Clinical trials: Labor Stage, First
Meconium Stained, Azithromycin
Efficacy of Azithromycin in MSAF Cases to Improve Maternal and Neonatal Outcomes
Meconium stained amniotic fluid increases the risk of maternal complications (e.g., dystocia, operative delivery, and postpartum endometritis) and neonatal complications (e.g., sepsis, admission to the neonatal intensive care…
- Conditions
- Meconium Stained, Azithromycin, Postpartum Endometritis
- Trial name
- NCT05118984
- Testing
- Azithromycin capsule (Zithromax, Pfizer) (250 mg)
- Where
- 2 sites in Egypt
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Cairo University
Prolonged Labor
Prediction of Delivery Mode by Ultrasound-assessed Fetal Position in Nulliparous Women With Prolonged First Stage of Labor.
In the past years, numerous studies have been published on the use of ultrasound during labor, showing this is an effective, accurate and objective tool for the assessment of the fetal head position and station.
- Trial name
- NCT05206409
- Testing
- Ultrasound
- Where
- Egypt
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Meditation
Meditation in Early Labor: Impact on Self-Efficacy and Childbirth Fear in First-Time Mothers
Aim-Introduction: The feeling of uncertainty about what will happen during labor, and the mother's perception of inadequacy regarding childbirth, can lead to anxiety and stress in some pregnant women, resulting in fear of…
- Trial name
- NCT07201220
- Testing
- meditation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Seyhan District Health Directorate, Adana
Effects of Movement
Upright Position During First Stage of Labour
There are several physiological advantages for being upright during labour. These include the effect of gravity on the fetus within the uterus; reduced risk of aorto-caval compression this maximizes uterine blood flow to the…
- Trial name
- NCT05392660
- Testing
- assumed upright position during first stage of labor
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Advanced Non-small Cell Lung Cancer, HER2 Mutation
A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called human epidermal growth factor receptor 2 (HER2) mutations.
- Trial name
- SOHO-02 (NCT06452277)
- Testing
- Sevabertinib, Pembrolizumab, Cisplatin
- Where
- 279 sites in United States, Argentina and 34 more
- Volunteers
- 444 people
- Sponsor
- Bayer
Parkinson's Disease
Study to Assess Real Life Effectiveness of Foslevodopa/Foscarbidopa in Adult German Participants at Initial Stages of Advanced Parkinson's Disease (EARLY-FOS)
Parkinson's disease (PD) is a neurological condition, which affects the brain. PD gets worse over time, but how quickly it progresses varies a lot from person to person.
- Trial name
- NCT06916507
- Where
- 19 sites in Germany
- Volunteers
- 125 people
- Sponsor
- AbbVie
Labor Pain
Programmed Intermittent Epidural Bolus for Labor Analgesia During First Stage of Labor: A Sequential Allocation Trial to Determine the Optimum Interval Time Between Boluses of a Fixed Volume of 2.5ml of Bupivacaine 0.25% Plus Fentanyl 8 mcg/ml
Programmed intermittent epidural bolus (PIEB) is a technique of epidural analgesia in which boluses of local anesthetic solutions are injected into the epidural space at a fixed time interval.
- Trial name
- NCT03735771
- Testing
- Bupivacaine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Labor (Obstetrics)--Complications, Labor; Prolonged, First Stage
BUSCLAB - Buscopan to Prevent Slow Progress in Labor
To study the effect of Butylscopolamine Bromide on duration of the active phase of first stage of labor in first time mothers who cross the alert-line for labor dystocia, according to the WHO partograph.
- Trial name
- NCT03961165
- Testing
- Butylscopolamine Bromide 20 MG/ML, Sodium Chloride 9mg/mL
- Where
- Norway
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Normal Labor
Paperless Partograph for Management of Low Risk Labor
Paperless partograph is a technique used for monitoring the progress of labor before delivery, and arriving at the accurate time to intervene for ensuring a safe delivery.
- Trial name
- NCT02714270
- Testing
- modified partograph, paperless partograph
- Where
- Egypt
- Volunteers
- 370 people
- Sponsor
- Assiut University
Substance Abuse, Substance Dependence
Cognitive Remediation and Work Therapy in the Initial Phase of Substance Abuse Treatment
The initial phase of substance abuse treatment is a vulnerable period for relapse. Cognitive impairments are common during this phase and may reduce the ability to benefit from other forms of substance abuse and rehabilitation…
- Conditions
- Substance Abuse, Substance Dependence, Cognitive Impairment
- Trial name
- NCT01410110
- Testing
- Cognitive Training + Work Therapy, Work Therapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Yale University
Labor Pain
Intravenous Infusion of Paracetamol for Intrapartum Analgesia of Labor
This is a double-blind randomized trial evaluates the efficacy of intravenous infusion of Paracetamol as intrapartum analgesic in the first stage of labour.
- Trial name
- NCT01428375
- Testing
- (1) Paracetamol injection, Sterile water
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Healthy
A Trial to Learn if REGN7999 is Safe and Well Tolerated, and How it Works in the Body of Healthy Participants
The primary objective of the study is to evaluate the safety and tolerability of single ascending intravenous (IV) and subcutaneous (SC) doses of REGN7999 in healthy adult participants.
- Trial name
- NCT05481333
- Testing
- REGN7999
- Where
- Belgium
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Labor Stage, First, Prolonged Labor
Maternal Maneuvers During Prolonged Labor
This pilot, randomized control trial will test whether or not a specific circuit of position changes improves maternal outcomes in cases of prolonged labor.
- Trial name
- CIRCUIT (NCT06636149)
- Testing
- Circuit of maternal position changes during labor
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Washington University School of Medicine
Labor Stage, First, Labor Stage, Second
Intrapartum Hydration
The purpose of this study is to determine that maternal hydration during labor with fluids containing glucose at a rate of 125 ml per hour does not affect the duration of labor compared to Ringer Lactate at a rate of 250 ml per…
- Trial name
- NCT01242293
- Testing
- 0.9% Saline with glucose 5%, Ringer lactate, Ringer lactate - Controls
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- HaEmek Medical Center, Israel
Pregnancy Related
The Effect of Hot Perfoming on the Soles of the Feet in the First Stage of Labor on Labor
This research was conducted to determine the effect of applying heat to the soles of the feet during the active phase (5-10 cm dilation) of the first stage of labor. It is a randomized controlled experimental study.
- Trial name
- NCT06518772
- Testing
- hot application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cumhuriyet University
Duration of Labor.
The Impact of Papaverine on First Stage of Labor
In the investigators institution, there is a wide use of Papaverine in delivery room, but this use is optional, and is left to the discretion of the physician.
- Trial name
- NCT02362139
- Testing
- The study group
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- eran ashwal
Obstetric Complication
Maternal Positioning to Correct Fetal Occiput Posterior
In evaluating a patient's ability to have a normal vaginal delivery, a practitioner must consider three factors. Commonly referred to as the three P's, these include Power (contractions), Passage (pelvis and soft tissue) and…
- Trial name
- NCT05307393
- Testing
- Positioning
- Where
- United States
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Labor, Pregnancy
The Effects of Warm Showers Application in Birth on Birth Pain, Birth Satisfaction and Birth Results
The use of non-pharmacological methods in labor pain is very important in order to improve the birth process, increase comfort and provide relaxation.
- Conditions
- Labor, Pregnancy, First Stage of Labor
- Trial name
- NCT05335681
- Testing
- Warm Showers Application
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Augmentation, Induction
The Effect of Consumption of Date Fruit and Nipple Stimulation in Late Pregnancy
The study was conducted to determine the effect of consumption of date fruit and nipple stimulation on labor. The samples were applied to pregnant women satisfying the research criteria in a state hospital in Istanbul between…
- Conditions
- Augmentation, Induction, Labor, Stimulation, Self
- Trial name
- NCT06280911
- Testing
- Date Fruit group, Nipple group
- Where
- Turkey (Türkiye)
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Pregnancy Related
Epidural Versus Low-dose Spinal for Analgesia of Late First Stage of Labor
The aim of this study is to compare the effect of epidural analgesia versus low-dose spinal analgesia in parturient in the late first stage of labor regarding time needed to perform the block, duration of the intra- and…
- Trial name
- NCT05056142
- Testing
- Epidural Anesthesia, Spinal Analgesia
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University