Clinical trials: Knee Pain Chronic, open to volunteers
Knee Osteoarthritis
Pulsed Radiofrequency Therapy vs Canal Adductor Blockade in Knee Osteoarthritis
This study is intended to prove the efficacy and safety of ultrasound-guided pulsed radiofrequency therapy on adductor canal nerves by patients with Knee osteoarthritis.
- Trial name
- NCT05962463
- Testing
- Canal adductor blockade, Canal adductor pulsed radio-frequency therapy
- Where
- Slovenia
- Volunteers
- 128 people
- Sponsor
- University Medical Centre Ljubljana
Osteo Arthritis Knee, Knee Pain Chronic
Optimizing Pain Self-Management in Total Knee Arthroplasty
The purpose of this study is to investigate the efficacy of a positive affect enhancing intervention designed to reduce pain and augment reward system function in knee osteoarthritis (KOA) patients undergoing total knee…
- Conditions
- Osteo Arthritis Knee, Knee Pain Chronic, Surgery
- Trial name
- NCT06038240
- Testing
- Savoring Meditation, Pain Self-Management and Education
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Virginia
Knee Osteoarthristis
Medication vs. Meditation for Chronic Knee Osteoarthritis
The purpose of this research study is to improve pain management for individuals with chronic knee osteoarthritis pain. Specifically, we are comparing the effects of a mindfulness meditation practice with those of oral…
- Trial name
- NCT07837284
- Testing
- Oral diclofenac potassium 50 mg, Mindfulness meditation
- Volunteers
- 30 people
- Sponsor
- Florida State University
Pain, Chronic, Dementia, Mild
Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia
The purpose of this study is to develop an exercise treatment program for knee osteoarthritis that works well for people with memory problems. This study will include two parts.
- Conditions
- Pain, Chronic, Dementia, Mild, Mobility Limitation, Physical Disability
- Trial name
- NCT06264362
- Testing
- Tailored Physical Activity Program
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Drexel University
Knee Osteoarthritis (Knee OA), Knee Pain Chronic
Advanced Brain Imaging-TKA (fMRI-TKA)
Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities.
- Conditions
- Knee Osteoarthritis (Knee OA), Knee Pain Chronic, Brain Network Connectivity, Patient Satisfaction
- Trial name
- fMRI-TKA (NCT07464080)
- Testing
- fMRI Brain Scan
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Hospital Research Institute
Knee Arthroplasty, Total, Partial Knee Arthroplasty
Opioid Reduction and Enhanced Recovery in Orthopaedic Surgery (OREOS)-Knee
Knee replacements are the second most common surgery in Canada. Most patients recover very well but research consistently shows that 1 in 5 patients still have pain many months after surgery.
- Conditions
- Knee Arthroplasty, Total, Partial Knee Arthroplasty, Chronic Pain, Postoperative, Osteoarthritis (OA) of the Knee
- Trial name
- OREOS-K (NCT07895472)
- Testing
- Standard care, Multicomponent opioid reduction and pain management pathway
- Volunteers
- 170 people
- Sponsor
- McMaster University
Knee Osteoarthritis, Chronic Knee Pain
Nerve to Vastus Medialis Branches in Chronic Knee Pain
This observational cohort study aims to evaluate the clinical effect of adding ultrasound-guided pulsed radiofrequency treatment of the distal superficial and deep sensory branches of the nerve to vastus medialis to conventional…
- Trial name
- NCT07703293
- Testing
- Conventional Genicular Nerve Radiofrequency, Conventional Genicular Nerve Radiofrequency Plus Pulsed Radiofrequency of the Distal Sensory Branches of the Nerve to Vastus Medialis
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Diskapi Teaching and Research Hospital
Osteoarthritis, Knee, Knee Osteoarthritis
Prospective Functional, Gait, and Outcome Comparison Study of Medial Pivot Versus Single Radius Design for Total Knee Arthroplasty
Patients with degenerative joint disease can effectively be treated with a primary total knee replacement to reduce pain and improve function in their daily lives.
- Conditions
- Osteoarthritis, Knee, Knee Osteoarthritis, Osteoarthritis Knees Both, Osteoarthritis Knee Left
- Trial name
- NCT04814082
- Testing
- MicroPort Evolution Medial-Pivot Knee System (Cruciate-substituting), Stryker Triathlon Tritanium Knee System (Condylar Stabilizing)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- LifeBridge Health
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Effect of Inspiratory Muscle Training on Knee Osteoarthritis Pain
Knee osteoarthritis (KOA) is a common joint disease that causes chronic pain and limits daily activities. Current treatments, such as painkillers or surgery, have limitations like side effects or high costs.
- Trial name
- NCT07698418
- Testing
- Inspiratory muscle training
- Volunteers
- 80 people
- Sponsor
- The Hong Kong Polytechnic University
Lipedema, Knee Osteoarthritis
The Effect of Lipedema on Knee Osteoarthritis
This study will be one of the few to examine the effect of lipedema on knee osteoarthritis in a comparative manner with a control group within the same osteoarthritis context.
- Conditions
- Lipedema, Knee Osteoarthritis, Knee Acute and Chronic Pain, Knee
- Trial name
- NCT07575555
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Izmir Democracy University
Activity-Related Knee Discomfort, Joint Discomfort
NT-II™ Collagen for Joint Discomfort and Function
The goal of this clinical trial is to learn whether a natural marine supplement called NT-II™ (Salmon Undenatured Type II Collagen) can help lower knee discomfort caused by physical activity in otherwise healthy adults.
- Conditions
- Activity-Related Knee Discomfort, Joint Discomfort, Functional Joint Pain, Functional Knee Pain
- Trial name
- NTII-JOINT (NCT07119645)
- Testing
- NT-II™ (240 mg), NT-II™ 480 mg, Glucosamine/Chondroitin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Hofseth Biocare ASA
Osteoarthritis, Knee, Osteoarthritis, Hip
Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee
In this work the investigators will study the relationship between chronic musculoskeletal pain and abnormal blood flow (neovascularity) around the shoulder, hip and knee.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Osteo Arthritis Shoulders, Synovitis of Knee
- Trial name
- MRI (NCT05700682)
- Testing
- Shoulder/Hip/Knee Embolization with Embozene Microspheres
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Palo Alto Veterans Institute for Research
Pain, Chronic
VR and Cooled Genicular Nerve Radio Frequency Ablation for Chronic Knee Pain
This study will examine the impact of virtual reality used in conjunction with sedation compared to sedation alone in patients undergoing watervcooled genicular nerve ablations for chronic knee pain.
- Trial name
- NCT06336447
- Testing
- Experimental: Group #1: Virtual Reality Headset, Group 2 No Virtual Reality Headset
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Northwestern University
Osteoarthritis Knee, Chronic Pain
Comparison of Denervation Techniques for the Treatment of Knee Osteoarthritis: Continuous Ablative Radiofrequency Vs. Chemical Denervation with Absolute Alcohol
This randomized clinical trial compares two minimally invasive treatments for knee osteoarthritis pain that has not responded to conventional therapies.
- Trial name
- NCT06858228
- Testing
- Continuous Ablative Radiofrequency, Chemical Denervation with Absolute Alcohol
- Where
- Brazil
- Volunteers
- 288 people
- Sponsor
- Federal University of São Paulo
Chronic Pain (Back / Neck), Chronic Pain Management
Evaluating the Auricular Point Acupressure-Self Management Program for Chronic Musculoskeletal Pain Among Rural Populations
The investigators will test an Auricular Point Acupressure Self-Management (APA-SM) program integrated into rural primary and specialty care and rural communities for chronic musculoskeletal pain (CMP).
- Conditions
- Chronic Pain (Back / Neck), Chronic Pain Management, Chronic Knee Pain, Joint Pain
- Trial name
- NCT07179016
- Testing
- Auricular Point Acupressure (APA) - Self Management (SM), Education Control
- Where
- 3 sites in United States
- Volunteers
- 693 people
- Sponsor
- The University of Texas Health Science Center, Houston
Knee Pain Chronic
A+HA Premium Oral Hyaluronic Acid Drink Functional Evaluation Trial for Delaying Joint Pain
Evaluate the effect of A+HA premium oral hyaluronic acid drink on relieving knee pain.
- Trial name
- NCT07800676
- Testing
- A+HA premium oral hyaluronic acid drink
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University
Knee Osteoarthritis
Effects of Music During Walking on Pain and Muscle Activation in People With Chronic Pain Due to Knee Osteoarthritis
The purpose of this research study is to compare muscle activation, changes in pain sensitivity, and brain function, between different walking conditions, including walking to music, walking to metronome, and walking without…
- Trial name
- NCT07537114
- Testing
- Rhythmic Auditory Stimulation with music, Rhythmic Auditory Stimulation with metronome, Control
- Volunteers
- 20 people
- Sponsor
- Boston University Charles River Campus