pain
Patients With Chronic Knee Pain Treated With Conventional Radiofrequency of the Genicular Nerves
Management of chronic knee pain remains a challenge to the treating physician. A radiofrequency treatment of the genicular nerves is a not yet established but promising technique.
- Trial name
- RECORGEN (NCT04234984)
- Where
- Belgium
- Volunteers
- 66 people
- Sponsor
- Ziekenhuis Oost-Limburg
Chronic Pain, Fibromyalgia
Chronic Pain, Couples, & Physical Activity
Chronic pain affects more than 50 million adults in the United States and is estimated to cost the nation more than $560 billion dollars each year.
- Conditions
- Chronic Pain, Fibromyalgia, Osteoarthritis, Knee, Osteoarthritis, Hip
- Trial name
- NCT04077164
- Testing
- No intervention, observational only.
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Illinois Institute of Technology
Knee Pain Chronic
Effects of Multi Radiance Medical® Super Pulsed Laser on Chronic Knee Pain
Knee pain is among the most common reasons for musculoskeletal pain consultations, accounting for nearly 4 million primary care visits annually.
- Trial name
- NCT05830344
- Testing
- Active Multi Radiance Medical® Super Pulsed Laser
- Where
- 2 sites in Brazil
- Volunteers
- 86 people
- Sponsor
- University of Nove de Julho
Osteoarthritis, Pain
Efficacy of Etoricoxib 60 mg in Modifying Pain Hypersensitivity in People With Knee Osteoarthritis
This study aims to better understand the way in which painful osteoarthritis affects different people and whether an anti-inflammatory medication such as Arcoxia (etoricoxib) can help to modify this pain.
- Trial name
- NCT00927004
- Testing
- Etoricoxib (Arcoxia), Sugar pill
- Where
- Australia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Curtin University
Knee Osteoarthritis, Knee Pain Chronic
Evaluation of NMES for Reducing Pain and Improving Functional Outcomes in Knee OA Patients
The present prospective trial is designed to evaluate the efficacy of CyMedica Orthopedics e-vive™ system, a multifunctional electrotherapy device providing neuromuscular electrical stimulation (NMES) for reducing pain and…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NMES (NCT03980964)
- Testing
- Active NMES
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CyMedica Orthopedics, Inc
Knee Pain Chronic
SMART Embedded Intervention for Military Postsurgical Engagement Readiness
The overarching objective of this proposal is to conduct a multi-site Sequential Multiple Assignment Randomized Trial (SMART) across multiple Military Health System (MHS) sites to optimize the sequencing and integration of two…
- Trial name
- SEMPER (NCT05050409)
- Testing
- Brief mindfulness, Mindfulness-Oriented Recovery Enhancement (MORE), Standard care
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Utah
Knee Osteoarthritis, Knee Discomfort
IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success
Several clinical trials on genicular artery embolization (GAE) show significant clinical benefit for the majority of patients. However, a proportion of patients do not benefit from GAE, and responses vary across individual…
- Conditions
- Knee Osteoarthritis, Knee Discomfort, Knee Pain Chronic, Knee Swelling Pain
- Trial name
- NCT07494838
- Testing
- Embolization
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Lucas R. Cusumano, MD
Arthritis, Degenerative
3VM for Treatment of Chronic Osteoarthritis Knee Pain
A double-blind, placebo-controlled, randomized dose ranging study for the use of 3VM1001 Cream, 2g three times daily, 3g three times daily, or 3g four times daily for treatment of chronic pain associated with osteoarthritis of…
- Trial name
- NCT03142178
- Testing
- Experimental: 3VM1001 active 2g Cream 3 times daily, Experimental: 3VM1001 active 3g Cream 3 times daily, Experimental: 3VM1001 active 3g Cream 4 times daily
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- CDA Research Group, Inc.
Knee Osteoarthritis, Joint Pain
Femoral Rotation and Patellar Positioning After TKA
Analysis of patellar positioning in the trochlear groove after TKA with and without the use of dynamic tensioner.
- Conditions
- Knee Osteoarthritis, Joint Pain, Joint Instability, Patella Disorder
- Trial name
- NCT05871112
- Testing
- Use of dynamic tensioner
- Where
- Poland
- Volunteers
- 125 people
- Sponsor
- Medical University of Warsaw