Clinical trials: Laboratory Procedure Development and Validation
Infections, Infection, Bacterial
Development and Validation of (Bio)Sensors for the Identification of Pathogens
The recent COVID-19 pandemic has revealed the need to develop tests that are accurate, rapid, and inexpensive for the diagnosis of infectious diseases.
- Conditions
- Infections, Infection, Bacterial, Infection Viral, Infection, Parasite
- Trial name
- NCT06548841
- Testing
- Nanobiotechnology platforms
- Where
- Italy
- Volunteers
- 149 people
- Sponsor
- University of Bologna
Frail Elderly Syndrome, Surgery
Development and Validation of a Preoperative Frailty Index Using Health Administrative Data
The investigators will create a frailty index using health administrative data available for older people having surgery. The index will be based on the Canadian Study of Health and Aging Frailty Index and standard…
- Conditions
- Frail Elderly Syndrome, Surgery, Outcomes, Predictive Value of Tests
- Trial name
- NCT03354546
- Testing
- Frailty index
- Volunteers
- 511,285 people
- Sponsor
- Ottawa Hospital Research Institute
Vision Disorder
A Novel Acuity Testing Method
The purpose of this protocol is to develop a valid, reliable, better standardized, and more efficient test of visual acuity (ability to see fine details) for use in clinical trials.
- Trial name
- NCT00013936
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Eye Institute (NEI)
Refractive Errors, Low Vision
A Web-based Digital Distance Visual Acuity Test
Primary objective of this study is the development and validation of a web-based application for the examination of the distance visual acuity of normal- and low-vision patients.
- Conditions
- Refractive Errors, Low Vision, Vision Disorders
- Trial name
- DDVIT (NCT04756596)
- Testing
- DDVIT testing, ETDRS testing
- Where
- 2 sites in Greece
- Volunteers
- 300 people
- Sponsor
- Democritus University of Thrace
Intermittent Self Catheterization
Intermittent Catheterization Acceptance Test
The aim of the study is to create and validate a specific test named Intermittent Catheterization Acceptance Test (I-CAT), assessing "the acceptance" of clean intermittent self catheterization (CISC) in a neurological and no…
- Trial name
- I-CAT (NCT01651546)
- Testing
- Intermittent catheterization test
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
NAFLD, NASH - Nonalcoholic Steatohepatitis
Development and Validation of a Multi-target, Blood-based NAFLD Diagnosis Test
Multi-omics approach was used to identify patterns of serological biomarkers to diagnose NAFLD. The purpose of this study is to develop and validate a blood-based assay to diagnose NAFLD by collecting blood sample from healthy…
- Trial name
- NCT05108415
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- HBI Solutions Inc.
Functional Capacity
6-Minute Walk Test Assessment Via Mobile App
This study aims to develop an Android-based 6-Minute Walk Test (6MWT) application to facilitate quick and efficient functional capacity assessment in clinical settings.
- Trial name
- NCT06839521
- Testing
- Walk Test-T, Walk Test-A
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Autism, ADHD
Five Digits Test - Validation of a Neuropsychological Test of Inhibition for Patients With Neuropsychiatric Conditions
Neuropsychiatric conditions such as Attention Deficit Hyperactivity Disorder (ADHD) and autism are characterized by specific deficits in cognitive functions.
- Trial name
- NCT07531914
- Testing
- Five Digits Test
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Umeå University
Osteo Arthritis Knee
Comprehensive Knee Osteoarthritis Index (CKOAI): Scale Development, Validation and Reliability Testing
Background: Symptoms, balance, mobility, activities of daily life (ADL) and quality of life (QoL) are to be considered in rehabilitation of the individuals with knee osteoarthritis (IKOA).
- Trial name
- CKOAI (NCT03498833)
- Testing
- Test-retest reliability testing
- Where
- India
- Volunteers
- 52 people
- Sponsor
- Maharishi Markendeswar University (Deemed to be University)
Laboratory Procedure Development and Validation
Specimen Collection Study for Development and Validation of Laboratory Procedures
Biologic samples are necessary for development and validation of laboratory procedures (e.g. novel biological and analytical assays, explant tissue models, validation of specimen collection and transport) to support future…
- Trial name
- NCT01236027
- Testing
- no intervention
- Where
- United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Non Small Cell Lung Cancer (NSCLC), Melanoma (Skin Cancer)
Neutrophil Biomarker Test for Predicting Clinical Benefit From Immunotherapy Based on Flow Cytometry Analysis
The NeutroFlow study is a multi-center clinical trial designed to develop a computational model that converts flow cytometry results into a prediction of clinical benefit.
- Conditions
- Non Small Cell Lung Cancer (NSCLC), Melanoma (Skin Cancer), Triple Negative Breast Cancer (TNBC), RCC, Renal Cell Cancer
- Trial name
- NEUTROFLOW (NCT07246759)
- Testing
- Blood sample collection
- Where
- 3 sites in Germany, Italy and 1 more
- Volunteers
- 600 people
- Sponsor
- OncoHost Ltd.
Healthy
The Closed Kinetic Chain Lower Extremity Stability Test (CKCLEST): A New Clinical Performance Test
It becomes important to evaluate closed kinetic chain activity. The aim of this study was to develop and to determine the test-retest, intra- and interreliability, and validity of the Closed Kinetic Chain Lower Extremity…
- Trial name
- NCT04695574
- Testing
- Some clinical evaluation performance tests together with procedure of Closed Kinetic Chain Lower Extremity Stability Test
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gazi University
Thrombocytopenia, Platelet Transfusion
Role of Viscoelastometric Testing in the Development and Validation of a Clinical-biological Score for Predicting Bleeding in Patients With Malignant Haematological Disorders and Severe Thrombocytopenia
The goal of this single-center, non-controlled, non-randomized exploratory clinical trial is To develop and validate a clinical-biological score (VISCOTHEM score) incorporating viscoelastometric tests parameters; based on an…
- Conditions
- Thrombocytopenia, Platelet Transfusion, Haemorrhage, Hematologic Malignancies
- Trial name
- VISCOTHEM-2 (NCT07653672)
- Testing
- Additional blood sample
- Where
- France
- Volunteers
- 410 people
- Sponsor
- Centre Hospitalier Annecy Genevois
Aging, Cognitive Performance
Development, Validity, and Reliability of the Reactive Skill Test in Older Adults
Aging is associated with cognitive and physical decline, leading to an increased risk of falls in older adults. Recent evidence highlights the critical role of cognitive functions-such as attention, memory, and executive…
- Trial name
- NCT07103837
- Testing
- Reactive Skill Test
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Cerebral Palsy (CP), Developmental Coordination Disorder (DCD)
Experimental Validation of the Virtual Eggs Test (VET) in the Pediatric Population
This study aims to investigate the validity of the Virtual Egg Test (VET) for the assessment of manual dexterity in children and adolescents with cerebral palsy and developmental coordination disorder (experimental group)…
- Trial name
- VET-PED (NCT07793032)
- Testing
- Virtual Eggs Test (VET)
- Where
- Italy
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Athletic Performance, Upper Extremity
DEVELOPMENT AND PSYCHOMETRIC EVALUATION OF THE NEUROCOGNITIVE UPPER EXTREMITY TESTS: A RELIABILITY AND VALIDITY STUDY
The goal of this observational study is to develop an upper extremity neurocognitive performance test battery, determine its reliability and validity, and investigate the effect of neurocognitive load on test performance in…
- Conditions
- Athletic Performance, Upper Extremity, Cognition, Physical Functional Performance
- Trial name
- NCT07579676
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Stroke
Development and Validation of a Language Screening Test in Acute Right Hemispheric Strokes
This is a bi-centric study whose main objective is the validation of a rapid screening test for language disorders in the acute phase of right hemisphere stroke.
- Trial name
- R-LAST (NCT03622606)
- Testing
- Right Language screening test (R-LAST)
- Where
- 2 sites in France
- Volunteers
- 400 people
- Sponsor
- Versailles Hospital
Cystic Fibrosis
The iStep Study: Development and Validation of an Incremental Exercise Step Test for Children With Cystic Fibrosis
The progression of lung disease in cystic fibrosis (CF) results inevitably in a reduction in exercise capacity. The assessment of fitness and exercise capacity in CF is an important measure of the impact of the disease process…
- Trial name
- NCT02199340
- Testing
- iStep exercise test, CPET exercise test
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Insulin Sensitivity/Resistance
Assessment of Insulin Sensitivity in Healthy Adults by a 13C-glucose Breath Test : Method Development and Validation
The current research project aims to assess the insulin resistance (less sensitivity), from measures of insulin and glucose in response to a standard oral intake of glucose (standardized oral glucose tolerance test).
- Trial name
- NCT06766617
- Testing
- 75 gr Glucose
- Where
- Switzerland
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Chest Tubes, Cognitive Skill
Development and Validation of a Theoretical Test for Chest Tube Insertion
The goal of the proposed study design is to develop and gather validity evidence of a theoretical test about cognitive skills which are important when performing Chest Tube Insertion (CTI).
- Trial name
- NCT05384327
- Testing
- Interview, Multiple Choice Question (MCQ) Test
- Where
- Belgium
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University Ghent