Clinical trials: Labor, Obstetric
Respiratory Distress Syndrome, Prematurity
The Effect of Surfactant Administration on Cerebral Oxygenation
The purpose of this study is to assess changes in cerebral oxygenation during two different types (beractant and poractant) and two different routes (double lumen or single lumen endotracheal tube) of surfactant administration…
- Trial name
- NCT01258517
- Testing
- near infrared spectroscopy (INVOS 5100)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Placenta Previa, Placenta Accreta Spectrum
Syncytiotrophoblast-derived Extracellular Vesicles in Placenta Previa and Accreta Spectrum
The main goal of this case-control study is to quantify the levels of circulating syncytiotrophoblast-derived extracellular vesicles (STBEVs) in maternal blood in a population of women with placenta previa and placenta accreta…
- Trial name
- PAS (NCT06867874)
- Testing
- Blood sample
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Preterm Birth, Short Cervix
Cervical Pessary vs Vaginal Progesterone in Preventing Preterm Birth Among Women Presenting With Short Cervix: An Open-label Randomized Controlled Trial
The purpose of this randomized control trial is to determine whether cervical pessary plus vaginal progesterone is superior to vaginal progesterone alone in decreasing preterm delivery rate, and improving perinatal outcome, among…
- Trial name
- NCT02470676
- Testing
- Pessary, Progesterone
- Volunteers
- 430 people
- Sponsor
- Hillel Yaffe Medical Center
Preterm Delivery, Cervical Length
RCT of Progesterone to Prevent Preterm Birth in Nulliparous Women With a Short Cervix
The purpose of this study is to see if giving progesterone medication to pregnant women, who have never delivered a baby after 19 weeks of pregnancy and who have a short cervix, lowers the risk of early delivery and improves the…
- Trial name
- SCAN (NCT00439374)
- Testing
- 17 alpha-hydroxyprogesterone caproate
- Where
- 14 sites in United States
- Volunteers
- 657 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Periodontitis, Premature Birth of Newborn
Feasibility and Acceptability of Use of Daily Oral Rinse in Pregnant Women in Rural Nepal
In Nepal, investigators are conducting a cohort study to estimate the relationship between signs of periodontal disease in pregnant women and preterm delivery.
- Trial name
- NCT02788786
- Testing
- Chlorhexidine, Cetylpyridinium chloride, Salt and Water
- Where
- Nepal
- Volunteers
- 175 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Body Weight Changes, Feeding and Eating Disorders of Childhood
Adjusted Individual Oral Feeding for Improving Short and Long Term Outcomes of Preterm Infants
The authors hypothesize that adjusted individual feeding (AIF) for preterm infant starting from transition to oral feeding (33 weeks corrected age) will result in less episodes of apnea/bradycardia, early achievement of full oral…
- Conditions
- Body Weight Changes, Feeding and Eating Disorders of Childhood, Breast Feeding, Evoked Response Audiometry
- Trial name
- NCT01989871
- Testing
- Adjusted individual feeding
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Placenta Accreta, Placenta Previa
Ultrasound in Prediction of Operative Findings in Cesarean Section Among Placenta Accreta Cases
A total of 60 women pregnant more than 28 weeks gestation will be recruited from obstetric outpatient clinic (faculty of medicine -Cairo University Hospital) after being diagnosed of having placenta previa or low lying placenta…
- Trial name
- NCT03286998
- Where
- 2 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
PROM, Preterm (Pregnancy)
Outcome of Conservative Management in Cases of Pre Mature Rupture of Membranes (PROM) Between 20 and 28 Weeks of Pregnancy in Sohag City Hospitals
Prospective observational study
- Trial name
- NCT06271863
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Obstetric Labor Complications
Comparison of Incision Angle of Mediolateral Episiotomy at 40 and 60 Degrees
The angle at which an episiotomy can be made is a continuous variable. If the investigators consider midline to be 0 degrees and a lateral episiotomy (never used today) to be 90 degrees, then it is theoretically possible to…
- Trial name
- IAME (NCT01930721)
- Testing
- episiotomy
- Where
- Egypt
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Infant, Premature, Leukomalacia, Periventricular
Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants
Periventricular leukomalacia (PVL) is one of the most common brain injuries that occur in preterm infants. Inflammation, hypoxia-ischemia, free oxygen radical formation and excitotoxicity are all known pathogenic mechanisms that…
- Conditions
- Infant, Premature, Leukomalacia, Periventricular, Intraventricular Hemorrhage, Retinopathy of Prematurity
- Trial name
- NCT00910234
- Testing
- recombinant human erythropoietin (rhEpo), Normal saline
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- China Medical University Hospital
Preterm Delivery
Biomechanics Based Prediction of Preterm Delivery
Quantitative information on the biomechanical properties of the ecto-cervix in mid-pregnancy will be compared between women with term vs. preterm delivery.
- Trial name
- Softcervix (NCT02037334)
- Testing
- Pregnolia System
- Where
- 13 sites in Belgium, Switzerland
- Volunteers
- 1,002 people, healthy volunteers welcome
- Sponsor
- David Scheiner
Preterm Infant, Delivery Room
Feasibility and Reliability of Synchronized Non-invasive Intermittent Positive Pressure Ventilation in Preterm Infants After Birth
The aim of this prospective observational study (pilot study) is to test if synchronized noninvasive positive pressure ventilation (S-NIPPV) is feasible and works appropriately during transition from intrauterine to extrauterine…
- Conditions
- Preterm Infant, Delivery Room, Respiratory Support, Synchronized Noninvasive Positive Pressure Ventilation (SNIPPV)
- Trial name
- SenSyNoPP (NCT05399914)
- Testing
- S-NIPPV
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University Hospital Tuebingen
Preterm Birth, Parent-Child Relations
Biological Underpinnings of Socio-emotional Regulation in Preterm Infants and Healthy Controls
Preterm infants (PT) often need to spend their first weeks of life in the Neonatal Intensive Care Unit (NICU) where they are exposed to several adverse conditions.
- Conditions
- Preterm Birth, Parent-Child Relations, Epigenetics
- Trial name
- NCT05253924
- Testing
- DNA methylation of target genes, EEG acquisition
- Where
- Italy
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Preeclampsia, Labor, Premature
Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia
A randomized controlled trial (RCT) of nitric-oxide donor (NOD) isosorbide mononitrate (IMN) versus placebo as an adjuvant to misoprostol/ intra-cervical Foley bulb for induction of labor to decrease rate of cesarean deliveries…
- Trial name
- NOPE (NCT03171480)
- Testing
- Monoket Pill
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Ohio State University
Premature Birth
Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)
Available data suggest that low dose aspirin may be a safe, widely available and inexpensive intervention that may significantly reduce the risk of preterm birth.
- Trial name
- ASPIRIN (NCT02409680)
- Testing
- Low dose aspirin
- Where
- 14 sites in United States, Democratic Republic of the Congo and 5 more
- Volunteers
- 11,976 people
- Sponsor
- NICHD Global Network for Women's and Children's Health
Premature, Respiratory Distress Syndrome in Premature Infant
Novel Low Cost Bubble CPAP as an Alternative Respiratory Support in Low Resource Setting
This is a single-blind randomized controlled trial done in a Level III neonatal intensive care unit. Preterm newborns with RDS were randomized to receive oxygen therapy through bubble CPAP vs ventilator-derived CPAP.
- Trial name
- NCT06082674
- Testing
- Vayu bCPAP, Mechanical Ventilator Driven CPAP
- Where
- Philippines
- Volunteers
- 70 people
- Sponsor
- Ilocos Training and Regional Medical Center
Preterm Infant
Executive Functions and Preterm Children in 3 to 4 Year Old
Preterm children have a high risk for neurodevelopmental impairments. The impact on motor functions and neurosensory functions is demonstrated but the incidenceof executive functions is not described for preterm infants.
- Trial name
- NCT03700463
- Testing
- BRIEF parental survey
- Where
- France
- Volunteers
- 356 people
- Sponsor
- Nantes University Hospital
Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn
Amniotic Fluid & the Preterm Gut
Background: Necrotizing enterocolitis (NEC) and sepsis in preterm infants have been linked to intestinal immaturity and preclinical gut microbiota alterations.
- Conditions
- Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn, Necrotizing Enterocolitis of Newborn, Neonatal Sepsis, Early-Onset
- Trial name
- AMFIBIE (NCT07152106)
- Where
- 2 sites in Netherlands
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center
Preterm Birth
Prevention of Preterm Birth Using Cervical Pessary in Pregnant Women After Threatened Preterm Labor(PECEP-RETARD)
Placement of a vaginal pessary reduces significantly the rate of spontaneous preterm birth in pregnant women with short cervical length after an episode of threatened preterm labour.
- Trial name
- PECEP-RETARD (NCT01242384)
- Testing
- Device: Silicon ring (Arabin Pessary)
- Where
- Spain
- Volunteers
- 500 people
- Sponsor
- Maternal-Infantil Vall d´Hebron Hospital
Mother-Child Relations, Preterm Birth
The 2015 Pelotas (Brazil) Birth Cohort Study
This is the fourth birth cohort to be carried out in the city of Pelotas (Brazil) including more than 4 thousand children followed-up since the pre-natal period to study maternal-child health.
- Conditions
- Mother-Child Relations, Preterm Birth, Infant Development, Breast Feeding
- Trial name
- NCT03271723
- Testing
- Observational study
- Where
- Brazil
- Volunteers
- 4,275 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.