Clinical trials: Labor, Second Stage
Perineal Tear, Perineum; Rupture
Vocalization for the Second Stage of Labor (VOCAL)
A randomized open-label trial will be conducted to evaluate the effect of vocalization as a perineal protection maneuver during the second period of labor.
- Trial name
- VOCAL (NCT03605615)
- Testing
- vocalization
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Parturition, Obstetric; Injury Pelvic Floor
Evaluation of the Effectiveness of Obstetric Lubricant Gel in Labor in Nulliparous and Primiparous Women: A Randomized Controlled Study
The investigators hypothesized that the application of lubricant gels at the beginning of the active phase of the labor may reduce duration of the delivery and episiotomy rates.
- Trial name
- NCT06069596
- Testing
- Natalis Obstetric Lubrican Gel
- Volunteers
- 220 people
- Sponsor
- Ankara University
Labor Pain
Effectiveness of Breathing Exercises During the Second Stage of Labor
To determine effectiveness of breathing exercises for pregnant women during the second stage of labor on maternal pain, duration of labor, dyspnea, oxygen saturation (SPO2) and the first-minute Appearance, Pulse, Grimace…
- Trial name
- NCT04556643
- Testing
- Breathing exercises
- Where
- Pakistan
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Abortion, Induced, Labor Stage, Third/Drug Effects
Oxytocin Infusion vs. Spontaneous Follow-up for Third-stage of Labor After Second-trimester Abortion
This study compares oxytocin infusion to spontaneous follow-up for third-stage of labor at induced mid-trimester abortions. Patients will be randomized to oxytocin infusion or observation with no pharmacologic intervention.
- Conditions
- Abortion, Induced, Labor Stage, Third/Drug Effects, Pregnancy Trimester, Second, Oxytocin/Administration & Dosage
- Trial name
- NCT02485444
- Testing
- Oxytocin
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Ataturk University
Childbirth, Aromatherapy
Comparison Of The Effects Of Swedish Massage With Natural Oils
Aim: This study aimed to evaluate the effects of Swedish massage combined with lavender and chamomile oils on childbirth outcomes during the first and second stages of labor.
- Conditions
- Childbirth, Aromatherapy, Pain Management, Fear
- Trial name
- Comparison (NCT07652957)
- Testing
- Aromatherapy and Massage Care for labor pain management
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Macular Edema Secondary to Retinal Vein Occlusion
A Study to Learn How Well a Higher Amount of Aflibercept Given as an Injection Into the Eye Works and How Safe it is in People With Reduced Vision Due to Swelling in the Macula, Central Part of the Retina Caused by a Blocked Vein in the Retina (Macula Edema Secondary to Retinal Vein Occlusion)
Researchers are looking for a better way to treat people who have macular edema secondary to retinal vein occlusion (RVO). In people with RVO, a blood vessel that carries blood away from the retina (vein) becomes blocked.
- Trial name
- QUASAR (NCT05850520)
- Testing
- Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_higher dose, Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_2 mg, Fluorescein
- Where
- 273 sites in United States, Australia and 25 more
- Volunteers
- 892 people
- Sponsor
- Bayer
Labor; Prolonged, Second Stage, Episiotomy Wound
The Impact of Different Skin Suture Methods in Episiotomy Repair on Healing and Pain
Episiotomy is the intentional incision of the perineum during vaginal birth in order to accelerate the active phase of labor. This study aimed to compare various skin closure techniques in episiotomy repair.
- Trial name
- NCT06379048
- Testing
- Mattress Suturing, Primary Suturing, Continuous Subcutaneous Suturing
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Pregnancies, Obstetric Labor
Head-perineum Distance and Delivery Mode
In a prospective cohort of patients in the second phase of labor, the investigators measured the head-perineum distance and correlate it to the mode of delivery (spontaneous delivery - instrumental delivery - ceasarean section).
- Trial name
- EchoPé (NCT04771091)
- Testing
- Mesure of head-perineum distance by transperineal ultrasound
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Rennes University Hospital
Delivery Outcomes
Interdisciplinary Practice Bundle for Second-Stage of Labor and Clinical Outcomes
This study aims to assess the effect of implementing an interdisciplinary practice bundle during second-stage of labor on clinical outcomes.
- Trial name
- NCT07055490
- Testing
- Interdisciplinary Practice Bundle
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Heat Therapy, Perineal Tear
The Effect of Using Perineal Warm Compress Techniques During the Second Stage of Labor on Perineal Outcomes
The goal of the clinical trial is to determine the effect of second-stage warm compress application on perineal pain and trauma among primiparous women.
- Conditions
- Heat Therapy, Perineal Tear, Pain, Labor
- Trial name
- NCT05955352
- Testing
- Perineal warm compression Technique
- Where
- Nepal
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Tribhuvan University, Nepal
Labor, Second Stage of Labor
The Effect of Chocolate Consumption During Labor on Second Stage Duration
Childbirth is an energy-intensive physiological process, requiring sustained effort comparable in intensity to moderate physical activity.
- Conditions
- Labor, Second Stage of Labor, Pregnancy
- Trial name
- NCT07375836
- Testing
- 50 g of milk chocolate cocoa content 25-30%
- Volunteers
- 180 people
- Sponsor
- Hillel Yaffe Medical Center
The Effect of Touching the Fetal Head of the Pregnant on the Duration of the Second Stage of Labor
The Effect of Touching the Fetal Head During the Perineal Crowning Phase
In this study, it is planned to shorten the second stage of labor by touching the fetal head during the second stage of labor. It is thought that touching will also have positive effects on the mother and the newborn.
- Trial name
- Touching (NCT06783972)
- Testing
- Touching
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ege University
Labor Stage, Second
Using a Mirror in the Second Stage of Labor: Effects on Duration and Birth Experience
This study aims to investigate the impact of using a labor mirror during the second stage of labor on both the duration of labor and the mother's overall experience.
- Trial name
- NCT06648161
- Testing
- Labor Mirror
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Resectable Non-small Cell Lung Cancer
A Trial to Learn if the Combination of Fianlimab, Cemiplimab, and Chemotherapy is Safe and Works Better Than the Combination of Cemiplimab and Chemotherapy in Adult Patients With Non-Small Cell Lung Cancer That Can be Treated With Surgery
This study is researching an experimental drug called fianlimab (also called REGN3767) with two other medications called cemiplimab and platinum-doublet chemotherapy, individually called a "study drug" or collectively called…
- Trial name
- NCT06161441
- Testing
- Fianlimab, Cemiplimab, Pemetrexed
- Where
- 123 sites in United States, Australia and 10 more
- Volunteers
- 195 people
- Sponsor
- Regeneron Pharmaceuticals
Prolonged Second Stage of Labor, Other Specified Trauma to Perineum and Vulva During Delivery
The Effect of Straining Techniques on Women and Newborn
Purpose: To examine the effects of straining techniques on the duration of labor, perineal trauma status and newborn apgar score. Method: This study is a randomized controlled trial.
- Conditions
- Prolonged Second Stage of Labor, Other Specified Trauma to Perineum and Vulva During Delivery, Newborn; Vitality
- Trial name
- NCT05578794
- Testing
- Straining types
- Where
- Turkey (Türkiye)
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Delivery, 2nd Stage of Labor
Study of the Type of Pushing at Delivery
The objective of this randomized clinical trial is to assess and compare the effectiveness of directed closed-glottis (Valsalva) pushing (pushing while holding one's breath) vs.
- Trial name
- EOLE (NCT02474745)
- Testing
- - Directed open-glottis pushing, Directed closed-glottis pushing
- Where
- France
- Volunteers
- 256 people
- Sponsor
- University Hospital, Clermont-Ferrand
Labor Pain, Labor; Prolonged, Second Stage
Remifentanil vs. Combined Spinal-epidural Analgesia for Labor Analgesia and Progress of Labor in Multiparous
Remifentanil may be an ideal drug for labor analgesia due to its pharmacodynamic and pharmacokinetic profile. As compared to epidural analgesia, it demonstrated satisfactory for pain relief at the beginning of labour with a…
- Conditions
- Labor Pain, Labor; Prolonged, Second Stage, Labor; Prolonged, First Stage
- Trial name
- NCT02963337
- Testing
- remifentanil, combined spinal-epidural analgesia
- Where
- Slovenia
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Second Stage of Labor
Caffeine in the Second Stage of Labor in Low-risk Nulliparous Mothers at Term
Single blind, randomized control trial to determine benefit of caffeine and sodium benzoate on the second stage of labor
- Trial name
- NCT05906303
- Testing
- Caffeine and Sodium Benzoate Injection, Normal Saline
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Reading Hospital and Medical Center
Second Stage of Labor
Searching for the Perfect Oil to Protect the Perineum: A Randomized-Controlled, Double-Blind Trial
In this study we intend to randomly assign each parturient one of two commonly used oils to be applied during the second stage of labor, one of them containing vitamin E.
- Trial name
- NCT00662974
- Testing
- perineal massage with Wheat Germ Oil during the second stage of labor, perineal massage with almond oil during the second stage of labor
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Post Partum Haemorrhage
Outcomes and Perceptions of the Implementation of the JADA Device in a Stage II Postpartum Hemorrhage Management Protocol in Referral Hospitals of the Colombian Pacific Region
This study focuses on postpartum hemorrhage (PPH), a condition that stands out as the leading cause of global maternal mortality. Annually, about 14 million women experience PPH, resulting in approximately 70,000 deaths.
- Trial name
- JADAValle (NCT06843265)
- Testing
- Vacuum- Induce Hemorrhage Control
- Volunteers
- 24 people
- Sponsor
- Fundacion Clinica Valle del Lili