Clinical trials: Labor Complications
Neonatal Complication, Labor (Obstetrics)--Complications
Can the Use of a Next Generation Partograph Improve Neonatal Outcomes? (PICRINO)
The overall aim is to evaluate the impact of the use of two different guidelines for monitoring labor progress, the WHOs LCG versus standard care, on neonatal and maternal outcomes.
- Trial name
- NCT05560802
- Testing
- WHOs Labour care guide
- Where
- 24 sites in Sweden
- Volunteers
- 120,000 people
- Sponsor
- Linkoeping University
Cesarean Section Complications
Tranexamic Acid for the Control of Blood Loss at Elective Cesarean Section
The aim of the study is to determine, out of two doses (a standard and a low dose) compared to placebo, the optimal and minimal dose of an intravenously administered single bolus of tranexamic acid(TA) to reduce blood loss when…
- Trial name
- NCT03710330
- Testing
- normal saline, 1gm tranexamic acid, 0.5 gm tranexamic acid
- Where
- Egypt
- Volunteers
- 360 people
- Sponsor
- Aswan University Hospital
Preterm Infants
Single-Session Physiotherapy Versus Massage in Premature Infants
This study investigates the effects of a single-session physiotherapy intervention compared to massage in premature infants hospitalized in the neonatal intensive care unit.
- Trial name
- SPIM-Preterm (NCT07207161)
- Testing
- Infant Massage, Physiotherapy (Moyer-Mileur Protocol)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Necmettin Erbakan University
Prematurity, Neonatal Encephalopathy
Evaluating the NeoTree in Malawi and Zimbabwe
Neonatal mortality remains unacceptably high. Globally, the majority of mothers now deliver in health facilities in low resource settings where quality of newborn care is poor.
- Conditions
- Prematurity, Neonatal Encephalopathy, Neonatal Sepsis, Neonatal Death
- Trial name
- NCT05127070
- Testing
- Neotree
- Where
- 5 sites in Malawi, Zimbabwe
- Volunteers
- 19,000 people
- Sponsor
- University College, London
Preterm Birth
Maternal and Fetal/Neonatal Pharmacokinetics and - Dynamics of Corticosteroids During Pregnancy
Improving pregnancy outcome is essential in improving health of both parents and their offspring during the life course. Preterm birth (PTB) occurs in 10-15% of all pregnancies, is the leading cause of perinatal mortality and…
- Trial name
- MaDyCo (NCT06264973)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Erasmus Medical Center
Preterm Membrane Rupture, Neonatal Sepsis
Comparison of the Effectiveness of Two Different Antibiotic Regimens of the Treatment of Pregnant Women With Preterm Rupture of Membranes
There is no consensus around the world on the treatment of preterm rupture of membranes, which is one of the important causes of early neonatal sepsis and one of the common causes of prematurity.
- Trial name
- NCT04528251
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Macrosomia, Fetal, Large for Gestational Age
Fetal Clavicular Measurement to Predict Fetal Macrosomia
Macrosomia is associated with increased risks for both the mother and the baby, including complications during delivery, injuries, and even death. The accurate diagnosis of macrosomia is often difficult before birth.
- Conditions
- Macrosomia, Fetal, Large for Gestational Age, Shoulder Dystocia
- Trial name
- NCT06283277
- Testing
- Obstetric Ultrasound
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Assiut University
Morbidly Adherent Placenta, Placenta Accreta
Delivery Timing in Morbidly Adherent Placentas: a Randomized, Controlled Trial
This is a randomized controlled trial to investigate the optimal timing of delivery in clinically stable women with a suspected morbidly adherent placenta.
- Trial name
- MAP (NCT02635412)
- Testing
- Scheduled timing of delivery
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Placenta Accreta Spectrum
Effectiveness of REBOA in Reducing Blood Loss During Cesarean Section in Patients with PAS
Obstetric hemorrhage is one of the leading causes of maternal mortality and morbidity worldwide. The major risk factors for obstetric hemorrhage include placenta previa and placenta accreta spectrum (PAS) disorders.
- Trial name
- NCT06721182
- Testing
- REBOA
- Volunteers
- 100 people
- Sponsor
- Nazarbayev University
Pain
Randomised Trial of Eutectic Mixture of Local Anaesthetics Cream and Oral Sucrose Solution for Venepuncture
This randomized bicentric trial will investigate the efficacy of topical EMLA cream with oral sucrose solution compared to oral sucrose solution alone before venepuncture in preterm infants.
- Trial name
- VIEP (NCT00470080)
- Testing
- venepuncture
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Preterm Birth
Does Fetal Fibronectin and Ultrasound Cervical Length Help in the Evaluation of Women With Suspected Preterm Labor?
The objective of this study is to investigate the effect of the use of both sonographic cervical length (CL) and fetal fibronectin (FFN) on the length of outpatient triage and preterm labor interventions in symptomatic women with…
- Trial name
- NCT00371046
- Testing
- Transvaginal ultrasound cervical length, Cervicovaginal fetal fibronectin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Premature Delivery
Interest of Placental Alpha-microglobulin-1 Detection Test to Assess Risk of Premature Delivery in Reunion Island
Prematurity is the leading cause of mortality and perinatal morbidity. Despite the many preventive measures and use of tocolytic therapy, the incidence of premature births has not decreased in recent decades.
- Trial name
- PARTOSURE-OI (NCT02904070)
- Testing
- Vaginal swabbing
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Hypoglycemia, Infant, Small for Gestational Age
Dextrose Gel Does Not Prevent Neonatal Hypoglycemia
This was a quasi-experimental pilot study comparing blood glucose values 30 minutes after feeding alone or feeding + dextrose gel in newborns at risk for transient neonatal hypoglycemia.
- Conditions
- Hypoglycemia, Infant, Small for Gestational Age, Premature Birth of Newborn, Fetal Macrosomia
- Trial name
- NCT02523222
- Testing
- 40% Dextrose gel
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Baylor College of Medicine
Prematurity
Preterm Neonates Brain Ultrasound With CEUS and Elastography
The aim of the study is to investigate levels of brain perfusion and elasticity in preterm neonates when they reach the estimated due date and to compare the data with magnetic resonance imaging at term.
- Trial name
- NCT05694611
- Testing
- Brain contrast enhanced ultrasound, brain ultrasound elastography, Sulfur Hexafluoride
- Where
- Finland
- Sponsor
- Turku University Hospital
Placenta Previa
Vaginal Progesterone Against a Second Attack of Antepartum Haemorrhage in Placenta Previa Women
Placenta praevia is associated with an increased risk of preterm delivery (PTD) especially if associated with bleeding and uterine contractions .
- Trial name
- NCT04725929
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Nourhan Ashraf ElSherbiny
Anemia, Ferritin
Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants
In developing countries up to 50% of children become anemic by 12 months of age(1. Iron deficiency anemia is a major risk factor for neonatal and infantile mortality and morbidity in Pakistan.
- Conditions
- Anemia, Ferritin, Complications, Hemorrhage
- Trial name
- NCT01081977
- Testing
- Early Cord Clamping, Delayed Cord Clamping
- Where
- Pakistan
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Motor Skills Disorders, Premature Birth
Premie DCD Imaging Intervention Study
This study will leverage a current longitudinal study of brain development in preterm children. In the Miller/Grunau Trajectories study, preterm children are returning for follow-up at 8-9 years.
- Trial name
- NCT04483401
- Testing
- Cognitive Orientation to Occupational Performance (CO-OP)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Postpartum Hemorrhage
Tranexamic Acid and Ethamsylate For Preventing PPH in Patient Undergoing LSCS at High Risk For PPH
The aim of this study is to compare the effect of low dose of Tranexamic acid (1gm) and Ethamsylate (1gm) after prophylactic oxytocin administration versus placebo with prophylactic oxytocin given in the 2 minutes after child…
- Trial name
- NCT02604719
- Testing
- Tranexamic Acid and Ethamsylate
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Ahmed Alanwar
Parenteral Nutrition, Necrotizing Enterocolitis
Neurodevelopment and Neuroimaging in Parenterally-fed Infants and Young Children
Manganese (Mn) is an essential metal required for normal growth and development. However, exposure to high Mn levels can be toxic to the brain.
- Conditions
- Parenteral Nutrition, Necrotizing Enterocolitis, Digestive System Abnormalities, Cholestasis
- Trial name
- NCT00392730
- Testing
- Remove Mn from PN if evidence of increased brain Mn on MRI
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Twin Pregnancy, Preeclampsia
Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies
Twin pregnancies are associated with increased risk of perinatal adverse outcomes , including preeclampsia , fetal growth restriction , preterm premature rupture of membranes and preterm birth.
- Conditions
- Twin Pregnancy, Preeclampsia, Preterm Birth, Fetal Growth Restriction
- Trial name
- NCT04051567
- Testing
- Aspirin 100mg
- Where
- China
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
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