Clinical trials: Knee Trauma
Anterior Cruciate Ligament Injuries
The Role of Muscle in Knee Stability
This project aims to compare the difference in muscle strength, muscle elasticity and muscle coordination of quadriceps and hamstring muscle and their association with knee biomechanics during single leg hop landing in patients…
- Trial name
- NCT04633161
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Vibration on Patellofemoral Joint Pain After ACLR
Anterior cruciate ligament (ACL) injury is a prevailing problem among sports participants, especially in non-contact sports. Studies have reported that 70-84% of ACL injuries are non-contact in nature, and movements like changing…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Patellofemoral Pain
- Trial name
- NCT05501210
- Testing
- WBV, PEMF
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Post-traumatic Osteoarthritis, Knee Sprain
Efficacy of an Evidence-based Telehealth Intervention in Modifying Health Behavior
The overall objective of this study is to evaluate the efficacy of the mare telehealth intervention platform and the intervention on patients' readiness to manage osteoarthritis and patient reported outcomes.
- Conditions
- Post-traumatic Osteoarthritis, Knee Sprain, Knee Injuries
- Trial name
- MIRROR_14 (NCT07187024)
- Testing
- mCare PTOA Intervention
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Keller Army Community Hospital
Iliotibial Band Syndrome
Effects of Posterior Oblique Sling Strengthening Exercises on Pain & Flexibility Among Runners With
The popularity of recreational running and rate of running related injuries are increasing. Research has shown that iliotibial band syndrome (ITBS) is one of the most common knee injuries among runners alongside plantar…
- Trial name
- ITBS (NCT05915754)
- Testing
- Hip abductors stretching and strengthening exercises, Posterior oblique sling strengthening exercises
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Knee Osteoarthristis, ACL Injuries
Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave Therapy
This study is recruiting current or former athletes who had ACL reconstruction surgery over a year ago and have been diagnosed with knee osteoarthritis (OA).
- Conditions
- Knee Osteoarthristis, ACL Injuries, Post-Traumatic
- Trial name
- PTOA Knee (NCT06686680)
- Testing
- extracorporeal shockwave therapy (ESWT)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Spaulding Rehabilitation Hospital
Glucose Metabolism Disorders, Lipid Metabolism Disorders
Metabolic Complications Following Knee Injury in Young and Middle Aged Patients
Introduction This study evaluates the effect on glucose, lipid and bone metabolism following knee orthopedic procedures in healthy and physically active individuals.
- Conditions
- Glucose Metabolism Disorders, Lipid Metabolism Disorders, Sedentary Lifestyle
- Trial name
- OrthoMetKnee (NCT02573662)
- Testing
- Blood and Urine sampling, DXA scan, OGTT
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Haugaard, Steen Bendix, M.D., DMSc
Injury; Nerve, Peripheral, Multiple, Chronic Post-Procedural Pain
Using Peripheral Nerve Stimulation (PNS) to Treat Chronic Post-surgical Pain (CPSP) After Knee Surgery
SPRINT PNS System will be offered to patients with postoperative knee pain following primary unilateral total knee arthroplasty (TKA) who meet eligibility criteria and consistent with established coverage policy.
- Conditions
- Injury; Nerve, Peripheral, Multiple, Chronic Post-Procedural Pain, Total Knee Arthroplasty, Surgery
- Trial name
- NCT04670042
- Testing
- SPRINT® Peripheral Nerve Stimulation (PNS) System (510k Cleared)
- Where
- United States
- Sponsor
- Stanford University
ACL - Anterior Cruciate Ligament Rupture
Optimizing Graft Selection for ACL Reconstruction
Purpose: To investigate the differences between the three most common methods for reconstruction of the anterior cruciate ligament (ACL), to support the development of the best method for the individual patient.
- Trial name
- GRASE-ACL (NCT05342441)
- Testing
- QT graft, ST/Gr graft, BPTB graft
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Hvidovre University Hospital
Knee Injuries
Clinical Evaluation of dCELL® Meniscus for Partial Replacement of the Meniscus
The safety and performance of dCELL® Meniscus will be evaluated in 60 patients after partial replacement of the native medial or lateral meniscus with the investigational product.
- Trial name
- NCT02270905
- Testing
- dCELL® Meniscus
- Where
- 4 sites in Poland, United Kingdom
- Volunteers
- 32 people
- Sponsor
- Tissue Regenix Ltd
ACL Injury
Influence of Combined Double-Bundle ACL Reconstruction With Lateral Retinacular Release to Prevent Patellofemoral Malalignment in Isolated ACL Rupture
Anterior knee pain which might be due to patellofemoral malalignment is an inevitable post operative complication after an ACL reconstruction (ACLR).
- Trial name
- NCT06004297
- Testing
- ACL reconstruction
- Where
- Indonesia
- Volunteers
- 100 people
- Sponsor
- Universitas Indonesia
Myotoxicity
Effects of Postoperative Analgesic Modalities on Plasma Creatine Phosphokinase(CPK) Levels After Knee Artroplasty
Regional anesthesia and analgesia technics are widely and securely used during orthopedic surgery. Interfascial plane blocks are the latest used ones for analgesia.
- Trial name
- NCT05505890
- Testing
- suprainguinal fascia iliaca block
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Samsun University
Meniscus; Detachment, Current Injury, Detachment
Comparison of the Results of Arthroscopic Suturing of the Medial Meniscus Using the Fast Fix and FiberStitch Systems
Clinical and comparative evaluation of the treatment results of arthroscopic reconstruction of the medial meniscus of the knee joint using the Fast Fix and FiberStitch systems.
- Conditions
- Meniscus; Detachment, Current Injury, Detachment, Medial Mensical Tear, Medial Meniscus Knee Injury
- Trial name
- NCT05318118
- Testing
- Medial Meniscus Arthroscopic Reconstruction Using the Fast Fix, Medial Meniscus Arthroscopic Reconstruction Using the Fiber Stitch
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- eMKa MED Medical Center
Arthropathy of Knee, Spinal Anesthesia
Dexmedetomidine on Tourniquet Induced -Systemic Effects
Eighty patients were randomly assigned to either control (CON) or dexmedetomidine (DEX) group. DEX group received a loading dose of 0.5 µg/ kg of intravenous dexmedetomidine over 10 minutes, followed by a continuous infusion of…
- Conditions
- Arthropathy of Knee, Spinal Anesthesia, Tourniquet, Ischemia-reperfusion Injury
- Trial name
- NCT04307290
- Testing
- Dexmedetomidine Hydrochloride, or Saline
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Wonkwang University Hospital
Knee Injuries
Knee Alignment Contributions to Anterior Cruciate Ligament (ACL) Injury
This study evaluates the the anatomic factors of the knee that may predispose to ACL injury.
- Trial name
- NCT00855023
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The Orthopaedic Center, Maryland
Anterior Cruciate Ligament Injuries
ALL Reconstruction Versus Modified Lemaire's LET in Combination With ACL Reconstruction With a Minimum Follow up of 2 Years
Anterior cruciate ligament (ACL) tears are associated with concomitant lesions of the anterolateral ligament (ALL), which increase rotatory instability of the knee.
- Trial name
- ARAVET (NCT06147427)
- Testing
- ACL reconstruction with hamstrings combined with ALL plasty, ACL reconstruction with hamstrings combined with modified Lemaire's LET
- Where
- France
- Volunteers
- 248 people
- Sponsor
- Hospices Civils de Lyon
Anterior Cruciate Ligament Injury, Knee Injury
Optimizing Plyometric Training for Functional Recovery Post-ACL Reconstruction
While surgical anterior cruciate ligament reconstruction (ACLR) of the knee restores passive stability, studies are showing consistently poor long-term outcomes.
- Trial name
- NCT02148172
- Testing
- Standard Plyometric Training, Plyometric Training with BWS
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Montana
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Chondrofix Osteochondral Allograft Prospective Study
The overall study objective is to evaluate Chondrofix Osteochondral Allograft ("Chondrofix") for the repair of osteochondral lesions in the knee.
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01410136
- Testing
- Chondrofix Osteochondral Allograft
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Platelets-rich Plasma, Osteoarthritis Knees Both
Effect of Platelet-rich Plasma (PRP) Injection on Knee Osteoarthritis
To evaluate the safety and effectiveness of PRP injection therapy in the repair of osteoarthritis and periarticular soft tissue injury through a single-center, exploratory clinical study, and to provide a more reliable basis for…
- Conditions
- Platelets-rich Plasma, Osteoarthritis Knees Both, Meniscus Disorder, Cartilage Injury
- Trial name
- NCT06082531
- Testing
- Sodium hyaluronate injection
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xijing Hospital
Anterior Cruciate Ligament Injury
Conditioning Brain Responses to Improve Thigh Muscle Function After Anterior Cruciate Ligament Reconstruction
The purpose of this study is to examine if thigh muscle weakness and the lack of muscle activation that accompanies ACL injury can be improved through a form of mental coaching and encouragement, known as operant conditioning.
- Trial name
- NCT03209531
- Testing
- Operant Conditioning, Control, Single Pulse Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Michigan
Knee Injuries
Epidemiological Evaluation of Knee Injuries in Children Admitted to Assiut University Hospitals From 2022 to 2025.
To categorize and analyze the incidence of the knee injuries in children admitted in Assiut University from 2022 to 2025 and to establish a data base about children less than 18 years who have knee injuries for further studies.
- Trial name
- NCT07300098
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Assiut University