Clinical trials: Labor Complication
Premature Infants
Targeted Protein Fortification in Extremely Low Birth Weight Preterm Infants
While new innovations in the care of extremely premature infants have led to decreased morbidity and mortality, poor postnatal growth remains as a major challenge.
- Trial name
- NCT02943746
- Testing
- Standard Protein Diet, High Protein Diet
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Postpartum Hemorrhage, Blood Loss, Postoperative
Comparing Tranexamic Acid Versus Ecbolics in Preventing Hemorrhage During and After Cesarean Section
The study will include 444 pregnant patients undergoing cesarean section in Kasr Al Aini. Following a proper medical history taking, examination will be done, investigations including laboratory tests and obstetric ultrasound…
- Conditions
- Postpartum Hemorrhage, Blood Loss, Postoperative, Cesarean Section Complications
- Trial name
- NCT06060327
- Testing
- Tranexamic acid
- Where
- 2 sites in Egypt
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hypoglycemia in Newborn Infants
Gel for Early Hypoglycaemia Prevention in Preterm Infants
The GEHPPI study is a multicentre placebo controlled randomized controlled trial that aims to prevent early hypoglycaemia in preterm newborns born at ≤32 week's gestation.
- Trial name
- GEHPPI (NCT04353713)
- Testing
- 40% Dextrose Gel, 2% carboxymethylcellulose gel
- Where
- 5 sites in Czechia, Ireland
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Preterm Birth
What is the Impact of Early Life Exposures on the Cardiovascular System in Young Adulthood?
The purpose of this study is to investigate whether early life exposures such as premature birth or exposure to preeclampsia before you are born results in long-term alterations in the cardiovascular system that increase risk of…
- Trial name
- EVS (NCT01487824)
- Where
- United Kingdom
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Psychological Distress
Preventing Premature Family Maladjustment: an e-Health Interdisciplinary Research
The consequences of preterm birth extend beyond the clinical conditions of the newborn, profoundly impacting the functioning and well-being of families.
- Trial name
- e-ParWelB (NCT06495762)
- Testing
- e-health assesment
- Where
- 6 sites in Italy
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
PreTerm Birth
The Effect of Zinc, β-carotene, and Vitamin D3 in Preterm Delivery Through Placental MyD88, TRIF, NFkB, and IL-1β
This study is a controlled trial which compares the effect of zinc, beta-carotene, and Vitamin D3 supplementation in pregnant women which has preterm birth.
- Trial name
- NCT03005496
- Testing
- Zinc, Nifedipine, Beta Carotene
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Preterm Birth
Hammock Positioning's Influence on the Electromyographic Activity in the Flexor Muscles in Newborn Preterm
The individual who is born premature, in addition to a CNS still in accelerated training suffers early loss of intrauterine restraint, conditions that promote hypotonia characteristic of premature birth.
- Trial name
- NCT02621996
- Testing
- hammock, containment nest
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Maternal Death, Neonatal Death
Evaluating the Effects of SMS Text Messaging Support System Among Frontline Health Workers in Ghana
Introduction Maternal and neonatal mortality continue to be to be prominent public health issues in sub Saharan Africa including Ghana, with slow progress made towards attainment of Millennium Development Goals (MDG) 4 \& 5.
- Conditions
- Maternal Death, Neonatal Death, Postpartum Haemorrhage, Pre-eclampsia
- Trial name
- Accelerate (NCT02468310)
- Testing
- Maternal and neonatal emergency protocols
- Where
- Ghana
- Volunteers
- 65,831 people, healthy volunteers welcome
- Sponsor
- Hannah Brown Amoakoh
Postpartum Hemorrhage
Impact of Uterotonic Agents on Isolated Human Myometrium
The purpose of this study is to compare the ability of a sample of uterine muscle tissue to contract in the presence of various drugs.
- Trial name
- NCT00989027
- Testing
- Oxytocin, Ergonovine, Carboprost
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Pregnancy, Eclampsia
A Cluster-Randomized Trial of Ultrasound Use to Improve Pregnancy Outcomes in Low Income Country Settings
In many low-income countries, the use of ultrasound by medical officers and non-physician health care staff (e.g., midwives) for antenatal identification of high risk pregnancies is a new intervention requiring authoritative…
- Conditions
- Pregnancy, Eclampsia, Placenta Previa, Stillbirth
- Trial name
- NCT01990625
- Testing
- Antenatal Ultrasound Scan
- Where
- 5 sites in Guatemala, Kenya and 3 more
- Volunteers
- 45,038 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature
Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA
This study is a non-blinded, prospective, randomized controlled trial designed to compare the effect of outpatient oral antibiotics (i.e., amoxicillin and azithromycin) on the length of time (days) that pregnancy continues after…
- Conditions
- Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture), Rupture of Membranes; Premature, Rupture of Membranes; Premature, Affecting Fetus, Preterm Birth
- Trial name
- NCT04047849
- Testing
- Antibiotics, oral Azithromycin and oral Amoxicillin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Woman's
Postpartum Hemorrhage
IV vs IM Oxytocin in the Third Stage of Labor for Prevention of Postpartum Hemorrhage
The study will evaluate whether prophylactic oxytocin administered in the third stage of labor via IV infusion results in a lower mean blood loss compared to IM injection.
- Trial name
- NCT01608958
- Testing
- Oxytocin
- Where
- 3 sites in Ecuador, Turkey (Türkiye) and 1 more
- Volunteers
- 653 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Healthy Participants
Rate of Tranexamic Acid Administration on Blood Pressure (RateTXA) Study.
Tranexamic acid is a well-established treatment for post-partum hemorrhage. This study aims to examine the effect of tranexamic acid administration rates on blood pressure changes over 1 minute compared to 10 minutes in healthy…
- Trial name
- RateTXA (NCT06356948)
- Testing
- Tranexamic Acid (TXA)
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Environmental Exposure, Pregnancy Related
Prenatal Education on Environmental Exposures During Pregnancy Study (PEEPS)
The purpose of this project is to reduce maternal environmental exposures to toxicants through a patient education program designed to help pregnant women learn about exposure through consumption of contaminated seafood and to be…
- Conditions
- Environmental Exposure, Pregnancy Related, Preterm Birth, Chronic Respiratory Disease
- Trial name
- PEEPS (NCT07758114)
- Testing
- Educational Intervention
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Depression, Child Development
Improving Preterm Outcomes by Safeguarding Maternal Mental Health
The investigators' goal is to optimize the developmental outcomes of preterm infants by preventing depression and improving functioning among their mothers during the critical first year of life.
- Trial name
- NCT01892982
- Testing
- Problem Solving Education tailored to NICU
- Where
- 4 sites in United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Placenta Accreta, Blood Pressure
CNAP vs IABP in Pregnant Women With Placenta Accreta
The objective of this study is to investigate a technique to monitor blood pressure in women undergoing cesarean delivery with suspected placenta accreta spectrum.
- Conditions
- Placenta Accreta, Blood Pressure, Hemorrhage, Hemorrhage, Postpartum
- Trial name
- NCT04671680
- Testing
- LiDCO CNAP Monitoring Equipment
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Cardiovascular Diseases
Continuation of the nuMoM2b Heart Health Study
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in U.S. women at all ages, and large knowledge gaps exist in CVD predictive and preventative strategies for women.
- Trial name
- nuMoM2b-HHS2 (NCT05472597)
- Where
- 14 sites in United States
- Volunteers
- 4,048 people, healthy volunteers welcome
- Sponsor
- RTI International
Postpartum Haemorrhage, Retained Placenta
Two Different Regimens of Misoprostol in Retained Placenta
This study evaluates intra umbilical vein injection of 800 µg versus 400 µg misoprostol for the treatment of retained placenta to reduce the need of manual removal of placenta under general anaesthesia
- Trial name
- NCT02704780
- Testing
- Misoprostol
- Where
- Iraq
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Premature Infants
The Effect of Using Clinical Guidelines on Kangaroo Care on Newborn and Maternal Outcomes
The aim of this study was to determine the effect of the use of clinical guidelines in kangaroo care (KB) practice on neonatal and maternal outcomes in premature infants.
- Trial name
- NCT05807191
- Testing
- Kangaroo care based on kangaroo care guide
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Preterm Birth, Parent-Child Relations
Biological Underpinnings of Socio-emotional Regulation in Preterm Infants and Healthy Controls
Preterm infants (PT) often need to spend their first weeks of life in the Neonatal Intensive Care Unit (NICU) where they are exposed to several adverse conditions.
- Conditions
- Preterm Birth, Parent-Child Relations, Epigenetics
- Trial name
- NCT05253924
- Testing
- DNA methylation of target genes, EEG acquisition
- Where
- Italy
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
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