Clinical trials: Labor Epidural Analgesia
Labor Pain
Programmed Intermittent Epidural Bolus for Labor Analgesia During First Stage of Labor: A Sequential Allocation Trial to Determine the Optimum Interval Time Between Boluses of a Fixed Volume of 2.5ml of Bupivacaine 0.25% Plus Fentanyl 8 mcg/ml
Programmed intermittent epidural bolus (PIEB) is a technique of epidural analgesia in which boluses of local anesthetic solutions are injected into the epidural space at a fixed time interval.
- Trial name
- NCT03735771
- Testing
- Bupivacaine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Effects of; Anesthesia, in Labor and Delivery, Pregnancy
Effects of Analgesic Techniques on Duration of Labor for Induction Patients
The purpose of this study is to determine if there is a difference in the duration of the first stage of labor in nulliparous women scheduled for an induction of labor, with whom analgesia is maintained with a combined spinal…
- Conditions
- Effects of; Anesthesia, in Labor and Delivery, Pregnancy, Prolonged First Stage of Labor
- Trial name
- NCT01982851
- Testing
- Epidural de novo, CSE
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Obstetric Labor
Multicenter Study of Chloroprocaine Versus Ropivacaine for Epidural Labor Analgesia
Women requiring epidural labor analgesia were randomized into two groups, one with the local anesthetic chloroprocaine and the other with ropivacaine.
- Trial name
- NCT06472232
- Testing
- Chloroprocaine
- Volunteers
- 356 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Analgesia, Obstetrical, Post-Dural Puncture Headache
Intrathecal Catheter Placement Versus Resiting Epidural Catheter After Dural Puncture in Obstetric Patients
Epidural anesthesia represents the most popular method for pain relief during labour. Unintentional dural puncture (UDP) occurs in 0.4-1.5% of labour epidural analgesia, representing therefore the most common complication.
- Trial name
- ItaREVI (NCT05977361)
- Testing
- Resiting Epidural Catheter, Intrathecal Catheter Placement
- Volunteers
- 181 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Labor Pain
Intermittent Ropivacaine Bolus for Epidural Labor Analgesia
Enhanced patient safety and satisfaction have contributed to growing use of epidural labor analgesia. Epidural analgesia appears to be currently the most effective technique in reducing pain during labor.
- Trial name
- OptimEpi (NCT02809742)
- Testing
- Ropivacaine
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Pierre and Marie Curie University
Epidural Anesthesia in Labor and Delivery
Pocket Warming of Epidural Medication
This study will examine recent claims regarding the beneficial effect of warming epidural medications in order to hasten the onset of labor analgesia.
- Trial name
- NCT02912078
- Testing
- Pocket-warming, Standard of Care Labor Epidural
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Ohio State University
Analgesia
Effect of Auto-Bolus Interval on Analgesic Quality During Labor Analgesia With Dural Puncture Epidural
It is aimed in this study to compare the effect of changing the interval time for programmed auto boluses of local anaesthetics on the total anesthetic consumption and quality of labor analgesia with dural puncture epidural…
- Trial name
- NCT06329713
- Testing
- Group I: 30 Min Interval Time, Group II: 60 Min Interval Time
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Depression, Postpartum, Labor Pain
CSE v. Epidural for Postpartum Depression
The purpose of this pilot prospective randomized control trial is to compare the initiation of labor epidural analgesia by combined spinal epidural vs. epidural for the influence on risk for postpartum depression symptoms.
- Trial name
- COPE (NCT03022526)
- Testing
- CSE, Epidural, Bupivacaine / fentaNYL
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Obstetric Labor
Carbohydrate-Optimized Nutritional Solution Versus Electrolyte Hydration in Labor
This is a pilot randomized, triple-blind clinical trial (pilot RCT) evaluating the preliminary effects of energy supplementation with carbohydrate-rich sports gels compared to a low-sugar sports drink during labor in low-risk…
- Trial name
- NCT07742748
- Testing
- High carbohydrate sports gel, Low carbohydrate hydrogel
- Where
- Spain
- Volunteers
- 147 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Labor Pain
Epidural Analgesia Versus IV Meperidine for Labor Pain Control
60 female that care for pain control during second stage of delivery, will choose between epidural or systemic analgesia. Continuous ECG (3 lead)monitoring will be recorded during the second stage for 10 minutes.
- Trial name
- NCT00296751
- Testing
- ECG recording, Epidural catheter insertion, Intravenous meperidine injection
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Epidural Analgesia, Labor Pain
Dexmedetomidine-esketamine-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia
Sufentanil-ropivacaine combination is commonly used for epidural labor anesthesia, but is associated with some adverse events. Dexmedetomidine and esketamine, each has been effectively used for neuraxial anesthesia in combination…
- Conditions
- Epidural Analgesia, Labor Pain, Sufentanil, Dexmedetomidine
- Trial name
- NCT07145775
- Testing
- sufentanil-ropivacaine combination, dexmedetomidine-esketamine-ropivacaine combination 1, dexmedetomidine-esketamine-ropivacaine combination 2
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University First Hospital
Preterm Birth
Labor Characteristics and Maternal-Infant Outcomes in Preterm Primiparous Women
This retrospective observational study evaluates labor characteristics in primiparous women with spontaneous preterm birth at different gestational ages and examines their associations with maternal and neonatal outcomes.
- Trial name
- NCT07844499
- Testing
- Gestational Age at Delivery
- Where
- China
- Volunteers
- 436 people
- Sponsor
- Maternal and Child Health Hospital, Jiading District
Labor Pain, Analgesia, Epidural
A Study on the Effect of Position on Walking Labour Epidural Efficacy
This study is being done to better understand how patient positioning can affect pain relief after an epidural. In addition to pain, the investigators will assess how position affects epidural spread, and its effects on maternal…
- Trial name
- NCT04469101
- Testing
- Lumbar Epidural
- Where
- Canada
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Labor Pain, Epidural
A Comparison Between 2 Methods of Local Anesthetic Administration for Maintaining Labor Analgesia After Dural Puncture Epidural
Intermittent epidural bolus technique opens a new era of interest for maintaining labor anlagesia. The study examines programmed intermittent epidural bolus technique on a scheduled basis to provider-administered bolus anlgesia…
- Conditions
- Labor Pain, Epidural, Pain, Labor
- Trial name
- NCT05034211
- Testing
- Programmed intermittent bolus epidural, Provider administered analgesia on patient request
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aretaieio Hospital
Labor Pain
Epidural Fentanyl-bupivacaine Versus Clonidine-bupivacaine for Breakthrough Pain in Advanced Labor
Epidural analgesia is widely regarding as the most effective analgesic strategy for labor pain. Modern practice is to utilize dilute local anesthetics as a continuous infusion along with an opioid, e.g., our common "recipe" of 12…
- Trial name
- NCT00691795
- Testing
- Clonidine or fentanyl
- Where
- United States
- Sponsor
- Columbia University
Labor (Obstetrics)--Complications
Scheduled Positioning With a Peanutball(SPP) on Labor Outcomes Among Primiparous Women Under Epidural Analgesia
Brief Summary The goal of this clinical trial is to evaluate whether scheduled maternal position changes using a peanut birthing ball improve labor outcomes in low-risk, primiparous women receiving epidural analgesia during…
- Trial name
- Peanutball (NCT07333209)
- Testing
- Scheduled Maternal Positioning with use of peanutball
- Where
- Qatar
- Volunteers
- 110 people
- Sponsor
- Hamad Medical Corporation
Shivering, Labor
Investigating the Effect of Acupressure on Shivering During a Cesarean Delivery in Women Who Were Previously Laboring With an Epidural
Shivering during a cesarean section can be quite uncomfortable for the patient as well as make it difficult for the anesthesiologist to obtain vital signs.
- Conditions
- Shivering, Labor, Cesarean Delivery
- Trial name
- NCT03497507
- Testing
- Acupressure bracelet
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Labor Pain
Dexmedetomidine for Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia
The aim of this study is to compare two modes of labour epidural analgesia: programmed intermittent epidural boluses (PIEB) versus continuous epidural infusion (CEI), with patient controlled epidural analgesia (PCEA), using…
- Trial name
- NCT05781854
- Testing
- Epidural analgesia with bupivacaine and dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
To Determine the Onset of Analgesia (Numerical Rating Scale for Pain = 1) in Minutes
Comparison of Labor Analgesia Between Modified Combined Spinal-Epidural and Dural Puncture Epidural Techniques
Epidural, Combined Spinal-Epidural, and more recently dural puncture epidural are forms of neuraxial anesthesia used to provide pain relief in laboring women .
- Trial name
- NCT03258879
- Testing
- Modified CSE, Dural puncture epidural
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Labor Pain, Analgesia
Comparison of Epidural, Combined and Dural Puncture Labor Epidural on Pain, and Course of Vaginal Delivery
The three standard techniques used for labor analgesia, thus epidural, combined spinal-epidural and dural puncture epidural will be compared regarding their impact on pain intensity, analgesic and local anesthetic consumption and…
- Trial name
- NCT04290702
- Testing
- regional analgesia for labor
- Where
- 2 sites in Greece
- Volunteers
- 90 people
- Sponsor
- University of Athens