Clinical trials: Labor and Delivery
Premature Birth
Neonatal Precursors of Neurodevelopment
The NEOPRENE project proposes to examine processes that are among the earliest precursors of cognitive functions and assess 1) the relationship between neonatal cognitive precursors and cortical structure, structural connectivity…
- Trial name
- NEOPRENE (NCT04703010)
- Testing
- Electroencephalography-Near infrared spectroscopy, Magnetic resonance imaging, Psychometric testing
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Caen
Working Memory
Development of a Model-based Working Memory Training and Investigation of Its Comparative Efficacy
This study is to investigate the efficacy of model-based Working Memory (WM) training using an appropriate control condition. The interventions are a model-based, a single-task and a multiple-task training on WM in order to…
- Trial name
- sMarT (NCT04042779)
- Testing
- model-based WM training, single-task WM training, multiple-task WM training
- Where
- Switzerland
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Cervical Incompetence
Cervical Occlusion Double-level Stitch Application
Cervical insufficiency is defined as painless dilatation of the cervix during the second trimester of pregnancy. As a result of shortening and opening of the cervix, despite the lack of uterine contractions, the fetal membranes…
- Trial name
- COSA (NCT05268640)
- Testing
- Double-level cervical cerclage, Single-level cervical cerclage
- Where
- 7 sites in Poland
- Volunteers
- 81 people
- Sponsor
- Centre of Postgraduate Medical Education
Preterm Birth
A Novel Technique for Prediction of Preterm Birth: Fetal Breathing Patterns
Preterm birth refers to a delivery that occurs before 37 weeks of gestation. Identification of those who will eventually deliver in the preterm period is very important.
- Trial name
- NCT03655379
- Testing
- Fetal nasal Doppler by ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Baskent University Ankara Hospital
Preterm Delivery
Serum Ferritin Concentration and Fetal MCA Doppler as Predictors for Preterm Delivery
Pregnant women with iron deficiency anemia during third trimester will be assessed for serum ferritin and peak systolic value for fetal middle cerebral artery to find out their correlation with preterm delivery.
- Trial name
- SFMCA (NCT02420743)
- Testing
- serum ferritin, MCA Doppler
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Prematurity
The Effect of Music on Preterm Infant's Brain Development
Studying the effect of music intervention on preterm infants' brain development by MRI and neurodevelopmental assessments
- Trial name
- NCT03689725
- Testing
- Music
- Where
- Switzerland
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Pediatric Clinical Research Platform
Cerebral Palsy, Intraventricular Hemorrhage
Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial)
As many more premature infants survive, the numbers of these infants with health problems increases. The rate of cerebral palsy (CP) in extremely premature infants is approximately 20%.
- Conditions
- Cerebral Palsy, Intraventricular Hemorrhage, Periventricular Leukomalacia, Pulmonary Edema
- Trial name
- BEAM (NCT00014989)
- Testing
- magnesium sulfate
- Where
- 17 sites in United States
- Volunteers
- 2,136 people
- Sponsor
- The George Washington University Biostatistics Center
Threatened Abortion, Pre-Eclampsia
Progesterone for First Trimester Vaginal Bleeding
The purpose of this study is to investigate whether treatment with progesterone for patients with first trimester vaginal bleeding will alter the rates of obstetrical complications and adverse pregnancy outcomes.
- Conditions
- Threatened Abortion, Pre-Eclampsia, Abruptio Placentae, Fetal Growth Retardation
- Trial name
- NCT01501890
- Testing
- dihydroxyprogesterone caproate
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Preterm Birth, Low Birth Weight
Perinatal Conditions Influencing Morbidity, Mortality, and Medical Care in Newborns
This study focuses on understanding the conditions that affect newborn health and survival from pregnancy to the first weeks of life at the Isidro Ayora Hospital.
- Conditions
- Preterm Birth, Low Birth Weight, Intrauterine Growth Restriction (IUGR), Perinatal Asphyxia
- Trial name
- UCE (NCT06653374)
- Testing
- Infant, Premature
- Where
- Ecuador
- Volunteers
- 26,000 people
- Sponsor
- HOSPITAL GINECO OBSTETRICO ISIDRO AYORA
Pre-eclampsia, Preterm Birth
Maternal Serum Markers Predicting Preeclampsia At Early Gestations
This observational study aims to assess the effectiveness of a maternal blood test as a prognostic tool for predicting early pregnancy risk of preeclampsia (PE).
- Trial name
- NCT05131282
- Testing
- Blood test of PE risk, Blood test of Preterm PE risk
- Where
- 6 sites in China
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- HBI Solutions Inc.
Mother-Child Relations, Preterm Birth
The 2015 Pelotas (Brazil) Birth Cohort Study
This is the fourth birth cohort to be carried out in the city of Pelotas (Brazil) including more than 4 thousand children followed-up since the pre-natal period to study maternal-child health.
- Conditions
- Mother-Child Relations, Preterm Birth, Infant Development, Breast Feeding
- Trial name
- NCT03271723
- Testing
- Observational study
- Where
- Brazil
- Volunteers
- 4,275 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Premature Birth, Premature Labor
Treatment of Preterm Labor With 17 Alpha-hydroxyprogesterone Caproate
The goal of our research will be to determine the effectiveness of 17 alpha-hydroxyprogesterone caproate (17P) in the treatment of preterm delivery.
- Trial name
- NCT00120640
- Testing
- 17 hydroxyprogesterone caproate intramuscular injections
- Sponsor
- Yale University
Pain, Labor
Analysis of Pain Management and Pain Perception Intrapartum and Postpartum in Women with Vaginal Births in Difference Between Physician-led and Midwife-led Birth
The aim of the analysis is to describe the differences and similarities in obstetric pain management and pain perception intrapartum and postpartum in women with vaginal births in contrast to physician-led births and midwife-led…
- Trial name
- NCT06357468
- Testing
- midwife-led births in low risk women in pregnancy
- Where
- Germany
- Volunteers
- 237 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Neonatal Respiratory Distress Syndrome, Prematurity
Breathing Variability and NAVA in Neonates
The current study is a crossover trial, aiming at evaluating the effect of NAVA -NIV compared to Nasal Intermittent Positive Pressure Ventilation (PC-NIV) at the same level of peak inspiratory pressure, in terms of…
- Trial name
- BRAVe NANO (NCT04000568)
- Testing
- Respiratory support: NAVA -NIV and PC-NIV
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Neonatal Intensive Care Unit
Reducing Fluids Intakes in Neonatal Intensive Care
During stay in the neonatal intensive care unit, newborns requires various treatments administered intravenously. The hidden fluid intake associated with these infusion can lead to fluid overlad, increasing the risk of…
- Trial name
- REFINI (NCT07715513)
- Testing
- hidden fluid intake
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Clermont-Ferrand
Post Partum Hemorrhage
Oxytocin in Cesarean Delivery
In this study the investigators hypothesize that infused combinations of oxytocin and ergometrine will exhibit fewer cardiac and neurological side effects than equipotent infusion of oxytocin alone.
- Trial name
- NCT01236482
- Testing
- Oxytocin versus oxytocin-ergometrine
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Hadassah Medical Organization
Von Willebrand Diseases
Von Willebrand Factor in Pregnancy (VIP) Study
In pregnant women with von Willebrand disease (VWD) who by the third trimester do not have von Willebrand factor (VWF) or factor VIII (FVIII) levels greater than 50-100%, specific guidance is lacking for delivery planning in…
- Trial name
- VIP (NCT04146376)
- Testing
- Use of a postpartum diary and additional blood draws, VWF replacement therapy with Wilate, Tranexamic acid
- Where
- 11 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Washington
Prematurity
Effect of Osteopathic Manipulative Treatment on Reduction of Pain in Complicated Newborns: RCT
The aim of the present 3 armed placebo control parallel group randomized control trial is to explore the extent to which osteopathic manipulative treatment is effective in reducing pain in a population of complicated newborns.
- Trial name
- NCT02146690
- Testing
- osteopathic manipulative treatment, usual care
- Where
- Italy
- Volunteers
- 225 people
- Sponsor
- European Institute for Evidence Based Osteopathic Medicine
Language Development
Language Development in Preterm Children
This research investigates the ways in which preterm birth affects how very young children learn to speak and understand language, and how older children gain efficiency in language processing.
- Trial name
- NCT01599780
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Stanford University
Preterm Birth, Short Cervix
Pessary Versus Progesterone in Singletons
This study compares the effectiveness of cervical pessary to vaginal progesterone for prevention of preterm birth in women with singleton pregnancies and a cervix ≤25 mm.
- Trial name
- NCT04300322
- Testing
- Cervical pessary, Vaginal Progesterone
- Where
- 3 sites in Vietnam
- Volunteers
- 804 people
- Sponsor
- Mỹ Đức Hospital