Clinical trials: Labor Complications
Respiratory Distress Syndrome, Preterm Infant
Nasal High Frequency Oscillation Ventilation(NHFOV) for Respiratory Distress Syndrome
In very preterm infants with severe respiratory distress syndrome(RDS), invasive ventilation(IV) , besides nasal continuous positive airway pressure (NCPAP) and early/selective pulmonary surfactant administration, is one key…
- Trial name
- NHFOV (NCT03140891)
- Testing
- NHFOV, NCPAP
- Where
- China
- Volunteers
- 206 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Infant, Premature, Diseases, Birth, Preterm
The NEU-STIM Trial
The aim of this study is to determine the effect of repetitive tactile stimulation compared to selective stimulation on oxygenation of the infant at 5 minutes after birth.
- Trial name
- NEU-STIM (NCT05942924)
- Testing
- Repeated tactile stimulation, Selective tactile stimulation
- Where
- 43 sites in Austria, Belgium and 17 more
- Volunteers
- 3,280 people
- Sponsor
- Leiden University Medical Center
Preterm
Bovine Colostrum in Prevention of Sepsis and Retinopathy of Prematurity
The aim of this study is to evaluate efficacy of bovine colostrum administration as a prophylaxis to decrease the incidence and the occurrence of retinopathy of prematurity in preterm neonates of gestational age less than 32…
- Trial name
- NCT05438680
- Testing
- The bovine colostrum ( trade name : baby steps sachets, 300mg )
- Where
- 2 sites in Egypt
- Volunteers
- 200 people
- Sponsor
- Alexandria University
Preterm Birth, Bronchopulmonary Dysplasia
Improving Prematurity-Related Respiratory Outcomes at Vanderbilt
The goal of IMPROV is to identify molecular mechanisms that contribute to lung injury and long-term breathing problems in preterm infants by investigating two interrelated biochemical pathways: the urea cycle-nitric oxide pathway…
- Conditions
- Preterm Birth, Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity
- Trial name
- IMPROV (NCT01460576)
- Where
- 2 sites in United States
- Volunteers
- 253 people
- Sponsor
- Vanderbilt University Medical Center
Pregnancy
Studying Fetal Breathing Patterns
Some babies have difficulty breathing, sucking, and swallowing at birth. The purpose of this study is to determine (before birth) the variables that will predict whether a newborn will experience these problems.
- Trial name
- NCT00066976
- Where
- 2 sites in United States
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Fullterm Birth, Neonate
Assessment of Autonomic Maturation in Neonatal Period and Early Neural Development From a Longitudinal Prospective Cohort
The heart rate variability assessment of the sympathetic-parasympathetic balance is a strong analytical tool in the autonomic nervous system (ANS) physiology, at each end of life.
- Conditions
- Fullterm Birth, Neonate, Prematurity
- Trial name
- AUBE (NCT00951860)
- Testing
- Autonomic Nervous System activity
- Where
- France
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Quality Improvement, Breast-feeding
To Improve the Rate of Mother's Own Milk Feeding of Premature Infants in NICU
Thirteen hospitals in China will participate in the study, which objectives of this study is to improve the rate of mother's own milk feeding of premature infants in neonatal intensive care unit(NICU), evaluate the effectiveness…
- Conditions
- Quality Improvement, Breast-feeding, Premature Infant
- Trial name
- NCT04383379
- Testing
- Experimental: Intervention group
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Nanjing Medical University
Uterine Atony, Postpartum Hemorrhage
Oxytocin Regimen to Prevent Atony and Postpartum Hemorrhage During Vaginal Delivery: 3-arm RCT
This is a double-blind 3-arm randomized clinical trial to determine whether higher dose oxytocin regimens (compared to the standard regimen) reduce the frequency of uterine atony and postpartum hemorrhage after vaginal delivery.
- Trial name
- NCT00790062
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 1,798 people
- Sponsor
- University of Alabama at Birmingham
Postpartum Hemorrhage
Impact of Uterotonic Agents on Isolated Human Myometrium
The purpose of this study is to compare the ability of a sample of uterine muscle tissue to contract in the presence of various drugs.
- Trial name
- NCT00989027
- Testing
- Oxytocin, Ergonovine, Carboprost
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Premature Birth, Mothers of Newborn Infants
Maternal Self-efficacy and Motor Development in Premature Infants: Clinical Trial Protocol
Mothers of premature newborns face special home care situations due to the conditions of their children after hospital discharge; This requires promoting the positive perception of maternal self-efficacy and thus achieving the…
- Trial name
- NCT06420635
- Testing
- Interdisciplinary intervention program on maternal self-efficacy and the motor development of premature children, Traditional kangaroo program
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Universidad de la Sabana
Placenta Previa Without Hemorrhage
Uterine Artery Ligation to Decrease Blood Loss With Central Placenta Previa
This trial will address the effect of uterine artery ligation during Cesarean section in cases with placenta previa to decrease blood loss.
- Trial name
- NCT02002026
- Testing
- Uterine artery ligation
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Minia Maternity University Hospital
Placenta Accreta
Placenta Accreta Spectrum Disorders: A. Chohan Continuous Squeezing Suture (ACCSS)
Placenta Accreta Spectrum (PAS) disorders are rising in incidence due to increased rate of repeat caesarean sections. Peripartum hysterectomy remains the only definitive treatment of massive postpartum haemorrhage related to this…
- Trial name
- ACCSS (NCT05070689)
- Testing
- ACCSS
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Sharif Medical Research Center
Antepartum Bleeding, Preterm Birth
Progesterone and Second Trimester Bleeding
Working hypothesis and aims: To investigate whether progesterone treatment affects the incidence of preterm labor compared to placebo, among women with 2nd trimester bleeding.
- Trial name
- NCT01269450
- Testing
- micronized progesterone 200 mg (Utrogestan)
- Where
- 3 sites in Israel
- Volunteers
- 128 people
- Sponsor
- HaEmek Medical Center, Israel
Premature Birth, Bacterial Vaginosis
Effect of Probiotic Lactobacilli on Vaginal Flora of Pregnant Women at High Risk for Preterm Delivery
Purpose of the study is to determine the effect of probiotic lactobacilli on the vaginal flora and cytokine profile during pregnancy, and the incidence of preterm labour in women at high risk for preterm birth.
- Trial name
- NCT00217308
- Testing
- Lactobacilli GR-1 and RC-14
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Dysphagia of Newborn
The Effects of Pacifier-Activated Lullaby on Oral Feeding Among Preterm Infants
Preterm infants often have difficulty learning how to feed by mouth because the coordination of sucking, swallowing, and breathing develops later in pregnancy.
- Trial name
- Music therapy (NCT07819734)
- Testing
- Pacifier-Activated Lullaby (PAL) Therapy
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Preterm Infant
Effects of Two Modalities of Non-invasive Ventilation After Extubation in Very Low Birth Weight Neonates
The objective of this study is to evaluate the effects of continuous positive airway pressure and nasal intermittent positive pressure ventilation on breathing pattern variables of very low birth weight neonates immediately after…
- Trial name
- NCT03551314
- Testing
- Nasal Intermittent Positive Pressure, Continuous Positive Airway Pressure
- Where
- 2 sites in Brazil
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Anemia, Cervix Neoplasms
Will Radiation/Chemotherapy Treatment of Cervical Cancer Work Better With Medication That May Improve Anemia?
This is a clinical trial (a type of research study) designed to describe the efficacy (effectiveness) and toxicity (safety) of a new medical treatment, NESP (Novel Erythropoiesis Stimulating Protein).
- Trial name
- NCT00039884
- Testing
- NESP - Novel Erythropoiesis Stimulating Protein
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Mirhashemi, Ramin, M.D.
Cerebrovascular Circulation, Premature Infants
Automated Adjustment of Inspired Oxygen to Maintaining Regional Cerebral Oxygenation in Preterm Infants on Respiratory Support
Background: fluctuation of cerebral blood flow and oxygenation in neonates who undergo intensive care is an important risk factor for risk of neurodevelopmental impairment.
- Trial name
- NCT02748447
- Testing
- Automated FiO2 adjustment
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- ASST Fatebenefratelli Sacco
Post Partum Bleeding
Balloon Catheters in Cases of Abnormal Placentation
Placenta accreta is a relatively rare event, in which the placenta is abnormally implanted into the uterine myometrium. The most significant complication is intense bleeding, mainly during labor.
- Trial name
- Accreta (NCT01373255)
- Testing
- internal iliac catheterization
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- HaEmek Medical Center, Israel
Prematurity, Feeding Intolerance
Feeding Tolerance in Preterm Infants
Premature infants, especially those less than 1250 gm at birth are extremely difficult to feed. For unknown physiologic reasons oral feeding also called enteral feeding is not well tolerated in these immature babies.
- Trial name
- NCT00450697
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Weill Medical College of Cornell University
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