Clinical trials: Knee Replacement
Arthroplasty, Replacement
Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Knee Arthroplasty Procedures
Background: REAL INTELLIGENCE™ CORI™ (CORI Robotics) is a computer-assisted orthopaedic surgical navigation and burring system. CORI Robotics is designed to help surgeons in planning and executing certain types of knee surgery…
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- NCT04786119
- Testing
- CORI Robotics
- Where
- 8 sites in United States, Germany and 2 more
- Volunteers
- 126 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Knee
MAKO Total Knee Artroplasty
The purpose of this study is to determine the early clinical and radiographic outcomes of robotically assisted total knee arthroplasty with the MAKO surgical robot using the Triathlon knee system.
- Trial name
- NCT05744895
- Testing
- Device: Robotic MAKO total knee, FocusMotion knee brace, Fitbit tracking device
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Washington University School of Medicine
Osteoarthritis
Prospective Clinical Study Evaluating Tibiofemoral Rotational Alignment Using Intraoperative Sensing During Total Knee Arthroplasty (TKA)
The objectives of the study are twofold: 1) Evaluate how intra-operative sensing may assist the surgeon with tibiofemoral rotational alignment by testing the precision and variability of setting tray rotation to the mid-third of…
- Trial name
- NCT02286739
- Testing
- TKA with "Verasense", TKA without "Verasense"
- Where
- 6 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Orthosensor, Inc.
Osteoarthritis
Effectiveness of Minimally Invasive Total Knee Replacement in Improving Rehabilitation and Function
Osteoarthritis (OA) is a long-term degenerative joint disease that disables about 10% of people over the age of 60 and compromises the quality of life of more than 20 million Americans.
- Trial name
- NCT00710840
- Testing
- Minimally Invasive Total Knee Arthroplasty [TKA Min], Total Knee Arthroplasty (TKA) Traditional
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- University of Colorado, Denver
Arthroplasty, Replacement, Knee
A Study of JNJ-70033093 (BMS-986177) Versus Subcutaneous Enoxaparin in Participants Undergoing Elective Total Knee Replacement Surgery
The purpose of this study is to determine the efficacy of JNJ-70033093 in preventing total venous thromboembolism (VTE) events (proximal and/or distal deep vein thrombosis [DVT] [asymptomatic confirmed by venography assessment or…
- Trial name
- AXIOMATIC-TKR (NCT03891524)
- Testing
- JNJ-70033093 25 mg, JNJ-70033093 50 mg, JNJ-70033093 100 mg
- Where
- 117 sites in United States, Argentina and 16 more
- Volunteers
- 1,242 people
- Sponsor
- Janssen Research & Development, LLC
Arthritis of the Knee
A Randomized, Study to Evaluate the Iovera° Device in Treating Pain Associated With Total Knee Arthroplasty
This study will evaluate the iovera° device in treating pain associated with total knee arthroplasty (TKA). This study will also assess if overall pain medication is reduced following TKA and will investigate the relationship…
- Trial name
- NCT02284113
- Testing
- iovera°
- Where
- 8 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Postoperative Inflammatory Response
Steroids in Bilateral Total Knee Replacement
Inflammation related to cytokine release is known to occur with surgery. The cytokine IL6, a major marker of inflammation is known to increase during total joint replacement surgery.
- Trial name
- NCT01399268
- Testing
- Hydrocortisone, Saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hospital for Special Surgery, New York
Arthroplasty, Replacement, Knee
Triathlon® Posteriorly Stabilized (PS) Total Knee System - Outcomes Study
The purpose of this study is to evaluate the clinical outcomes (range of motion, pain, function, radiographic stability, and health related quality of life) of patients receiving the Triathlon® Posterior Stabilized (PS) Total…
- Trial name
- NCT00957021
- Testing
- Triathlon® PS Total Knee System
- Where
- 11 sites in United States
- Volunteers
- 409 people
- Sponsor
- Stryker Orthopaedics
Knee Osteoarthritis, Primary Total Knee Arthroplasty
Evaluation of Utility of Ultrasound Guided iPACK Block for Knee Extension After Total Knee Arthroplasty.
The purpose of this study is to learn if using an Interspace between the Popliteal Artery and Capsule of the Knee (iPACK) injection technique (also called a "nerve block") that numbs the nerves going to the back part of the knee…
- Conditions
- Knee Osteoarthritis, Primary Total Knee Arthroplasty, Physical Therapy, Pain
- Trial name
- NCT03353233
- Testing
- Ropivacaine, Interspace Between the Popliteal Artery and Capsule of the Knee (iPACK) Block, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Osteo Arthritis Knee
Analgesic Value of Adductor Canal vs Femoral Block After Total Knee Arthroplasty
An observational study of the effect of femoral nerve block in addition to an adductor canal block for pain following total knee arthroplasty.
- Trial name
- NCT03395990
- Testing
- Active comparator: chloroprocaine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Venous Thromboembolism, Arthroplasty, Replacement
Pradaxa (Dabigatran Etexilate) VTE Prevention After Elective Total Hip or Knee Replacement Surgery
an open, prospective, observational study to collect data on safety (major bleeding events) and efficacy (symptomatic venous thromboembolism(VTE)) of a switch from Enoxaparin to dabigatran etexilate in patients with total knee…
- Trial name
- NCT01153698
- Testing
- dabigatran
- Where
- 7 sites in Austria
- Volunteers
- 167 people
- Sponsor
- Boehringer Ingelheim
Osteoarthritis, Rheumatoid Arthritis
Robotic Arm Assisted Total Knee Arthroplasty
The Investigation will be conducted as a single-submission, multi-center study with approval from and in compliance of the Western Institutional Review Board (WIRB).
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis
- Trial name
- NCT02058069
- Testing
- Robotic Arm Assisted Total Knee Arthroplasty
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- MAKO Surgical Corp.
Arthroplasty, Replacement, Knee
Polyethylene Wear Study on the Triathlon Total Knee Prosthesis
Comparison of conventional UHMWPE (ultra-high-molecular-weight polyethylene) with highly cross-linked polyethylene (X3) in a condylar stabilizing (CS) fixed bearing total knee prosthesis by means of RSA and clinical evaluation.
- Trial name
- X3vsN2Vac (NCT02525588)
- Testing
- Triathlon CS fixed bearing total knee prosthesis
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Stryker Orthopaedics
Osteoarthritis
Pain Expectations in Subjects With Osteoarthritis
The purpose of this research study is to test whether or not researchers can alter or change expectations on pain. The researchers will test whether there is an effect on the size of the pupil and responses to thermal heat…
- Trial name
- NCT02155257
- Testing
- Modafinil, Gabapentin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Total Knee Replacement Surgery
Adductor Canal Catheter Effectiveness and Safety Study
PRIMARY OBJECTIVE: Compare the effect of usual care with an adductor canal catheter (ACC) containing ropivacaine to the effect of usual care without an ACC on the second-postoperative-day pain levels among patients undergoing…
- Trial name
- ACCESS (NCT04639128)
- Testing
- Adductor Canal Catheter
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Kaiser Permanente
Arthritis Knee, Pain, Postoperative
Exparel Use in Adductor Canal Block After Total Knee Arthroplasty
Exparel has been shown to have better pain control compared to previously used infiltration agents, including bupivacaine, while having a minor side effect profile.
- Conditions
- Arthritis Knee, Pain, Postoperative, Opioid Use
- Trial name
- NCT04910165
- Testing
- Exparel, Ropivacaine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital, Pennsylvania
Venous Thromboembolism
A Phase 3 Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Knee Arthroplasty
The objective of this study is to assess the efficacy and safety of DU-176b compared with enoxaparin sodium for the prevention of venous thromboembolism in patients after elective total knee arthroplasty.
- Trial name
- NCT01181102
- Testing
- edoxaban, enoxaparin sodium
- Where
- 3 sites in Japan, Taiwan
- Volunteers
- 716 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Postoperative Pain Following Knee Arthroplasty
Femoral Versus Adductor Canal Continuous Peripheral Nerve Blocks for Knee Arthroplasty
Patients typically experience moderate-to-severe pain following knee arthroplasty that is usually treated with a combination of oral and intravenous analgesics and enhanced by continuous peripheral nerve blocks.
- Trial name
- NCT01759277
- Testing
- Control: Femoral perineural local anesthetic infusion, Experimental: Adductor Canal perineural local anesthetic infusion
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Diego
Surgical Robotics, Knee Replacement
A Retrospective Study of the Navio Robotic-assisted Surgical System
A retrospective, multi-center, cohort study with prospective follow-up and comparison to historical control
- Trial name
- NAVIO (NCT03072459)
- Where
- 5 sites in United States
- Volunteers
- 128 people
- Sponsor
- Smith & Nephew, Inc.
Knee Pain, Chronic Osteoarthritis
ROSA Robot Used in Total Knee Replacement Post Market Study
This is a prospective, multicenter clinical study designed to facilitate the collection and evaluation of workflow efficiency, patient pain and function, and adverse event data.
- Conditions
- Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities
- Trial name
- NCT03969654
- Testing
- PERSONA Total Knee, Vanguard Total Knee, NexGen Total Knee
- Where
- 5 sites in United States
- Volunteers
- 181 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet