Clinical trials: Labor Delivery
Chickenpox, Rubella
MMR and Varicella Vaccine in Premature Infants
This research is designed to address the question, "Does the relative deficit in vaccine immunogenicity in extremely premature infants persist beyond the first 6 months of life?" We propose to measure the immunogenicity of…
- Conditions
- Chickenpox, Rubella, Rubeola, Mumps
- Trial name
- NCT00156559
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Pelvic Floor Disorders, Urinary Incontinence
Maternal Musculoskeletal Factors of the Hip, Lumbopelvic, Abdominal and Pelvic Floor Regions and Their Association With Mode of Delivery and Postpartum Pelvic Floor Dysfunction
This prospective observational cohort study aims to investigate the association between maternal musculoskeletal factors of the hip, lumbopelvic, abdominal, and pelvic floor regions and childbirth outcomes, as well as their…
- Conditions
- Pelvic Floor Disorders, Urinary Incontinence, Perineal Trauma, Pelvic Floor Dysfunction
- Trial name
- NCT07478159
- Testing
- Maternal Musculoskeletal Assessment
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Twin Pregnancy With Antenatal Problem, Preterm Birth
Cerclage for Twins With Short Cervical Length ≤ 15mm
This is a multicenter randomized study designed to determine if ultrasound indicated cerclage reduces the incidence of spontaneous preterm birth <34 weeks in asymptomatic women with twin gestations and cervical length ≤15mm…
- Conditions
- Twin Pregnancy With Antenatal Problem, Preterm Birth, Short Cervix
- Trial name
- TWIN-UIC (NCT03340688)
- Testing
- Cervical cerclage
- Where
- 8 sites in United States, Egypt and 2 more
- Volunteers
- 200 people
- Sponsor
- Thomas Jefferson University
Labor Onset, Gravidity
Correlation Between Coital Activity During Pregnancy and Premature Delivery Related to Prostanoid Receptor Polymorphisms
The purpose of our study is correlate between premature delivery (between week 23-35 of the pregnancy) in women that had intercourse up to 12 hours prior to beginning of labor and polymorphisms in the gene Prostanoid receptor.
- Trial name
- NCT00433303
- Testing
- Correlation between early delivery and coital activity
- Where
- Israel
- Sponsor
- Shaare Zedek Medical Center
Neonatal Respiratory Distress Syndrome, Prematurity
Breathing Variability and NAVA in Neonates
The current study is a crossover trial, aiming at evaluating the effect of NAVA -NIV compared to Nasal Intermittent Positive Pressure Ventilation (PC-NIV) at the same level of peak inspiratory pressure, in terms of…
- Trial name
- BRAVe NANO (NCT04000568)
- Testing
- Respiratory support: NAVA -NIV and PC-NIV
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Prematurity, Apnea
Caffeine to Reduce Mechanical Ventilation in Preterm Infants
Most premature infants require mechanical ventilation for prolonged periods of time and a significant proportion of them develop Bronchopulmonary Dysplasia (BPD).
- Conditions
- Prematurity, Apnea, Respiratory Failure
- Trial name
- NCT01751724
- Testing
- Caffeine citrate, Normal saline
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Miami
Retinopathy of Prematurity, Pain
The Effect of Eyemasks on Neonatal Stress Following Dilated Retinal Examination
Although screening exams for retinopathy of prematurity (ROP) prevent blindness they are physiologically stressful for infants. The investigators postulate that photosensitivity during mydriasis contributes to post-examination…
- Conditions
- Retinopathy of Prematurity, Pain, Premature Infant, Retinal Disease
- Trial name
- MASK-ROP (NCT03824782)
- Testing
- Phototherapy Mask
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Sunnybrook Health Sciences Centre
Premature Birth, Obstetric Labor, Premature
Family Nurture Intervention in the NICU
The purpose of this study is to compare neurodevelopment and activity in infants born very preterm (26 to 33 6/7 weeks gestational age (GA)) receiving Standard Care (SC) or Family Nurture Intervention (FNI) in the neonatal…
- Trial name
- NCT02710474
- Testing
- Family Nurture Intervention, Standard Care
- Where
- 2 sites in United States
- Volunteers
- 461 people
- Sponsor
- Columbia University
Pregnancy Preterm, Premature Birth
The Periviable GOALS Decision Support Tool
The Periviable GOALS (Getting Optimal Alignment around Life Support) decision support tool (DST) is meant to facilitate informed shared decision-making regarding neonatal resuscitation for families facing the threat of a…
- Conditions
- Pregnancy Preterm, Premature Birth, Pregnancy Complications, Obstetric Labor, Premature
- Trial name
- NCT05264779
- Testing
- Periviable GOALS DST
- Where
- 12 sites in United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Apnea, Infant, Premature
Randomized Trial of Nasal Continuous Positive Airway Pressure or Synchronized Nasal Ventilation in Premature Infants.
Very premature infants uniformly do not have mature functioning lungs to breathe well nor mature regulation mechanisms to breathe regularly. Assistance with a mechanical respirator is common.
- Conditions
- Apnea, Infant, Premature, Bronchopulmonary Dysplasia
- Trial name
- NCT00188968
- Testing
- Nasal Continuous Positive Airway Pressure, Synchronized Nasal Positive Pressure Ventilation
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- University of Manitoba
White Matter Injury, Brain Injury, Fetus and Neonate
Neonatal White Matter Injury Trial (WRAP)
The researchers are investigating a new treatment for white matter injury, which is a common type of brain injury in premature babies. The drug, clemastine, is experimental.
- Conditions
- White Matter Injury, Brain Injury, Fetus and Neonate, Neonatal Brain Injury, Periventricular Leukomalacia
- Trial name
- WRAP (NCT07688746)
- Testing
- Clemastine fumarate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Bridget LaMonica Ostrem, M.D., Ph.D.
Pre-eclampsia, Preterm Birth
Maternal Serum Markers Predicting Preeclampsia At Early Gestations
This observational study aims to assess the effectiveness of a maternal blood test as a prognostic tool for predicting early pregnancy risk of preeclampsia (PE).
- Trial name
- NCT05131282
- Testing
- Blood test of PE risk, Blood test of Preterm PE risk
- Where
- 6 sites in China
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- HBI Solutions Inc.
Failed Induction of Labor
Concurrent Oxytocin With Membrane Sweeping Versus Dinoprostone Pessary in Labor Induction of Multiparous Women at Term
The purpose of this study is to compare concurrent oxytocin with membrane sweeping versus dinoprostone pessary in labor induction for multiparas at term with an unfavorable cervix.
- Trial name
- NCT02618096
- Testing
- Oxytocin, Dinoprostone, Membrane sweeping
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Seoul National University Hospital
Pregnancy
Studying Fetal Breathing Patterns
Some babies have difficulty breathing, sucking, and swallowing at birth. The purpose of this study is to determine (before birth) the variables that will predict whether a newborn will experience these problems.
- Trial name
- NCT00066976
- Where
- 2 sites in United States
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Preterm Infant, Placental Insufficiency
Effect of Delayed Cord Clamping in Preterm Neonates With Placental Insufficiency
To investigate the effect of delayed cord clamping (DCC) on hematopoietic progenitor cells (HPCs), hematological parameters including haemoglobin concentration and hematocrit value in premature infants (34 weeks gestational age…
- Conditions
- Preterm Infant, Placental Insufficiency, Placental Transfusion
- Trial name
- NCT03731546
- Testing
- Delayed cord clamping
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University Children Hospital
Labor Pain
Failure of Vaginal Delivery After Induction
The study will compare the number of women who deliver vaginally after artificial initiation of labor pains(i.e. induction of labor) by two methods.
- Trial name
- NCT02758340
- Testing
- Misoprostol, foley's balloon catheter
- Where
- Pakistan
- Volunteers
- 335 people, healthy volunteers welcome
- Sponsor
- Karachi Medical and Dental College
Feeding Difficulties, Sucking Behavior
Premature Infant Oral Motor Intervention vs. Pacifier for Oral Feeding Transition in Preterm Infants
This study compares three approaches to help premature babies learn to feed by mouth: a special mouth exercise program (called PIOMI), using a pacifier, and standard care.
- Conditions
- Feeding Difficulties, Sucking Behavior, Premature
- Trial name
- PIOMI (NCT07460089)
- Testing
- Premature Infant Oral Motor Intervention (PIOMI), Pacifier Use (Non-Nutritive Sucking)
- Where
- Iraq
- Volunteers
- 150 people
- Sponsor
- University of Baghdad
Heart Rate Variability, Preterm Infant
Skin to Skin and Heart Rate Variability
The objective of this study is to monitor heart rate variability in preterm infants receiving respiratory support, including conventional mechanical ventilation, during skin-to-skin care.
- Trial name
- NCT05018910
- Testing
- Skin to Skin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of New Mexico
Preeclampsia
Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery
Preeclampsia is a syndrome that occurs in approximately 3% to 8% of pregnancies and is associated with considerable maternal and neonatal morbidity and mortality.
- Trial name
- RAAPID-II (NCT01404910)
- Testing
- Apheresis using Liposorber LA-15 System
- Where
- 3 sites in United States, Germany
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Prematurity, Neonatal Screening
Amino Acid and Acylcarnitine Profiles in Premature Neonates
Primary Hypotheses of the study include: Metabolic profiles are influenced by gestational age, chronological age, type and degree of nutritional support and illness Metabolic profiles differ between neonates who receive…
- Conditions
- Prematurity, Neonatal Screening, Parenteral Nutrition
- Trial name
- NCT00865150
- Where
- 2 sites in United States
- Volunteers
- 1,003 people, healthy volunteers welcome
- Sponsor
- Pediatrix
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