Clinical trials: Labor, Premature
Retinal Anomalies, Premature Birth
CLAIR -FO: Clinical Trial of Ophthalmic Insert Mydriasert® Versus Reference Treatment
Pupillary dilation to perform a fundus in premature newborns and neonates is often difficult to obtain, because of the non mature iris sphincter.
- Trial name
- NCT00642135
- Testing
- Mydriasert®, phenylephrine and tropicamide eyedrops
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator Lung, Echocardiography
Integrated Echocardiography and Chest Ultrasound Assessment of Lung Recruitment in Preterm Infants
The primary aim of this work is to evaluate the role of high frequency oscillatory ventilation (HFOV) in recruitment of lung in preterm newborns 32 to 37 weeks gestational age with moderate to severe respiratory distress.
- Conditions
- Ventilator Lung, Echocardiography, Chest Ultrasound, High Frequency Ventilation
- Trial name
- NCT05726578
- Testing
- Lung recruitment
- Where
- 2 sites in Egypt
- Volunteers
- 72 people
- Sponsor
- Alexandria University
Bronchopulmonary Dysplasia, Premature Birth
Corticosteroid Use in Premature Babies and Lung Ultrasonografi Use in the Progression to Bronchopulmonary Dysplasia
Bronchopulmonary dysplasia (BPD) is one of the most common morbidities in premature infants and is associated with poor neurodevelopmental outcomes .
- Trial name
- NCT05621785
- Testing
- Lung Ultrasonografi
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kırıkkale University
Premature Birth, Preeclampsia
A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders
This study evaluates the effectiveness of maternal supplementation with Docosahexaenoic acid (DHA) early in pregnancy to reduce the incidence of deep placentation disorders: preterm birth, preterm labor, preterm premature rupture…
- Conditions
- Premature Birth, Preeclampsia, Fetal Growth Retardation, Stillbirth
- Trial name
- NCT02336243
- Testing
- Docosahexaenoic acid (DHA)
- Where
- 5 sites in Chile
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Hypotension
Treatment of Hypotension of Prematurity (TOHOP)
Hypotension in the very preterm infant (gestational age [GA] <32 wks) is a frequently occurring clinical problem. Although no real consensus has been reached on the definition of hypotension in these infants, in clinical practice…
- Trial name
- TOHOP (NCT01434251)
- Testing
- Anti-hypotensive treatment
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- UMC Utrecht
Respiratory Distress Syndrome, Newborn, Infant, Premature
Measuring Diaphragm Electrical Activity in Neonates Using a Smaller Inter-electrode Distance
Neurally Adjusted Ventilatory Assist (NAVA) is a mode of ventilation where the electrical activity of the diaphragm (EDI) - a signal representing the baby's respiratory drive - is used to control the timing and amount of assist…
- Trial name
- NCT05427929
- Testing
- NVR 4mm Edi catheter
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Mount Sinai Hospital, Canada
Respiratory Distress Syndrome, Intraventricular Hemorrhage
Antenatal Betamethasone Compared to Dexamethasone - "BETACODE TRIAL"
Antenatal corticosteroids result in substantial decrease in neonatal morbidity and mortality by specifically reducing the risk of respiratory distress syndrome, intraventricular hemorrhage and neonatal death among premature…
- Conditions
- Respiratory Distress Syndrome, Intraventricular Hemorrhage, Neonatal Mortality
- Trial name
- NCT00418353
- Testing
- Betamethasone(Celestone soluspan) and Dexamethasone
- Where
- United States
- Sponsor
- University of Oklahoma
Preterm Infant
Cardiorespiratory Effects of "Higher" Versus "Equivalent" CPAP Upon Extubation From High EAP in Preterm Infants
The aim of this study is to compare the cardiovascular and respiratory effects of "higher" versus "equivalent" CPAP pressures post-extubation from high endotracheal airway pressures (EAP), defined as at least 8 cm H2O (water), in…
- Trial name
- CO-PAP (NCT02528851)
- Testing
- Extubation from endotracheal mechanical ventilation to CPAP
- Volunteers
- 14 people
- Sponsor
- McMaster University
Preeclampsia
PI4 - A Trial Assessing Metformin to Prolong Gestation in Preterm Preeclampsia
Preterm preeclampsia is a severe condition for both the mother and the fetus. Currently, the only treatment available to stop disease progression is termination/delivery of the fetus and placenta.
- Trial name
- PI4 (NCT06033131)
- Testing
- Metformin ER
- Where
- 18 sites in Finland, Norway and 1 more
- Volunteers
- 294 people
- Sponsor
- Lina Bergman
Neonatal Sepsis
Role of Montelukast in Modulation of Response to Sepsis in Preterm Infants
The investigators will conduct this study to explore the role of Montelukast in treatment of neonatal sepsis and whether it has an effect on inflammatory markers, the duration of antibiotic use, or on the patients´ outcome.
- Trial name
- NCT04474327
- Testing
- Montelukast Sodium
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University Children Hospital
Premature, Thrombosis
Thrombophilic Risk Factors in Preterm and Infants Treated at Ha'Emek Medical Center Between the Years 1990 to 2010
There are several factor that can be related to Neonatal Thrombotic events. Among them hypercoagulability can be the cause of those events.
- Trial name
- NCT01443273
- Testing
- Medical Records study
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- HaEmek Medical Center, Israel
Anatomic Abnormality, Internal Jugular Vein
Ultrasound Measurement of RIJV in Patients Between 0-2 Years
After obtaining parental consent ultrasonographic evaluation of right internal jugular vein will be performed in pediatric patients undergoing elective surgeries between 0-2 years of age.
- Conditions
- Anatomic Abnormality, Internal Jugular Vein, Neonates, Infants, Premature
- Trial name
- NCT03604094
- Testing
- Ultrasonographic evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Preterm
Effect of Bathing on Pain, Sleep and Vital Signs of Premature Babies
This study was conducted as a randomized controlled experimental study to determine the effect of bathing given to premature babies on pain, sleep and vital signs.
- Trial name
- NCT05135429
- Testing
- Bathing
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Karamanoğlu Mehmetbey University
Acute Kidney Injury, Premature Infant
NIRS Monitoring to Detect AKI in Preterm Infants
This study will examine the relationship of oxygen levels, using Near-infrared spectroscopy (NIRS) monitoring, and kidney injury in infants born prematurely.
- Trial name
- nNIRS-AKI (NCT03384173)
- Testing
- Near Infrared Spectroscopy
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Wisconsin, Madison
Premature Infants
Effect of Erythropoietin on Neurodevelopmental Outcomes in Very Preterm Infants With Intraventricular Hemorrhage
Erythropoietin (EPO) has been shown to be neurotrophic and neuroprotective in several animal models and some clinical studies. Our hypothesis is that EPO could improve long-term neurological outcomes in very preterm infants with…
- Trial name
- NCT03914690
- Testing
- Erythropoietin, Normal saline
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Zhengzhou University
Preterm Birth, Tube Feeding
Maternal Role in Oral Feed Establishment in Preterm Neonates
Hypothesis Preterm babies who receive sensory motor stimulation from their mothers as compared to trained nurses will 1. Start taking oral feed at the same time as compared to control group 2.
- Conditions
- Preterm Birth, Tube Feeding, Swallowing Disorder, Maternal Care Patterns
- Trial name
- NCT05484726
- Testing
- perioral sensory motor stimulation
- Where
- Pakistan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Fatima Memorial Hospital
Low Birthweight, Preterm Birth
Enhancing Nutrition and Antenatal Infection Treatment for Maternal and Child Health in Ethiopia
The ENAT study will test the impact of packages of antenatal interventions to enhance maternal nutrition and manage pregnancy infections on the outcomes of infant birth size, gestational length, and infant growth in the first 6…
- Conditions
- Low Birthweight, Preterm Birth, Maternal; Malnutrition, Affecting Fetus, Sexually Transmitted Diseases
- Trial name
- ENAT (NCT04171388)
- Testing
- Azithromycin 500 mg, Multiple Micronutrient or Fortified Balanced Energy Protein Supplement, Enhanced Infection Management Package (EIMP)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Fatty Acid Metabolism
Activity of Essential Fatty Acid Elongation/Desaturation Pathway During Early Life in Human Infants, In Vivo
We will test the following hypotheses: 1. The activity of the desaturating/elongating enzymes assessed by the in vivo conversion of deuterated a-linolenic and linoleic acids to DHA and AA, respectively, will be related to the…
- Trial name
- NCT00342303
- Where
- 2 sites in Chile
- Volunteers
- 110 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Prematurity
Developmental Impact of NICU Exposures (DINE)
The DINE study will test the hypothesis that potentially avoidable NICU-based exposures contribute to the neuro-cognitive and somatic impairments prevalent among NICU graduates.
- Trial name
- DINE (NCT03061890)
- Where
- 11 sites in United States
- Volunteers
- 600 people
- Sponsor
- Albert Einstein College of Medicine
Breastfeeding, Quality of Life
The Effectiveness of Proactive Telephone Support Provided to Breastfeeding Mothers of Preterm Infants
Although breast milk has numerous benefits for infants' development, with heightened effects in those born preterm (at < 37 gestational weeks), mothers of preterm infants have shorter breastfeeding duration than mothers of term…
- Conditions
- Breastfeeding, Quality of Life, Parental Stress, Attachment
- Trial name
- NCT01806480
- Testing
- Person-centred proactive breastfeeding telephone support
- Where
- 6 sites in Sweden
- Volunteers
- 493 people, healthy volunteers welcome
- Sponsor
- Uppsala University