Clinical trials: LPS
Critically Ill
Link Between Plasma Citrulline and Lipopolysaccharide Concentrations in the Critically Ill
In critically ill patients, the small bowel permeability is increased, leading to bacterial translocation, and systemic inflammatory response syndrome. Plasma citrulline is a validated biomarker of functional enterocyte mass.
- Trial name
- CITRANS (NCT02902276)
- Testing
- additional blood sample
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Alcohol Consumption, Inflammation
Effect of Alcohol Consumption on Markers of Inflammation
Rationale: High-density lipoprotein (HDL), which is consistently increased after moderate alcohol consumption, is an abundant plasma lipoprotein that is generally thought to be anti-inflammatory in both health and infectious…
- Trial name
- AR23 (NCT00918918)
- Testing
- Alcohol + orange juice, Orange juice
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TNO
Solid Tumor
Safety and Preliminary Efficacy of SA53-OS in Patients With Locally Advanced or Metastatic Solid Tumors
The objective of this study is to assess the safety, efficacy, and pharmacokinetics of SA53-OS in adult participants with refractory solid tumors.
- Trial name
- NCT06578624
- Testing
- SA53-OS (phase 1), SA53-OS (phase 2)
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- Lamassu Bio Inc
Dental Caries
Randomized Clinical Trial of Occlusal Sealant
This study assessed long-term impact of tooth Eruption Stages (ES) on sealant retention on occlusal surfaces previously coated with intermediary bonding layer and it determined caries incidence outcome evolved.
- Trial name
- NCT02589743
- Testing
- Sealant, Adhesive and Sealant
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Healthy
Microdose and First-In-Human (FIH) Study of Recombinant Human Placental Alkaline Phosphatase (hRESCAP)
In the present study human recombinant placental alkaline phosphatase (hRESCAP) will be investigated. Alkaline Phosphatase is naturally present in the body and reported to use lipopolysaccharde (LPS, bacterial endotoxins) and…
- Trial name
- NCT01889147
- Testing
- hRESCAP
- Where
- Netherlands
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- TNO
Pregnancy Related, Infertility, Female
Comparison of Live Birth Rate in Natural Cycle Single Euploid FET Versus Without Luteal Phase Support
To evaluate whether single euploid embryo transfer in NC without routinely administered LPS is non-inferior to NC with routinely administered LPS.
- Trial name
- NCT05969795
- Testing
- Transvaginal ultrasound, Serial serum LH, E2, P4, Progesterone 100 Mg Vaginal Insert
- Where
- 3 sites in United Arab Emirates
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Major Depressive Disorder
Lipopolysaccharide (LPS) Challenge in Depression
LPS Challenge in Individuals with Major Depressive Disorder
- Trial name
- NCT03142919
- Testing
- Lipopolysaccharide
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Sepsis, Inflammation
Possible Links Between Inflammation and Lipid Metabolism
It has been recognized lately that sepsis and inflammation has an important impact on lipid metabolism and that the extent of hypocholesterolemia may even be a marker of severity of illness.
- Conditions
- Sepsis, Inflammation, LPS, Lipid Metabolism Disorder
- Trial name
- NCT03392701
- Testing
- LPS infusion
- Where
- Austria
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Barmherzige Brüder Linz
Osteoarthritis Arthritis, Joint Diseases
Persona Versus NexGen
The NexGen TKR (Zimmer, Warsaw, Indiana, USA) is a proven TKR design that has reported excellent medium and long-term results in clinical studies and in implant registries all around the world.
- Conditions
- Osteoarthritis Arthritis, Joint Diseases, Musculoskeletal Diseases, Rheumatic Diseases
- Trial name
- NCT02269254
- Testing
- Persona PS Knee Prosthesis by Zimmer, NexGen PS Knee Prosthesis by Zimmer
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Leiden University Medical Center
HIV
Vaccination of HIV-1 Infected Patients With Dendritic Cells in Addition to Antiretroviral Treatment - (DALIA Trial)
The purpose of this study is to determine whether the administration of a dendritic cell vaccine is a safe and effective treatment for HIV-1 patients.
- Trial name
- NCT00796770
- Testing
- Dendritic Cell Vaccine
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor Research Institute
Sepsis, Septic Shock
Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Sepsis
One of the major health problems in the world is sepsis, the number of cases of which, according to WHO, annually reaches 20-30 million.
- Trial name
- LASSONEO (NCT05707494)
- Testing
- Efferon LPS NEO
- Where
- 7 sites in Russia
- Volunteers
- 78 people
- Sponsor
- Efferon JSC
Autistic Disorder, Dental Caries
Effectiveness of Sealants and Fluoride Varnish in Caries Prevention in Children With Autism Spectrum Disorders
The aim of the study is to compare application of sealants together with fluoride varnishes versus only fluoride varnishes in preventing caries lesions development in the occlusal surface of first permanent molars of children…
- Conditions
- Autistic Disorder, Dental Caries, Pit and Fissure Caries
- Trial name
- NCT05146479
- Testing
- Fluoride varnish and pit and fissure sealants onto first permanent molars
- Where
- Italy
- Volunteers
- 232 people
- Sponsor
- University of Milan
Burns
Lipopolysaccharide Adsorption (Efferon LPS) in Patients With Thermal Burns
This observational pilot study aims to establish criteria for evaluating the effectiveness of hemoadsorption with the Efferon LPS device in adult patients with burn injury.
- Trial name
- NCT07259668
- Testing
- Efferon LPS
- Where
- Russia
- Sponsor
- Efferon JSC
Pulmonary Disease, Chronic Obstructive
Neutrophil Imaging in Healthy Subjects Following Lipopolysaccharide or Saline Challenge and in Subjects With Chronic Obstructive Pulmonary Disease
This is an exploratory study to further develop an imaging platform for the assessment of whole lung neutrophil retention. The primary objective of the study is to quantify and compare neutrophil retention in the lungs of…
- Trial name
- NCT02551614
- Testing
- Lipopolysaccharide challenge, Saline challenge, Labelled neutrophils and Imaging assessment
- Where
- 2 sites in United Kingdom
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Compromised Health, Healthy
Ex Vivo LPS Stimulation in Healthy and Compromised Subjects
Ex vivo LPS stimulation of whole blood will be a good alternative challenge to induce an inflammatory response and examine differences in the inflammatory response between healthy and compromised subjects.
- Trial name
- NCT01656915
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- TNO
Healthy
PH-797804 LPS Study in Healthy Volunteers
The study was performed to assess the effect of PH-797804 on neutrophils (white cells) in the sputum after a challenge with an endotoxin (inhaled LPS).
- Trial name
- NCT02084485
- Testing
- PH-797804
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Pit and Fissure Caries (Disorder), Pit and Fissure Sealants
Evaluation of the Clinical Success of Hydrophilic Fissure Sealants
The study group will consist of children aged 7-11 years who are systemically healthy and who apply to the Pediatric Dentistry Clinic of the Faculty of Dentistry, Afyonkarahisar Health Sciences University for routine dental…
- Trial name
- NCT07262502
- Testing
- pit and fissure sealant
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Hepatitis, Alcoholic
Safety and Efficacy of IMM 124-E for Patients With Severe Alcoholic Hepatitis
Hypothesis: Oral administration of hyperimmune bovine colostrum enriched with anti-LPS antibodies will reduce endotoxemia, and improve pathophysiological and clinical parameters related to severe alcoholic hepatitis (SAH).
- Trial name
- TREAT (NCT01968382)
- Testing
- IMM 124-E (Hyperimmune Bovine Colostrum)
- Where
- 3 sites in United States
- Volunteers
- 57 people
- Sponsor
- Virginia Commonwealth University
Chronic Obstructive Pulmonary Disease
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Repeat Doses of CHF6297 in Healthy Subjects and Patients With COPD
CHF6297 is a potent and selective inhibitor of human MAP kinase p38 being developed as an anti-inflammatory agent for the treatment of inflammatory airways diseases.
- Trial name
- CHF6297 FIH (NCT02815488)
- Testing
- CHF6297 (Part 1 - SAD), CHF6297 (Part 2 - MAD), CHF6297 (Part 3)
- Where
- 2 sites in United Kingdom
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Healthy
Nasal LPS Challenge in Healthy Volunteers
The purpose of this study is to develop a nasal challenge model that causes a mild degree of inflammation, without causing any pain or symptoms, but that allows us to measure a variety of proteins in nasal secretions which causes…
- Trial name
- NCT02284074
- Testing
- Nasal LPS spray, Experimental: Nasal LPS spray 1µg, Experimental: Nasal LPS spray 10 µg
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Imperial College London