Clinical trials: LARS - Low Anterior Resection Syndrome
Endometriosis, Rectum
Surgery for Lower Rectum Deep Endometriosis (Segmental/Disc) - Prospective Comparison of Digestive Symptoms and Pain
Several studies show a significant drop in pain scores, improved fertility outcomes and amelioration of impaired sexual functioning in women following surgical resection of colorectal endometriosis.
- Trial name
- NCT04398641
- Testing
- Evaluation of pre- and postoperative gastrointestinal functional outcomes
- Where
- 2 sites in Austria
- Volunteers
- 300 people
- Sponsor
- Univ.-Doz. Dr.med.univ. Gernot Hudelist, MSc.
Low Anterior Resection Syndrome, Malignant Anal Neoplasm
Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study
This phase II trial studies how well sacral nerve stimulation works in treating low anterior resection syndrome or fecal incontinence (the body's passage of stool without control) in patients with rectal cancer that has spread to…
- Conditions
- Low Anterior Resection Syndrome, Malignant Anal Neoplasm, Malignant Bladder Neoplasm, Malignant Cervical Neoplasm
- Trial name
- NCT04066894
- Testing
- Explantation, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
AI Care Device
Artificial Intelligence-based Dietary Care System
Patients with rectal cancer complicated by low anterior resection syndrome who undergo anal-preserving surgery may experience severe distress in daily life due to changes in bowel function, thus requiring significant…
- Trial name
- AI DC-system (NCT07637565)
- Testing
- Artificial Intelligence-based Dietary Care System, Routine Care
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Rectal Cancer, Surgery
Impact of a Patient-Centered Program for Low Anterior Resection Syndrome a Multicenter Randomized Controlled Trial
After undergoing restorative proctectomy for rectal cancer, many patients are left with significant bowel dysfunction, known as Low Anterior Resection Syndrome (LARS).
- Conditions
- Rectal Cancer, Surgery, Patient Activation, Low Anterior Resection
- Trial name
- NCT03828318
- Testing
- Patient Activation Booklet and nursing support for patients with LARS
- Where
- 6 sites in United States, Canada
- Volunteers
- 160 people
- Sponsor
- Jewish General Hospital
Low Anterior Resection Syndrome, Rectal Cancer
Experiences and Needs of Patients, Their Informal Caregiver and Healthcare Professionals Regarding LARS
Exploration of the experiences and needs of patients with the low anterior resection syndrome, their informal caregiver and health care professionals.
- Trial name
- NCT04896879
- Testing
- interviews
- Volunteers
- 69 people
- Sponsor
- University Hospital, Ghent
Sphincter Ani Incontinence, Rectal Cancer
Patient Reported Outcomes Following Cancer of the Rectum
The surgical management of rectal cancer includes a Total Mesorectal Excison (TME); depending on the height of the tumor, the problem of preservation of the anal sphincter arises, being able to perform a low anterior resection…
- Trial name
- PROCaRe (NCT04936581)
- Testing
- Open Total Mesorectal Excision, Laparoscopic Total Mesorectal Excision, Robotic Total Mesorectal Excision
- Where
- 2 sites in Spain
- Volunteers
- 200 people
- Sponsor
- University Hospital Gregorio Marañón
Rectal Cancer Patients
Validation of the French Version of the Low Anterior Resection Syndrome (LARS) Among Rectal Cancer Patients
Oncological rectal cancer outcomes have improved considerably because of optimal surgery by total mesorectal excision in conjunction with multidisciplinary team management by selective multimodal therapy (ie, neo-adjuvant…
- Trial name
- LARS (NCT03569488)
- Testing
- FT-LARS questionnaire
- Where
- 8 sites in France
- Volunteers
- 1,100 people
- Sponsor
- University Hospital, Caen
Low Anterior Resection Syndrome
Acupuncture in Low Anterior Resection Syndrome Treatment
Acupuncture has it's role in treating patients with fecal incontinence and diarrhea-predominant irritable bowel syndrome. There is no trial or case-report assessing it's role in treatment of Low anterior resection syndrome.
- Trial name
- AcuLARS (NCT03916549)
- Testing
- Acupuncture
- Where
- Lithuania
- Volunteers
- 10 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
LARS - Low Anterior Resection Syndrome
HEM1036 Phase 2 Study in Low Anterior Resection Syndrome
Double-blind, randomized, placebo controlled phase 2 study to explore the efficacy and safety of HEM1036 in the treatment of subjects with LARS
- Trial name
- NCT05527301
- Testing
- Lactobacillus Fermentum
- Volunteers
- 67 people
- Sponsor
- HEM Pharma Inc.
Rectal Cancer, LARS - Low Anterior Resection Syndrome
Personalized Care Pathways for Bowel Symptoms in Rectal Cancer Patients_contributing Factors (Treatable)
Colorectal cancer is the 2nd and 3rd most common cancer in respectively women and men, of which about 40% is located in the rectum.
- Conditions
- Rectal Cancer, LARS - Low Anterior Resection Syndrome, Active Surveillance
- Trial name
- Treatable (NCT06914245)
- Testing
- Electronic bowel diary, Faecal Incontinence Quality of Life questionnaire (FIQL), EuroQoL 5 dimensions, 5 levels (EQ-5D-5L)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- KU Leuven
Low Anterior Resection Syndrome, Sacral Neuromodulation - Interstim Therapy
Effectiveness of Sacral Neuromodulation in Low Anterior Resection Syndrome
Low anterior resection syndrome (LARS) is a complex disorder suffered by patients who undergo rectal resection mainly due to rectal cancer.
- Conditions
- Low Anterior Resection Syndrome, Sacral Neuromodulation - Interstim Therapy, Rectal Cancer
- Trial name
- SANLARS (NCT03598231)
- Testing
- Sacral neuromodulation
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Rectal Cancer
Efficacy of Ondansetron in LARS Treatment
Patients will be randomized (1:1 ratio) to receive either 4 weeks of Ondansetron followed by 4 weeks of placebo (O-P sequence) or 4 weeks of placebo followed by 4 weeks of Ondansetron (P-O sequence).
- Trial name
- Hodolar (NCT03182179)
- Testing
- Ondansetron 4 MG
- Where
- 2 sites in Switzerland
- Volunteers
- 48 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Low Anterior Resection Syndrome, Radiotherapy
Development and Validation of The Post-RT LARS Prediction Model (PORTLARS)
Bowel dysfunction is common after a restorative rectal cancer resection. Neoadjuvant radiotherapy is an influential factor that impairs bowel function and quality of life.
- Conditions
- Low Anterior Resection Syndrome, Radiotherapy, Rectal Cancer
- Trial name
- PORTLARS (NCT05129215)
- Testing
- Questionnaire
- Where
- China
- Volunteers
- 901 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Anterior Resection Syndrome
Low Anterior Resection Syndrome and Rectal Irrigation Study
Prospective study assessing treatment acceptability and the impact of rectal irrigation on patients with low anterior resection syndrome (LARS) in terms of quality of life and bowel function.
- Trial name
- LARRIS (NCT04246775)
- Testing
- Peristeen
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Cardiff and Vale University Health Board
Low Anterior Resection Syndrome, Rectal Cancer
The Value of Botox-A for Management of Low Anterior Resection Syndrome
Low anterior resection syndrome (LARS) is frequent after treatment for low rectal cancer. Increased bowel frequency and urgency with rectal spasms and incontinence have deleterious impacts on quality of life in a third of the…
- Trial name
- NCT01589471
- Testing
- intra-rectal Botulinum toxin A injection
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Low Anterior Resection Syndrome
Pathway of Low Anterior Resection Syndrome Relief After Surgery: a Feasibility Study
Currently, no standard exists for the treatment and management of Low Anterior Resection Syndrome (LARS)- a common disorder that affects patients who have had part of their bowel removed due to colorectal cancer.
- Trial name
- POLARiS (NCT05319054)
- Testing
- Sacral NeuroModulation, Trans-Anal Irrigation, Optimised Conservative Management
- Where
- 4 sites in United Kingdom
- Volunteers
- 187 people
- Sponsor
- Cardiff and Vale University Health Board
Low Anterior Resection Syndrome
Paula Method of Exercises in Patients With LARS Syndrome
Sphincter sparing rectal resection surgery, either total mesorectal excision (TME) with a temporary loop ileostomy or partial mesorectal excision (PME), is the mainstay of rectal cancer treatment , however, these treatments are…
- Trial name
- NCT05016583
- Testing
- Paula Method
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Hadassah Medical Organization
Rectal Cancer, Low Anterior Resection Syndrome
Autologous Fecal Microbiota Transplantation for Anal Function Recovery After Ileostomy Reversal in Rectal Cancer
This prospective, single-center, single-arm, open-label clinical study aims to evaluate whether autologous fecal microbiota transplantation can improve bowel and anal function after ileostomy reversal in patients with rectal…
- Conditions
- Rectal Cancer, Low Anterior Resection Syndrome, Fecal Incontinence, Diversion Colitis
- Trial name
- NCT07711509
- Testing
- Autologous Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Peking University People's Hospital
Faecal Incontinence With Faecal Urgency, Rectal Cancer
Efficacy of a Novel High Intensive Percutaneous Tibial Nerve Stimulation on Faecal Incontinence in Patients With Low Anterior Resection Cancer Syndrome After Rectal Cancer Surgery
This study aims to assess and evaluate the clinical efficacy of an intensified form of Percutaneous tibial nerve stimulation (PTNS) compared to standard conservative treatment for low anterior resection syndrome (LARS).
- Conditions
- Faecal Incontinence With Faecal Urgency, Rectal Cancer, Radiotherapy Side Effects, Low Anterior Resection Syndrome (LARS>20)
- Trial name
- HiPLARS (NCT07862673)
- Testing
- Percutaneous Tibial Nerve Stimulation
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Neoplasm of Rectum, Surgery--Complications
Validation of Low Anterior Resection Syndrome Score in Korean Version
In contemporary era of rectal cancer treatment, development of surgical technique and tool, adaptation of chemoradiation therapy, as well as multidisciplinary approach have led increased survival as well as rate of sphincter…
- Conditions
- Neoplasm of Rectum, Surgery--Complications, Surgery
- Trial name
- NCT03211715
- Testing
- questionnaire
- Volunteers
- 300 people
- Sponsor
- Saint Vincent's Hospital, Korea