Clinical trials: Knee Rheumatism
Knee Osteoarthritis
Safety, Tolerability and Pharmacokinetics of SAR113945 in Japanese Patients With Knee Osteoarthritis
Primary Objective: To assess the safety and tolerability of SAR113945 in Japanese patients with knee osteoarthritis after ascending single intra-articular doses Secondary Objective: To assess the pharmacokinetics of SAR113945 in…
- Trial name
- NCT01511549
- Testing
- SAR113945
- Where
- Japan
- Volunteers
- 24 people
- Sponsor
- Sanofi
Osteoarthritis, Knee
A Safety and Tolerability Study of UBX0101 in Patients With Osteoarthritis of the Knee
A study to evaluate safety, tolerability, and pharmacokinetics of a single intra-articular injection of UBX0101 in patients diagnosed with painful osteoarthritis of the knee.
- Trial name
- NCT03513016
- Testing
- UBX0101
- Where
- 7 sites in United States
- Volunteers
- 78 people
- Sponsor
- Unity Biotechnology, Inc.
Knee Osteoarthritis
Catabolic Marker Levels After Platelet Poor Plasma (PPP) Lavage
The purpose of this study is to understand how the components of osteoarthritic knee joint fluid (synovial fluid) change after lavage treatment with platelet poor plasma.
- Trial name
- PPP (NCT03120988)
- Testing
- Lavage with Platelet Poor Plasma (PPP)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Regenexx, LLC
Primary Body Region (Arranged Most Common to Least), Lumbar/SI
ATI Evidence-based Guide Investigating Clinical Services
The goal of this study is to evaluate how standard-of-care outpatient rehabilitation is delivered and how variation in care delivery mechanisms relates to clinical outcomes, service utilization, and value in patients receiving…
- Conditions
- Primary Body Region (Arranged Most Common to Least), Lumbar/SI, Knee, Shoulder
- Trial name
- AEGIS (NCT02285868)
- Where
- United States
- Volunteers
- 4,000,000 people, healthy volunteers welcome
- Sponsor
- ATI Holdings, LLC
Osteoarthritis, Knee
The Impact of Procedural Awareness of Knee Injections for Osteoarthritis on Patient Perceptions of Effectiveness
The purpose of this study is to determine whether outcomes for patients receiving intra-articular platelet-rich plasma (PRP) injections for knee osteoarthritis are influenced by observation of the preparatory steps to the…
- Trial name
- NCT04111718
- Testing
- Platelet-rich plasma (PRP), Viewing of preparation
- Where
- Canada
- Volunteers
- 158 people
- Sponsor
- ArthroBiologix Inc.
Osteoarthritis of the Knee, Arthroplasty, Replacement, Knee
Flex Intramedullary Rod Study
The purpose of this study is to compare the effect of post-operative ROM between Flex IM rod and Rigid IM rod, to collect bone morphology of Japanese lower extremity and to research the incidence of overhung with Flex IM rod.
- Trial name
- NCT02543489
- Testing
- Flex IM rod
- Where
- 3 sites in Japan
- Volunteers
- 100 people
- Sponsor
- Stryker Japan K.K.
Osteoarthritis, Knee, Rheumatoid Arthritis
Vanguard Rocc Post Market Surveillance
The objective of this project is to obtain prospective, multi-center, long term (10 year) clinical data on the Vanguard Rocc knee prosthesis.
- Conditions
- Osteoarthritis, Knee, Rheumatoid Arthritis, Traumatic Arthritis, Posttraumatic Deformity
- Trial name
- NCT03664791
- Testing
- Vanguard Rocc
- Where
- 9 sites in Belgium, Denmark and 2 more
- Volunteers
- 450 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Knee, Osteoarthritis, Hip
Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip
The primary objective of the study is to evaluate the efficacy of fasinumab compared to placebo, when administered for up to 24 weeks in patients with pain due to osteoarthritis (OA) of the knee or hip.
- Trial name
- FACT OA2 (NCT03304379)
- Testing
- Fasinumab, Diclofenac, Celecoxib
- Where
- 71 sites in United States
- Volunteers
- 1,650 people
- Sponsor
- Regeneron Pharmaceuticals
Knee Osteoarthristis
geniculaR Artery eMBolization for Knee Osteoarthritis (RAMBO) Registry
The goal of this observational study (prospective registry) is to collect long-term real-world data on the effectiveness and safety of genicular artery embolization (GAE) for knee osteoarthritis in adults aged 18 years or older…
- Trial name
- RAMBO (NCT07380906)
- Testing
- Genicular Artery Embolization
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Joint & Vascular Institute
Osteoarthrosis of Knee
Clinical and Functional Outcome of the GEMINI SL Fixed Bearing PS Knee Prosthesis
This is a prospective, multicenter, observational study with a planned follow-up period of 10 years to confirm the safety and performance of the GEMINI SL Fixed Bearing PS knee prosthesis in longterm follow-up under routine…
- Trial name
- NCT04858347
- Testing
- Total knee replacement
- Where
- Colombia
- Volunteers
- 350 people
- Sponsor
- Waldemar Link GmbH & Co. KG
Knee Pain Chronic, Osteoarthritis, Knee
Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)
The main objective of the study is to evaluate the safety, performance and clinical benefits of the Persona implant and its instrumentation in primary total knee arthroplasty
- Conditions
- Knee Pain Chronic, Osteoarthritis, Knee, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- NCT05787821
- Testing
- Total Knee Arthroplasty
- Where
- 16 sites in United States
- Volunteers
- 760 people
- Sponsor
- Zimmer Biomet
Pain, Osteoarthritis
Comparison of BTDS (Buprenorphine Transdermal System) and Placebo in Osteoarthritic Pain
The primary objective of this study is to evaluate the efficacy and safety of BTDS compared to placebo in subjects with moderate to severe osteoarthritic pain of the hip or knee.
- Trial name
- NCT00345787
- Testing
- Buprenorphine Transdermal System
- Where
- 28 sites in Japan
- Volunteers
- 262 people
- Sponsor
- Mundipharma K.K.
Knee Osteoarthritis, Knee Osteoarthritis (Knee OA)
Efficacy of Platelet-Rich Plasma Combined With Hyaluronic Acid in Knee Osteoarthritis
This prospective, randomized, open-label, single-centre post-market clinical follow-up (PMCF) study evaluates the clinical performance and safety of a single intra-articular injection of hyaluronic acid (HA) combined with…
- Conditions
- Knee Osteoarthritis, Knee Osteoarthritis (Knee OA), Knee Osteoarthritis (OA), Osteoarthritis (OA) of the Knee
- Trial name
- NCT07784907
- Testing
- Hyaluronic Acid (HA) and Platelet rich plasma (PRP), Hyaluronic Acid (HA)
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Implai Sp z o.o
Osteoarthritis of the Knee
Exploratory Study of PENNSAID Gel to Treat Symptoms of Knee Osteoarthritis
Osteoarthritis (OA) is the most common form of arthritis. It can cause pain, swelling, and reduced motion in the joints. That can reduce quality of life.
- Trial name
- NCT01119898
- Testing
- PENNSAID Gel, Vehicle
- Where
- 26 sites in United States
- Volunteers
- 260 people
- Sponsor
- Mallinckrodt
Painful Osteoarthritis of the Knee
A Study of the Efficacy and Safety of MEDI7352 in Participants With Painful Osteoarthritis of the Knee
This is a Phase IIb randomised, double-blind, placebo-controlled, dose-response study in participants with painful osteoarthritis (OA) of the knee.
- Trial name
- BESPOKE (NCT04675034)
- Testing
- MEDI7352
- Where
- 41 sites in Denmark, Estonia and 4 more
- Volunteers
- 345 people
- Sponsor
- AstraZeneca
Osteoarthritis, Knee
Study of the KinexConnect Telerehabilitation System (KCTRS)
A randomized, single-blind study comparing telerehabilitation at home with continuous passive motion (CPM) and a tablet-based patient engagement application (KinexConnect) versus traditional outpatient physical therapy (PT)…
- Trial name
- KCTRS (NCT04191798)
- Testing
- Telerehabilitation using the KinexConnect system for rehabilitation after TKA., Traditional outpatient PT for rehabilitation after TKA.
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kinex Medical Company, LLC
Osteoarthritis, Knee
A Phase 3 Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain
This is a phase 3, randomized, double-blind, placebo-controlled, single injection, 52-week study to evaluate the analgesic efficacy and safety of a single intra-articular (IA) CNTX-4975-05 (capsaicin), compared to IA placebo, in…
- Trial name
- NCT03429049
- Testing
- CNTX-4975-05
- Where
- 33 sites in United States
- Volunteers
- 332 people
- Sponsor
- Centrexion Therapeutics
Osteoarthritis, Knee
Safety and Efficacy of the Journey II BCS Total Knee System
Assess the safety and efficacy of the JOURNEY II BCS Total Knee System in subjects with degenerative knee disease requiring primary total knee replacement.
- Trial name
- NIMBLE (NCT01705067)
- Testing
- TKA with Journey II BCS Total Knee System
- Where
- 12 sites in United States
- Volunteers
- 209 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis of the Knee
Axial Alignment in Patients Operated Using the Visionaire Patient Matched Cutting Blocks
Title: PATIENT-MATCHED INSTRUMENTATION VS. STANDARD INSTRUMENTATION: A RANDOMIZED CLINICAL TRIAL COMPARING POSTOPERATIVE AXIAL ALIGNMENT and COMPONENT POSITION Short Title: Visionaire Alignment Methodology: Monocentric, Single…
- Trial name
- Visionaire (NCT01224522)
- Testing
- Visionaire, Standard surgical technique
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Smith & Nephew Orthopaedics AG
Osteoarthritis, Knee
A Study To Investigate Whether PF-04457845 Is Effective In Treating Pain, Is Safe And Tolerable In Patients With Osteoarthritis Of The Knee
Inactivation of the FAAH (Fatty Acid Amide Hydrolase) enzyme has been shown to relieve pain and inflammation in animal studies. PF-04457845 has been shown to inactivate the FAAH enzyme in animals and healthy human volunteers.
- Trial name
- NCT00981357
- Testing
- PF-04457845, Naproxen
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 76 people
- Sponsor
- Pfizer
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