Clinical trials: Knee Replacement Arthroplasty
Total Knee Replacement
Innovative Gait Training for People With Knee Osteoarthritis Using Dual Belt Treadmill
Knee osteoarthritis (OA) is the most common form of arthritis and is the leading cause of chronic musculoskeletal pain and functional disability. Gait assessment is essential for the rehabilitation of people with knee OA.
- Trial name
- NCT05958212
- Testing
- Gait training program, Conventional training only
- Where
- Hong Kong
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Knee Osteoarthritis, Total Knee Arthroplasty
Open and Closed Platform Robotic-assisted Versus Conventional Total Knee Arthroplasty
REAL INTELLIGENCE™ CORI™ (CORI Surgical System) is a computer-assisted orthopedic surgical system. CORI Surgical System is designed to aid surgeons in planning and executing a procedure involving bone preparation for total knee…
- Trial name
- NCT06305065
- Testing
- KUNWU Navigation TKA procedure, CORI Surgical System TKA procedure, Conventional TKA procedure
- Where
- Hong Kong
- Volunteers
- 90 people
- Sponsor
- Chinese University of Hong Kong
Muscles Ischemia
Clinical, Biochemical and Neurophysiological Consequences of Intraoperative Tourniquet During Total Knee Arthroplasty
Clinical, Biochemical and Neurophysiological Consequences of Intraoperative Tourniquet During Total Knee Arthroplasty: WOMAC-Score Knee-Score Radiographic Evaluations and Scoring System Biochemical muscle biopsy analysis
- Trial name
- NCT02475603
- Testing
- Total knee arthroplasty
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Elderly, Total Knee Arthroplasty
Dexmedetomidine as an Adjuvant for Femoral Nerve Block and Functional Recovery After Total Knee Arthroplasty
Femoral nerve block (FNB) is a first-line analgesic technique for multimodal analgesia after total knee arthroplasty (TKA). Recent studies and meta-analysis indicate that dexmedetomidine combined with local anesthetics for FNB…
- Conditions
- Elderly, Total Knee Arthroplasty, Femoral Nerve Block, Dexmedetomidine
- Trial name
- NCT04642651
- Testing
- Dexmedetomidine
- Where
- 2 sites in China
- Volunteers
- 170 people
- Sponsor
- Peking University First Hospital
Knee Osteoarthritis, Arthropathy of Knee
A Prospective Clinical Trial Comparing Serum Mast Cell Tryptase (SMCT) Levels to Arthrofibrosis Rates Among Primary Total Knee Arthroplasty (TKA) Patients
This research is being done to see if the amount of an enzyme in blood (called serum mast cell tryptase) changes before and after surgery.
- Conditions
- Knee Osteoarthritis, Arthropathy of Knee, Arthrofibrosis
- Trial name
- NCT03598829
- Testing
- Tryptase, Serum test
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- Mayo Clinic
Ascorbic Acid, Postoperative Pain
The Impact of Intravenous Vitamin C Combined With Nerve Blocks on Postoperative Pain and Recovery After Total Knee Arthroplasty
The aim of this prospective randomized-control study was to evaluate the impact of a single high-dose intravenous vitamin C added to ultrasound-guided blocks at induction on postoperative pain, sngception and early functional…
- Trial name
- NCT05514197
- Testing
- Ascorbic acid 100mg/kg, Maximus 10g, Control Rx
- Where
- Taiwan
- Volunteers
- 73 people
- Sponsor
- Chimei Medical Center
Anesthesia, Total Knee Arthroplasty
The Efficacy of Peripheral Nerve Blocks With Intrathecal Morphine in Improving Analgesia After Unilateral Total Knee Arthroplasty
The purpose of this study is to determine whether intrathecal morphine (ITM) alone or its combination with peripheral nerve blocks (PNB) provides better analgesia for patients undergoing total knee arthroplasty (TKA).
- Trial name
- NCT02135120
- Testing
- Combined spinal epidural anesthesia technique with intrathecal morphine, A combination of combined spinal-epidural (with intrathecal morphine) and femoral nerve block, A combination of combined spinal-epidural (with intrathecal morphine) and femoral nerve block as well as sciatic nerve block
- Where
- Lebanon
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Knee Arthroplasty, Total, Robotic Assisted Arthroplasty
Randomized Controlled Trial Comparing Robotic-Assisted Versus Conventional Total Knee Arthroplasty
To evaluate whether patients undergoing robotic-assisted TKA achieve better clinical-functional, radiological, and satisfaction outcomes compared with those undergoing the conventional technique, and whether operative time and…
- Conditions
- Knee Arthroplasty, Total, Robotic Assisted Arthroplasty, Arthropathy of Knee
- Trial name
- NCT07212296
- Testing
- Conventional total knee replacement, Robotic TKR
- Where
- Spain
- Volunteers
- 95 people
- Sponsor
- Hospital de Terrassa
Musculoskeletal Diseases
Medacta NextAR TKA Pivotal Trial
The goal of this study is to assess the efficacy and safety of a navigation system providing personalized soft tissue balance data in medially-stabilized total knee arthroplasty (TKA).
- Trial name
- NCT04844879
- Testing
- NextAR TKA system
- Where
- 4 sites in Switzerland
- Volunteers
- 40 people
- Sponsor
- Medacta International SA
Pain, Osteoarthritis
Adductor Canal Block With Posterior Capsular Injection for Total Knee Replacement
To compare early ambulation and ability to participate in rehabilitation in patients undergoing total knee replacement using two different nerve block techniques for pain control.
- Trial name
- NCT01805661
- Testing
- Canal Block and Capsular Injection, Femoral with Tibial Nerve Block
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Trinity Health Of New England
Total Knee Anthroplasty, Venous Insufficiency (Chronic)(Peripheral)
Impact of Chronic Venous Insufficiency on Outcomes After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is an effective treatment for end-stage knee osteoarthritis; however, postoperative complications-particularly wound healing problems-remain a significant concern.
- Conditions
- Total Knee Anthroplasty, Venous Insufficiency (Chronic)(Peripheral), Doppler Ultrasound Diagnosis
- Trial name
- VENOUS-TKA (NCT07577141)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- SB Istanbul Education and Research Hospital
Osteoarthritis
A Study on Rosa Roxburghii for Knee Replacement Recovery
This clinical trail is to investigates the effect of Rosa roxburghii juice freeze-dried powder on the recovery of patients undergoing total knee arthroplasty due to knee osteoarthritis.
- Trial name
- NCT07395856
- Testing
- Rosa roxburghii
- Volunteers
- 184 people
- Sponsor
- Shuguang Gao
Total Knee Anthroplasty, Patient Reported Outcome Measurements
Recovery Trajectories After Total Knee Arthroplasty
This prospective cohort study aimed to compare recovery trajectories following cruciate-retaining (CR) and posterior-stabilized (PS) total knee arthroplasty (TKA) using rehabilitation-centered patient-reported outcome measures…
- Conditions
- Total Knee Anthroplasty, Patient Reported Outcome Measurements, Cruciate Ligament Reconstruction
- Trial name
- NCT07595861
- Testing
- Cruciate-Retaining Total Knee Arthroplasty, Posterior-Stabilized Total Knee Arthroplasty
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Prevention, Venous Thromboembolism
Regulation of Coagulation in Orthopedic Surgery to Prevent Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE). A Study of BAY 59-7939 in the Prevention of VTE in Subjects Undergoing Elective Total Knee Replacement.
The purpose of this study is to assess if 10 mg Bay 59-7939, taken once daily as a tablet, is safe and prevents blood clot which may form after a knee replacement operation.
- Trial name
- RECORD 3 (NCT00361894)
- Testing
- Rivaroxaban (BAY59-7939), Enoxaparin
- Where
- 143 sites in Austria, Belgium and 17 more
- Volunteers
- 2,531 people
- Sponsor
- Bayer
Knee Osteoarthritis
Effect of Noise Control During Total Knee Arthroplasty
Music has emerged as a well-received medical intervention. Patients may be uncomfortable during total joint replacement, which can result in high sedation requirements. These requirements put patients at risk of surgical stress.
- Trial name
- NCT05714267
- Testing
- Active noise cancelling, Passive noice cancelling, Active noise cancelling with music therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bezmialem Vakif University
Improve Quality of Life
Exercise Program After Total Hip and Knee Replacement: a Randomized Controlled Trial
Randomized controlled trial. Patients will be enrolled at the moment of the pre-surgery assessment after verifying the inclusion/exclusion criteria and signing written informed consent.
- Trial name
- PAIR (NCT04761367)
- Testing
- Physical activity. Physical Activity program is performed in a group in a gym
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis
The goal of this study is to create a prospective registry (<100 patients) to show the effectiveness of the genicular artery embolization procedure overtime in reducing bilateral or unilateral osteoarthritic knee pain as measured…
- Conditions
- Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA)
- Trial name
- GAE (NCT06781463)
- Testing
- Registry (N/A)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Chicago
Arthroplasty, Replacement, Knee, Pain, Postoperative
Central Sensitization and Alteration of Circulating Neurosteroid
For patients who underwent two-stage replacement of both knee joints (one knee surgery - one week term- the other knee surgery), postoperative pain and analgesic usage with patient-controlled analgesia (PCA) increased at the…
- Trial name
- NCT03298711
- Where
- South Korea
- Volunteers
- 69 people
- Sponsor
- Seoul National University Bundang Hospital
Osteoarthritis, Knee
Pre-operative Intravenous Steroid in Total Knee Replacement for Pain Relief and Recovery
Osteoarthritis of the knee is a common and important condition in our society. Despite various anesthetic methods and pain medications, pain after operation still remains as a challenge.
- Trial name
- NCT03082092
- Testing
- Methylprednisolone Sodium Succinate
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Queen Elizabeth Hospital, Hong Kong
Knee Osteoarthritis, Knee Arthropathy
Mechanical Alignment vs Kalipered Kinematic Alignment Total Knee Arthroplasty
Knee replacement surgery can be performed in one of two ways. Traditionally the goal was for the new joint to be in a neutral position with respect to the femur (thigh bone). This is called Mechanical Alignment (MA).
- Trial name
- NCT06617871
- Testing
- Mechanical Alignment (MA), Kinematic Alignment (KA) Interventions:
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Northwestern University
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