Clinical trials: Labor, Obstetric
Preterm Infant, Premature Birth
The Effect of Tub vs Sponge Bathing on the Comfort of Premature Infants
The integumentary system protects the underlying body from the external environment, such as shocks, temperature, ultraviolet radiation, chemicals, and other threats.
- Trial name
- ComfortNEO (NCT03796312)
- Testing
- Tub Bathing, Sponge Bathing
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Akdeniz University
Breech Fetal Presentation
Comparison of Pelvimetric Measurements Between MRI and Low-dose Stereoradiography (EOS® Imaging System)
The main objective of this study is to compare pelvimetric measurements performed by Magnetic Resonance Imaging (MRI) and by the EOS imaging system.
- Trial name
- CAPEOS® (NCT04849975)
- Testing
- Pelvimetric measurements
- Where
- France
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Preterm Birth, Pregnancy
Clinical, Biochemical, Histological and Biophysical Parameters in the Prediction of Cerebral Palsy in Patients With Preterm Labor and Premature Rupture of Membranes
A major goal of modern perinatal and neonatal medicine is to reduce the rate of developmental disabilities, especially mental retardation.
- Trial name
- NCT00342667
- Where
- 5 sites in United States, Chile and 2 more
- Volunteers
- 4,673 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Premature Infant
Erythropoietin Protects Very Preterm Infants Against Necrotizing Enterocolitis
This study evaluates the effect of repeated low-dose erythropoietin (EPO) treatment on necrotizing enterocolitis (NEC) in very preterm infants. Half of participants will receive EPO, while the other half will receive a placebo.
- Trial name
- NCT03919500
- Testing
- EPO, Normal saline
- Where
- China
- Volunteers
- 1,285 people
- Sponsor
- Zhengzhou University
Infant, Premature
Influence of Intestinal Microbiota Implantation in Preterm Infants on Microbiota and Immune Orientation at 3 Years
The main objective of this research is to study the links between changes in the intestinal microbiota (in terms of diversity) during the first 6 weeks of life for preterm infants and the presence / absence of a TH1 immune status…
- Trial name
- PrimiBiota (NCT02738411)
- Where
- 3 sites in France
- Volunteers
- 130 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pregnancy, Prolonged, Pre Eclampsia
Foley Catheter Versus Vaginal Misoprostol for Cervical Ripening and Induction of Labor
PURPOSE: The purpose of this study is to determine the effectiveness of balloon dilatation (Foley) with vaginal misoprostol for cervical ripening and induction of labor.
- Conditions
- Pregnancy, Prolonged, Pre Eclampsia, Oligohydramnios
- Trial name
- NCT01140971
- Testing
- Misoprostol, Foley
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- Municipal Hospital Vila Nova Cachoeirinha
Postpartum Hemorrhage
Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human Myometrium
This study will investigate the effects of drugs called "uterotonics" that help with the contraction of the uterus after a baby is born. This uterine contraction is very important to stop the bleeding after delivery.
- Trial name
- NCT06285409
- Testing
- Carbetocin, Oxytocin, Ergonovine
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
HIV Infections
Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV Transmission
The purpose of this study is to see if antibiotic drugs given to treat an infection of the uterus during pregnancy can reduce the chances of HIV being passed from an HIV-positive mother to her baby.
- Trial name
- NCT00021671
- Testing
- Erythromycin, Nevirapine, Ampicillin sodium
- Where
- United States
- Volunteers
- 3,720 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Microbial Colonization, Preterm Birth
Matching Donor Human Milk On Maternal Secretor Status (MMOMSS) Study
This study will evaluate the impact of matching donor human milk to the maternal secretor status of very preterm infants (<34 weeks gestation) on the gut microbiome.
- Trial name
- MMOMSS (NCT04130165)
- Testing
- Matched donor human milk
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- University of Manitoba
Infant, Premature, Ductus Arteriosus, Patent
Plasma B-Type Natriuretic Peptide Concentrations in Preterm Infants < 28 Weeks
The aim of the study was to evaluate BNP in preterm infants < 28 weeks on the second day of life, when it is still unknown, if a patent ductus arteriosus is hemodynamic significant or not.
- Conditions
- Infant, Premature, Ductus Arteriosus, Patent, Natriuretic Peptide Brain
- Trial name
- NCT00528736
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- Charite University, Berlin, Germany
Pain, Stress, Physiological
The Effect of a Musical Intervention on Stress Response to Venepuncture
Randomised Crossover Trial in Preterm Infants less than 32 weeks to assess Music therapy and sucrose versus sucrose on stress
- Trial name
- NCT03028844
- Testing
- Music therapy
- Where
- Ireland
- Volunteers
- 20 people
- Sponsor
- University College Cork
Prematurity, Framing
Framing and Decision Making in Neonatology
The purpose of this study is to study how people make decisions regarding delivery room management for infants born extremely premature when survival and long term outcomes are uncertain.
- Conditions
- Prematurity, Framing, Perinatal Decision Making
- Trial name
- NCT01421238
- Testing
- Survey
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Columbia University
Infant, Very Low Birth Weight, Growth Failure
Preterm Infants on Early Solid Foods
Introduction: Preterm infants with a birth weight less than 1500 grams have special nutritional needs in comparison to full-term neonates.
- Trial name
- PIES-Project (NCT01809548)
- Testing
- Early intervention group, Late intervention group
- Where
- Austria
- Volunteers
- 177 people
- Sponsor
- Medical University of Vienna
Preterm Birth
Study of the Risk of PREMaturité According to the Balance of Bacterial Flora VAginale
Objective To compare vaginal microbiota in the first trimester of pregnancy between spontaneous preterm and term deliveries
- Trial name
- PREMEVA2 (NCT03618836)
- Testing
- Microbiological and biological patterns on vaginal samples
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Lille
Pregnancy, Fetal Presentation
Clinical Validation of an Artificial Intelligence System for De-termining Fetal Lie and Position in 3rd Trimester
This prospective clinical validation study aims to evaluate the diagnostic performance of an artificial intelligence (AI)-based navigational support system for determining fetal lie and presentation during third-trimester…
- Conditions
- Pregnancy, Fetal Presentation, Breech Fetal Presentation, Cephalic Fetal Presentation
- Trial name
- NCT07754071
- Where
- 3 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Necrotizing Enterocolitis
Pentoxifylline in the Treatment of NEC in Premature Neonates
Pentoxifylline improves microcirculation and decreases TNF alpha levels associated with sepsis, rendering it of potential therapeutic value in necrotizing enterocolitis in premature neonates.
- Trial name
- NCT00271336
- Testing
- Pentoxifylline
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Shaare Zedek Medical Center
Premature Birth
Cardiovascular Health Assessment of Preterm- and TERm-born Children
The purpose of the CHAPTER study is to help understand how complications during pregnancy, such as preterm birth, affect how childrens' hearts and blood vessels develop.
- Trial name
- CHAPTER (NCT05698836)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Oxford
Complications of Prematurity
Prematurity Related Risks of Cognitive Impairment at School Age
The main purpose of this study is to better evaluate prematurely born children cognitive development at school age, with regards to birth conditions but also to social situation, intra family relationships, and modalities of…
- Trial name
- NEORIS (NCT02054507)
- Testing
- Cognitive evaluation (Wechsler IV tests)
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jean Michel Hascoet
Placental Insufficiency, Preterm Infant
Impact of Umbilical Cord Milking in Preterm Neonates With Placental Insufficiency
To investigate the effect of umbilical cord milking (UCM) on peripheral hematologic parameters including hematopoietic progenitor cells in premature infants ≤ 34 weeks gestational age with placental insufficiency.
- Trial name
- NCT03731611
- Testing
- Umbilical Cord Milking
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University Children Hospital
Hypothyroxinemia
L-Thyroxine Supplementation for Preterm Newborns Less Than 32 Weeks of Gestation With Hypothyroxinemia
Transient hypothyroxinemia of prematurity (THOP) is associated with neurodevelopmental impairment in preterm newborns < 32 weeks of gestation (WG).
- Trial name
- NCT01306227
- Testing
- L-Thyroxine, water
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
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