Clinical trials: Knee Replacement
Knee Prosthesis
In Vivo Kinematics Comparison of Stryker or Zimmer Total Knee Arthroplasty
This study will compare the kinematics data collected from patients with implants created by different manufacturers to see which of these implants provides a more normal-like kinematic pattern compared to the normal knee.
- Trial name
- NCT01864434
- Testing
- Stryker posterior cruciat retaining (PCR) total knee arthroplasty (TKA), Zimmer PCR TKA
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- The University of Tennessee, Knoxville
Postoperative Recovery
A Study to Evaluate the Effect of GRF6021 on Postoperative Recovery Following Primary Hip or Knee Arthroplasty
This study will evaluate the safety, tolerability and effect of GRF6021 on clinical recovery parameters in participants undergoing primary hip or knee arthroplasty.
- Trial name
- NCT03981419
- Testing
- GRF6021
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Alkahest, Inc.
Antibotics in Cementless Knees
Intraarticular Antibiotic in TKA
The purpose of the study is to determine the intra-articular concentration of vancomycin and tobramycin after administration of vancomycin and tobramycin powder in primary cementless total knee arthroplasty and determine the…
- Trial name
- NCT04297631
- Testing
- Tobramycin Powder, Vancomyscin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Osteoarthritis, RheumatoId Arthritis
Zimmer POLAR - Total Knee Arthroplasty (TKA)
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for commercially available Persona fixed bearing knee implants used in total knee arthroplasty.
- Conditions
- Osteoarthritis, RheumatoId Arthritis, Traumatic Arthritis, Polyarthritis
- Trial name
- NCT01859130
- Testing
- Zimmer Persona Total Knee System
- Where
- 4 sites in United States
- Volunteers
- 299 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Osteoarthritis
Midvastus Versus Medial Parapatellar Approach for Minimally Invasive Total Knee Arthroplasty
The purpose of this study is to compare two different surgical approaches for total knee replacement surgery. The mini-midvastus approach involves cutting less of the thigh muscle (quadriceps) tendon than the classic approach…
- Trial name
- NCT01132378
- Testing
- Total knee arthroplasty
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Heekin Orthopedic Research Institute
Insomnia, Pain
Effectiveness of Healthy Habits for Hospitalized Older Adults to Optimize Rehabilitation
This study aims to evaluate behavioral interventions in conjunction with medical rehabilitation to promote functional health in patients recovering from orthopedic surgery.
- Conditions
- Insomnia, Pain, Osteoarthritis, Knee, Osteoarthritis, Hip
- Trial name
- HH (NCT04269239)
- Testing
- Healthy Habits, Sleep Habits
- Where
- 3 sites in United States
- Volunteers
- 73 people
- Sponsor
- Baylor College of Medicine
Sleep Apnea, Obstructive
Prevalence of Sleep Apnea in Patients Presenting for Hip or Knee Replacement Surgery
The study hypothesis is that the prevalence of obstructive sleep apnea in patients presenting for total knee or total hip arthroplasty is higher than generally suspected.
- Trial name
- NCT00874822
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- University of Nebraska
Total Knee Arthroplasty
Single Injection Adductor Canal Block vs Catheter for Total Knee Arthroplasty
This study investigates single injection adductor canal block (ACB) with or without intravenous dexamethasone and adductor canal catheter for pain management of total knee arthroplasty.
- Trial name
- NCT02798835
- Testing
- Adductor canal block, Adductor canal block with dexamethasone, Adductor canal catheter
- Volunteers
- 180 people
- Sponsor
- University of British Columbia
Arthroplasties, Knee Replacement
A Trial of Mechanical Axis vs Kinematic Alignment in Total Knee Replacement
This is a prospective, randomized, longitudinal study of the clinical outcomes of osteoarthritis patients treated by two different alignment philosophies for total knee replacement.
- Trial name
- NCT02527148
- Testing
- OtisMed® ShapeMatch® Technology, Stryker Precision Knee Navigation, Total Knee Replacement
- Volunteers
- 100 people
- Sponsor
- Stryker South Pacific
Knee Osteoarthritis, Primary Total Knee Arthroplasty
Evaluation of Utility of Ultrasound Guided iPACK Block for Knee Extension After Total Knee Arthroplasty.
The purpose of this study is to learn if using an Interspace between the Popliteal Artery and Capsule of the Knee (iPACK) injection technique (also called a "nerve block") that numbs the nerves going to the back part of the knee…
- Conditions
- Knee Osteoarthritis, Primary Total Knee Arthroplasty, Physical Therapy, Pain
- Trial name
- NCT03353233
- Testing
- Ropivacaine, Interspace Between the Popliteal Artery and Capsule of the Knee (iPACK) Block, Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Osteoarthritis
Adductor Canal Block Versus Periarticular Bupivicaine Injection in Total Knee Arthroplasty
The objective of the study is to compare the efficacy of adductor canal blocks versus periarticular bupivacaine injections for pain management in total knee arthroplasty.
- Trial name
- NCT02777749
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Columbia University
Venous Thromboembolism
A Trial to Learn How Well REGN9933 Works for Preventing Blood Clots After Knee Replacement Surgery in Adult Participants
The primary objective of the study is to evaluate the efficacy of REGN9933 for the prevention of venous thromboembolism (VTE) after unilateral total knee arthroplasty (TKA), compared to enoxaparin The secondary objectives of the…
- Trial name
- NCT05618808
- Testing
- REGN9933, Enoxaparin, Apixiban
- Where
- 16 sites in Belgium, Bulgaria and 5 more
- Volunteers
- 373 people
- Sponsor
- Regeneron Pharmaceuticals
PAIN
Postoperatory Analgesia After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is a worldwide realized procedure, with 600.000 surgeries performed per year in the United States, with a 673% increase estimated until 2030.
- Trial name
- PAINCONTROL (NCT01700517)
- Testing
- Spinal anesthesia, Femoral nerve block, sciatic nerves block
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospital Madre Teresa
Post Operative Pain
Efficacy and Safety Trial to Evaluate the Sufentanil NanoTab® PCA System/15 mcg (Zalviso™) for Post-Operative Pain in Patients After Knee or Hip Replacement Surgery
The purpose of this study is to compare the efficacy and safety of the Sufentanil NanoTab PCA System/15 mcg to the Placebo Sufentanil NanoTab PCA System for the management of acute moderate to severe post-operative pain after…
- Trial name
- NCT01660763
- Testing
- Sufentanil NanoTab PCA System/15 mcg
- Where
- United States
- Volunteers
- 419 people
- Sponsor
- Talphera, Inc
Osteoarthritis, Knee
Brain Stimulation and Meditation for Pain After Total Knee Arthroplasty
Feasibility, acceptability, and preliminary efficacy of combined transcranial direct current stimulation and mindfulness for pain after total knee arthroplasty
- Trial name
- NCT05673720
- Testing
- active tDCS paired with active MBM
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Florida State University
Complications; Arthroplasty, Knee Injuries
Ultrasound-guided Adductor Canal Block for Total Knee Replacement
Total knee arthroplasty is associated with intense early postoperative pain. Fast track recovery programs including early therapy protocols and early hospital discharge are being implemented at various hospitals.
- Trial name
- NCT02100579
- Testing
- Bupivacaine, Preservative free normal saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Arthroplasty, Replacement, Knee
Triathlon® Cruciate Retaining (CR) Total Knee System Outcomes Study
The purpose of this study is to evaluate the clinical outcomes (range of motion, pain, function, radiographic stability, and health related quality of life) of patients receiving the Triathlon® Cruciate Retaining (CR) Total Knee…
- Trial name
- NCT00957723
- Testing
- Triathlon® CR Total Knee System
- Where
- 11 sites in United States
- Volunteers
- 419 people
- Sponsor
- Stryker Orthopaedics
Post-Operative Pain
A Multicenter, Randomized, Open-Label, Parallel-Group Trial to Compare the Efficacy and Safety of the Sufentanil NanoTab PCA System/15 mcg (Zalviso™)to Intravenous Patient-Controlled Analgesia With Morphine for the Treatment of Acute Post-Operative Pain
The study is intended to show that the Sufentanil NanoTab PCA System is as effective as morphine intravenous patient-controlled analgesia (IV PCA) for treating pain after surgery.
- Trial name
- NCT01539538
- Testing
- Sufentanil NanoTab PCA System/15 mcg, morphine IV PCA
- Where
- 16 sites in United States
- Volunteers
- 357 people
- Sponsor
- Talphera, Inc
Knee Prosthesis, Knee Replacement Arthroplasty
Mechanics Analysis of Patients Having a Sigma Mobile Bearing TKA
Utilize previously developed mathematical model to determine in vivo knee mechanics (kinematics, forces, stresses, areas and sound) for subjects having a Sigma Posterior Stabilizing (PS) mobile bearing (MB) total knee…
- Trial name
- Sigma MB TKA (NCT01714492)
- Testing
- Sigma Posterior Stabilizing Rotating Platform TKA Beaded Poly
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- The University of Tennessee, Knoxville