Clinical trials: LPS
Arthritis, Rheumatoid
Lipopolysaccharide (LPS) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Challenge Study on Healthy Subjects
This exploratory study aims to assess exposure of healthy subjects to systemic challenge with either LPS or GM-CSF. This will be done by measuring inflammatory mediators and cellular activation markers both in circulation and in…
- Trial name
- NCT03306589
- Testing
- Cantharidin, Lipopolysaccharide, Granulocyte-Macrophage Colony-Stimulating Factor
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Alcohol Use Disorder, Inflammatory Response
Endotoxin Exposure to Examine the Role of Inflammation in Alcohol Use
The study design consists of a randomized, double-blind, placebo-controlled study of low dose endotoxin. Individuals with current AUD (n=32) and matched controls without AUD (n=32) will be randomly assigned to receive a single…
- Conditions
- Alcohol Use Disorder, Inflammatory Response, Craving
- Trial name
- NCT07452146
- Testing
- Endotoxin
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Resin Infiltration, Pit and Fissure Sealant
Resin Infiltrate as Pit and Fissure Sealant in Permanent Molars
The aim of this study is to evaluate and compare the clinical effectiveness of ICON resin Infiltration versus conventional sealant and the microleakage and penetration depth of the two sealant materials.
- Conditions
- Resin Infiltration, Pit and Fissure Sealant, Permanent Molars
- Trial name
- NCT06729788
- Testing
- ICON resin infiltration Material group in vivo, Resin-based fissure sealant group in vivo, ICON resin infiltration in vitro
- Where
- Egypt
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Tanta University
Abdominal Cancer, Malignancy
Feasibility Study of Intra-Tumoral Lipopolysaccharide Immunotherapy for Intra-Abdominal Tumors
The purpose of this research study is to determine whether a sterile bacteria wall chemical, called lipopolysaccharide (LPS), can be injected safely into abdominal tumors during routine laparoscopic surgery performed as a…
- Trial name
- LPS (NCT05751837)
- Testing
- Lipopolysaccharide
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Patrick Wagner, MD, FACS
Endotoxemia
The Role of Dietary Fat on Postprandial Endotoxemia in Healthy Adults
The purpose of this study was to determine the effect of different dietary fats (saturated or unsaturated) on postprandial endotoxemia and systemic low grade acute inflammation.
- Trial name
- NCT02521779
- Testing
- Low-fat Treatment Meal, Saturated-fat Treatment Meal, N-3 fat Treatment Meal
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Iowa State University
Total Knee Arthroplasty
NexGen Gender Fixed Bearing Knee Versus NexGen Legacy Knee Posterior Stabilized (LPS) - Flex Fixed Bearing Knee: A Study Comparing Two Different Knee Prostheses
The purpose of this trial is to study potential differences between two prostheses, including: "feel of prosthesis" (i.e., how natural does the prosthesis feel), range of motion (ROM), pain perception for each prosthesis…
- Trial name
- NCT00901329
- Testing
- NexGen Gender Fixed Bearing Knee prosthesis, NexGen LPS-Flex Fixed Bearing Knee prosthesis
- Where
- 2 sites in Denmark
- Volunteers
- 24 people
- Sponsor
- Hvidovre University Hospital
Pulmonary Hypertension
LenusPro Safety (LPS) Study in Patients With PH
The clinical study aims to investigate the numbers of predefined complications in the first six month after implantation of the implantable LENUS Pro® medications pump for intravenous application of treprostinil sodium in…
- Trial name
- NCT01979822
- Testing
- PH patients with LenusPro pump
- Where
- 4 sites in Austria, Germany and 1 more
- Volunteers
- 30 people
- Sponsor
- University Medicine Greifswald
Inflammation Biomarkers, Inflammation
Individual Differences in Acute Response to Experimental Inflammation: Microcirculatory Changes and Psychological Predictors
The physiological and behavioral responses to inflammatory vary greatly between individuals. The knowlegde about what causes these differences is sparse but plausible explanations are variations in sensitivity to peripheral…
- Trial name
- NCT06618716
- Testing
- endotoxin escherichia coli (E. coli) lipopolysaccharide (LPS), Placcebo
- Where
- Sweden
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Prematurity, Histologic Chorioamnionitis
Infant Immune Response to Bacterial Infection
This study will examine the response of white blood cells to bacterial infection in blood taken from the umbilical cords of newly delivered infants.
- Trial name
- NCT00546195
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Retina, Regional Blood Flow
Effect of Antioxidants on Ocular Blood Flow, Endothelial Function, and Cytokine Levels in LPS Induced Inflammatory Model in Humans.
Oxidative stress, which refers to cellular damage caused by reactive oxygen intermediates, has been implicated in many disease processes, especially age-related disorders.
- Conditions
- Retina, Regional Blood Flow, Endotoxin, Escherichia Coli
- Trial name
- NCT00431691
- Testing
- vitamin and mineral supplement, Escherichia coli Endotoxin (LPS), 100% O2
- Where
- Austria
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Inflammation, Glucose Metabolism Disorders
Endotoxin & Cytokines. Do Protein Loss and Metabolic Effects Depend on Central Nervous System (CNS) Activation of Stress Hormones or on Local Mechanisms in Muscle and Fat?
Main objective : The purpose of this study is to prove that the effects of bacterial endotoxin and cytokine TNF-α, on protein loss, fatty acid release, and glucose metabolism depend on two mechanisms: 1.
- Trial name
- NCT01452958
- Testing
- TNF-alpha, Endotoxin
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
GnRHa;LPS
Gonadotrophin Releasing Hormone Agonist Addition for Luteal Support in In-vitro Fertilization and Embryo Transfer Cycles
The study was designed to investigate the effect of luteal-phase administration of gonadotrophin releasing hormone agonist(GnRHa) on pregnancy outcomes in in-vitro fertilization-embryo transfer.
- Trial name
- NCT02908438
- Testing
- Gonadotrophin releasing hormone agonist(GnRHa)
- Volunteers
- 400 people
- Sponsor
- Northwest Women's and Children's Hospital, Xi'an, Shaanxi
Acute Inflammatory Response to Non-antigenic Stimulus
Phase 1a Study in Healthy Smokers to Investigate the Effect With MMI-0100 on Airway Inflammation in Induced Sputum After Challenge With Inhaled Lipopolysaccharide
A Phase 1a, randomized, placebo controlled, two-way crossover study is to determine the effect of inhaled MMI-0100 compared to placebo following LPS challenge on inflammatory markers.
- Trial name
- LPS (NCT02515396)
- Testing
- MMI-0100
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Moerae Matrix, Inc.
Septic Shock
Lipopolysaccharide Adsorption At Septic Shock
Sepsis is a global healthcare burden sepsis, it reaches 20-30 million cases annually (WHO data). Numerous studies have shown that extracorporeal hemoperfusion therapies that eliminate endotoxin and\or excess of cytokines improve…
- Trial name
- LASSO (NCT04827407)
- Testing
- Efferon LPS hemoperfusion
- Where
- 4 sites in Russia
- Volunteers
- 58 people
- Sponsor
- Efferon JSC
Systemic Inflammatory Response Syndrome
Serum Level of Lipopolysaccharide-binding Protein (LBP) and Atherosclerosis in Hemodialysis Patients
Background In hemodialysis (HD) patients, impaired gut barrier and alteration in microbiota in the gut is thought to increase the risk of bacterial translocation and chronic inflammation.
- Trial name
- NCT03427307
- Where
- Taiwan
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Fatty Liver, Steatohepatitis
Efficacy of Rifaximin on Hepatosteatosis and Steatohepatitis Patients
Non alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease, it encompasses from simple steatosis to non alcoholic steatohepatitis (NASH) and, eventually leads to cirrhosis and hepatocellular carcinoma…
- Trial name
- NCT02009592
- Testing
- Rifaximin
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Bezmialem Vakif University
Hypersensitive, Molar Incisor Hypomineralization
Effect of Glass-Ionomer Sealing Technique on Hypersensitive Teeth With Molar Incisor Hypomineralisation
This single armed cohort study is aimed to assess the acceptance, durability and efficiency of glass-Ionomer sealing technique on hypersensitive MIH molars (TNI-3 \& 4a/b/c) clinically shortly (15 minutes) after the application…
- Conditions
- Hypersensitive, Molar Incisor Hypomineralization, Pit and Fissure Sealants
- Trial name
- MIH_GIC (NCT05945381)
- Testing
- GIC on MIH
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Burns
Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Thermal Burns
This observational pilot study aims to identify criteria for evaluating the effectiveness of hemoadsorption with the Efferon LPS NEO device in pediatric burn injury.
- Trial name
- NCT07248930
- Testing
- Efferon LPS NEO
- Where
- 2 sites in Russia
- Sponsor
- Efferon JSC
Pancreatitis, Acute
Efferon LPS Hemoadsorption in Patients With Acute Pancreatitis
The goal of the study is to evaluate the safety and efficacy of multimodal (cytokine and lipopolysaccharide) hemoperfusion using the Efferon® LPS device in combination with hemofiltration (HF) / hemodiafiltration (HDF), with the…
- Trial name
- NCT07267169
- Testing
- Efferon LPS
- Where
- 8 sites in Russia
- Volunteers
- 150 people
- Sponsor
- Efferon JSC
Healthy
Effect of Antioxidants on Oxygen Induced Vasoconstriction in Lipopolysaccharide (LPS) Induced Inflammatory Model in Humans
Oxidative stress has been implicated in playing a pathogenic role in many disease processes, especially in age-related disorders.
- Trial name
- NCT00914576
- Testing
- Vitamin and mineral supplement, 100% Oxygen, Escherichia coli Endotoxin
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna