Clinical trials: LGG
Colic, Inflammation
Effect of Lactobacillus Rhamnosus GG (LGG) on Infant Colic
This study will compare 2 currently marketed formulas in healthy full term babies: Nutramigen A+ (a hypoallergenic formula) and Nutramigen-Enflora (hypoallergenic formula with Lactobacillus GG (LGG)) during 3 months of formula…
- Trial name
- LGG (NCT01279265)
- Testing
- Nutramigen with Enflora, Nutramigen A+
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Spinal Cord Injuries, Neurogenic Bladder
Intravesical LGG VS Saline Bladder Wash RCT
This is the first ever comparative effectiveness study of an antibiotic-sparing novel self-management intervention to prevent complicated urinary tract infection (UTI).
- Trial name
- NCT05230511
- Testing
- Lactobacillus RhamnosusGG, Saline bladder wash
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Medstar Health Research Institute
Oral Mucositis
Lactobacillus Rhamnosus GG Alleviates Oral Mucositis in Patients Undergoing Radiotherapy
Radiation therapy is a common treatment modality in the management of head and neck malignancies. However, head and neck tumors often have some adverse reactions when receiving radiation therapy, such as dry mouth, change of…
- Trial name
- NCT06390176
- Testing
- Lactobacillus rhamnosus GG, Radiotherapy
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Diffuse Astrocytoma, Anaplastic Astrocytoma
Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation Positive LGG or Relapsed or Refractory HGG Tumors
The purpose of this study was to investigate the activity of dabrafenib in combination with trametinib in children and adolescent patients with BRAF V600 mutation positive low grade glioma (LGG) or relapsed or refractory high…
- Conditions
- Diffuse Astrocytoma, Anaplastic Astrocytoma, Astrocytoma, Oligodendroglioma, Childhood
- Trial name
- NCT02684058
- Testing
- Dabrafenib, trametinib, Carboplatin
- Where
- 57 sites in United States, Argentina and 18 more
- Volunteers
- 151 people
- Sponsor
- Novartis Pharmaceuticals
Colorectal Cancer
Lactobacillus Rhamnosus in Prevention of Chemotherapy-related Diarrhoea
Chemotherapy may cause diarrhoea, which may be associated with treatment delay and infections. The purpose of the study is to investigate whether oral supplementation with lactobacilli will alleviate chemotherapy related…
- Trial name
- NCT00197873
- Testing
- Lactobacillus Rhamnosus supplementation
- Where
- Finland
- Volunteers
- 84 people
- Sponsor
- University of Helsinki
Low Grade Glioma
A Vaccine Trial for Low Grade Gliomas
The study will assess the immunogenicity, safety and preliminary clinical efficacy of the glioma associated antigen (GAA)/tetanus toxoid (TT) peptide vaccine and poly-ICLC in HLA-A2+ children with unresectable low-grade gliomas…
- Trial name
- NCT02358187
- Testing
- Experimental: HLA-A2 Restricted Glioma Antigen-Peptides with Poly-ICLC
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- James Felker
Nosocomial Infection, Diarrhea, Infantile
Effect and Tolerability of Lactobacillus Rhamnosus GG LA801 for the Preventive Nutritional Care of Nosocomial Diarrhea in Children
One of the most common infections acquired in hospital, also known as nosocomial infections, is intestinal infections. These infections can lead to the development of nosocomial diarrhea which can have serious consequences in…
- Trial name
- EPISODE (NCT04628819)
- Where
- 2 sites in France
- Volunteers
- 61 people
- Sponsor
- PiLeJe
Periodontal Health, Dental Plaque Accumulation
Effects of Probiotics on Oral Health
Some probiotics have been shown to have preventive effects on infectious diseases and allergies. Because their long-term enhancement of the immune responses of children, they have been recommended for infants in some countries.
- Trial name
- NCT02444182
- Testing
- Probiotics
- Where
- Kuwait
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Kuwait University
Glioma, Epilepsy
Connectivity Alterations After Levetiracetam Application
This study aimed to analyze the connectivity alterations in brain networks of LGG patients with epilepsy who take levetiracetam at short-term preoperatively.
- Trial name
- NCT04425798
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Neurosurgical Institute
Graft Versus Host Disease
Lactobacillus Rhamnosus GG in Reducing Incidence of Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant
This randomized pilot clinical trial studies Lactobacillus rhamnosus GG in reducing incidence of graft-versus-host disease in patients who have undergone donor stem cell transplant.
- Trial name
- NCT02144701
- Testing
- Lactobacillus rhamnosus GG, laboratory biomarker analysis was not performed because of no differences in the clinical outcomes
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Rutgers, The State University of New Jersey
Low Grade Glioma
Vinblastine +/- Bevacizumab in Children With Unresectable or Progressive Low Grade Glioma (LGG)
This is an open-label, randomized, multi-center, comparator Phase II trial looking at the addition of Bevacizumab to Vinblastine in chemotherapy naïve pediatric patients with progressive Low Grade Glioma aged 6 months to less…
- Trial name
- NCT02840409
- Testing
- Vinblastine, Bevacizumab
- Where
- 21 sites in United States, Australia and 2 more
- Volunteers
- 109 people
- Sponsor
- The Hospital for Sick Children
Diabetes Mellitus, Type 1
Probiotics in Newly Recognized Type 1 Diabetes
They are major genera of bacteria that make up the colon flora in human, constitute intestinal microbial homeostasis, inhibit growth of pathogens, improve the gut mucosal barrier and modulate local and systemic immune responses.
- Trial name
- NCT03032354
- Testing
- Lactobacillus rhamnosus GG and Bifidobacterium lactis BB12
- Volunteers
- 96 people
- Sponsor
- Medical University of Warsaw
Melanoma, Glioma
A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors
The purpose of this clinical trial is to learn the safety and effects of the study medicine (PF-07799544) alone or in combination as a potential cancer treatment for adults with advanced solid tumors.
- Conditions
- Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer
- Trial name
- NCT05538130
- Testing
- PF-07799544, PF-07799933
- Where
- 66 sites in United States, Australia and 5 more
- Volunteers
- 148 people
- Sponsor
- Pfizer
Brain Tumor Adult, Low Grade Glioma (LGG), High Grade Glioma (HGG)
A Study to Test a New Fluid to Improve the Quality of Images Obtained by Using Sound Waves (Ultrasound) During Surgery
The objective of this clinical investigation is to assess the safety and performance of the SonoClear® System. Performance will be assessed by analysis of the contrast-to-noise ratio (CNR) and assessment of image quality by using…
- Conditions
- Brain Tumor Adult, Low Grade Glioma (LGG), High Grade Glioma (HGG), Glioblastoma
- Trial name
- NCT07042620
- Testing
- SonoClear(R) System
- Where
- 4 sites in Germany
- Volunteers
- 15 people
- Sponsor
- SonoClear AS
Hyperlipidemias
Effect of Different Probiotic Strains in Hypercholesterolemic Patients
Regular probiotic use for 8 weeks was evaluated in individual with mild to moderate hyperlipidemia. Current study have been determined the use of different probiotics strains on lipid parameters such as; total cholesterol, HDL…
- Trial name
- NCT04701775
- Testing
- Only Lactobacillus rhamnosus GG strains, Combined Lactobacillus acidophilus and Bifidobacterium animalis subsp.lactis strains
- Where
- Cyprus
- Volunteers
- 51 people
- Sponsor
- Eastern Mediterranean University
Healthy
Probiotics to Enhance Immunogenicity of Influenza Vaccine in Healthy Adults
The purpose of this study is to determine whether the food supplement called Lactobacillus rhamnosus GG (LGG) may help boost the effectiveness of the nasal flu vaccine.
- Trial name
- NCT00620412
- Testing
- Lactobacillus rhamnosus, Influenza Virus Vaccine Live, Intranasal
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Cancer
Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare Cancers
This was a Phase II, open-label, non-randomized, multi-center study of oral dabrafenib in combination with oral trametinib in subjects with rare cancers harboring the BRAF V600E mutation including anaplastic thyroid cancer (ATC)…
- Trial name
- NCT02034110
- Testing
- Dabrafenib, Trametinib
- Where
- 41 sites in United States, Austria and 12 more
- Volunteers
- 206 people
- Sponsor
- Novartis Pharmaceuticals
Clostridium Difficile Infection
CDI Synbiotic Study
The investigators hypothesize that treatment with a synbiotic mixture consisting of inulin Lactobacillus rhamnosus (LGG®), Lactobacillus acidophilus (LA-5®), Lactobacillus paracasei (L.
- Trial name
- NCT04012788
- Testing
- Synbiotic mixture
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Hvidovre University Hospital
Functional Abdominal Pain
Efficacy of Lactobacillus GG (LGG) in Children With Abdominal Pain
Probiotics play an important role in preventing overgrowth of potentially pathogenic bacteria and maintaining the integrity of the gut mucosal barrier.
- Trial name
- LGGDAR (NCT00876291)
- Testing
- Lactobacillus GG (probiotic )
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- University of Bari
Gastroesophageal Reflux Disease, Gastrointestinal Infections
LGG for Prevention of Infectious Complications During PPI Treatment in Children
Background: Proton pump inhibitors (PPI) are effective for treating gastroesophageal reflux disease (GERD). However, they may be associated with an increased risk of gastrointestinal and respiratory tract infections.
- Conditions
- Gastroesophageal Reflux Disease, Gastrointestinal Infections, Respiratory Tract Infections
- Trial name
- NCT01782118
- Testing
- Lactobacillus GG
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Warsaw