Clinical trials: Knee Replacement
Degenerative Arthritis
Combined Administration of Intravenous and Topical Tranexamic Acid in Total Knee Arthroplasty
This prospective randomized controlled trial was conducted To compare the efficacy of TNA in terms of total blood loss and the allogenic transfusion rate among the three study groups; intravenous alone, combined intravenous and…
- Trial name
- NCT02286973
- Testing
- Tranexamic Acid
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Knee Instability in Total Knee Artrhroplasty
Knee Arthroplasty Instability Study
Total knee replacement (TKR) instability is a poorly defined entity. The diagnosis is based on symptoms and clinical tests of knee laxity.
- Trial name
- KISS (NCT05676437)
- Testing
- Stress radiography
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Diakonhjemmet Hospital
Arthrofibrosis
STAK Tool for Treatment of Arthrofibrosis Post Total Knee Replacement
A common complication following total knee replacement (TKR) is arthrofibrosis, a severe stiffening of the knee caused by scar tissue.
- Trial name
- STAK (NCT04019847)
- Testing
- STAK Tool, Standard treatment
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Osteo Arthritis Knee, Total Knee Arthroplasty
Comparing Surgical and Economical Parameters of Total Knee Replacement.
Randomized study comparing surgical and economic parameter of Total Knee Arthroplasty performed using two different specific surgical techniques.
- Trial name
- NCT03427047
- Testing
- MyKnee with single use Efficiency Instrument, Stryker Navigational with conventional metal instruments
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Knee Osteoarthritis, Total Knee Replacement
Movement Dynamics of Knee Osteoarthritis and Total Knee Replacement
This research aims to explore differences in walking and functional movement mechanics, exercise response, and physical activity between people with osteoarthritis (OA), those who have undergone total joint replacement, and…
- Trial name
- MDOA&TKR (NCT06829433)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Unilateral Primary Osteoarthritis of Knee
Bone Mineral Density Changes Under Two Tibial Components in Total Knee Arthroplasty
Osteoarthritis is a progressive disease afflicting to two thirds of Americans. Today, an estimated 43 million individuals have arthritis. By 2020, more than 59.4 million Americans will be affected by the disease.
- Trial name
- NCT01764984
- Testing
- Total knee arthroplasty
- Where
- 3 sites in Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Comparative Study of Total Knee Arthroplasty Using a Customized-patient Specific Instrument System.
Patient-specific instrumentation (PSI) has been introduced in total knee arthroplasty (TKA) as a new technology for improving accuracy in restoration of the alignment and biomechanics of the lower limb.
- Trial name
- NCT02500160
- Testing
- Patient specific instrumentation (MRI), Patient specific instrumentation (CT)
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kyung Hee University Hospital at Gangdong
Osteoarthritis, Total Knee Arthroplasty
Predictability of the Ability to Perform an Emergency Stop
Several studies exist on patient performance in drive simulators especially around and after surgery. Recommendations concerning the ability to drive preoperatively are based on these studies, which generated their data using…
- Trial name
- NCT02175160
- Testing
- Braking and functionality
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Total Knee Arthroplasty, Knee Osteoarthritis
Patient-navigation-based Preoperative Rehabilitation Exercise Program in Patients Undergoing TKA
This study aimed to assess the effectiveness of a patient navigation-based preoperative rehabilitation exercise program for patients undergoing total knee arthroplasty.
- Trial name
- NCT07047079
- Testing
- Autonomous preoperative rehabilitation exercises, The navigator provided full-period preoperative rehabilitation exercise guidance+navigation services
- Where
- China
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Anna Sun
Total Knee Arthroplasty
ATTUNE TM Video-fluoroscopy Study
The proposed study is a retrospective, observational study. A group of 5 subjects with the AttuneTM cruciate retaining (CR) fixed bearing total knee arthroplasty (TKA) are analysed during level walking, a deep knee bend, sitting…
- Trial name
- NCT02358434
- Testing
- Observational use of fluoroscopy
- Where
- Switzerland
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Dr. Renate List
Postoperative Urinary Retention, Total Hip Arthroplasty
RCT Foley Catheter Study for Elective TJA
Urinary retention is a known complication following surgical procedures, with a theoretical increased risk in patients receiving neuraxial anesthesia due to a decreased ability to sense bladder distension.
- Conditions
- Postoperative Urinary Retention, Total Hip Arthroplasty, Total Knee Arthroplasty
- Trial name
- NCT05428020
- Testing
- Indwelling foley catheter, No foley catheter
- Where
- United States
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Osteoarthritis, Knee
Finnish Unicompartmental and Total Knee Arthroplasty Investigation
Unicondylar knee arthroplasty (UKA) can be used as the treatment of knee OA isolated to a single compartment instead of TKA. Both UKA and TKA have been used for decades as a treatment of knee OA.
- Trial name
- FUNCTION (NCT02481427)
- Testing
- Unicondylar Knee Replacement, Total Knee Replacement
- Where
- 3 sites in Finland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Medial Knee Compartment Arthritis
Oxford Partial Knee Kinematics Gait Analysis Study
The objective of this study is to compare the effect on gait of unicompartmental knee arthroplasty (UKA), using the Oxford Partial Knee, versus normal knee.
- Trial name
- NCT01454908
- Testing
- Oxford Partial Knee
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The CORE Institute
Postoperative Urinary Retention
Routine Bladder Catheterisation Through Fast-track Hip and Knee Replacement - What Are the Consequences?
To describe the need for re-catheterization and incidence of urological complications of routine use of perioperative fixed urinary catheter (KAD) for up to 24 hours of fast-track THA and TKA
- Trial name
- NCT02133768
- Where
- Denmark
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Lundbeck Foundation
Catastrophization
Preoperative Cognitive Therapy for Improving Health Outcomes After TKA in High-risk Catastrophizing Subjects
The investigators propose a randomized controlled trial to evaluate the effects of treatment intended to reduce pain catastrophizing among patients reporting high pain catastrophizing prior to total knee replacement(TKR), total…
- Trial name
- CT_TKA (NCT01772329)
- Testing
- Cognitive Therapy, Routine Care
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Pain, Postoperative, Surgery
The Effect of Baduanjin on Patients Undergoing Knee Replacement Surgery
This randomized controlled trial aims to evaluate the effects of Baduanjin, a traditional Chinese mind-body exercise, on pain, comfort, and quality of recovery in patients undergoing total knee arthroplasty (TKA).
- Conditions
- Pain, Postoperative, Surgery, Knee Replacement, Nurse's Role
- Trial name
- NCT07109557
- Testing
- Baduanjin
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Niran Çoban
Cryotherapy Effect
Cryocompression After Total Knee Arthroplasty
The overall aim of this study is to evaluate the effectiveness of a cryocompression device after total knee arthroplasty (TKA) compared to standard therapy.
- Trial name
- NCT05395273
- Testing
- Game Ready cryocompression
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Knee Osteoarthritis
Persona MC vs Attune Total Knee Replacement Study
This study aims to compare clinical and functional outcomes of a cohort of patients that have undergone a medial congruent TKR to a similar cohort of patients that have undergone a conventional TKR and a cohort of control…
- Trial name
- PERTUNE (NCT03580772)
- Testing
- Persona TKR, Attune TKR
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Osteoarthritis, Knee
Prehabilitation Using Aquatic Exercise
With aging population, total knee arthroplasty is performed with increasing frequency. Although the surgery is successful in general, significant number of patients suffers persistent pain and disability.
- Trial name
- NCT02773745
- Testing
- Aquatic Prehab
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Total Knee Arthroplasty
The Analgesic Effect of Nitroglycerin Patch for Postoperative Pain After Total Knee Replacement
Patients who undergo general anestheesia for total knee arthroplasty pften have sever postoperative pain which hinders their rehabilitation.
- Trial name
- NCT00375362
- Testing
- Nitroderm patch
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center