Clinical trials: Knee Replacement, Total
Thromboembolism
Factor Xa Inhibitor for Prevention of Venous Thromboembolism in Patients Undergoing Elective Total Knee Replacement
Evaluate the safety and tolerability of escalating oral doses of YM150 in patients undergoing elective primary total knee replacement surgery
- Trial name
- PEARL-1 (NCT00408239)
- Testing
- YM150, enoxaparin
- Where
- 19 sites in Indonesia, Japan and 6 more
- Volunteers
- 367 people
- Sponsor
- Astellas Pharma Inc
Prevention, Venous Thromboembolism
Regulation of Coagulation in Orthopedic Surgery to Prevent Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE). A Study of BAY 59-7939 in the Prevention of VTE in Subjects Undergoing Elective Total Knee Replacement.
The purpose of this study is to assess if 10 mg Bay 59-7939, taken once daily as a tablet, is safe and prevents blood clot which may form after a knee replacement operation.
- Trial name
- RECORD 3 (NCT00361894)
- Testing
- Rivaroxaban (BAY59-7939), Enoxaparin
- Where
- 143 sites in Austria, Belgium and 17 more
- Volunteers
- 2,531 people
- Sponsor
- Bayer
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery, Osteoarthritis (OA) of the Knee
Does the Use of Patient Specific Instrumentation Improve Outcomes in Knee Arthroplasty Surgery for Osteoarthritis When Compared to Standard Posterior Referenced Instrumentation?
The goal of this randomized study is to see if using patient-specific instruments (PSI) during total knee replacement surgery improves outcomes compared to standard instruments.
- Trial name
- PRIPSI (NCT06720012)
- Testing
- Patient specific instrumentation (PSI), Conventional instruments, Cemented Total Knee Arthroplasty
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Vastra Gotaland Region
Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint
The Use of CCK vs PS in Revision TKAs
This study aims to compare the clinical impact of Constrained Condylar versus Posterior Stabilized Knee (PS) bearings on patient satisfaction and surgical outcomes including mid-term survivorship among patients undergoing…
- Conditions
- Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint, Reimplantation for Periprosthetic Joint Infection, Femoral Revision Indicated
- Trial name
- NCT06782295
- Testing
- Constrained Condylar bearing, posterior stabilized bearing
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Rush University Medical Center
Osteoarthritis (OA) of the Knee
Optimization of Obesity for Total Knee Replacement With Glucagon-like Peptide-1 Receptor Agonist
Studies have shown that obese patients undergoing total knee replacement (TKR) surgery face a higher risk of perioperative issues such as increased use of pain medication, surgical site infections, and the need for revision…
- Trial name
- NPO-OOPS-TKR (NCT06807970)
- Testing
- Glucagon-like peptide-1 receptor agonists (GLP 1 RA), Control (Standard treatment)
- Where
- Hong Kong
- Volunteers
- 54 people
- Sponsor
- The University of Hong Kong
Varus Deformity
Assessment of Foot Alignment and Pressure After Correction of Varus Knee by High Tibial Osteotomy or Total Knee Replacement
This study evaluated the change in foot alignment after TKA or HTO by prospectively analyzing the correlation between the knee joint and the foot deformity, the post-operative improvement in the foot deformity, and the long-term…
- Trial name
- NCT05314972
- Volunteers
- 200 people
- Sponsor
- Assiut University
Blood Loss
Evaluating the Use of Tranexamic Acid (TXA) in Total Joint Arthroplasty
This research study aims to study the use of tranexamic acid (TXA) in total joint replacement (arthroplasty) of the hip (THR) and knee (TKR).
- Trial name
- NCT03825939
- Testing
- Intravenous Tranexamic Acid
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- NYU Langone Health
Postoperative Pain Following Knee Arthroplasty
The Effect of Distal Versus Proximal iPACK on Pain After Total Knee Arthroplasty
Total knee arthroplasty (TKA) often results in significant postoperative pain, which can hinder recovery despite advances in surgical and anesthetic techniques.
- Trial name
- eDIPACK (NCT07080892)
- Testing
- distal iPACK, proximal iPACK
- Where
- Slovakia
- Volunteers
- 120 people
- Sponsor
- Comenius University
Osteoarthritis, Knee
Preoperative Strength Training in Patients With Total Knee Arthroplasty
The purpose of this study is to investigate if preoperative strength training will result in faster recovery and higher level of function six weeks after total knee arthroplasty (TKA).
- Trial name
- NCT01647243
- Testing
- Preoperative strength training
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- University of Aarhus
Venous Thromboembolism (VTE), Total Joint Arthroplasty
Efficacy of Aspirin in Preventing Venous Thromboembolism
Efficacy of aspirin and enoxaparin in preventing venous tromboembolism was compared after total knee or hip arthroplasty.
- Conditions
- Venous Thromboembolism (VTE), Total Joint Arthroplasty, Total Hip Arthroplasty (THA)
- Trial name
- NCT06635317
- Testing
- Aspirin, enoxaparin
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Knee Osteoarthritis
Conventional Instrumentation, Computer Navigation, and Robotic Assistance Techniques in TKA
Knee osteoarthritis is a debilitating disease that can cause severe knee pain and significant limitations to patients' activities of daily living.
- Trial name
- NCT05629715
- Testing
- ROSA Knee System, KneeAlign Computer Assisted Navigation System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Osteo Arthritis Knee
The Effect of Smart Ring Assisted Physiotherapeutic Intervention After TKR
The goal of this randomized controlled trial is to learn about the effect of a wearable activity tracker assisted physiotherapeutic intervention on the risk of poor patient reported outcome after a primary total knee replacement.
- Trial name
- SmarTKRing (NCT05599776)
- Testing
- Smart ring assisted physiotherapeutic intervention
- Where
- Finland
- Volunteers
- 338 people
- Sponsor
- Coxa, Hospital for Joint Replacement
Knee Osteoarthritis, Musculoskeletal Disease
Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.
The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving…
- Conditions
- Knee Osteoarthritis, Musculoskeletal Disease, Surgery
- Trial name
- TKACSI (NCT07151417)
- Testing
- PAI, PAI + steroid, PAI + zilretta
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Walter Reed National Military Medical Center
Arthroplasty, Replacement, Knee, Osteoarthritis, Knee
TracPatch in Total Knee Arthroplasty
Total Knee Arthroplasty is becoming an increasingly common operation. An important part of a successful overall patient outcome is regaining functional range of motion after surgery.
- Trial name
- NCT03466476
- Testing
- Consensus TracPatch
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Miami
Osteoarthritis, Hip, Osteoarthritis, Knee
Study on Costs and Effects of Waiting Time in Total Hip and Knee Replacements
The aim of this study is to compare the cost-effectiveness of major joint replacement in patients with short and non-fixed (control group) waiting time (WT).
- Trial name
- NCT00294424
- Testing
- Short waiting time, Non-fixed waiting time
- Where
- Finland
- Volunteers
- 833 people
- Sponsor
- Academy of Finland
Knee Osteoarthritis (OA), Total Knee Arthroplasty (TKA)
Manual Traction and Rehabilitation After Knee Replacement Surgery
The goal of this clinical trial is to determine whether the addition of manual traction to a standard rehabilitation protocol improves early recovery after primary total knee arthroplasty (TKA) in women aged 50-75 years with knee…
- Trial name
- SMART-TKA (NCT07722559)
- Testing
- Manual Tibiofemoral Traction
- Where
- Kosovo
- Volunteers
- 48 people
- Sponsor
- Alma Mater Europaea - Slovenia
Total Knee Arthroplasty
Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery
Intra-articular Posteromedial Surgeon Administered (IPSA) Block in this study describes a new type of medical procedure where a surgeon provides anesthetic medication directly into a specific area inside a knee joint to numb the…
- Trial name
- NCT06946368
- Testing
- Intra-articular Posteromedial Surgeon Administered (IPSA) Block of EXPAREL, Adductor Canal Block (ACB) and Local Local Infiltration Analgesia of EXPAREL, Local Infiltration Analgesia (LIA) of EXPAREL
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Hip Osteoarthritis, Knee Osteoarthritis
What Matters to Patients With Severe Hip or Knee Osteoarthritis?
This clinical trial aims to investigate if shared decision-making, and the use of an in-consultation patient decision aid (PtDA), increases the decisional quality and therefore treatment satisfaction and outcome of patients with…
- Trial name
- PATI-Project (NCT05972525)
- Testing
- Shared decision-making supported by an in-consultation PtDA to patients with severe osteoarthritis in their hip or knee
- Where
- 3 sites in Denmark
- Volunteers
- 615 people
- Sponsor
- Vejle Hospital
Excessive Amount of Blood / Fluid Transfusion
Iron and Vitamin Adminstration Prior to Joint Replacement to Prevent Transfusion
To establish the efficacy of screening for anemia and treatment of mild anemia with iron and vitamins prior to THR and TKR as a means of increasing hemoglobin and reducing perioperative allogeneic blood transfusion.
- Trial name
- NCT01676740
- Testing
- Iron Supplement,
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Meir Medical Center
Osteo Arthritis Knee, Knee Arthroplasty
Physiotherapy and Therapeutic Education on Patients With Pain Catastrophism Scheduled for a Total Knee Arthroplasty
The purpose of this study is to test whether adding a treatment using pain neuroscience education (PNE) and multimodal physiotherapy to usual care, in subjects with knee osteoarthritis and pain catastrophizing, who are scheduled…
- Conditions
- Osteo Arthritis Knee, Knee Arthroplasty, Catastrophizing, Pain
- Trial name
- NCT03847324
- Testing
- Pain Neuroscience Education, Multimodal Physiotherapy, Usual Care
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Barcelona