Clinical trials: Labor, Second Stage
Perineal Tear Resulting From Childbirth
Perineal Massage and Warm Compresses - RCT for Reduce Perineal Trauma During Labor
The aim of this study is to evaluate the effect of a combined perineal massage and warm compresses intervention on the perineum integrity during second stage of labor.
- Trial name
- PeMWaC (NCT05854888)
- Testing
- Perineal Massage and Warm Compresses (PeMWaC), Control Group (Hands-on)
- Where
- Portugal
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Labor Complication, Avulsion
The Association Between Kristeller Maneuver and Pelvic Floor Trauma After Vaginal Delivery
We want to investigate the association between fundal pressure in the second stage and the risk of levator ani muscle (LAM) injury.
- Trial name
- NCT03752879
- Testing
- Fundal Pressure
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Neovascular (Wet) Age-related Macular Degeneration
A Study to Learn How Well Aflibercept Injected Into the Eye Works and How Safe it is When Given in Customized Treatment Intervals in Patients With an Eye Disease Called Neovascular Age-related Macular Degeneration After Start of Treatment
Researchers are looking for a better way to treat people who have neovascular (wet) age-related macular degeneration (nAMD or wet AMD).
- Trial name
- XPAND (NCT05473715)
- Testing
- Aflibercept(BAY86-5321, Eylea)
- Where
- 3 sites in Canada, United Kingdom
- Volunteers
- 3 people
- Sponsor
- Bayer
Other
Effect of Peanut Balls Used of the Second Stage of Labor, Pushing Perceptions, Fatigue and Birth Outcomes
This study aims to explore the use of peanut balls during the second stage of labor. It compares three different positions: traditional lithotomy position, lateral position, and lateral position with peanut ball in terms of…
- Trial name
- NCT06312449
- Testing
- The side-lying position with the peanut ball during the second stage of labor., During the second stage, the patient is placed in a lateral position
- Where
- Taiwan
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Tung Yu-Ching
Pelvic Pain
Impact of Thermotherapy During Childbirth on Postpartum Perineal Pain (PERISAFE)
Perineal pain is common after vaginal birth. Thermotherapy might be effective to limit postpartum perineal pain, thanks to the effects of local heating or cooling application.
- Trial name
- PERISAFE (NCT04778631)
- Testing
- Heat therapy, Cryotherapy
- Where
- 2 sites in France
- Volunteers
- 115 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Management of the Second Stage of Labor in Obese Nulliparous Women by Either Passive Descent or Immediate Pushing.
Passive Descent in Obese Nulliparous Gravidae
Obesity rates in reproductive aged women in the United States are rising. It is now universally accepted that obesity is associated with many adverse pregnancy outcomes and post-operative complications following cesarean section.
- Trial name
- NCT02080429
- Testing
- Passive Descent, Pushing
- Where
- United States
- Volunteers
- 540 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Labor, First Stage, Labor, Second Stage
Effect of Dianatal Obstetric Gel (Cross-linked Polyacrylic Acid) on Outcomes in Vaginal Delivery
Perineal massage at the end of labor stage 2 has been investigated in 2 randomized controlled trials using a water soluble lubricant.
- Trial name
- NCT01546129
- Testing
- Dianatal Obstetric Gel (Cross-linked polyacrylic acid)
- Where
- Israel
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Persistent Occipital Posterior Presentation During Labor Delivery
Trial of Prophylactic Manual Rotation of Persistent Occiput Posterior Presentation During the Early Second Stage of Labor to Reduce Operative Delivery: a Prospective Multicenter Randomized Control Trial
Superiority multicenter prospective randomized study on operative delivery (instrumental delivery or caesarean section) of prophylactic manual rotation in case of persistent occipital posterior presentation during the second…
- Trial name
- PROPOP (NCT02695238)
- Testing
- Prophylactic Manual Rotation of persistent occipital posterior presentation
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Active Second Stage
Alternative to Intensive Management of the Active Phase of the Second Stage of Labor
Active phase of the second stage of labor corresponds to period of maternal expulsive efforts (i.e. pushing). An intensive management of this phase is usual in France.
- Trial name
- PASST (NCT03018860)
- Testing
- "Moderate" management, "Intensive" management
- Where
- France
- Volunteers
- 1,701 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Labor Onset and Length Abnormalities
Goal-directed Labor Epidural Analgesia Maintenance
The GLEAM trial is a multicenter, pragmatic, cluster-randomized trial to assess the effects of programmed intermittent epidural bolus versus continuous epidural infusion on the rate of spontaneous vaginal delivery and several…
- Trial name
- GLEAM (NCT05255263)
- Testing
- PIEB, CEI
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Childbirth Experience, Urinary Retention
Analgesia in the Second Stage of Labour
This study investigates efficacy, safety and childbirth experience in women receiving pudendal block during the final stage of delivery. It is an observational study and half of included primarous women recieve a pudendal block.
- Conditions
- Childbirth Experience, Urinary Retention, Satisfaction, Personal, Pain, Obstetric
- Trial name
- ASL (NCT04391075)
- Testing
- Pudendal nerve block
- Volunteers
- 1,007 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Labor, Second Stage
Urinary Catheterization and Second Stage of Labor
Labor is divided into three stages: the first stage is from labor onset until full dilation, second stage is from full dilation until delivery of the baby, and the third stage from the delivery of the baby until the delivery of…
- Trial name
- cath2stage (NCT02198157)
- Testing
- urinary catheterization
- Where
- Israel
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Raed Salim
Sphincter (Anal); Perineal Rupture, Obstetric, Perineal Tear
One Plus One Equals Two, Will That do?
A new clinical practice to reduce perineal trauma has been adopted by many maternity wards in Sweden. This practice involves collegial midwifery assistance during the second stage of labor and the birth of the baby.
- Conditions
- Sphincter (Anal); Perineal Rupture, Obstetric, Perineal Tear, Pelvic Floor Disorders, Experience, Life
- Trial name
- Oneplus (NCT03770962)
- Testing
- Two midwives
- Where
- 4 sites in Sweden
- Volunteers
- 3,058 people
- Sponsor
- Region Skane
Pregnancy
Effects of Bupivacaine Induced Motor Blockade During the Second Stage of Labor
The aim of this study is to measure the effects of bupivacaine administered via epidural catheters on indices of motor blockade ascertained during the second stage of labor.
- Trial name
- BUP (NCT01621230)
- Testing
- Epidural Bupivacaine plus fentanyl, Epidural fentanyl
- Where
- United States
- Volunteers
- 481 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Labor
Dental Support Device in the Second Stage of Labor
Obstetric practices now allow for prolonged second stage of labor to accomplish vaginal delivery. However, this practice may lead to either operative delivery (vacuum or forceps assisted delivery) or cesarean section with…
- Trial name
- NCT03138798
- Testing
- Laboraide TM dental support device
- Where
- United States
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- Angela Bianco
Rupture of Membranes Prior to Onset of Labor, Induction of Labor
Intravenous Dexamethasone for Inducing Labor in Women With Term Pregnancy and Pre-Labour Rupture of Membranes
This clinical trial aims to determine whether giving intravenous dexamethasone can shorten the time it takes for women to deliver after labor induction in term pregnancies with pre-labour rupture of membranes (PROM).
- Conditions
- Rupture of Membranes Prior to Onset of Labor, Induction of Labor, Dexamethasone
- Trial name
- NCT07503184
- Testing
- Dexamethasone, Prostaglandin E1, Normal Saline
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Nishtar Medical University
Obstetric Labor Complications, Vacuum Extraction; Failure, Affecting Fetus or Newborn
Comparison of Prevention and Appropiate Obstetric Interventions for Prolonged Second Stage Labor at Term Pregnancies During Vaginal Delivery
Randomized Control Trial for Comparison of Prevention and Appropiate Obstetric Interventions for Prolonged Second Stage Labor at Term Pregnancies During Vaginal Delivery.
- Conditions
- Obstetric Labor Complications, Vacuum Extraction; Failure, Affecting Fetus or Newborn, Complicated Labour/Delivery Livebirth
- Trial name
- NCT04888871
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Labor Stage, Second
Obstetrical Gel Use to Shorten Labor and Prevent Lower Genital Tract Trauma
Recent literature shows that birth injury is associated with postpartum pelvic floor dysfunction (pelvic organ prolapse and fecal and urinary incontinence).
- Trial name
- NCT03518684
- Testing
- Natalis
- Where
- Lebanon
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Length of Labor, Second Stage of Labor
Effects of Rate and/or Presence of Dextrose on the Labor Course of Nulliparas
This randomized controlled trial aims to compare three groups of intravenous fluids and their impact on labor: 1) 125 mL/hr of 5% dextrose in normal saline 2) 250 mL/hr of normal saline 3) 250 mL/hr of 5% dextrose in normal saline
- Conditions
- Length of Labor, Second Stage of Labor, Intravenous Hydration of Labor
- Trial name
- NCT01904617
- Testing
- Dextrose, Normal Saline
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- MemorialCare Health System
Breast Milk Expression
Early Initiation of Milk Expression in Mothers of Very Low Birth Weight Infants
Compelling evidence exists that breast milk helps protect very premature infants from prematurity-specific morbidities. Unfortunately, mothers of premature infants often exhibit delayed lactogenesis stage II (when the milk "comes…
- Trial name
- NCT01892085
- Testing
- Early initiation, Intermediate expression, Late initiation
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Florida