Clinical trials: Laboratory Procedure Development and Validation
Renal Failure, End Stage Renal Disease
Development, Feasibility Testing and Validation of a Survey Set to Measure Patient-Reported Outcomes Among Hemodialysis Patients in Turkey
Development, feasibility testing and validation of a Survey Set to Measure Patient-Reported Outcomes among Hemodialysis Patients in Turkey: Creating and testing an electronic patient questionnaire that is suitable to measure…
- Trial name
- DOPRO (NCT05441020)
- Testing
- Administration of patient questionnaire
- Where
- 7 sites in Turkey (Türkiye)
- Volunteers
- 173 people
- Sponsor
- Fresenius Medical Care Deutschland GmbH
Chronic Urticaria
Validation of an Urticaria Control Test
The aim of this study is to validate a previously developed patient reported outcome instrument (in project UCT-D) to assess disease control in chronic urticaria patients (Urticaria Control Test - UCT) of age 12 and older.
- Trial name
- UCT-V (NCT01614834)
- Where
- 2 sites in Germany
- Volunteers
- 120 people
- Sponsor
- Charite University, Berlin, Germany
Stroke, Spatial Neglect
Validation of Web-Based Star Cancellation and Line Bisection Tests in Hemiplegic Stroke
The goal of this observational study is to evaluate the clinical usability and diagnostic performance of newly developed web-based Star Cancellation and Line Bisection tests in assessing visuospatial neglect in hemiplegic stroke…
- Conditions
- Stroke, Spatial Neglect, Spatial Neglect After Stroke
- Trial name
- NCT07538076
- Testing
- Web-Based Star Cancellation Test, Web-Based Line Bisection Test
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Dengue
Dengue - Sample Collection Study Pakistan
The objective of this study is to collect well-characterized serum and plasma specimens from confirmed dengue positive and dengue negative subjects to support dengue diagnostic products development.
- Trial name
- NCT07203183
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Abbott Rapid Dx
Heparin-induced Thrombocytopenia
Heparin-Induced Thrombocytopenia: Development and Validation of a Predictive Clinical
Although Heparin-induced thrombocytopenia (HIT) is a rare complication of heparin treatment, it results in a high rate of morbidity and mortality, the cumulative rate of thrombosis recurrence, amputation and death approaching 52…
- Trial name
- Score-TIH (NCT00748839)
- Where
- 27 sites in France
- Volunteers
- 2,700 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Lung Cancer, Red Blood Cells
The Red Blood Cells Based Blood Test for Lung Cancer EARLY Detection
This study plan to enroll 852 patients with pulmonary nodules smaller than 3 cm in diameter, whose DNA and RNA will be extracted from mature red blood cells isolated from peripheral blood.
- Conditions
- Lung Cancer, Red Blood Cells, Methylation
- Trial name
- NCT05380999
- Testing
- Methylation tests of nucleic acids extracted from mature red blood cells (RBCs)
- Volunteers
- 852 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Growth Hormone Deficiency
Comparative Validation of the Growth Hormone Releasing Hormone and Arginine Test for the Diagnosis of Adult Growth Hormone Deficiency
The aim of the study is to determine the specificity and sensitivity of the combined growth hormone releasing hormone (GHRH) + Arginine test in healthy volunteers, subjects with highly probable adult growth hormone deficiency…
- Trial name
- NCT01060488
- Testing
- GHRH+Arg, GHRH+Arg, ITT, ITT, ITT, GHRH+Arg.
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Cardiac Arrythmias, Valve Heart Disease
FRAILTY Classification Algorithm for the Corsano CARDIOWATCH 287-2: a Development and Validation Study
The FRAILTY-CARDIOWATCH study is investigating how well the Corsano CardioWatch 287-2, a wrist-worn medical device, can classify frailty in patients.
- Conditions
- Cardiac Arrythmias, Valve Heart Disease, Cardiac Ischemia
- Trial name
- FRAILTY-CW2 (NCT06930833)
- Testing
- Corsano CardioWatch 287-2
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Corsano Health B.V.
Child Development, Child Development Disorder
The Indonesian Version of Ages and Stages Questionnaire III Accuracy Compared to Bayley Scales of Infant Development III
This study aimed to evaluate the concurrent validity information of the 24-, 30-, and 36-month Indonesian ASQ-3 with the Bayley Scales of Infant and Toddler Development 3rd Edition (BSID-III) in Indonesian children.
- Conditions
- Child Development, Child Development Disorder, Development Delay, Developmental Delay
- Trial name
- NCT05408351
- Where
- Indonesia
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Normal Healthy Volunteers
Development and Validation of a Novel Stereoacuity Test Using Head-mounted Display
This prospective study investigated the validity and test-retest reliability of stereopsis test using head-mount display (HMD). Contour-based circles (crossed disparity: 1,960 to 195 arc of seconds(arc secs)) were generated as…
- Trial name
- NCT03234504
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Asphyxia Neonatorum
Biomarkers And Neurological Outcome in Neonates (BANON)
Validation of biomarkers in a human population for their ability to diagnose the severity of neonatal asphyxia. These biomarkers linked to asphyxia have been identified in animal studies and a preliminary human study.
- Trial name
- NCT03357250
- Where
- 11 sites in Germany
- Volunteers
- 553 people, healthy volunteers welcome
- Sponsor
- Life Science Inkubator
Cancer
Development and Validation of the EFT for Adolescents With Cancer
There is increasing evidence of interventions shown to be effective to promote physical activity in adolescents with cancer. Nevertheless, adolescents with cancer become physically inactive after the end of the interventions.
- Trial name
- NCT05304988
- Testing
- Testing of the EFT
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- The Hong Kong Polytechnic University
Liver Diseases, Healthy
Blood Collection for Development and Validation of Point-of-Care Diagnostic Liver Function Tests
This is an observational study exploring the performance of a novel point-of-care diagnostic testing platform designed to quantitate the presence of liver function biomarkers such as bilirubin.
- Conditions
- Liver Diseases, Healthy, Liver Cirrhosis, Liver Fibrosis
- Trial name
- NCT05457543
- Testing
- Adult
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Group K Diagnostics Inc.
Melioidosis, Systemic Inflammatory Response Syndrome
Study to Obtain Blood and Voided Urine Samples to Improve the Diagnosis of Melioidosis
Clinical samples [blood and voided urine (only for phase A)] from patient recruited at Sihanouk Hospital Centre of HOPE (SHCH) and HOPE Community Medical Center (CMC) will be processed (decontamination) and shipped to SRI…
- Conditions
- Melioidosis, Systemic Inflammatory Response Syndrome, Suspected or Confirmed Bloodstream Infections
- Trial name
- NCT02668406
- Testing
- Venous blood sampling (2 timepoints) (Phase A and B), Venous blood sampling (1 timepoint) (Phase A and B), Voided urine sampling (first sample) (Phase A)
- Where
- 2 sites in Cambodia
- Volunteers
- 4,203 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Colo-rectal Cancer, Cancer Colon
AI-EMERGE: Development and Validation of a Multi-analyte, Blood-based Colorectal Cancer Screening Test
Freenome is using a type of artificial intelligence, called machine learning, to identify patterns of cell-free biomarkers in blood to detect cancer early.
- Conditions
- Colo-rectal Cancer, Cancer Colon, Cancer, Rectum, Neoplasms,Colorectal
- Trial name
- NCT03688906
- Where
- 30 sites in United States, Canada
- Volunteers
- 3,275 people, healthy volunteers welcome
- Sponsor
- Freenome Holdings Inc.
Validity-evidence for a Simulator-based Test, Virtual Simulation
Development and Validation of a Simulator-based Test in Transurethral Resection of Bladder Tumors
Bladder cancer (BC) is the seventh most common cancer in men worldwide and fourth most common cancer among Danish men. BC is estimated to be the most cost expensive cancer pr. patient life.
- Conditions
- Validity-evidence for a Simulator-based Test, Virtual Simulation, Bladder Cancer, Surgical Skill Training
- Trial name
- NCT03863028
- Testing
- Simulation training
- Where
- 2 sites in Denmark
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pectus Excavatum
Field-test and Psychometric Validation of the Pectus Excavatum Evaluation Questionnaire in the Dutch Pectus Excavatum Population
A questionnaire that can measure disease severity from the patients perspective in patients with pectus excavatum already exists in English (Pectus Excavatum Evaluation Questionnaire; PEEQ).
- Trial name
- TRANSLATE (NCT06918392)
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Erik de Loos
Chromosome 13 Aneuploidy, Chromosome 18 Aneuploidy
Non-invasive Prenatal Diagnostic Validation Study
The primary purpose of this study is to collect maternal blood samples from pregnant women to develop a non-invasive prenatal diagnostic test based on fetal DNA isolated from maternal blood.
- Conditions
- Chromosome 13 Aneuploidy, Chromosome 18 Aneuploidy, Chromosome 21 Aneuploidy, Sex Chromosome Aberrations
- Trial name
- NIPD (NCT01574781)
- Testing
- Blood draw, Cheek swab/Saliva Sampling
- Where
- United States
- Volunteers
- 1,781 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Ulcerative Colitis (Disorder)
Development and External Validation of a Machine Learning Model for Pre-Endoscopic Prediction of Montreal Disease Extent (E1/E2/E3) in Ulcerative Colitis Using Symptoms, Signs, and Laboratory Tests: A Multicenter Retrospective Observational Study
This multicenter retrospective observational study aims to develop and externally validate a machine learning model that predicts Montreal ulcerative colitis (UC) disease extent (E1: limited/proctitis; E2: left-sided; E3…
- Trial name
- NCT07721987
- Volunteers
- 1,500 people
- Sponsor
- Beijing University of Chinese Medicine
Skin Cancer, Diagnostic
Validation of Clinical Biomarkers Using Spatial Transcriptomics and Development of a Diagnostic Test to Characterize the Progression Potential of Cutaneous Precancerous Lesions
Actinic keratoses are precancerous skin lesions that are the most common among all cancers and precancerous conditions in fair-skinned populations.
- Trial name
- DIAGNO-KA (NCT07624981)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville